Researcher Profile

James S. Goydos, MD

Professor of Surgery, Surgical Oncology
Robert Wood Johnson Medical School
Rutgers, The State University of New Jersey

Rutgers Cancer Institute of New Jersey
195 Little Albany Street
New Brunswick, NJ 08901-1914

Phone: (732) 235-7593

Assistant: Iris Blick
(732) 235-7563

Resident Member, Rutgers Cancer Institute of New Jersey

Research Program Alignment

Membership Type: Full

Research Interests

  • Melanoma and soft tissue tumors
  • Lymph node mapping
  • Selective lymphadenectomy
  • Isolated limb profusions
  • Potential role of the aberrant expression of Grm1 in human melanoma development and progression

Selected Publications

Pollock PM, Cohen-Solal K, Sood R, Namkoong J, Martino JJ, Koganti A, Zhu H, Robbins C, Makalowska I, Shin SS, Marin Y, Roberts KG, Yudt LM, Chen A, Cheng J, Incao A, Pinkett HW, Graham CL, Dunn K, Crespo-Carbone SM, Mackason KR, Ryan KB, Sinsimer D, Goydos J, Reuhl KR, Eckhaus M, Meltzer PS, Pavan WJ, Trent JM, Chen S. Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nature Genetics 2003, 34(1):108-12

Alsina J, Gorsk DH, Germino FJ, Shih W, Lu SE, Zhang ZG, Yang JM, Hait WN, Goydos JS. Detection of Mutations in the Mitogen-Activated Protein Kinase (MAPK) Pathway in Human Melanoma. Clin Cancer Res. 2003 Dec 15;9(17):6419-25.

Goydos JS, Mann B, Kim H, Gabriel M, Shih W, Germino FJ, Gorski DH. Detection of B-RAF and N-RAS mutations in human melanoma. J Am Coll Surg. 2005 Mar;200(3):362-70.

Namkoong J, Shin S-S, Lee HJ, Marin YE, Wall BA, Goydos JS, Chen S. Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma, Cancer Research, 2007, 67 (5): pp2298-2305

Lopez-Bergami P, Huang C, Goydos JS, Yip, D, Bar-Eli M, Herlyn M, Smalley KSM, Mahale A, Aaronson S, and Ronai Z. Re-wired ERK-JNK signaling pathways in melanoma Cancer Cell 2007 May;11(5):447-60.

Qi J, Nakayama K, Gaitonde S, Goydos JS, Krajewski S, Eroshkin A, Bar-Sagi D, Bowtell D, Ronai Z. The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16713-8. PMCID: PMC2575485

Yip D, Le M, Chan J-L, Lee JH, Mehnert JM, Yudd A, Kempf J, Shih WJ, Chen S, and Goydos JS. A Phase 0 Trial of Riluzole in Patients with Resectable Stage III and IV Melanoma. Clin Cancer Res. 2009 Jun 1;15(11):3896-902. PMCID: PMC2812866

Shin SS, Wall BA, Goydos JS, and Chen S. AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1). Pigment Cell Melanoma Res. 2009 Oct 20, 23 (1), 103–111. PMCID: PMC2810105

Lopez-Bergami P, Kim H, Dewing A, Goydos JS, Aaronson S, and Ronai Z. C-Jun Regulates PDK1 Transcription: Implication For AKT And PKC Activities And Melanoma Tumorigenesis. J Biol Chem. 2010 Jan 8;285(2):903-13. PMCID: PMC2801291

Le MN, Chan LJ, Rosenberg SA, Nabatian AN, Merrigan K, Cohen-Solal K, Goydos JS. The Glutamate Release Inhibitor Riluzole Decreases Migration, Invasion and Proliferation of Melanoma Cells. Journal of Investigative Dermatology 2010 Sep;130(9):2240-9.

Khan AJ, Wall BA, Ahlawat S, Green C, Schiff D, Mehnert JM, Goydos JS, Chen S, and Haffty BG, Riluzole Enhances Ionizing Radiation-induced Cytotoxicity in Human Melanoma Cells that Ectopically Express Metabotropic Glutamate Receptor 1 In Vitro and In Vivo Clin Cancer Res. 2011 April 1 17(7): 1807-1814. PMCID: PMC3070864

Lee JH, Chen Y, Chan JL, Qian YW, Goydos JS. Molecular analysis of melanoma-induced sentinel lymph node immune dysfunction. Cancer Immunol Immunother. 2011 May;60(5):685-92. Epub 2011 Feb 16.

Lee HJ, Wall BA, Wangari-Talbot J, Shin SS, Rosenberg S, Chan JL, Namkoong J, Goydos JS, Chen S. Glutamatergic pathway targeting in melanoma: single-agent and combinatorial therapies. Clin Cancer Res. 2011 Nov 15;17(22):7080-92. Epub 2011 Aug 15. PMCID: PMC3218300

Gembarska A, Luciani F, Fedele C, Russell EA, Dewaele M, Villar S, Zwolinska A, Haupt S, de Lange J, Yip D, Goydos J, Haigh JJ, Haupt Y, Larue L, Jochemsen A, Shi H, Moriceau G, Lo RS, Ghanem G, Shackleton M, Bernal F, Marine JC. MDM4 is a key therapeutic target in cutaneous melanoma. Nature Med. 2012 Jul 22. doi: 10.1038/nm.2863. [Epub ahead of print] PMID: 22820643

Ochoa-Alvarez JA, Krishnan H, Shen Y, Acharya NK, Han M, McNulty DE, Hasegawa H, Hyodo T, Senga T, Geng JG, Kosciuk M, Shin SS, Goydos JS, Temiakov D, Nagele RG, Goldberg GS. Plant lectin can target receptors containing sialic Acid, exemplified by podoplanin, to inhibit transformed cell growth and migration. PLoS One. 2012;7(7):e41845. Epub 2012 Jul 23. PMID:22844530

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