Researcher Profile

Karine A. Cohen-Solal, PhD

Assistant Professor of Medicine, Medical Oncology
Robert Wood Johnson Medical School
Rutgers, The State University of New Jersey

Rutgers Cancer Institute of New Jersey
195 Little Albany Street
New Brunswick, NJ 08901-1914

Phone: (732) 235-8512

Assistant: Pat Walker
(732) 235-6031

Research Program Alignments

Membership Type: Full

Research Interests

  • Melanoma
  • Resistance to TGF Beta
  • Crosstalks between TGF Beta and Other Signaling Pathways
  • Role of TGF Beta in Melanoma Development and Progression

Selected Publications

Cohen-Solal, K., Reuhl, K. R., Ryan, K. B., Roberts, K. G. And Chen, S.Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase. Pigment Cell Research (2001) 14, 466-474.

Cohen-Solal, K., Crespo-Carbone, S.M., Namkoong, J., Mackason, K. R., Roberts, K. G, Reuhl, K. R. And Chen, S. Progressive appearance of pigmentation in amelanotic melanoma lesions. Pigment Cell Research (2002) 15, 282-289.

Pollock, P., Cohen-Solal, K., Sood, R., Namkoong, J., Koganti, A., Zhu, H., Robbins, C., Makalowska, I., Martino, J.M., Shin, S., Marin, Y., Roberts, K. G., Yudt, L.M., Chen, A., Cheng, J., Incao, A., Pinkett, H.W., Graham, C.L., Dunn, K., Galdzicki, M., Crespo-Carbone, S.M., Mackason, K. R., Ryan, K.B., Sinsimer, D., Goydos, J., Reuhl, K. R., Eckhaus, M., Meltzer, P.S., Pavan, W.J., Trent, J.M. And Chen, S. Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nature Genetics (2003) 34, 108-112.

Cohen-Solal, K., Sood, R., Marin, Y., Crespo-Carbone, S.M., Sinsimer, D., Martino, J.J., Robbins, C., Makalowska, I., Trent, J.M. And Chen, S. Identification and characterization of mouse rab 32 by mrna and protein expression analysis. Biochimica Biophysica Acta (2003) 1651, 68-75.

Marin, Y., Namkoong, J., Cohen-Solal, K., Shin, S., Martino, J., Oka, M. And Chen, S. Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates Erk1/2 via PKCe. Cell Signaling (2006) 18, 1279-1286.

Le, M. N., Chan, J. L.-K., Rosenberg, S., Nabatian, A., Merrigan, K., Cohen-Solal, K. and Goydos J. S. The glutamate release inhibitor Riluzole decreases migration, invasion and proliferation of melanoma cells. Journal of Investigative Dermatology (2010) 130, 2240-2249.

Lasfar, A. and Cohen-Solal, K. Resistance to Transforming Growth Factor-β-mediated tumor suppression in melanoma: Are multiple mechanisms in place? Carcinogenesis (2010) 31, 1710-1717.

Cohen-Solal, K.,  Merrigan, K., Chan, J. L.-K., Goydos J. S., Chen, W., Foran, D.J., Liu, F., Lasfar, A. and Reiss, M. Constitutive Smad linker phosphorylation in melanoma: A mechanism of resistance to Transforming Growth Factor-β-mediated tumor suppression. Pigment Cell Melanoma Res. (2011) 24. 512-524

Lasfar, A, Abushahba, W., Balan, M. and Cohen-Solal, K.  Interferon lambda: A new sword in cancer immunotherapy. (2011) Clinical and Developmental Immunology (2011);2011:349575. Epub 2011 Dec 6.
Abushahba, W., Olabisi, O. O., Jeong, B-S., Boregowda, R. K. , Wen, Y., Liu, F., Goydos, J. S., Lasfar, A. and Cohen-Solal, K. Non-canonical Smads phosphorylation induced by the glutamate release inhibitor, riluzole, through GSK3 activation in melanoma. In Press in PLoS ONE, 2012. DOI 10.1371/journal.pone.0047312
Cohen-Solal, K., Bailly, A., Rauch, C., Quesne, M. And Milgrom, E. "Specific binding of progesterone receptor to progesterone-responsive elements does not require prior dimerization". Eur. J. Biochem. (1993) 214, 189-195.

Chauchereau, A., Cohen-Solal, K., Jolivet, A., Bailly, A. And Milgrom, E. "Phosphorylation sites in ligand-induced and ligand-independent activation of the progesterone receptor". Biochemistry (1994) 33, 14333-14338.

Cohen-Solal, K., Villeval, J. L., Titeux, M., Lok, S., Vainchenker, W. And Wendling, F. Constitutive expression of mpl ligand transcripts during thrombocytopenia or thrombocytosis. Blood (1996) 88, 2578-2584.

Cohen-Solal, K., Debili, N., Vainchenker, W. And Wendling, F. Thrombopoietin (Mpl Ligand) and the regulation of platelet production. Thrombosis And Haemostasis (1997) 78, 37-41.

Villeval, J. L., Cohen-Solal, K., Tulliez, M., Giraudier, S., Guichard, J., Burstein, S., Cramer, E., Vainchenker, W. And Wendling, F. High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice. Blood (1997) 90, 4369-4383.

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