Researcher Profile

Leroy F. Liu, PhD

Professor of Pharmacology
Robert Wood Johnson Medical School
Rutgers, The State University of New Jersey

RWJMS Research Tower
675 Hoes Lane West, Room 436
Piscataway, NJ 08854

Phone: (732) 235-4592

Assistant: Lucyna Lis
(732) 235-5526

Research Program Alignment

Membership Type: Full

Research Interests

  • Drug development
  • And cancer pharmacology

Selected Publications

Sui Zhang, Xiaobing Liu, Tasneem Bawa-Khalfe, Long-Sheng Lu, Yi Lisa Lyu, Leroy F. Liu, & Edward T.H. Yeh. Identification of the Molecular Basis of Doxorubicin-Induced Cardiotoxicity. Nature Medicine, in press (Oct. 2012 issue).

Wan S, Pestka S, Jubin RG, Lyu YL, Tsai Y-C, and Liu, L. F. (2012) Chemotherapeutics and Radiation Stimulate MHC Class I Expression through Elevated Interferon-beta Signaling in Breast Cancer Cells. PLoS ONE 7(3): e32542. doi:10.1371/journal.pone.0032542.

Desai, S. D, Reed, R. E. Burks, J., Wood, L. M., Pullikuth, A. K., Haas, A. L., and Liu, L. F., Breslin, J. B., Meiners S. and Sankar S. ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells. Experimental Biol. and Medicine, 237:38-49 (2012).

Lin, R.-K., Zhou, N., Lyu, Y. L., Tsai, Y.-C., Lu, C.-H., Kerrigan, J., Chen, Y-C., Guan, Z., Hsieh, T.-H., and Liu, L. F. Dietary Isothiocyanates-Induced Apoptosis via Thiol Modification of DNA Topoisomerase IIa. J. Biol. Chem. 286:33591-600 (2011).

Tsai, Y.-C., Pestka, S. Lu-Hai Wang, L.-H. Runnels, L. Wan, S. and Liu, L. F., Interferon-b Autocrine Signaling Contributes to Oncogenic Ras Transformation. PLoS ONE, 6(8): e24291. doi:10.1371/journal.pone.0024291 (2011).

Wood, L. M., Sankar, S., Reed, R. E., Haas, A. L., Liu, L. F. McKinnon, P. and Desai, S. D. A Novel Role for ATM in Regulating Proteasome-Mediated Protein Degradation through Suppression of the ISG15 Conjugation Pathway. PLoS ONE, 6:16422 (2011).

Azarova, A. M., Lin, R.-K., Tsai, Y.-C, Liu, L. F., Lin, C.-P. and Lyu, Y. L. Genistein induces topoisomerase IIbeta- and proteasome-mediated DNA sequence rearrangements: Implications in infant leukemia, Biochem. Biophys. Res. Comm, 399:66-71 (2010).

Satyanarayana M, Kim YA, Rzuczek SG, Pilch DS, Liu AA, Liu, L.F, Rice JE, LaVoie EJ. Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity. Bioorg Med Chem Lett. 20:3150-3154 (2010).

Rzuczek SG, Pilch DS, Liu A, Liu L, Lavoie EJ, Rice JE Macrocyclic Pyridyl Polyoxazoles: Selective RNA and DNA G-Quadruplex Ligands as Antitumor Agents. J Med Chem, 53:3632-3644 (2010).

Lin, C. P., Ban, P., Lyu, Y. L. and Liu, L. F.  Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double-strand breaks at arrested replication forks. J. Biol. Chem. 284:28082-92 (2009).

Tsai YC, Qi H, Lin CP, Lin RK, Kerrigan JE, Rzuczek SG, Lavoie EJ, Rice JE, Pilch DS, Lyu YL, Liu L.F., A G-quadruplex stabilizer induces M phase cell cycle arrest. J. Biol. Chem. 284:22535-43 (2009).

Sharma L, Tsai YC, Liu AA, Liu L.F., LaVoie EJ. Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones. Eur J Med Chem. 44:1471-6 (2009).

Feng W, Satyanarayana M, Tsai YC, Liu AA, Liu L.F., LaVoie EJ. Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide. Eur J Med Chem. 44:3433-8 (2009).

Feng W, Satyanarayana M, Tsai YC, Liu AA, Liu L.F., LaVoie EJ. 12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents. Bioorg Med Chem. 17:2877-85 (2009)

Feng, W, Satyanarayana, M, Cheng, L, Liu, A, Tsai, YC, Liu, L. F. and Lavoie, E. J. Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents. Bioorg Med Chem. 16(20):9295-301. (2008).

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