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Xia Laboratory - Select Publications

  1. Foo TK and Xia, B. (2022) BRCA1-dependent and independent recruitment of PALB2-BRCA2-RAD51 in the DNA damage response and cancer. Cancer Res 2022 Jul 12;can.22.1535. doi: 10.1158/0008-5472.CAN-22-1535. Online ahead of print.
  2. Xia B, Biswas K, Foo TK, Torres T, Riedel-Topper M, Southon E, Kang Z, Huo Y, Reid S, Stauffer S, Zhou W, Zhu B, Koka H, Xiao Y, Brodie SA, Jones K, Vogt A, Zhu B, Cater B, Freedman ND, Hicks B, Yeager M, Chanock SJ, Couch FJ, Parry DM, Monteiro AN, Goldstein AM, Carvalho MA, Sharan SK, Yang XR. (2022) Rare germline variants in PALB2 and BRCA2 in familial and sporadic chordoma. Hum Mutat 2022 Jun 28. doi: 10.1002/humu.24427. Online ahead of print.
  3. Huo Y, Sawant A, Tan Y, Mahdi AH, Li T, Ma H, Bhatt V, Yan R, Coleman J, Dreyfus CF, Guo JY, Mouradian MM, White E, and Xia B. (2022) Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration. PLOS Genet 2022 Apr 11;18(4):e1010138. doi: 10.1371/journal.pgen.1010138.
  4. Ma H, Kang Z, Foo TK, Zhen Z and Xia B. (2022) Disrupted BRCA1-PALB2 Interaction Induces Tumor Immunosuppression and T-Lymphocyte Infiltration in Hepatocellular Carcinoma Through the cGAS-STING Pathway. Hepatology 2022 Jan 10:10.1002/hep.32335. doi: 10.1002/hep.32335. Online ahead of print.
  5. Kang Z, Fu P, Alcivar AL, Fu H, Rdeon C, Foo TK, Zuo Y, Ye C, Baxley R, Madireddy A, Buisson R, Bielinsky A, Zou L, Shen Z, Aladjem MI and Xia B. (2021) BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded DNA gap formation after DNA damage. Nat Commun 2021 Oct 13;12(1):5966. doi: 10.1038/s41467-021-26227-6.
  6. Foo TK, Vincelli G, Huselid E, Her J, Zheng H, Simhadri S, Wang M, Huo Y, Li T, Yu X, Li H, Zhao W, Bunting SF and Xia B. (2021) ATR/ATM-mediated phosphorylation of BRCA1 T1394 promotes homologous recombinational repair and G2/M checkpoint maintenance. Cancer Res 2021 Sep 15;81(18):4676-4684. doi: 10.1158/0008-5472.CAN-20-2723. Epub 2021 Jul 23.
  7. Huo Y, Selenica P, Mahdi A, Pareja F, Kyker-Snowman K, Chen Y, Kumar R, Da Cruz Paula A, Basili T, Brown DN, Pei X, Riaz N, Tan Y, Huang Y, Li T, Barnard NJ, Reis-Filho JS, Weigelt B and Xia B. (2021) Genetic interactions among Brca1, Brca2, Palb2 and Trp53 in mammary tumor development. npj Breast Cancer 2021;7(1):45. doi: 10.1038/s41523-021-00253-5.
  8. Mahdi AH, Huo Y, Selenica P, Chen Y, Sharma A, Merritt E, Barnard NJ, Chan C, Ganesan S, Reis-Filho JS, Weigelt B, De S, and Xia B. (2020) Loss of the BRCA1-PALB2 interaction accelerates p53-associated tumor development in mice. Genes Dis 2020 Sep 5;9(3):807-813. doi: 10.1016/j.gendis.2020.08.012.
  9. Simhadri S, Vincelli G, Huo Y, Misenko S, Foo TK, Ahlskog J, Sorenson CS, Oakley GG, Ganesan S, Bunting SF and Xia, B. (2019) PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response. Oncogene 38(10):1585-1596.
  10. Mahdi A, Huo Y, Tan Y, Simhadri S, Vincelli G, Gao J, Ganesan S and Xia B. (2018) Evidence of inter-tissue difference in the DNA damage response and the pro-oncogenic role of NFκB in mice with disengaged BRCA1-PALB2 interaction. Cancer Res 78:3969-3981.
  11. Foo TK, Tischkowitz M, Simhadri S, Boshari T, Zayed N, Burke KA, Berman SH, Blecua P, Riaz N, Huo Y, Ding YC, Neuhausen SL, Weigelt B, Reis-Filho JS, Foulkes WD and Xia B. (2017) Compromised BRCA1-PALB2 interaction is associated with breast cancer risk. Oncogene 36(29):4161-4170.
  12. Lu K, Alcivar AL, Ma J, Foo TK, Zywea S, Mahdi A, Huo Y, Kensler TW, Gatza ML and Xia B. (2017) NRF2 induction supporting breast cancer cell survival is enabled by oxidative stress-induced DPP3-KEAP1 interaction. Cancer Res 77(11):2881-2892.
  13. Anantha RW, Simhadri S, Foo TK, Miao S, Liu J, Shen Z, Ganesan S and Xia B. (2017) Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance. eLife 2017;10.7554/eLife.21350
  14. Simhadri S, Peterson S, Patel D, Huo Y, Cai H, Miller S, Ludwig T, Ganesan S, Bhaumik M, Bunting S, Jasin M and Xia B. (2014) Male fertility defect associated with a disruption of BRCA1-PALB2 interaction in mice. J Biol Chem 289:24617-29.
  15. Huo Y, Cai H, Teplova I, Bowman-Colin C, Chen G, Price S, Barnard N, Ganesan S, Karantza V, White E and Xia B. (2013) Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer. Cancer Discov 3:894-907.
  16. Ma J, Cai H, Wu T, Sobhian B, Huo Y, Mehta M, Cheung KL, Ganesan S, Kong T, Zhang DD and Xia B. (2012) PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. Mol Cell Biol 32:1506-17.
  17. Zhang F, Ma J, Wu J, Ye L, Cai H, Xia B (co-corresponding author) and Yu X. (2009) PALB2 links BRCA1 and BRCA2 in the DNA damage response. Curr Biol 19:524-529.
  18. Xia B, Dorsman JC, Ameziane N, de Vries Y, Rooimans MA, Sheng Q, Pals G, Errami A, Gluckman E, Llera J, Wang W, Livingston DM, Joenje H and de Winter, JP (2007) Fanconi anemia is associated with a defect in the BRCA2 partner PALB2. Nat Genet 39:165-167.
  19. Erkko H, Xia B (co-first author), Nikkilä J, Schleutker J, Syrjäkoski K, Mannermaa A, Kallioniemi A, Pylkäs K, Karppinen S, Rapakko K, Miron A, Sheng Q, Li G, Mattila H, Bell DW, Haber DA, Grip M, Jukkola-Vuorinen A, Mustonen A, Kere J, Altonen LA, Kosma V, Kataja V, Soini Y, Drapkin RI, Livingston DM # and Winqvist R. (2007) A recurrent mutation in PALB2 in Finnish cancer families. Nature 446:316-319.
  20. Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, Liu X, Jasin M, Couch FJ, and Livingston DM. (2006) Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell 22:719-729.


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