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Hu Laboratory - Select Publications

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Zhang C, Liu J, Huang G, Zhao Y, Yue X, Wu H, Li J, Zhu J, Shen Z, Haffty BG, Hu W, Feng Z. Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progressionGenes & Development. 2016; 30(17):1956-70. PubMed [journal]PMID: 27664236

Yue X, Zhao Y, Liu J, Zhang C, Yu H, Wang J, Zheng T, Liu L, Li J, Feng Z, Hu W. BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and functioneLife. 2015; 4. PubMed [journal]PMID: 26271008 PMCID: PMC4561369

Zhao Y, Zhang C, Yue X, Li X, Liu J, Yu H, Belyi VA, Yang Q, Feng Z, Hu W. Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53Cell Death and Differentiation. 2015; 22(11):1824-36. PubMed [journal]PMID: 25857266 PMCID: PMC4648328

Yu H, Yue X, Zhao Y, Li X, Wu L, Zhang C, Liu Z, Lin K, Xu-Monette Z, Young K, Liu J, Shen Z, Feng Z, Hu W. LIF negatively regulates tumor suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. Nature Communications. 2014; 5:5218 doi:10.1038/ncomms6218. (PMC4203416)

Zheng T, Wang J, Zhao Y, Zhang C, Lin M, Wang X, Yu H, Liu L, Feng Z, Hu W. Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. Nature Communications. 2013; 4:2996 doi: 10.1038/ncomms3996. (PMC3960723) 

Zhang C, Liu J, Liang Y, Wu R, Zhao Y, Hong X, Lin M, Yu H, Liu L, Levine A, Hu W, Feng Z. Tumor-Associated Mutant p53 Drives the Warburg Effect. Nature Communications. 2013; 4:2935 doi: 10.1038/ncomms3935. (PMC3969270) 

Feng Z, Liu L, Zhang C, Zheng T, Wang J, Lin M, Zhao Y, Wang X, Levine A, Hu W. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. PNAS. 2012; 109:7013-7018. (PMC3345015)

Kang H, Feng Z, Sun Y, Atwal G, Murphy M, Rebbeck T, Rosenwaks Z, Levine AJ, Hu W. Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci U S A. 2009; 106:9761-9766. (PMC2700980)

Hu W, Feng Z, Teresky A, Levine AJ. p53 regulates maternal reproduction through LIF. (with commentary) Nature. 2007; 450:721-724.

Bond GL, Hu W (co-first author), Bond EE, Robins H, Lutzker SG, Arva NC, Bargonetti J, Bartel F, Taubert H, Wuerl P, Onel K, Yip L, Hwang SJ, Strong LC, Lozano G, Levine AJ. A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. (with commentary) Cell. 2004; 119:591-602.