Feng Laboratory - Select Publications

Click here for a complete list of publications by Dr. Zhaohui Feng

  1. Liu J, Zhang C, Xu D, Zhang T, Chang CY, Wang J, Liu J, Zhang L, Haffty BG, Zong WX, Hu W, Feng Z. The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer. J Clin Invest. 2023 Mar 15;133(6). doi: 10.1172/JCI164354. PubMed PMID: 36749630; PubMed Central PMCID: PMC10014102.
  2. Liu J, Zhang C, Zhang T, Chang CY, Wang J, Bazile L, Zhang L, Haffty BG, Hu W, Feng Z. Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer. Nat Metab. 2022;4(12):1830-1846. doi: 10.1038/s42255-022-00708-4.  PMID: 36536137.
  3. Wang J, Chang CY, Yang X, Zhou F, Liu J, Zhu S, Yu XZ, Liu C, O'Sullivan TE, Xie P, Feng Z, Hu W. Leukemia inhibitory factor protects against graft-versus-host disease while preserving graft-versus-leukemia activity. Blood. 2022 Nov 10;140(19):2076-2090.  PMID: 35981499.
  4. Chang CY, Wang J, Zhao Y, Liu J, Yang X, Yue X, Wang H, Zhou F, Inclan-Rico JM, Ponessa JJ, Xie P, Zhang L, Siracusa MC, Feng Z, Hu W. Tumor suppressor p53 regulates intestinal type 2 immunity. Nat Commun. 2021;12(1):3371.  PMID: 34099671.
  5. Liu J, Zhang C, Wu H, Sun XX, Li Y, Huang S, Yue X, Lu SE, Shen Z, Su X, White E, Haffty BG, Hu W, Feng Z.  Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression. J Clin Invest. 130(6):3253-3269. PMID: 32478681. (2020).
  6. Yue X, Zhang C, Zhao Y, Liu J, Lin AW, Tan V, Drake JM, Liu L, Boateng MN, Li J, Feng Z* (co-corresponding), Hu W*.  Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression.  Genes & Development.  2017, 31: 1641-54. PMID: 28947497
  7. Liu J, Zhang C, Zhao Y, Yue X,  Wu H, Huang S,  Chen J,   Tomsky K, Xie H, Khella K, Gatza M,  Xia D,  Gao J, White E, Haffty BG, Hu W,  Feng Z.  (2017) Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progressionNature Communications. 2017;8(1):1823. PMID: 29180628
  8. Zhang C, Liu J, Huang G, Zhao Y, Yue X, Wu H, Li J, Zhu J, Shen Z, Haffty BG, Hu W, Feng Z. Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progressionGenes & Development. 2016; 30(17):1956-70.  PMID: 27664236
  9. Zhang C, Liu J, Zhao Y, Yue X, Zhu Y, Wang X, Wu H, Blanco F, Li S, Bhanot G, Haffty BG, Hu W, Feng Z.  Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.  eLife. 2016; 5:e10727. PMID: 26751560
  10. Yue X, Zhao Y, Liu J, Zhang C, Yu H, Wang J, Zheng T, Liu L, Li J, Feng Z*, Hu W*. BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function. eLife. 2015; 4.  PMID: 26271008
  11. Yu H, Yue X, Zhao Y, Li X, Wu L, Zhang C, Liu Z, Lin K, Xu-Monette Z, Young K, Liu J, Shen Z, Feng Z*, Hu W*. LIF negatively regulates tumor suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. Nature Communications. 2014; 5:5218 doi:10.1038/ncomms6218. (PMC4203416)
  12. Liu J, Zhang C, Wang XL, Ly P, Belyi V, Xu-Monette ZY, Young KH, Hu W, Feng Z. E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. Cell death and differentiation. 2014; 21(11):1792-804. PMID: 25146927
  13. Zheng T, Wang J, Zhao Y, Zhang C, Lin M, Wang X, Yu H, Liu L, Feng Z*, Hu W*. Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. Nature Communications. 2013; 4:2996 doi: 10.1038/ncomms3996. (PMC3960723) 
  14. Zhang C, Liu J, Liang Y, Wu R, Zhao Y, Hong X, Lin M, Yu H, Liu L, Levine A, Hu W, Feng Z. Tumor-Associated Mutant p53 Drives the Warburg Effect. Nature Communications. 2013; 4:2935 doi: 10.1038/ncomms3935.
  15. Feng Z, Liu L, Zhang C, Zheng T, Wang J, Lin M, Zhao Y, Wang X, Levine A, Hu W. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. PNAS. 2012; 109:7013-7018. PMC3345015
  16. Zhang C, Lin M, Wu R, Wang X, Yang B, Levine AJ, Hu W, Feng Z.  Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. PNAS. 2011; 108(39):16259-64.
  17. Hu W, Chan CS, Wu R, Zhang C, Sun Y, Song JS, Tang LH, Levine AJ, Feng Z. Negative regulation of tumor suppressor p53 by microRNA miR-504. Molecular cell. 2010; 38(5):689-99. PMID: 20542001
  18. Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. PNAS. 2010; 107(16):7455-60.
  19. Hu W*, Feng Z*, Teresky A, Levine AJ. p53 regulates maternal reproduction through LIF. Nature. 2007; 450:721-724.
  20. Feng Z, Hu W, Yu H, Tang MS (2006) Acrolein is a major cigarette-related lung cancer agent: preferential binding at p53 mutational hotspots and inhibition of DNA repair. PNAS, 2006; 103:15404-15409. PMID: 17030796.
  21. Feng Z, Zhang H, Levine AJ, Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. PNAS. 2005; 102:8204-8209. PMID: 15928081