Researcher Profile

Alice Y.C. Liu, PhD

Professor of Cell Biology and Neuroscience
School of Arts and Sciences
Rutgers, The State University of New Jersey

Nelson Biology Laboratories
604 Allison Road, Room C210
Piscataway, NJ 08855-8082

Phone: (732) 445-2730

Research Program Alignment

Membership Type: Associate

Research Interests

  • Stress and aging
  • And biochemical and molecular changes in aging.

Selected Publications

Lu JB, Park J, Liu AY-C and Chen KY. (2000) Osmotic stress-induced activation of HSF1 DNA binding activity is dramatically attenuated in senescent human cells. J. Cell. Physiol. 184:183-190.

Park J and Liu AY-C. (2000) Pervanadate induces the hyperphosphorylation but not the activaton of human heat shock factor 1. J. Cell. Physiol. 185: 348-357.

Park J and Liu AY-C. (2001) c-Jun-N-terminal kinase phosphorylates the HSF1 transcriptional activation domain: Role of JNK in the regualtion of the heat shock response. J. Cell. Biochemistry 82: 326-338.

Manalo D J and Liu AY-C. (2001) Resolution, detection, and characterization of redox conformers of human HSF1. J. Biol. Chem. 276: 23554-23561.

Manalo DJ, Lin Z and Liu AY-C. (2002) Redox-dependent regulation of the function and conformation of human HSF1. Biochemistry, 41: 2580-2588.

Khalil S, Luciano J, Chen W, Liu, A. Y.-C. (2006) Dynamic regulation and involvement of the heat shock transcriptional response in arsenic carcinogenesis. J. Cell Physiology, 207: 562-569.

Oza J, Yang JX, Chen KY and Liu, A. Y.-C. (2008) Changes in the regulation of heat shock gene expression in neural differentiation. Cell Stress & Chaperones 13(1): 73-84.

Yang JX, Oza J, Bridges K, Chen KY, Liu, A. Y.-C. (2008) Neural differentiation and the attenuated heat shock response. Brain Research 1203: 39-50.

Yang JX, Bridges K, Chen KY, Liu, A. Y.-C. (2008) Riluzole increases the amount of latent HSF1 for an amplified heat shock response and cytoprotection. PLoSONE, 3(8):e2864. doi:10.1371/journal.pone.0002864.

Lu J, Gosslau A, Liu A Y-C and Chen KY (2008) PCR differential display-based identification of regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by black tea polyphenol theaflavin monogallate. European Journal of Pharmacology 601: 66-72.

Gosslau A, Jao DL, Butler R, Liu AY-C, Chen KY. (2009) Thermal killing of human colon cancer cells is associated with the loss of eukaryotic initiation factor 5A. Journal of Cellular Physiology, 219:485-493.

Lee YK, Liu DJ, Lu J, Chen KY, and Liu AY-C. (2009) Aberrant regulation and modification of heat shock factor 1 in senescent human diploid fibroblasts. J. Cellular Biochemistry. 106:267-278.

Liu A Y-C, Mathur R, Mei N, Langhammer CG, Babiarz B, and Firestein BL. (2011) The neuroprotective drug riluzole amplifies the heat shock factor 1 (HSF1)- and glutamate transporter 1 (GLT1)-dependent cytoprotective mechanisms for neuronal survival. J. Biological Chemistry. 286: 2785-2794.

Daniel Komlos, Kara D. Mann1, Yue Zhuo, Christopher L. Ricupero, Ronald P. Hart, Alice Y.-C. Liu, and Bonnie L. Firestein. Glutamate dehydrogenase 1 dn SIRT4 regulate glial development. GLIA, in press.

Diana J. Liu, David Hammer, Daniel Komlos, Kuang Yu Chen, Bonnie L. Firestein, and Alice Y.-C. Liu. SIRT1 deacetylase regulates neuronal differentiation and HSP70 induction. Submitted.

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