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Edmond J. LaVoie, PhD

Publications since 2011

Sagong, H. Y. Bauman, J. D. Patel, D. Das, K. Arnold, E. LaVoie, E. J. Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease. J Med Chem, In process, . (PMID: 25225968)

Dorrani, M. Kaul, M. Parhi, A. LaVoie, E. J. Pilch, D. S. Michniak-Kohn, B. TXA497 as a topical antibacterial agent: Comparative antistaphylococcal, skin deposition, and skin permeation studies with mupirocin. Int J Pharm, In process, . (PMID: 25263100)

Kaul, M. Zhang, Y. Parhi, A. K. Lavoie, E. J. Pilch, D. S. Inhibition of RND-Type Efflux Pumps Confers the FtsZ-Directed Prodrug TXY436 with Activity Against Gram-Negative Bacteria. Biochem Pharmacol, 89:321-328, . (PMID: 24637241)

Kaul, M. Mark, L. Zhang, Y. Parhi, A. K. LaVoie, E. J. Pilch, D. S. Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723. Biochem Pharmacol, 86:1699-1707, . (PMID: 24148278)

Kaul, M. Mark, L. Zhang, Y. Parhi, A. K. Lavoie, E. J. Pilch, D. S. A FtsZ-Targeting Prodrug with Oral Antistaphylococcal Efficacy In Vivo. Antimicrob Agents Chemother, 57:5860-5869, . (PMID: 24041882, PMCID: PMC3837898)

Bauman, J. D. Patel, D. Baker, S. F. Vijayan, R. S. Xiang, A. Parhi, A. K. Martinez-Sobrido, L. Lavoie, E. J. Das, K. Arnold, E. Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors. ACS Chem Biol, 8:2501-2508, . (PMID: 23978130, PMCID: PMC3928712)

Parhi, A. K. Xiang, A. Bauman, J. D. Patel, D. Vijayan, R. S. Das, K. Arnold, E. Lavoie, E. J. Phenyl substituted 3-hydroxypyridin-2(1H)-ones: Inhibitors of influenza A endonuclease. Bioorg Med Chem, 21:6435-6446, . (PMID: 24055080)

Kaul, M. Zhang, Y. Parhi, A. K. Lavoie, E. J. Tuske, S. Arnold, E. Kerrigan, J. E. Pilch, D. S. Enterococcal and streptococcal resistance to PC190723 and related compounds: Molecular insights from a FtsZ mutational analysis. Biochimie, 95:1880-1887, . (PMID: 23806423)

Parhi, A. K. Zhang, Y. Saionz, K. W. Pradhan, P. Kaul, M. Trivedi, K. Pilch, D. S. Lavoie, E. J. Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines. Bioorg Med Chem Lett, 23:4968-4974, . (PMID: 23891185)

Blankson, G. A. Pilch, D. S. Liu, A. A. Liu, L. F. Rice, J. E. LaVoie, E. J. Macrocyclic biphenyl tetraoxazoles: synthesis, evaluation as G-quadruplex stabilizers and cytotoxic activity. Bioorg Med Chem, 21:4511-4520, . (PMID: 23787291)

Sagong, H. Y. Parhi, A. Bauman, J. D. Patel, D. Vijayan, R. S. Das, K. Arnold, E. LaVoie, E. J. 3-Hydroxyquinolin-2(1H)-ones As Inhibitors of Influenza A Endonuclease. ACS Med Chem Lett, 4:547-550, . (PMID: 24936242, PMCID: PMC4056971)

Zhang, Y. Giurleo, D. Parhi, A. Kaul, M. Pilch, D. S. LaVoie, E. J. Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents. Bioorg Med Chem Lett, 23:2001-2006, . (PMID: 23481648)

Kelley, C. Lu, S. Parhi, A. Kaul, M. Pilch, D. S. Lavoie, E. J. Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes. Eur J Med Chem, 60:395-409, . (PMID: 23314053)

Blankson, G. Rzuczek, S. G. Bishop, C. Pilch, D. S. Liu, A. Liu, L. Lavoie, E. J. Rice, J. E. Macrocyclic Pyridyl Polyoxazoles: Structure-Activity Studies of the Aminoalkyl Side-Chain on G-Quadruplex Stabilization and Cytotoxic Activity. Molecules, 18:11938-11963, . (PMID: 24077174, PMCID: PMC3949622)

Kelley, C. Zhang, Y. Parhi, A. Kaul, M. Pilch, D. S. Lavoie, E. J. 3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents. Bioorg Med Chem, 20:7012-7029, . (PMID: 23127490)

Parhi, A. Kelley, C. Kaul, M. Pilch, D. S. Lavoie, E. J. Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives. Bioorg Med Chem Lett, 22:7080-7083, . (PMID: 23084900)

Kaul, M. Parhi, A. K. Zhang, Y. Lavoie, E. J. Tuske, S. Arnold, E. Kerrigan, J. E. Pilch, D. S. A Bactericidal Guanidinomethyl Biaryl That Alters the Dynamics of Bacterial FtsZ Polymerization. J Med Chem, 55:10160-10176, . (PMID: 23050700)

Parhi, A. Lu, S. Kelley, C. Kaul, M. Pilch, D. S. Lavoie, E. J. Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives. Bioorg Med Chem Lett, 22:6962-6966, . (PMID: 23058886)

Kurtzberg, L. S. Roth, S. Krumbholz, R. Crawford, J. Bormann, C. Dunham, S. Yao, M. Rouleau, C. Bagley, R. G. Yu, X. J. Wang, F. Schmid, S. M. Lavoie, E. J. Teicher, B. A. Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. Clin Cancer Res, 17:2777-2787, . (PMID: 21415217)