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Edmond J. LaVoie, PhD

Publications since 2011

Kaul, M. Mark, L. Zhang, Y. Parhi, A. K. Lyu, Y. L. Pawlak, J. Saravolatz, S. Saravolatz, L. D. Weinstein, M. P. LaVoie, E. J. Pilch, D. S. TXA709: A FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus. Antimicrob Agents Chemother, In process, . (PMID: 26033735)

Sagong, H. Y. Bauman, J. D. Patel, D. Das, K. Arnold, E. LaVoie, E. J. Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease. J Med Chem, 57:8086-8098, . (PMID: 25225968, PMCID: PMC4191602)

Dorrani, M. Kaul, M. Parhi, A. LaVoie, E. J. Pilch, D. S. Michniak-Kohn, B. TXA497 as a topical antibacterial agent: Comparative antistaphylococcal, skin deposition, and skin permeation studies with mupirocin. Int J Pharm, In process, . (PMID: 25263100)

Kaul, M. Zhang, Y. Parhi, A. K. Lavoie, E. J. Pilch, D. S. Inhibition of RND-Type Efflux Pumps Confers the FtsZ-Directed Prodrug TXY436 with Activity Against Gram-Negative Bacteria. Biochem Pharmacol, 89:321-328, . (PMID: 24637241)

Kaul, M. Mark, L. Zhang, Y. Parhi, A. K. LaVoie, E. J. Pilch, D. S. Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723. Biochem Pharmacol, 86:1699-1707, . (PMID: 24148278)

Kaul, M. Mark, L. Zhang, Y. Parhi, A. K. Lavoie, E. J. Pilch, D. S. A FtsZ-Targeting Prodrug with Oral Antistaphylococcal Efficacy In Vivo. Antimicrob Agents Chemother, 57:5860-5869, . (PMID: 24041882, PMCID: PMC3837898)

Bauman, J. D. Patel, D. Baker, S. F. Vijayan, R. S. Xiang, A. Parhi, A. K. Martinez-Sobrido, L. Lavoie, E. J. Das, K. Arnold, E. Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors. ACS Chem Biol, 8:2501-2508, . (PMID: 23978130, PMCID: PMC3928712)

Parhi, A. K. Xiang, A. Bauman, J. D. Patel, D. Vijayan, R. S. Das, K. Arnold, E. Lavoie, E. J. Phenyl substituted 3-hydroxypyridin-2(1H)-ones: Inhibitors of influenza A endonuclease. Bioorg Med Chem, 21:6435-6446, . (PMID: 24055080)

Kaul, M. Zhang, Y. Parhi, A. K. Lavoie, E. J. Tuske, S. Arnold, E. Kerrigan, J. E. Pilch, D. S. Enterococcal and streptococcal resistance to PC190723 and related compounds: Molecular insights from a FtsZ mutational analysis. Biochimie, 95:1880-1887, . (PMID: 23806423)

Parhi, A. K. Zhang, Y. Saionz, K. W. Pradhan, P. Kaul, M. Trivedi, K. Pilch, D. S. Lavoie, E. J. Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines. Bioorg Med Chem Lett, 23:4968-4974, . (PMID: 23891185)

Blankson, G. A. Pilch, D. S. Liu, A. A. Liu, L. F. Rice, J. E. LaVoie, E. J. Macrocyclic biphenyl tetraoxazoles: synthesis, evaluation as G-quadruplex stabilizers and cytotoxic activity. Bioorg Med Chem, 21:4511-4520, . (PMID: 23787291)

Sagong, H. Y. Parhi, A. Bauman, J. D. Patel, D. Vijayan, R. S. Das, K. Arnold, E. LaVoie, E. J. 3-Hydroxyquinolin-2(1H)-ones As Inhibitors of Influenza A Endonuclease. ACS Med Chem Lett, 4:547-550, . (PMID: 24936242, PMCID: PMC4056971)

Zhang, Y. Giurleo, D. Parhi, A. Kaul, M. Pilch, D. S. LaVoie, E. J. Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents. Bioorg Med Chem Lett, 23:2001-2006, . (PMID: 23481648)

Kelley, C. Lu, S. Parhi, A. Kaul, M. Pilch, D. S. Lavoie, E. J. Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes. Eur J Med Chem, 60:395-409, . (PMID: 23314053)

Blankson, G. Rzuczek, S. G. Bishop, C. Pilch, D. S. Liu, A. Liu, L. Lavoie, E. J. Rice, J. E. Macrocyclic Pyridyl Polyoxazoles: Structure-Activity Studies of the Aminoalkyl Side-Chain on G-Quadruplex Stabilization and Cytotoxic Activity. Molecules, 18:11938-11963, . (PMID: 24077174, PMCID: PMC3949622)

Kelley, C. Zhang, Y. Parhi, A. Kaul, M. Pilch, D. S. Lavoie, E. J. 3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents. Bioorg Med Chem, 20:7012-7029, . (PMID: 23127490)

Parhi, A. Kelley, C. Kaul, M. Pilch, D. S. Lavoie, E. J. Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives. Bioorg Med Chem Lett, 22:7080-7083, . (PMID: 23084900)

Kaul, M. Parhi, A. K. Zhang, Y. Lavoie, E. J. Tuske, S. Arnold, E. Kerrigan, J. E. Pilch, D. S. A Bactericidal Guanidinomethyl Biaryl That Alters the Dynamics of Bacterial FtsZ Polymerization. J Med Chem, 55:10160-10176, . (PMID: 23050700)

Parhi, A. Lu, S. Kelley, C. Kaul, M. Pilch, D. S. Lavoie, E. J. Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives. Bioorg Med Chem Lett, 22:6962-6966, . (PMID: 23058886)

Kurtzberg, L. S. Roth, S. Krumbholz, R. Crawford, J. Bormann, C. Dunham, S. Yao, M. Rouleau, C. Bagley, R. G. Yu, X. J. Wang, F. Schmid, S. M. Lavoie, E. J. Teicher, B. A. Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. Clin Cancer Res, 17:2777-2787, . (PMID: 21415217)