Researcher Profile

Debra L. Laskin, PhD

Director of Flow Cytometry / Cell Sorting Shared Resource
Distinguished Professor and Chair, Roy A. Bowers Endowed Chair of Pharmacology and Toxicology
Ernest Mario School of Pharmacy
Rutgers, The State University of New Jersey

William Levine Hall
160 Frelinghuysen Road, Room 001
Piscataway, NJ 08854

Phone: (848) 445-5862
Email: laskin@eohsi.rutgers.edu

Assistant: Sandi Selby
(848) 445-0213
Email: selby@eohsi.rutgers.edu

Research Program Alignment

Membership Type: Full


Research Interests

  • Immunology
  • Inflammation
  • Immune mechanisms of tissue injury
  • Biochemical and molecular mechanisms of immune cell activation and signaling

Selected Publications

Fakhrzadeh, L., Laskin, J.D., and Laskin, D.L. (2008). Regulation of caveolin-1 expression, nitric oxide production and oxidant-induced tissue injury by tumor necrosis factor-alpha following ozone inhalation. Toxicology and Applied Pharmacology, 227: 380-389.

Chen, L.C., Gordon, M., Laskin, J.D., and Laskin, D.L. (2008). Regulation of TREM   expression in hepatic macrophages and endothelial cells during acute endotoxemia. Experimental and Molecular Pathology, 84:145-155.

Weinberger, B., Vetrano, A., Laskin, J.D., and Laskin, D.L. (2008). Mechanisms mediating reduced responsiveness of neonatal neutrophils to lipoxin A4. Pediatric Research, 64: 393-398.

Gardner, C.R., Gray, J.P., Joseph, L.B., Cervelli, J., Bremer, N., Kim, Y., Mishin, V., Laskin, J.D., and Laskin, D.L. (2010). Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity. Toxicology and Applied Pharmacology, 245: 36-46.

Wang, Y., Gray, J.P, Mishin, V., Heck, D.E., Laskin, D.L., and Laskin, J.D. (2010). Distinct roles of cytochrome P450 reductase in mitomycin c redox cycling and cytotoxicity. Molecular Cancer Therapeutics, 9: 1852-1863. 

Vetrano, A.M., Laskin, D.L., Archer, F., Syed K., Gray, J.P., Laskin, J.D., Nwebube, N., and Weinberger, B. (2010). Inflammatory effects of phthalates in neonatal neutrophils. Pediatric Research, 68: 134-139.

Laskin, D.L., Chen, L., Hankey, P.A., and Laskin, J.D. (2010). Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia. Journal of Leukocyte Biology. 88: 373-382.

Malaviya, R., Sunil, V.R., Cervelli, J., Anderson, D.R., Holmes, W.W., Conti, M.L., Gordon, R.E., Laskin, J.D., and Laskin, D.L. (2010). Inflammatory effects of inhaled sulfur mustard in rat lung. Toxicology and Applied Pharmacology, 248: 89-99.

Laskin, D.L., Sunil, V.R., and Laskin, J.D. (2011). Macrophages and tissue Injury: agents of defense or destruction? Annual Review of Pharmacology and Toxicology, 51, 267-288.

Sunil, V.R., Patel-Vayas, K., Shen, J., Gow, A.J., Laskin, J.D., and Laskin, D.L. (2011). Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. Toxicology and Applied Pharmacology, 250: 245-255.

Dragomir A.C., Laskin, J.D., and Laskin, D.L. (2011). Macrophage activation by factors released from acetaminophen-injured hepatocytes: Potential role of HMGB1. Toxicology and Applied Pharmacology, 253: 170-177.

Connors, A., Laskin, J.D., Laskin, D.L. (2012). Ozone-induced lung Injury and sterile inflammation. Role of toll-like receptor 4. Experimental and Molecular Pathology, 92: 229-235.

Dragomir, A., Laskin, J.D., Laskin, D.L. (2012). Role of galectin-3 in acetaminophen-induced hepatotoxicity and inflammatory mediator production. Toxicological Sciences, 127:609-619.

Gardner, C.R., Mishin, V., Hankey, P., Laskin, J.D., Laskin, D.L. (2012). Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase. Toxicology and Applied Pharmacology, 262:139-148.

Sunil, V.R., Shen, J., Patel-Vayas, K., Gow, A.J., Laskin, J.D., Laskin, D.L. (2012). Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning. Toxicology and Applied Pharmacology, 26: 22-30.

The content for this Research Profile is maintained by Paul Novembre (novembre@cinj.rutgers.edu)