Program Leaders: Eileen White, PhD and Wei-Xing Zong, PhD

Overall Goals:

To determine how oncogenic signaling promotes tumor cell metabolism, growth, and survival, and alters tumor-host interaction to facilitate disease progression.  The ultimate goal is to identify new targets for drug development to improve cancer therapy.

Specific Aims:

• To establish the role of cellular and mammalian metabolism in the control of tumor cell growth and survival and to modulate metabolic pathways to improve cancer therapy
• To define the basic mechanisms of cell growth, proliferation, survival, stress adaptation, and metastasis in tumor cells
• To identify the functional relationship between the tumor and host and how to harness host metabolism and immune response for anti-cancer therapy

Useful Links:

• CALENDAR: Program Meetings, Lectures and Other Events for Research Members
• List of Program Members