White Laboratory - Select Publications

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, Lopez-Otin C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Munoz-Pinedo C, Nunez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Essential Versus Accessory Aspects of Cell Death: Recommendations of the NCCD 2015. Cell Death and Differentiation. 2014. Epub 2014/09/23. doi: 10.1038/cdd.2014.137. PubMed PMID: 25236395.

White E. Q&A: Targeting Autophagy in Cancer - A New Therapeutic? Cancer & Metabolism. 2014;2:14. Epub 2014/09/13. doi: 10.1186/2049-3002-2-14. PubMed PMID: 25215185; PubMed Central PMCID: PMC4160717.

Mathew R, Khor S, Hackett SR, Rabinowitz JD, Perlman DH, White E. Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity. Molecular Cell. 2014. Epub 2014/09/02. doi: 10.1016/j.molcel.2014.07.019. PubMed PMID: 25175026.

Liu Z, Chen P, Gao H, Gu Y, Yang J, Peng H, Xu X, Wang H, Yang M, Liu X, Fan L, Chen S, Zhou J, Sun Y, Ruan K, Cheng S, Komatsu M, White E, Li L, Ji H, Finley D, Hu R. Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression. Cancer Cell. 2014;26(1):106-20. Epub 2014/07/16. doi: 10.1016/j.ccr.2014.05.015. PubMed PMID: 25026213.

Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, White E. Autophagy is Required for Glucose Homeostasis and Lung Tumor Maintenance. Cancer Discovery. 2014. Epub 2014/05/31. doi: 10.1158/2159-8290.CD-14-0363. PubMed PMID: 24875857.

Strohecker AM, White E. Targeting Mitochondrial Metabolism by Inhibiting Autophagy in BRAF-Driven Cancers. Cancer Discovery. 2014. Epub 2014/05/27. doi: 10.1158/2159-8290.CD-14-0196. PubMed PMID: 24860158.

Andrianasolo EH, Haramaty L, White E, Lutz R, Falkowski P. Mode of Action of Diterpene and Characterization of Related Metabolites from the Soft Coral, Xenia elongata. Marine Drugs. 2014;12(2):1102-15. Epub 2014/02/25. doi: 10.3390/md12021102. PubMed PMID: 24562393.

White E, Green DR and Letai AG. Apoptosis, Necrosis and Autophagy. The Molecular Basis of Cancer, J. Mendelsohn, P.M. Howley, M. Israel, J.W. Gray, and C.B. Thompson, Elsevier, 2014; Chapter 14: 209-227.

Laddha SV, Ganesan S, Chan CS, White E. Mutational landscape of the essential autophagy gene BECN1 in human cancers. Molecular Cancer Research : MCR. 2014. Epub 2014/01/31. doi: 10.1158/1541-7786.MCR-13-0614. PubMed PMID: 24478461. [Epub ahead of print]

Autophagy coverStrohecker AM, White E. Autophagy promotes -driven lung tumorigenesis by preserving mitochondrial metabolism. Autophagy. 2013;10(2). Epub 2013/12/24. PubMed PMID: 24362353.

Guo JY, Xia B, White E. Autophagy-mediated tumor promotion. Cell. 2013;155(6):1216-9. Epub 2013/12/10. doi: 10.1016/j.cell.2013.11.019. PubMed PMID: 24315093.

Fan J, Kamphorst JJ, Mathew R, Chung MK, White E, Shlomi T, Rabinowitz JD. Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Molecular Systems Biology. 2013;9:712. Epub 2013/12/05. doi: 10.1038/msb.2013.65. PubMed PMID: 24301801.

Cancer Discovery coverStrohecker AM, Guo JY, Karsli-Uzunbas G, Price SM, Chen GJ, Mathew R, McMahon M and White E. Autophagy sustains mitochondrial glutamine metabolism and growth of BRAFV600E-driven lung tumorsCancer Discovery. 2013. Epub 2013/08/24. doi: 10.1158/2159-8290.CD-13-0397. PubMed PMID: 23965987.

Huo Y, Cai H, Teplova I, Bowman-Colin C, Chen G, Price S, Barnard N, Ganesan S, Karantza V, White E, Xia B. Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer. Cancer Discovery. 2013. Epub 2013/05/08. doi: 10.1158/2159-8290.CD-13-0011. PubMed PMID: 23650262.

Guo JY, White E. Autophagy is required for mitochondrial function, lipid metabolism, growth and fate of KRAS (G12D)-driven lung tumors. Autophagy. 2013;9(10). Epub 2013/08/21. PubMed PMID: 23959381.

Andrianasolo EH, Haramaty L, Rosario-Passapera R, Vetriani C, Falkowski P, White EP, Lutz R. Ammonificins C and D, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans. Marine Drugs. 2012;10(10):2300-11. Epub 2012/11/22. doi: 10.3390/md10102300. PubMed PMID: 23170085; PubMed Central PMCID: PMC3497024.

Lau A, Zheng Y, Tao S, Wang H, Whitman SA, White E, Zhang DD. Arsenic inhibits autophagic flux activating the Nrf2-Keap1 pathway in a p62-dependent manner. Molecular and Cellular Biology. 2013. Epub 2013/04/17. doi: 10.1128/MCB.01748-12. PubMed PMID: 23589329.

Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen J, Price S, Lu W, Rabinowitz JD, White E. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes & Development. 2013;27(13):1447-61. Epub 2013/07/05. doi: 10.1101/gad.219642.113. PubMed PMID: 23824538; PubMed Central PMCID: PMC3713426.

Kamphorst JJ, Cross JR, Fan J, De Stanchina E, Mathew R, White EP, Thompson CB, Rabinowitz JD. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(22):8882-7. Epub 2013/05/15. doi: 10.1073/pnas.1307237110. PubMed PMID: 23671091; PubMed Central PMCID: PMC3670379.

Xie X, White E, Mehnert JM. Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma. PLoS One. 2013; 8(1):e55096. Epub 2013/02/06. doi: 10.1371/journal.pone.0055096. PubMed PMID: 23383069; PubMed Central PMCID: PMC3559441.

Martino JJ, Wall BA, Mastrantoni E, Wilimczyk BJ, La Cava SN, Degenhardt K, White E and Chen S., Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. Oncogene. 2012. Epub 2012/10/23. doi: 10.1038/onc.2012.471. PubMed PMID: 23085756.

Bray K, Mathew R, Lau A, Kamphorst JJ, Fan J, Chen J, Chen HY, Ghavami A, Stein M, DiPaola RS, Zhang D, Rabinowitz JD, White E. Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One. 2012; 7(7):e41831. Epub 2012/08/01. doi: 10.1371/journal.pone.0041831. PubMed PMID: 22848625; PubMedCentral PMCID: PMC3406086.

Ladoire S, Chaba K, Martins I, Sukkurwala AQ, Adjemian S, Michaud M, Poirier-Colame V, Andreiuolo F, Galluzzi L, White E, Rosenfeldt M, Ryan KM, Zitvogel L, Kroemer G. Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens. Autophagy. 2012;8(8). Epub 2012/06/01. PubMed PMID: 22647537.

White E. Deconvoluting the context-dependent role for autophagy in cancer. Nature Reviews Cancer. 2012;12(6):401-10. Epub 2012/04/27. doi: 10.1038/nrc3262. PubMed PMID: 22534666; PubMed Central PMCID: PMC3664381.

Saleem A, Dvorzhinski D, Santanam U, Mathew R, Bray K, Stein M, White E, DiPaola RS. Effect of dual inhibition of apoptosis and autophagy in prostate cancer. The Prostate. 2012; 72(12):1374-81. Epub 2012/01/14. doi: 10.1002/pros.22487. PubMed PMID: 22241682.

Mathew R, White E. Autophagy, Stress, and Cancer Metabolism: What Doesn't Kill You Makes You Stronger. Cold Spring Harbor Symposia on Quantitative Biology. 2011; 76:389-96. Epub 2012/03/24. doi: 10.1101/sqb.2012.76.011015. PubMed PMID: 22442109.

Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Golstein P, Gottlieb E, Green DR, Hengartner M, Kepp O, Knight RA, Kumar S, Lipton SA, Madeo F, Malorni W, Mehlen P, Nunez G, Peter ME, Piacentini M, Rubinstein DC, Simon HU, Vandenabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death and Differentiation. 2012; 19(1):107-20. Epub 2011/07/16. doi: 10.1038/cdd.2011.96. PubMed PMID: 21760595; PubMed Central PMCID: PMC3252826.

Karantza-Wadsworth V, White, E. Programmed Cell Death. Cancer: Principles and Practice of Oncology: VT DeVita, TS Hellman and SA Rosenberg, eds. Wolters Kluwer Health Lippinocott Williams and Wilkins, Mechanisms of Cell Death, 2011; Chapter 7: 82-90

Andrianasolo EH, Haramaty L, McPhail KL, White E, Vetriani C, Falkowski P, Lutz R. Bathymodiolamides A and B, ceramide derivatives from a deep-sea hydrothermal vent invertebrate mussel, Bathymodiolus thermophilus. Journal of Natural Products. 2011; 74(4):842-6. Epub 2011/01/13. doi: 10.1021/np100601w. PubMed PMID: 21222464; PubMed Central PMCID: PMC3081957.

Mehnert JM, Tan AR, Moss R, Poplin E, Stein MN, Sovak M, Levinson K, Lin H, Kane M, Gounder M, Lin Y, Shih WJ, Weichung JS, White E, Rubin EH, Karantza V. Rationally designed treatment for solid tumors with MAPK pathway activation: a phase I study of paclitaxel and bortezomib using an adaptive dose-finding approach. Molecular Cancer Therapeutics. 2011; 10(8):1509-19. Epub 2011/06/18. doi: 10.1158/1535-7163.MCT-10-0944. PubMed PMID: 21680752; PubMed Central PMCID: PMC3155243.

Cancer Prevention ResearchKamphorst JJ, Fan J, Lu W, White E, Rabinowitz JD. Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism. Analytical Chemistry. 2011; 83(23):9114-22. Epub 2011/10/19. doi: 10.1021/ac202220b. PubMed PMID: 22004349; PubMed Central PMCID: PMC3230881.

Mathew R, White E. Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night. Current Opinion in Genetics & Development. 2011; 21(1):113-9. Epub 2011/01/25. doi: 10.1016/j.gde.2010.12.008. PubMed PMID: 21255998; PubMed Central PMCID: PMC3039840.

Amaravadi RK, Lippincott-Schwartz J, Yin XM, Weiss WA, Takebe N, Timmer W, DiPaola RS, Lotze MT, White E. Principles and current strategies for targeting autophagy for cancer treatment. Clinical Cancer Research: An official journal of the American Association for Cancer Research. 2011; 17(4):654-66. Epub 2011/02/18. doi: 10.1158/1078-0432.CCR-10-2634. PubMed PMID: 21325294; PubMed Central PMCID: PMC3075808.

Chen HY, White E. Role of autophagy in cancer prevention. Cancer Prev Res (Phila). 2011; 4(7):973-83. Epub 2011/07/08. doi: 10.1158/1940-6207.CAPR-10-0387. PubMed PMID: 21733821; PubMed Central PMCID: PMC3136921.

Genes and Development coverGuo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst J, Chen G, Lemons JM, Karantza V, Coller HA, DiPaola RS, Gelinas C, Rabinowitz JD and White E., Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes & Development. 2011; 25(5):460-70. Epub 2011/02/15. doi: 10.1101/gad.2016311. PubMed PMID: 21317241; PubMed Central PMCID: PMC3049287.

Sulzmaier FJ, Valmiki MK, Nelson DA, Caliva MJ, Geerts D, Matter ML, White E, Ramos JW. PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D. Oncogene. 2011. Epub 2011/11/23. doi: 10.1038/onc.2011.514. PubMed PMID: 22105357;       PubMed Central PMCID: PMC3295902.

Lu H, Huang YY, Mehrotra S, Droz-Rosario R, Liu J, Bhaumik M, White E, Shen Z. Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes. PLoS Genetics. 2011; 7(9):e1002291. Epub 2011/10/04. doi: 10.1371/journal.pgen.1002291. PubMed PMID: 21966279; PubMed Central PMCID: PMC3178617.

Eng CH, Yu K, Lucas J, White E, Abraham RT. Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Science Signaling. 2010; 3(119):ra31. Epub 2010/04/29. doi: 10.1126/scisignal.2000911. PubMed PMID: 20424262.

DiPaola RS, Chen YH, Stein M, Vaughn D, Patrick-Miller L, Carducci M, Roth B, White E, Wilding G. A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899. Journal of Translational Medicine. 2010; 8:20. Epub 2010/02/25. doi: 10.1186/1479-5876-8-20. PubMed PMID: 20178647; PubMed Central PMCID: PMC2837641.

Kroemer G, White E. Autophagy for the avoidance of degenerative, inflammatory, infectious, and neoplastic disease. Current Opinion in Cell Biology. 2010; 22(2):121-3. Epub 2010/03/06. doi: 10.1016/j.ceb.2010.02.003. PubMed PMID: 20202808; PubMed Central PMCID: PMC2854209.

White E, Karp C, Strohecker AM, Guo Y, Mathew R. Role of autophagy in suppression of inflammation and cancer. Current Opinion in Cell Biology. 2010; 22(2):212-7. Epub 2010/01/09. doi: 10.1016/j.ceb.2009.12.008. PubMed PMID: 20056400; PubMed Central PMCID: PMC2857707.

Fan G, Simmons MJ, Ge S, Dutta-Simmons J, Kucharczak J, Ron Y, Weissmann D, Chen CC, Mukherjee C, White E, Gelinas C. Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma. Blood. 2010; 115(17):3559-69. Epub 2010/02/27. doi: 10.1182/blood-2009-08-236760. PubMed PMID: 20185581; PubMed Central PMCID: PMC2867266.

Singh SB, Ornatowski W, Vergne I, Naylor J, Delgado M, Roberts E, Ponpuak M, Master S, Pillie M, White E, Komatsu M, Deretic V. Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nature Cell Biology. 2010; 12(12):1154-65. Epub 2010/11/26. doi: 10.1038/ncb2119. PubMed PMID: 21102437; PubMed Central PMCID: PMC2996476.

Rabinowitz JD, White E. Autophagy and metabolism. Science. 2010; 330(6009):1344-8. Epub 2010/12/04. doi: 10.1126/science.1193497. PubMed PMID: 21127245; PubMed Central PMCID: PMC3010857.

Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang D. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Molecular and Cellular Biology. 2010; 30(13):3275-85. Epub 2010/04/28. doi: 10.1128/MCB.00248-10. PubMed PMID: 20421418; PubMed Central PMCID: PMC2897585.

Kongara S, Kravchuk O, Teplova I, Lozy F, Schulte J, Moore D, Barnard N, Neumann CA, White E, Karantza V. Autophagy regulates keratin 8 homeostasis in mammary epithelial cells and in breast tumors. Molecular Cancer Research: MCR. 2010; 8(6):873-84. Epub 2010/06/10. doi: 10.1158/1541-7786.MCR-09-0494. PubMed PMID: 20530580; PubMed Central PMCID: PMC2891319.

Stein M, Lin H, Jeyamohan C, Dvorzhinski D, Gounder M, Bray K, Eddy S, Goodin S, White E, DiPaola RS. Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies. The Prostate. 2010; 70(13):1388-94. Epub 2010/08/06. doi: 10.1002/pros.21172. PubMed PMID: 20687211.

Mathew R, Karantza-Wadsworth V, White E. Assessing metabolic stress and autophagy status in epithelial tumors. Autophagy in Disease and Clinical Applications. D. Klionsky, Methods in Enzymology. 2009; 453:53-81. Epub 2009/02/17. doi: 10.1016/S0076-6879(08)04004-4. PubMed PMID: 19216902; PubMed Central PMCID: PMC2857509.

Stein M, White E, DiPaola RS. Targeted Approaches to the Treatment of Prostate Cancer at the Cancer Institute of New Jersey. Grand Rounds in Urology. 2009; 8:11-5.

White E, Lowe SW. Eating to exit: Autophagy-enabled senescence revealed. Genes & Development. 2009; 23(7):784-7. Epub 2009/04/03. doi: 10.1101/gad.1795309. PubMed PMID: 19339684.

Mao L, Tang Y, Vaiphei ST, Shimazu T, Kim SG, Mani R, Fakhoury E, White E, Montelione GT, Inouye M. Production of membrane proteins for NMR studies using the condensed single protein (cSPP) production system. Journal of Structural and Functional Genomics. 2009; 10(4):281-9. Epub 2009/10/27. doi: 10.1007/s10969-009-9072-0. PubMed PMID: 19856129; PubMed Central PMCID: PMC2923930.

Andrianasolo EH, Haramaty L, Rosario-Passapera R, Bidle K, White E, Vetriani C, Falkowski P, Lutz R. Ammonificins A and B, hydroxyethylamine chroman derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans. Journal of Natural Products. 2009; 72(6):1216-9. Epub 2009/06/11. doi: 10.1021/np800726d. PubMed PMID: 19507867; PubMed Central PMCID: PMC2880718.

Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, Chen G, DiPaola RS, Karantza-Wadsworth V, White E. Autophagy suppresses tumorigenesis through elimination of p62. Cell. 2009; 137(6):1062-75. Epub 2009/06/16. doi: 10.1016/j.cell.2009.03.048. PubMed PMID: 19524509; PubMed Central PMCID: PMC2802318.

Fu J, Jiang J, Li J, Wang S, Shi G, Feng Q, White E, Qin J, Wong J. Deleted in breast cancer 1, a novel androgen receptor (AR) coactivator that promotes AR DNA-binding activity. The Journal of Biological Chemistry. 2009; 284(11):6832-40. Epub 2009/01/08. doi: 10.1074/jbc.M808988200. PubMed PMID: 19126541; PubMed Central PMCID: PMC2652261.

Bray K, Chen HY, Karp CM, May M, Ganesan S, Karantza-Wadsworth V, DiPaola RS, White E. Bcl-2 modulation to activate apoptosis in prostate cancer. Molecular Cancer Research: MCR. 2009; 7(9):1487-96. Epub 2009/09/10. doi: 10.1158/1541-7786.MCR-09-0166. PubMed PMID: 19737977; PubMed Central PMCID: PMC2855683.

White E, DiPaola RS. The double-edged sword of autophagy modulation in cancer. Clinical Cancer Research: an official journal of the American Association for Cancer Research. 2009; 15(17):5308-16. Epub 2009/08/27. doi: 10.1158/1078-0432.CCR-07-5023. PubMed PMID: 19706824; PubMed Central PMCID: PMC2737083.