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Researcher Publications

Nan Gao, PhD

Selected Publications

  1. Feng Q, Bonder EM, Engevik AC, Zhang L, Tyska MJ, Goldenring JR, Gao N. Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy. J Cell Sci. 2017 Aug 1;130(15):2491-2505. doi: 10.1242/jcs.201897. Epub 2017 Jun 8. PubMed PMID: 28596241; PubMed Central PMCID: PMC5558269.
  2. Sun J, Yu S, Zhang X, Capac C, Aligbe O, Daudelin T, Bonder EM, Gao N. A Wntless-SEC12 complex on the ER membrane regulates early Wnt secretory vesicle assembly and mature ligand export. J Cell Sci. 2017 Jul 1;130(13):2159-2171. doi: 10.1242/jcs.200634. Epub 2017 May 17. PubMed PMID: 28515233; PubMed Central PMCID: PMC5536887.
  3. Balasubramanian I, Gao N. From sensing to shaping microbiota: insights into the role of NOD2 in intestinal homeostasis and progression of Crohn's disease. Am J Physiol Gastrointest Liver Physiol. 2017 Jul 1;313(1):G7-G13. doi: 10.1152/ajpgi.00330.2016. Epub 2017 Apr 27. Review. PubMed PMID: 28450278; PubMed Central PMCID: PMC5538831.
  4. Kishida K, Pearce SC, Yu S, Gao N, Ferraris RP. Nutrient sensing by absorptive and secretory progenies of small intestinal stem cells. Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1;312(6):G592-G605. doi: 10.1152/ajpgi.00416.2016. Epub 2017 Mar 23. PubMed PMID: 28336548; PubMed Central PMCID: PMC5495913.
  5. Kumar N, Srivillibhuthur M, Joshi S, Walton KD, Zhou A, Faller WJ, Perekatt AO, Sansom OJ, Gumucio DL, Xing J, Bonder EM, Gao N, White E, Verzi MP. A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development. 2016 Oct 15;143(20):3711-3722. PubMed PMID: 27802136; PubMed Central PMCID: PMC5087649.
  6. Mahon M, Xu J, Yi X, Liu X, Gao N, Zhang L. Paneth Cell in Adenomas of the Distal Colorectum Is Inversely Associated with Synchronous Advanced Adenoma and Carcinoma. Sci Rep. 2016 May 18;6:26129. doi: 10.1038/srep26129. PubMed PMID: 27188450; PubMed Central PMCID: PMC4870568.
  7. Yu S, Tong K, Zhao Y, Balasubramanian I, Yap GS, Ferraris RP, Bonder EM, Verzi MP, Gao N. Paneth Cell Multipotency Induced by Notch Activation following Injury. Cell Stem Cell. 2018 Jul 5;23(1):46-59.e5. doi: 10.1016/j.stem.2018.05.002. Epub 2018 Jun 7. PubMed PMID: 29887318; PubMed Central PMCID: PMC6035085.
  8. Das S, Yu S, Sakamori R, Vedula P, Feng Q, Flores J, Hoffman A, Fu J, Stypulkowski E, Rodriguez A, Dobrowolski R, Harada A, Hsu W, Bonder EM, Verzi MP, Gao N. Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche. Development. 2015 Jun 15;142(12):2147-62. doi: 10.1242/dev.121046. Epub 2015 May 26. PubMed PMID: 26015543; PubMed Central PMCID: PMC4483769.
  9. Knowles BC, Weis VG, Yu S, Roland JT, Williams JA, Alvarado GS, Lapierre LA, Shub MD, Gao N, Goldenring JR. Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes. J Cell Sci. 2015 Apr 15;128(8):1617-26. doi: 10.1242/jcs.163303. Epub 2015 Feb 11. PubMed PMID: 25673875; PubMed Central PMCID: PMC4518445.
  10. Yu S, Yehia G, Wang J, Stypulkowski E, Sakamori R, Jiang P, Hernandez-Enriquez B, Tran TS, Bonder EM, Guo W, Gao N. Global ablation of the mouse Rab11a gene impairs early embryogenesis and matrix metalloproteinase secretion. J Biol Chem. 2014 Nov 14;289(46):32030-43. doi: 10.1074/jbc.M113.538223. Epub 2014 Sep 30. PubMed PMID: 25271168; PubMed Central PMCID: PMC4231680.
  11. Sakamori R, Yu S, Zhang X, Hoffman A, Sun J, Das S, Vedula P, Li G, Fu J, Walker F, Yang CS, Yi Z, Hsu W, Yu DH, Shen L, Rodriguez AJ, Taketo MM, Bonder EM, Verzi MP, Gao N. CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer Res. 2014 Oct 1;74(19):5480-92. doi: 10.1158/0008-5472.CAN-14-0267. Epub 2014 Aug 11. PubMed PMID: 25113996; PubMed Central PMCID: PMC4184946.
  12. Yu S, Nie Y, Knowles B, Sakamori R, Stypulkowski E, Patel C, Das S, Douard V, Ferraris RP, Bonder EM, Goldenring JR, Ip YT, Gao N. TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis. EMBO J. 2014 Sep 1;33(17):1882-95. doi: 10.15252/embj.201487888. Epub 2014 Jul 24. PubMed PMID:25063677; PubMed Central PMCID: PMC4195784.
  13. Chahar S, Gandhi V, Yu S, Desai K, Cowper-Sal-lari R, Kim Y, Perekatt AO, Kumar N, Thackray JK, Musolf A, Kumar N, Hoffman A, Londono D, Vazquez BN, Serrano L, Shin H, Lupien M, Gao N, Verzi MP. Chromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4α during colitis. Mol Cell Biol. 2014 Sep;34(17):3291-304. doi: 10.1128/MCB.00349-14. Epub 2014 Jun 30. PubMed PMID: 24980432; PubMed Central PMCID: PMC4135557.
  14. Perekatt AO, Valdez MJ, Davila M, Hoffman A, Bonder EM, Gao N, Verzi MP. YY1 is indispensable for Lgr5+ intestinal stem cell renewal. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7695-700. doi: 10.1073/pnas.1400128111. Epub 2014 May 12. PubMed PMID: 24821761; PubMed Central PMCID: PMC4040551.
  15. Sakamori R, Das S, Yu S, Feng S, Stypulkowski E, Guan Y, Douard V, Tang W, Ferraris RP, Harada A, Brakebusch C, Guo W, Gao N. Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice. J Clin Invest. 2012 Mar;122(3):1052-65. doi: 10.1172/JCI60282. Epub 2012 Feb 22. PubMed PMID: 22354172; PubMed Central PMCID: PMC3287229.

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