A Phase 3 Randomized Study Comparing Talquetamab SC in Combination With Daratumumab SC and Pomalidomide (Tal-DP) or Talquetamab SC in Combination With Daratumumab SC (Tal-D) Versus Daratumumab SC, Pomalidomide and Dexamethasone (DPd), in Participants With Relapsed or Refractory Multiple Myeloma who Have Received at Least 1 Prior Line of Therapy.

Inclusion Criteria

- Documented multiple myeloma as defined: a) Multiple myeloma diagnosis according to the

International Myeloma Working Group (IMWG) diagnostic criteria and b) Measurable

disease at screening as defined by any of the following: i) Serum M-protein level

greater than or equal to (>=) 0.5 grams per deciliter (g/dL) (central laboratory); ii)

Urine M-protein level >= 200 milligram (mg) per 24 hours (central laboratory); iii)

Light chain multiple myeloma without measurable M-protein in the serum or the urine:

serum immunoglobulin free light chain >= 10 milligram per deciliter (mg/dL) (central

laboratory), and abnormal serum immunoglobulin kappa lambda free light chain ratio

- Relapsed or refractory disease as defined by: i) Relapsed disease is defined as an

initial response to prior treatment, followed by confirmed progressive disease by IMWG

criteria greater than (>) 60 days after cessation of treatment; ii) Refractory disease

is defined as less than (<) 25 percent (%) reduction in monoclonal paraprotein

(M-protein) or confirmed progressive disease by IMWG criteria during previous

treatment or less than or equal to (<=) 60 days after cessation of treatment

- Received at least 1 prior line of antimyeloma therapy including a proteasome inhibitor

(PI) and lenalidomide. Participants who have received only 1 prior line of antimyeloma

therapy must be considered lenalidomide-refractory (that is, have demonstrated

progressive disease by IMWG criteria on or within 60 days of completion of

lenalidomide-containing regimen). Participants who have received >=2 prior lines of

antimyeloma therapy must be considered lenalidomide exposed

- Documented evidence of progressive disease based on investigator's determination of

response by the IMWG criteria on or after their last regimen

- Have an Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1, or

2 at screening and immediately prior to the start of administration of study treatment

Exclusion Criteria

- Contraindications or life-threatening allergies, hypersensitivity, or intolerance to

study drug excipients

- Disease is considered refractory to an anti-cluster of differentiation 38 (CD38)

monoclonal antibody as defined per IMWG consensus guidelines (progression during

treatment or within 60 days of completing therapy with an anti-CD38 monoclonal

antibody)

- Received prior pomalidomide therapy

- A maximum cumulative dose of corticosteroids to >=140 milligrams (mg) of prednisone or

equivalent within 14-day period before the first dose of study drug

- Known active central nervous system (CNS) involvement or exhibits clinical signs of

meningeal involvement of multiple myeloma. If either is suspected, negative whole

brain magnetic resonance imaging (MRI) and lumbar cytology are required

- Plasma cell leukemia (per IMWG criteria) at the time of screening, Waldenström's

macroglobulinemia, polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin

changes (POEMS syndrome), or primary amyloid light chain amyloidosis