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Researcher Publications

X. F. Steven Zheng, PhD

Selected Publications

  • Tsang, CK, Chen, M., Cheng, X., Qi, YM, Cehn, Y., Das, I., Li., XX., Vallat, B., Fu, LW, Qian, CN., Wang HY, White, E., Burley, S., and Zheng, X.F. SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation Molecular Cell 2018, 70:502-515. PMID:29727620.
    Featured Article in the June 2018 Issue of Molecular Cell; Preview, Molecular Cell 70, 383-384; Meet with Author
  • Zhang H, Li, XX, Yang, Y, Zhang, YJ, Wang, HY and Zheng, X.F. Significance and Mechanism of Androgen Receptor (AR) Overexpression and AR-mTOR Crosstalk in Hepatocellular Carcinoma. Hepatology 2018. 67:2271-2286. doi: 10.1002/hep.29715.
  • Li, Y., Kwan Tsang, C., Wang, S., Li, X., Yang, Y., Fu, L., Huang, W., Li, M., Wang, H.-Y. and Zheng, X.F. MAF1 Suppresses AKT-mTOR Signaling and Liver Cancer through Activation of PTEN Transcription. Hepatology, (2016). 63:1928-42. doi: 10.1002/hep.28507.
  • Wu, TJ, Wang, XW, Zhang, YJ, Meng, L.H., Kerrigan, J, Burley, SK and Zheng, X.F. Identification of a non-gatekeeper hotspot for drug-resistant mutations in mTOR kinase using a novel S. cerevisiae system, Cell Reports, 2015; 11:446-459
  • Thomas JD*, Zhang, YJ*, Wei, YH, Cho JH, Wang HY and Zheng, X.F. Rab1 is an mTORC1 activator and a colorectal oncogene. Cancer Cell 2014; 26, 754–769 (*co-first authors)
    Featured in Preview by Cancer Cell 26:601–602; Research Watch by Cancer Discovery 4:1366
  • Tsang, CK, Liu, Y, Thomas, JD, Zhang, YJ and Zheng, X.F. Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance, Nature Communications, 2014; 5:3446 doi:10.1038/ncomms4446
  • Wei, Y.H., Tsang, C.K., and Zheng, X.F. Regulatory Mechanisms of Pol III-dependent Transcription by TORC1, The EMBO Journal, 2009; 28: 2220-2230
  • Tsang, C.K., Li, H. and Zheng, X.F. Nutrient Starvation Promotes Condensin Loading to Maintain rDNA Stability, The EMBO Journal 2007; 26: 448-458.
    This paper was featured in: EMBO Journal Online, 2007
  • Tsang, C.K. Qi, H.Y. Liu, L.F. Zheng, X.F. Targeting mammalian target of rapamycin (mTOR) for health and diseases, Drug Discovery Today 2007; 12: 112-124
  • Li, H., Tsang, C.K., Watkins, M., Bertram, P.G. and Zheng, X.F. Nutrient Regulates Tor1 Nuclear Localization and Association with rDNA Promoter, Nature 2006; 442, 1058-1061
    This paper was featured by the following journals:
    Science’s STKE Vol. 2006, Issue 351, pp. tw302, 5 September 2006;
    Cell Metabolism 2006, 4:259-260;
  • Tsang, C.K., Bertram, P.G., Ai, W.D., Drenan, R. and Zheng, X.F. Chromatin-mediated Regulation of Nucleolar Structure and RNA Polymerase I Localization by TOR, The EMBO Journal 2003; 22: 6045-6056
  • Choi, J.H., Bertram, P.G., Drenan, R., Carvalho, J., Zhou, H. and Zheng, X.F. FKBP12-Rapamycin-Associated Protein (FRAP) Is A CLIP-170 Kinase, The EMBO Reports 2002; 3: 988-994
  • Ai, W.D., Bertram, P.B., Tsang, C.K, Chan, T.F. and Zheng, X.F. Regulation of Subtelomeric Silencing during Stress Response, Molecular Cell 2002; 10: 1295-1305
  • Choi, J., Adames, N.R., Chan, T.F., Zeng, C.B., Cooper, J.A. and Zheng, X.F. TOR Signaling Regulates Microtubule Stability and Functions. Current Biology 2000; 10: 861-864
  • Chan, T.F., Carvalho, J., Riles, L. and Zheng, X.F. A Chemical Genomics Approach towards Understanding the Global Functions of TOR. Proc Natl Acad Sci USA 2000; 97: 13227-13232

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