Guo Laboratory - Select Publications

  1. Zhong H, Lu W, Tang Y, Wiel C, Wei Y, Cao J, Riedlinger G, Papagiannakopoulos T, Guo JY, Bergo MO, Kang Y, Ganesan S, Sabaawy HE, Pine SR. SOX9 drives KRAS-induced lung adenocarcinoma progression and suppresses anti-tumor immunity. Oncogene. 2023. Epub 20230531. doi: 10.1038/s41388-023-02715-5. PubMed PMID: 37258742.
  2. Cararo Lopes E, Sawant A, Moore D, Ke H, Shi F, Laddha S, Chen Y, Sharma A, Naumann J, Guo JY, Gomez M, Ibrahim M, Smith TL, Riedlinger GM, Lattime EC, Trooskin S, Ganesan S, Su X, Pasqualini R, Arap W, De S, Chan CS, White E. Integrated metabolic and genetic analysis reveals distinct features of human differentiated thyroid cancer. Clin Transl Med. 2023;13(6):e1298. doi: 10.1002/ctm2.1298. PubMed PMID: 37317665; PMCID: PMC10267429.
  3. Bartman CR, Weilandt DR, Shen Y, Lee WD, Han Y, TeSlaa T, Jankowski CSR, Samarah L, Park NR, da Silva-Diz V, Aleksandrova M, Gultekin Y, Marishta A, Wang L, Yang L, Roichman A, Bhatt V, Lan T, Hu Z, Xing X, Lu W, Davidson S, Wuhr M, Vander Heiden MG, Herranz D, Guo JY, Kang Y, Rabinowitz JD. Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature. 2023. Epub 20230201. doi: 10.1038/s41586-022-05661-6. PubMed PMID: 36725930.
  4. Bhatt V, Lan T, Wang W, Kong J, Lopes EC, Wang J, Khayati K, Raju A, Rangel M, Lopez E, Hu ZS, Luo X, Su X, Malhotra J, Hu W, Pine SR, White E, Guo JY. Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors. Cell Death Dis. 2023;14(1):61. Epub 20230126. doi: 10.1038/s41419-023-05592-8. PubMed PMID: 36702816; PMCID: PMC9879981.
  5. Khayati K, Bhatt V, Lan T, Alogaili F, Wang W, Lopez E, Hu ZS, Gokhale S, Cassidy L, Narita M, Xie P, White E, Guo JY. Transient Systemic Autophagy Inhibition is Selectively and Irreversibly Deleterious to Lung Cancer. Cancer research. 2022. Epub 20220926. doi: 10.1158/0008-5472.CAN-22-1039. PubMed PMID: 36156071.
  6. Dai W, Shen J, Yan J, Bott AJ, Maimouni S, Daguplo HQ, Wang Y, Khayati K, Guo JY, Zhang L, Wang Y, Valvezan A, Ding WX, Chen X, Su X, Gao S, Zong WX. Glutamine synthetase limits b-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1. The Journal of clinical investigation. 2022. Epub 20221018. doi: 10.1172/JCI161408. PubMed PMID: 36256480.
  7. Yue X, Wang J, Chang CY, Liu J, Yang X, Zhou F, Qiu X, Bhatt V, Guo JY, Su X, Zhang L, Feng Z, Hu W. Leukemia inhibitory factor drives glucose metabolic reprogramming to promote breast tumorigenesis. Cell Death Dis. 2022;13(4):370. Epub 20220419. doi: 10.1038/s41419-022-04820-x. PubMed PMID: 35440095; PMCID: PMC9018736.
  8. Huo Y, Sawant A, Tan Y, Mahdi AH, Li T, Ma H, Bhatt V, Yan R, Coleman J, Dreyfus CF, Guo JY, Mouradian MM, White E, Xia B. Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration. PLoS Genet. 2022;18(4):e1010138. Epub 20220411. doi: 10.1371/journal.pgen.1010138. PubMed PMID: 35404932.
  9. Guzman S, Dragan M, Kwon H, de Oliveira V, Rao S, Bhatt V, Kalemba KM, Shah A, Rustgi VK, Wang H, Bech PR, Abbara A, Izzi-Engbeaya C, Manousou P, Guo JY, Guo GL, Radovick S, Dhillo WS, Wondisford FE, Babwah AV, Bhattacharya M. Targeting hepatic kisspeptin receptor ameliorates non-alcoholic fatty liver disease in a mouse model. The Journal of clinical investigation. 2022. Epub 20220329. doi: 10.1172/JCI145889. PubMed PMID: 35349482.
  10. Nunn K, Guo JY. Transient systemic autophagy ablation irreversibly inhibits lung tumor cell metabolism and promotes T-cell mediated tumor killing. Autophagy. 2022:1-3. Epub 20221108. doi: 10.1080/15548627.2022.2141534. PubMed PMID: 36314942.
  11. Rangel M, Kong J, Bhatt V, Khayati K, Guo JY. Autophagy and Tumorigenesis. FEBS J. 2021. Epub 2021/07/17. doi: 10.1111/febs.16125. PubMed PMID: 34270851.
  12. White E, Lattime E, Guo JY. Autophagy regulates stress responses, metabolism and anti-cancer Immunity. Trends in Cancer. 2021.Epub 2021/06/12. doi: 10.1016/j.trecan.2021.05.003. PubMed PMID: 34112622.
  13. Liu Y, Gokhale S, Jung J, Zhu S, Luo C, Saha D, Guo JY, Zhang H, Kyin S, Zong WX, White E, Xie P. Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes. Front Immunol. 2021;12:670338. Epub 2021/11/09. doi: 10.3389/fimmu.2021.670338. PubMed PMID: 34745083; PMCID: PMC8564014.
  14. Jariwala N, Mehta GA, Bhatt V, Hussein S, Parker KA, Yunus N, Parker JS, Guo JY, Gatza ML. CPT1A and fatty acid beta-oxidation are essential for tumor cell growth and survival in hormone receptor-positive breast cancer. NAR Cancer. 2021;3(3):zcab035. Epub 2021/09/14. doi: 10.1093/narcan/zcab035. PubMed PMID: 34514415; PMCID: PMC8428294.
  15. Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, Guo JY, Pine S, Van Remmen H, Li H, White E, Liu C, Kiledjian M, Pestov DG, Steven Zheng XF. SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer. Nat Commun. 2021;12(1):2259. Epub 2021/04/17. doi: 10.1038/s41467-021-22480-x. PubMed PMID: 33859191.
  16. Khayati K, Bhatt V, Hu ZS, Fahumy S, Luo X, Guo JY. Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival. Elife. 2020;9. Epub 2020/11/26. doi: 10.7554/eLife.62377. PubMed PMID: 33236987; PMCID: PMC7714393.
  17. Ghergurovich JM, Esposito M, Chen Z, Wang J, Bhatt V, Lan T, White E, Kang Y, Guo JY#, Rabinowitz JD#. Glucose-6-phosphate dehydrogenase is not essential for K-Ras-driven tumor growth or metastasis. Cancer research. 2020. Epub 2020/07/15. doi: 10.1158/0008-5472.CAN-19-2486. PubMed PMID: 32661137.
    # Co-corresponding author
  18. Feng WW, Wilkins O, Bang S, Ung M, Li J, An J, Del Genio C, Canfield K, DiRenzo J, Wells W, Gaur A, Robey RB, Guo JY, Powles RL, Sotiriou C, Pusztai L, Febbraio M, Cheng C, Kinlaw WB, Kurokawa M. CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies. Cell Rep. 2019;29(11):3405-20 e5. Epub 2019/12/12. doi: 10.1016/j.celrep.2019.11.008. PubMed PMID: 31825825; PubMed Central PMCID: PMC6938262.
  19. Bott AJ, Shen J, Tonelli C, Zhan L, Sivaram N, Jiang YP, Yu X, Bhatt V, Chiles E, Zhong H, Maimouni S, Dai W, Velasquez S, Pan JA, Muthalagu N, Morton J, Anthony TG, Feng H, Lamers WH, Murphy DJ, Guo JY, Jin J, Crawford HC, Zhang L, White E, Lin RZ, Su X, Tuveson DA, Zong WX. Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. Cell Rep. 2019;29(5):1287-98 e6. Epub 2019/10/31. doi: 10.1016/j.celrep.2019.09.056. PubMed PMID: 31665640; PubMed Central PMCID: PMC6886125.
  20. Malhotra J, Jabbour S, Orlick M, Riedlinger G, Guo JY, White E, Aisner J. Phase Ib/II study of hydroxychloroquine in combination with chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC). Cancer Treat Res Commun. 2019;21:100158. Epub 2019/09/15. doi: 10.1016/j.ctarc.2019.100158. PubMed PMID: 31521049.
  21. Liu J, Zhang Q, Ruan B, Chen W, Zheng J, Xu B, Jiang P, Miao Z, Li F, Guo JY, Cao L, Wang G. MORC2 regulates C/EBPalpha-mediated cell differentiation via sumoylation. Cell Death Differ. 2019;26(10):1905-17. Epub 2019/01/16. doi: 10.1038/s41418-018-0259-4. PubMed PMID: 30644437; PubMed Central PMCID: PMC6748086.
  22. Bhatt V, Khayati K, Hu ZH, Lee A, Kamran W, Su X, Guo JY. Autophagy Modulates Lipid Metabolism to Maintain Metabolic Flexibility for Lkb1-Deficient Kras-Driven Lung Tumorigenesis; Genes & Development. 2019. Epub 2019/01/30. doi: 10.1101/gad.320481.118. PubMed PMID: 30692209.
  23. Poillet-Perez L, Xie X, Zhan L, Yang Y, Sharp DW, Hu ZS, Su X, Maganti A, Jiang C, Lu W, Zheng H, Bosenberg MW, Mehnert JM, Guo JY, Lattime E, Rabinowitz JD, White E. Autophagy maintains tumour growth through circulating arginine. Nature. 2018;563(7732):569-73. Epub 2018/11/16. doi: 10.1038/s41586-018-0697-7. PubMed PMID: 30429607.
  24. Hui S, Ghergurovich J, Morscher RJ, Cholsoon J, Teng X, Lu W, Esparza LA, Reya, T, Zhan L, Guo JY, White E, and Rabinowitz JD. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017. doi:10.1038/nature24057 Pubmed PMID: 29045397.
  25. Guo JY and White E. Autophagy, Metabolism, and Cancer. Cold Spring Harbor Symposia on Quantitative Biology, 2016;81:73-8. Epub 2017/02/18. doi: 10.1101/sqb.2016.81.030981. PubMed PMID: 28209717; PMCID: PMC5521269.
  26. Qiu G, Liu J, Cheng Q, Wang Q, Jing Z, Pei Y, Zhao M, Wang J, Guo JY, Zhang J. Impaired Autophagy and Defective T Cell Homeostasis in Mice with T Cell-Specific Deletion of Receptor for Activated C Kinase 1. Front Immunol. 2017;8:575. doi: 10.3389/fimmu.2017.00575. PubMed PMID: 28572806; PMCID: PMC5435764.
  27. Lashinger LM, O'Flanagan CH, Dunlap SM, Rasmussen AJ, Sweeney S, Guo JY, Lodi A, Tiziani S, White E, Hursting SD. Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors. Cancer Metab. 2016;4:18.
  28. Guo JY#, Teng X, Laddha SV, Ma S, Van Nostrand SC, Yang Y, Khor S, Chan CS, Rabinowitz JD, White E#. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes & development 30: 1704-1717; 2016
    # Co-corresponding author

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