Researcher Profile

Honghua Li, PhD

Associate Professor of Pharmacology
Robert Wood Johnson Medical School
Rutgers, The State University of New Jersey

Staged Research Building
661 Hoes Lane West, Room 110
Piscataway, NJ 08854

Phone: (732) 235-7330
Email: holi@rwjms.rutgers.edu


Research Program Alignment

Membership Type: Associate


Research Interests

  • The genetic basis of breast cancer.

Selected Publications

Greenawalt, D. M., Cui, X., Wu, Y., Lin, Y., Wang, H. Y., Luo, M., Tereshchenko, I. V., Hu, G., Li, J. Y., Chu, Y., Azaro, M. A., Decoste, C. J., Chimge, N. O., Gao, R., Shen, L., Shih, W. J., Lange, K., Li, H.: Strong correlation between meiotic crossovers and haplotype structure in a 2.5-Mb region on the long arm of chromosome 21. Genome Res 2006, 16(2):208-214.

Hu, G., Wang, H. Y., Greenawalt, D. M., Azaro, M. A., Luo, M., Tereshchenko, I. V., Cui, X., Yang, Q., Gao, R., Shen, L., Li, H.: AccuTyping: new algorithms for automated analysis of data from high-throughput genotyping with oligonucleotide microarrays. Nucleic Acids Res 2006.

Li, H., Cui, X., Greenawalt, D. M., Hu, G., Chimge, N. O., Pramanik, S., Luo, M., Wang, H.-Y., Tereshchenko, I. V., Azaro, M. A., Lin, Y., Yang, Q., Li, J. Y., Chu, Y., Lin, Z., Gao, R., Shen, L., Decoste, C. J., Shih, W. J.: Microarray Analysis of a Large Number of Single Nucleotide Polymorphisms in Individual Human Spermatozoa. In: Genetics of Male Infertility. Edited by Carrell DT. Totowa, New Jersey: Humana Press Inc.; 2006: 55-76.

Li, H., Wang, H. Y., Cui, X., Luo, M., Hu, G., Greenawalt, D. M., Tereshchenko, I. V., Li, J. Y., Chu, Y., Gao, R.: High-throughput Genotyping of Single Nucleotide Polymorphisms with High Sensitivity. In: Methods in Molecular Biology. Edited by Bergman N, vol. Comparative Genomics. Totowa, New Jersey: Humana Press Inc.; 2006.

Hu, G., Yang, Q., Cui, X., Yue, G., Azaro, M. A., Wang, H. Y., Li, H.: A highly sensitive and specific system for large-scale gene expression profiling. BMC Genomics 2008, 9:9.

Yin, B. C., Li, H., Ye, B. C.: A dual-probe hybridization method for reducing variability in single nucleotide polymorphism analysis with oligonucleotide microarrays. Anal Biochem 2008, 383(2):270-278.

Yin, B. C., Li, H., Ye, B. C.: Microarray-based Estimation of SNP Allele-frequency in Pooled DNA Using the Langmuir Kinetic Model. BMC Genomics 2008, 9(1):605.

Yue, G., Shi, G., Azaro, M. A., Yang, Q., Hu, G., Luo, M., Yin, K., Nagele, R. G., Fine, D. H., Yang, J. M., Li, H.: Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expression. BMC Genomics 2008, 9(1):608.

Luo, M., Cui, X., Fredman, D., Brookes, A. J., Azaro, M. A., Greenawalt, D. M., Hu, G., Wang, H.-Y., Tereshchenko, I. V., Shentu, Y., Gao, R., Shen, L., Li, H.: Genetic structures of duplicated sequences revealed by genotyping single sperm. PLoS One 2009, 4(4):e5236..

Wang, H.-Y., Greenawalt, D. M., Cui, X., Tereshchennko, I. V., Luo, M., Yang, Q., Azaro, M. A., Hu, G., Chu, Y., Li, J. Y., Shen, L., Lin, Y., Li, H.: Identification of Possible Genetic Alterations in the Breast Cancer Cell Line MCF-7 Using High-density SNP Genotyping Microarray. J Carcinog, 2009, 8:6.

Huang GL, Li BK, Zhang MY, Zhang HZ, Wei RR, Yuan YF, Shi M, Chen XQ, Huang L, Li AH, Huang BJ, Li HH, Wang HY. LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma. World J Gastroenterol. 2010 16:2046.

Pramanik, S., Cui, X., Wang, H. Y., Chimge, N. O., Hu, G., Shen, L., Gao, R., Li, H.: Segmental duplication as one of the driving forces underlying the diversity of the human immunoglobulin heavy chain variable gene region. BMC Genomics 2011, 12:78.

Huang, G. L., Li, B. K., Zhang, M. Y., Wei, R. R., Yuan, Y. F., Shi, M., et al. Allele loss and down-regulation of heparanase gene are associated with the progression and poor prognosis of hepatocellular carcinoma. PLoS One (2012) 7, e44061.

Cui, X., Wang, Q., Li, H.: Chromosome 18 non-disjunction during meiosis I. Submitted.

Cui, X., Wang, Q. and Li, H. Whole genome amplification of single haploid sperm genome. Submitted

Pramanik, S., Cui, X., Wang, H. Y., Chimge, N. O., Hu, G., and Li, H.: Major impact of segmental duplication on the diversity of the human immunoglobulin heavy chain variable gene region. Submitted.

The content for this Research Profile is maintained by Paul Novembre (novembre@cinj.rutgers.edu)