Alice Y.C. Liu, PhD
Professor of Cell Biology and Neuroscience
Nelson Biology Laboratories
Phone: (732) 445-2730
Research Program Alignment
Membership Type: Associate - CCSG
- Stress and aging
- And biochemical and molecular changes in aging.
Lu JB, Park J, Liu AY-C and Chen KY. (2000) Osmotic stress-induced activation of HSF1 DNA binding activity is dramatically attenuated in senescent human cells. J. Cell. Physiol. 184:183-190.
Park J and Liu AY-C. (2000) Pervanadate induces the hyperphosphorylation but not the activaton of human heat shock factor 1. J. Cell. Physiol. 185: 348-357.
Park J and Liu AY-C. (2001) c-Jun-N-terminal kinase phosphorylates the HSF1 transcriptional activation domain: Role of JNK in the regualtion of the heat shock response. J. Cell. Biochemistry 82: 326-338.
Manalo D J and Liu AY-C. (2001) Resolution, detection, and characterization of redox conformers of human HSF1. J. Biol. Chem. 276: 23554-23561.
Manalo DJ, Lin Z and Liu AY-C. (2002) Redox-dependent regulation of the function and conformation of human HSF1. Biochemistry, 41: 2580-2588.
Khalil S, Luciano J, Chen W, Liu, A. Y.-C. (2006) Dynamic regulation and involvement of the heat shock transcriptional response in arsenic carcinogenesis. J. Cell Physiology, 207: 562-569.
Oza J, Yang JX, Chen KY and Liu, A. Y.-C. (2008) Changes in the regulation of heat shock gene expression in neural differentiation. Cell Stress & Chaperones 13(1): 73-84.
Yang JX, Oza J, Bridges K, Chen KY, Liu, A. Y.-C. (2008) Neural differentiation and the attenuated heat shock response. Brain Research 1203: 39-50.
Yang JX, Bridges K, Chen KY, Liu, A. Y.-C. (2008) Riluzole increases the amount of latent HSF1 for an amplified heat shock response and cytoprotection. PLoSONE, 3(8):e2864. doi:10.1371/journal.pone.0002864.
Lu J, Gosslau A, Liu A Y-C and Chen KY (2008) PCR differential display-based identification of regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by black tea polyphenol theaflavin monogallate. European Journal of Pharmacology 601: 66-72.
Gosslau A, Jao DL, Butler R, Liu AY-C, Chen KY. (2009) Thermal killing of human colon cancer cells is associated with the loss of eukaryotic initiation factor 5A. Journal of Cellular Physiology, 219:485-493.
Lee YK, Liu DJ, Lu J, Chen KY, and Liu AY-C. (2009) Aberrant regulation and modification of heat shock factor 1 in senescent human diploid fibroblasts. J. Cellular Biochemistry. 106:267-278.
Liu A Y-C, Mathur R, Mei N, Langhammer CG, Babiarz B, and Firestein BL. (2011) The neuroprotective drug riluzole amplifies the heat shock factor 1 (HSF1)- and glutamate transporter 1 (GLT1)-dependent cytoprotective mechanisms for neuronal survival. J. Biological Chemistry. 286: 2785-2794.
Daniel Komlos, Kara D. Mann1, Yue Zhuo, Christopher L. Ricupero, Ronald P. Hart, Alice Y.-C. Liu, and Bonnie L. Firestein. Glutamate dehydrogenase 1 dn SIRT4 regulate glial development. GLIA, in press.
Diana J. Liu, David Hammer, Daniel Komlos, Kuang Yu Chen, Bonnie L. Firestein, and Alice Y.-C. Liu. SIRT1 deacetylase regulates neuronal differentiation and HSP70 induction. Submitted.