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Chan Laboratory - Select Publications

  1. Feng X, Lu H, Yue J, Schneider N, Liu J, Denzin LK, Chan CS, De S, Shen Z. Loss of Setd4 delays radiation-induced thymic lymphoma in mice. DNA Repair. 2020 Feb;86:102754.
  2. Laddha SV, da Silva EM, Robzyk K, Untch BR, Ke H, Rekhtman N, Poirier JT, Travis WD, Tang LH, Chan CS.  Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids.  Cancer Res. 2019 Sep 1;79(17):4339-4347.
  3. Choi S, Wang D, Chen X, Tang LH, Verma A, Chen Z, Kim BJ, Selesner L, Robzyk K, Zhang G, Pang S, Han T, Chan CS, Fahey TJ 3rd, Elemento O, Du YN.  Function and clinical relevance of RHAMM isoforms in pancreatic tumor progression.  Mol Cancer. 2019 May 9;18(1):92.
  4. Levine AJ, Chan CS, Dudgeon C, Puzio-Kuter A, Hainaut P. The Evolution of Tumors in Mice and Humans with Germline p53 Mutations. Cold Spring Harbor symposia on quantitative biology. 2015;  PMID: 26642854
  5. Joshi S, Tolkunov D, Aviv H, Hakimi AA, Yao M, et al. The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. Cell reports. 2015; 13(9):1895-908.  PMID: 26655904
  6. White E, Mehnert JM, Chan CS. Autophagy, Metabolism, and Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015; 21(22):5037-46. NIHMSID: NIHMS728175  PMID: 26567363, PMCID: PMC4646728
  7. Puzio-Kuter AM, Laddha SV, Castillo-Martin M, Sun Y, Cordon-Cardo C, et al. Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma. Cell death and differentiation. 2015; 22(11):1785-91. PMID: 25822339, PMCID: PMC4648325
  8. Dudgeon C, Chan C, Kang W, Sun Y, Emerson R, et al. The evolution of thymic lymphomas in p53 knockout mice. Genes & development. 2014; 28(23):2613-20. PubMed [journal] PMID: 25452272, PMCID: PMC4248292
  9. Ariffin H, Hainaut P, Puzio-Kuter A, Choong SS, Chan AS, et al. Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li-Fraumeni cancer predisposition syndrome. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(43):15497-501.  PMID: 25313051, PMCID: PMC4217424
  10. Zhang C, Liu J, Wang X, Wu R, Lin M, et al. MicroRNA-339-5p inhibits colorectal tumorigenesis through regulation of the MDM2/p53 signaling. Oncotarget. 2014; 5(19):9106-17.  PMID: 25193859, PMCID: PMC4253422
  11. Wong C, Laddha SV, Tang L, Vosburgh E, Levine AJ, et al. The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors. Cell death & disease. 2014; 5:e1450. PMID: 25299775, PMCID: PMC4237236
  12. Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, et al. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer discovery. 2014; 4(8):914-27. NIHMSID: NIHMS600167  PMID: 24875857, PMCID: PMC4125614
  13. Zhang C, Liu J, Wu R, Liang Y, Lin M, et al. Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD. Oncotarget. 2014; 5(14):5535-46.  PMID: 25114038, PMCID: PMC4170611
  14. Laddha SV, Ganesan S, Chan CS, White E. Mutational landscape of the essential autophagy gene BECN1 in human cancers. Molecular cancer research : MCR. 2014; 12(4):485-90. NIHMSID: NIHMS560860  PMID: 24478461, PMCID: PMC3989371
  15. Sagne C, Marcel V, Bota M, Martel-Planche G, Nobrega A, et al. Age at cancer onset in germline TP53 mutation carriers: association with polymorphisms in predicted G-quadruplex structures. Carcinogenesis. 2014; 35(4):807-15. PubMed [journal] PMID: 24336192, PMCID: PMC3977145
  16. Hu W, Chan CS, Wu R, Zhang C, Sun Y, et al. Negative regulation of tumor suppressor p53 by microRNA miR-504. Molecular cell. 2010; 38(5):689-99. NIHMSID: NIHMS211731 PMID: 20542001, PMCID: PMC2900922
  17. Chan CS, Song JS. CCCTC-binding factor confines the distal action of estrogen receptor. Cancer research. 2008; 68(21):9041-9.  PMID: 18974150
  18. Chan CS, Elemento O, Tavazoie S. Revealing posttranscriptional regulatory elements through network-level conservation. PLoS computational biology. 2005; 1(7):e69. PMID: 16355253, PMCID: PMC1309705