Researcher Publications

Wei-Xing Zong, PhD

Selected Publications

  1. Pan JA, Sun Y, Jiang YP, Bott AJ, Jaber N, Dou Z, Yang B, Chen JS, Catanzaro JM, Du C, Ding WX, Diaz-Meco MT, Moscat J, Ozato K, Lin RZ, and Zong WX. 2016. TRIM21 ubiquitylates SQSTM1/p62 and suppresses protein sequestration to regulate redox homeostasis. Mol Cell 61: 720-733. “Featured Article”. PMID: 26942676
  2. Zong WX, Rabinowitz JD, and White E. 2016. Mitochondria and cancer. Mol Cell 61: 667-676. PMID: 26942671
  3. Bott AJ, Peng IC (co-first author), Fan Y, Faubert B, Zhao L, Li J, Neidler S, Sun Y, Jaber N, Krokud D, Lu W, Rabinowitz J, Hatzoglou M, Powers S, Murphy DJ, Jones R, Wu S, Girnun G, and Zong WX. 2015. Myc induces expression of glutamine synthetase through thymine DNA glycosylase-mediated promoter demethylation. Cell Metab 22:1068-1077. PMID: 26603296
  4. Sheshadri N, Catanzaro JM (co-first author), Bott A, Sun Y, Ullman E, Wu S, Pan JA, Chen E, Crawford HC, Zhang J, and Zong WX. 2014. Squamous cell carcinoma antigen 1 (SCCA1)/SerpinB3 promotes tumorigenesis through induction of unfolded protein response and IL-6 signaling. Cancer Res 74:6318-6329. PMID: 25213322
  5. Catanzaro JM, Sheshadri N (co-first author), Pan JA, Shi C, Li J, Powers RS, Crawford HC, and Zong WX. 2014. Oncogenic Ras induces cytokine production by up-regulating squamous cell carcinoma antigens SerpinB3/B4. Nat Commun. 5:3729. PMID: 24759783
  6. Dou Z, Pan JA, Dbouk HA, Ballou LM, DeLeon JL, Fan YJ, Chen JS, Liang Z, Li G, Backer JM, Lin RZ, and Zong WX. 2013. Class IA PI3-kinase p110β subunit promotes autophagy through Rab5 small GTPase in response to trophic factor limitation. Mol Cell 50:29-42. PMID: 23434372
  7. Pan JA. Fan Y. Gandhirajan RK, Madesh M. and Zong WX. 2013. Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis. J Biol Chem 288:2952-2963. “Paper-of-the-week”.  PMID: 23239879
  8. Jaber N, Dou Z, Chen JS, Catanzaro JM, Jiang YP, Ballou LM, Selinger E, Ouyang X, Lin RZ, Zhang J, and Zong WX. 2012. Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Proc Nat Acad Sci, USA109:2003-2008. PMID: 22308354
  9. Ullman E, Pan JA, and Zong WX.  2011. Squamous cell carcinoma antigen 1 (SCCA1) promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibits necrosis induced by lysosomal injury.  Mol Cell Biol 31:2902-2919. PMID: 21576355
  10. Pan JA, Ullman E, Dou Z, and Zong WX.  2011. Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes. Mol Cell Biol 31:3158-3170. PMID: 21628531
  11. Guerriero JL, Ditsworth D, Catanzaro JM, Sabino G, Furie MB, Kew R, and Zong WX. 2011. DNA alkylating therapy induces an HMGB1-dependent activation of innate immunity and tumor clearance.  J Immunol 186:3517-3626. “Featured Article”. PMID: 21300822
  12. Catanzaro JM, Guerriero JL (co-first author), Liu J, Ullman E, Sheshadri N, Chen JJ, and Zong WX. 2011. Elevated expression of squamous cell carcinoma antigen (SCCA) is associated with human breast carcinoma.  PLoS One 6: e19096. PMID: 21526154
  13. Dou Z, Chattopadhyay M, Pan JA, Guerriero JL, Jiang YP, Ballou LM, Yue Z, Lin RZ, and Zong WX. 2010. The Class IA phosphatidylinositol 3-kinase p110β subunit is a positive regulator of autophagy.  J Cell Biol 191:827-843. PMID: 21059846
  14. Fan Y, Dickman K, and Zong WX. 2010. Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition. J Biol Chem 285: 7324-7333. PMID: 20018866
  15. Guerriero JL, Ditsworth D, Fan Y, Zhao F, Crawford HC, Zong WX.  2008. Chemotherapy induces tumor clearance independent of apoptosis. Cancer Res 68: 9595-9600. PMID: 19047135
  16. Ullman E, Fan Y (co-first author), Stawowczyk M, Chen HM, Yue Z, and Zong WX.  2008. Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress. Cell Death Diff 16:422-425. PMID: 17917679

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