Researcher Profiles

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Shaohua Li, MD

Selected Publications

  1. Li S, Harrison D, Carbonetto S, Edgar D, Smyth N, Fässler R, Yurchenco PD. Matrix assembly, regulation and survival functions of laminin and its receptors in embryonic stem cell differentiation. J Cell Biol 157(7):1279-1290 (2002). PMCID: PMC2173546
  2. Sakai T, Li S, Docheva D, Grashoff C, Sakai K, Kostka G, Braun A, Pfeider A, Yurchenco PD, Fässler R.  Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion and controlling actin accumulation. Genes Dev 17(7):926-940 (2003). PMCID: PMC196029
  3. Li S, Edgar D, Fässler R, Wadsworth W, Yurchenco PD. The role of laminin in embryonic cell polarization and tissue organization. Dev Cell 4(5):613-624 (2003)
  4. Li S, Liquari P, McKee KK, Harrison D, Patel R, Lee S, Yurchenco PD. Laminin-sulfatide binding initiates basement membrane assembly and enables receptor signaling in Schwann cells and fibroblasts. J Cell Biol 169(1):179-189 (2005). PMCID: PMC2171891
  5. Li S, Bordoy R, Stanchi F, Moser M, Braun A, Kudlacek O, Wever UM, Yurchenco PD, Fässler R. PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during peri-implantation stage. J Cell Sci 118(13):2913-2921 (2005)
  6. Wu X*, Li S*, Chrostek-Grashoff A, Czuchra A, Meyer H, Yurchenco PD, Brakebusch C. Cdc42 is crucial for the establishment of cell polarity during early embryonic development. Dev Dyn 236:2767-2778 (2007) (*equal contributors)
  7. Liu J, He X, Corbett SA, Lowry SF, Graham AM, Fässler R, Li S. Integrins are required for the differentiation of visceral endoderm. J Cell Sci 122(2): 233-242 (2009). PMCID: PMC2714419
  8. Qi Y, Liu J, Wu X, Brakebusch C, Leitges M, Han Y, Corbett SA, Lowry SF, Graham AM, Li S. Cdc42 controls vascular network assembly through protein kinase Ci during embryonic vasculogenesis. Arterioscler Thromb Vasc Biol 31(8):1561-1870 (2011). PMCID: PMC3166614
  9. Seidl S, Braun U, Roos N, Li S, Lüdtke TH, Kispert A, Leitges M. Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at embryonic day 7.5. PLoS One 14;8(5):e62756. (2013)
  10. Qi Y, Saadat S, Liu J, Graham AM, Li S. A chimeric embryoid body model to study vascular morphogenesis. Methods in Molecular Biology, 1214:215-24 (2015)