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Zheng Laboratory - Select Publications


Tsang, CK, Chen, M., Cheng, X., Qi, YM, Cehn, Y., Das, I., Li., XX., Vallat, B., Fu, LW, Qian, CN., Wang HY, White, E., Burley, S., and Zheng, X.F. SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation Molecular Cell 2018, forthcoming

Zhang H, Li, XX, Yang, Y, Zhang, YJ, Wang, HY and Zheng, X.F. Significance and Mechanism of Androgen Receptor (AR) Overexpression and AR-mTOR Crosstalk in Hepatocellular Carcinoma. Hepatology 2018, Epub 2017 Dec 8. doi: 10.1002/hep.29715.

Zhang SS., Li, XX, Wang, HY and Zheng, X.F. Beyond Regulation of Pol III: Role of MAF1 in Growth, Metabolism and Cancer. BBA Gene Regulatory Mechanisms, 2018, 1861:338-343. DOI: 10.1016/j.bbagrm.2018.01.019

Zhang, YJ, Huang, B., Wang, HY., Chang, A. and X.F. Zheng. Emerging Role of MicroRNAs in mTOR Signaling. Cell. Mol. Life Sci. 2017, Jul;74(14):2613-2625. Epub 2017 Feb 25. doi:10.1007/s00018-017-2485-1.

Li, Y., Kwan Tsang, C., Wang, S., Li, X., Yang, Y., Fu, L., Huang, W., Li, M., Wang, H.-Y. and Zheng, X.F. MAF1 Suppresses AKT-mTOR Signaling and Liver Cancer through Activation of PTEN Transcription. Hepatology, (2016). 63:1928-42. doi: 10.1002/hep.28507.

Yang, X.Z., Li, X.X., Zhang, Y.J., Rodriguez-Rodriguez, L., Xiang, M.Q., Wang, H.Y. and Zheng, X.F. Rab1 in Cell Signaling, Cancer and Other Diseases. Oncogene, 2016, 35(44):5699-5704. doi: 10.1038/onc.2016.81

Wu, TJ, Wang, XW, Zhang, YJ, Meng, L.H., Kerrigan, J, Burley, SK and Zheng, X.F. Identification of a non-gatekeeper hotspot for drug-resistant mutations in mTOR kinase using a novel S. cerevisiae system, Cell Reports, 2015; 11:446-459

Zhang, Y.J., Wang, X.W., Qin, X.Y., Wang, X.X., Liu, Feng, White, E., and Zheng, X.F. PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer, EBioMedicine, 2015, 2: 1944–1956.

Thomas JD*, Zhang, YJ*, Wei, YH, Cho JH, Wang HY and Zheng, X.F. Rab1 is an mTORC1 activator and a colorectal oncogene. Cancer Cell 2014; 26, 754–769 (*co-first authors)
Featured in Preview by Cancer Cell 26:601–602; Research Watch by Cancer Discovery 4:1366

Tsang, CK, Liu, Y, Thomas, JD, Zhang, YJ and Zheng, X.F. Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance, Nature Communications, 2014; 5:3446 doi:10.1038/ncomms4446

Zhang, Y.J. and Zheng, X.F. mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors. Cell Cycle, 2012; 11: 594 – 603

Zhang, YJ, Duang, YW and Zheng, X.F. Targeting the mTOR kinase domain: the second generation of mTOR inhibitors, Drug Discovery Today 2011; 16, 325-331

Wei, Y.H., Tsang, C.K., and Zheng, X.F. Regulatory Mechanisms of Pol III-dependent Transcription by TORC1, The EMBO Journal, 2009; 28: 2220-2230

Tsang, C.K., Li, H. and Zheng, X.F. Nutrient Starvation Promotes Condensin Loading to Maintain rDNA Stability, The EMBO Journal 2007; 26: 448-458. (This paper was featured in: EMBO Journal Online, 2007)

Tsang, C.K. Qi, H.Y. Liu, L.F. Zheng, X.F. Targeting mammalian target of rapamycin (mTOR) for health and diseases, Drug Discovery Today 2007; 12: 112-124

Li, H., Tsang, C.K., Watkins, M., Bertram, P.G. and Zheng, X.F. Nutrient Regulates Tor1 Nuclear Localization and Association with rDNA Promoter, Nature 2006; 442, 1058-1061
This paper was featured by the following journals:
Science’s STKE Vol. 2006, Issue 351, pp. tw302, 5 September 2006;
Cell Metabolism 2006, 4:259-260;

Tsang, C.K., Bertram, P.G., Ai, W.D., Drenan, R. and Zheng, X.F. Chromatin-mediated Regulation of Nucleolar Structure and RNA Polymerase I Localization by TOR, The EMBO Journal 2003; 22: 6045-6056

Choi, J.H., Bertram, P.G., Drenan, R., Carvalho, J., Zhou, H. and Zheng, X.F. FKBP12-Rapamycin-Associated Protein (FRAP) Is A CLIP-170 Kinase, The EMBO Reports 2002; 3: 988-994

Ai, W.D., Bertram, P.B., Tsang, C.K, Chan, T.F. and Zheng, X.F. Regulation of Subtelomeric Silencing during Stress Response, Molecular Cell 2002; 10: 1295-1305

Choi, J., Adames, N.R., Chan, T.F., Zeng, C.B., Cooper, J.A. and Zheng, X.F. TOR Signaling Regulates Microtubule Stability and Functions. Current Biology 2000; 10: 861-864

Chan, T.F., Carvalho, J., Riles, L. and Zheng, X.F. A Chemical Genomics Approach towards Understanding the Global Functions of TOR.  Proc Natl Acad Sci USA 2000; 97: 13227-13232