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Alexander Ploss, PhD

Publications since 2011

Winer, B. Y. Ding, Q. Gaska, J. Ploss, A. In vivo models of hepatitis B and C virus infection. FEBS Lett, In process, . (PMID: 27009462)

Douam, F. Ding, Q. Ploss, A. Recent advances in understanding hepatitis C. F1000Res, 5:, . (PMID: 26918166)

Douam, F. Gaska, J. M. Winer, B. Y. Ding, Q. von Schaewen, M. Ploss, A. Genetic Dissection of the Host Tropism of Human-Tropic Pathogens. Annu Rev Genet, In process, . (PMID: 26407032)

Winer, B. Y. Ploss, A. Breaking the species barrier for hepatitis delta virus. Hepatology, In process, . (PMID: 26289017)

Perin, P. M. Haid, S. Brown, R. J. Doerrbecker, J. Schulze, K. Zeilinger, C. von Schaewen, M. Heller, B. Vercauteren, K. Luxenburger, E. Baktash, Y. M. Vondran, F. W. Speerstra, S. Awadh, A. Mukhtarov, F. Schang, L. M. Kirschning, A. Muller, R. Guzman, C. A. Kaderali, L. Randall, G. Meuleman, P. Ploss, A. Pietschmann, T. Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1. Hepatology, In process, . (PMID: 26248546)

Ploss, A. Walker, C. Editorial overview: Progress and challenges in modeling human viral diseases in vivo. Curr Opin Virol, 13:v-vii, . (PMID: 26219570)

Winer, B. Y. Ploss, A. Determinants of hepatitis B and delta virus host tropism. Curr Opin Virol, In process, . (PMID: 26164658)

Scull, M. A. Shi, C. de Jong, Y. P. Gerold, G. Ries, M. von Schaewen, M. Donovan, B. M. Labitt, R. N. Horwitz, J. A. Gaska, J. M. Hrebikova, G. Xiao, J. W. Flatley, B. Fung, C. Chiriboga, L. Walker, C. M. Evans, D. T. Rice, C. M. Ploss, A. Hepatitis C virus infects rhesus macaque hepatocytes and simianized mice. Hepatology, 62:57-67, . (PMID: 25820364, PMCID: PMC4482775)

Siu, E. Ploss, A. Modeling malaria in humanized mice: opportunities and challenges. Ann N Y Acad Sci, 1342:29-36, . (PMID: 25678404)

Gaska, J. M. Ploss, A. Study of viral pathogenesis in humanized mice. Curr Opin Virol, 11:14-20, . (PMID: 25618248, PMCID: PMC4456257)

Douam, F. Ploss, A. Proteomic approaches to analyzing hepatitis C virus biology. Proteomics, In process, . (PMID: 25809442)

Gardner, M. R. Kattenhorn, L. M. Kondur, H. R. von Schaewen, M. Dorfman, T. Chiang, J. J. Haworth, K. G. Decker, J. M. Alpert, M. D. Bailey, C. C. Neale, E. S. Jr Fellinger, C. H. Joshi, V. R. Fuchs, S. P. Martinez-Navio, J. M. Quinlan, B. D. Yao, A. Y. Mouquet, H. Gorman, J. Zhang, B. Poignard, P. Nussenzweig, M. C. Burton, D. R. Kwong, P. D. Piatak, M. Jr Lifson, J. D. Gao, G. Desrosiers, R. C. Evans, D. T. Hahn, B. H. Ploss, A. Cannon, P. M. Seaman, M. S. Farzan, M. AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges. Nature, 519:87-91, . (PMID: 25707797, PMCID: PMC4352131)

Stoddard, M. B. Li, H. Wang, S. Saeed, M. Andrus, L. Ding, W. Jiang, X. Learn, G. H. von Schaewen, M. Wen, J. Goepfert, P. A. Hahn, B. H. Ploss, A. Rice, C. M. Shaw, G. M. Identification, molecular cloning, and analysis of full-length hepatitis C virus transmitted/founder genotypes 1, 3, and 4. MBio, 6:e02518, . (PMID: 25714714, PMCID: PMC4358020)

Ding, Q. von Schaewen, M. Ploss, A. The impact of hepatitis C virus entry on viral tropism. Cell Host Microbe, 16:562-568, . (PMID: 25525789, PMCID: PMC4272444)

Lacek, K. Urbanowicz, R. A. Troise, F. De Lorenzo, C. Severino, V. Di Maro, A. Tarr, A. W. Ferrara, F. Ploss, A. Temperton, N. Ball, J. K. Nicosia, A. Cortese, R. Pessi, A. Dramatic Potentiation of the Antiviral Activity of HIV Antibodies by Cholesterol Conjugation. J Biol Chem, In process, . (PMID: 25342747)

Billerbeck, E. Labitt, R. N. Vega, K. Frias-Staheli, N. Dorner, M. Xiao, J. Rice, C. M. Ploss, A. Insufficient IL-12 signaling favors differentiation of human CD4+ and CD8+ T cells into GATA-3 and GATA-3 T-bet subsets in humanized mice. Immunology, 143:202-218, . (PMID: 24766459, PMCID: PMC4172137)

de Jong, Y. P. Dorner, M. Mommersteeg, M. C. Xiao, J. W. Balazs, A. B. Robbins, J. B. Winer, B. Y. Gerges, S. Vega, K. Labitt, R. N. Donovan, B. M. Giang, E. Krishnan, A. Chiriboga, L. Charlton, M. R. Burton, D. R. Baltimore, D. Law, M. Rice, C. M. Ploss, A. Broadly neutralizing antibodies abrogate established hepatitis C virus infection. Sci Transl Med, 6:254ra129, . (PMID: 25232181)

Ploss, A. Mouse models for human infectious diseases. J Immunol Methods, 410:1-2, . (PMID: 25017506)

von Schaewen, M. Ding, Q. Ploss, A. Visualizing hepatitis C virus infection in humanized mice. J Immunol Methods, 410:50-59, . (PMID: 24642425, PMCID: PMC4163068)

von Schaewen, M. Ploss, A. Murine models of hepatitis C: what can we look forward to? Antiviral Res, 104:15-22, . (PMID: 24462693, PMCID: PMC4068254)

Sheahan, T. Imanaka, N. Marukian, S. Dorner, M. Liu, P. Ploss, A. Rice, C. M. Interferon lambda alleles predict innate antiviral immune responses and hepatitis C virus permissiveness. Cell Host Microbe, 15:190-202, . (PMID: 24528865, PMCID: PMC4104123)

Frias-Staheli, N. Dorner, M. Marukian, S. Billerbeck, E. Labitt, R. N. Rice, C. M. Ploss, A. Utility of humanized BLT mice for analysis of dengue virus infection and antiviral drug testing. J Virol, 88:2205-2218, . (PMID: 24335303, PMCID: PMC3911540)

Horwitz, J. A. Halper-Stromberg, A. Mouquet, H. Gitlin, A. D. Tretiakova, A. Eisenreich, T. R. Malbec, M. Gravemann, S. Billerbeck, E. Dorner, M. Buning, H. Schwartz, O. Knops, E. Kaiser, R. Seaman, M. S. Wilson, J. M. Rice, C. M. Ploss, A. Bjorkman, P. J. Klein, F. Nussenzweig, M. C. HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. Proc Natl Acad Sci U S A, 110:16538-16543, . (PMID: 24043801, PMCID: PMC3799352)

Dorner, M. Horwitz, J. A. Donovan, B. M. Labitt, R. N. Budell, W. C. Friling, T. Vogt, A. Catanese, M. T. Satoh, T. Kawai, T. Akira, S. Law, M. Rice, C. M. Ploss, A. Completion of the entire hepatitis C virus life cycle in genetically humanized mice. Nature, 501:237-241, . (PMID: 23903655, PMCID: PMC3858853)

Vogt, A. Scull, M. A. Friling, T. Horwitz, J. A. Donovan, B. M. Dorner, M. Gerold, G. Labitt, R. N. Rice, C. M. Ploss, A. Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines. Virology, 444:1-11, . (PMID: 23777661, PMCID: PMC3755106)

Billerbeck, E. Horwitz, J. A. Labitt, R. N. Donovan, B. M. Vega, K. Budell, W. C. Koo, G. C. Rice, C. M. Ploss, A. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. J Immunol, 191:1753-1764, . (PMID: 23833235, PMCID: PMC3735836)

Gruell, H. Bournazos, S. Ravetch, J. V. Ploss, A. Nussenzweig, M. C. Pietzsch, J. Antibody and antiretroviral preexposure prophylaxis prevent cervicovaginal HIV-1 infection in a transgenic mouse model. J Virol, 87:8535-8544, . (PMID: 23720722, PMCID: PMC3719827)

Anggakusuma Colpitts, C. C. Schang, L. M. Rachmawati, H. Frentzen, A. Pfaender, S. Behrendt, P. Brown, R. J. Bankwitz, D. Steinmann, J. Ott, M. Meuleman, P. Rice, C. M. Ploss, A. Pietschmann, T. Steinmann, E. Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Gut, In process, . (PMID: 23903236)

Guermonprez, P. Helft, J. Claser, C. Deroubaix, S. Karanje, H. Gazumyan, A. Darasse-Jeze, G. Telerman, S. B. Breton, G. Schreiber, H. A. Frias-Staheli, N. Billerbeck, E. Dorner, M. Rice, C. M. Ploss, A. Klein, F. Swiecki, M. Colonna, M. Kamphorst, A. O. Meredith, M. Niec, R. Takacs, C. Mikhail, F. Hari, A. Bosque, D. Eisenreich, T. Merad, M. Shi, Y. Ginhoux, F. Renia, L. Urban, B. C. Nussenzweig, M. C. Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection. Nat Med, 19:730-738, . (PMID: 23685841)

Horwitz, J. A. Dorner, M. Friling, T. Donovan, B. M. Vogt, A. Loureiro, J. Oh, T. Rice, C. M. Ploss, A. Expression of heterologous proteins flanked by NS3-4A cleavage sites within the hepatitis C virus polyprotein. Virology, 439:23-33, . (PMID: 23485372, PMCID: PMC3620014)

Shi, C. Ploss, A. Hepatitis C virus vaccines in the era of new direct-acting antivirals. Expert Rev Gastroenterol Hepatol, 7:171-185, . (PMID: 23363265)

Dorner, M. Rice, C. M. Ploss, A. Study of hepatitis C virus entry in genetically humanized mice. Methods, 59:249-257, . (PMID: 22687621, PMCID: PMC3652663)

Sandmann, L. Ploss, A. Barriers of hepatitis C virus interspecies transmission. Virology, 435:70-80, . (PMID: 23217617, PMCID: PMC3523278)

Billerbeck, E. de Jong, Y. Dorner, M. de la Fuente, C. Ploss, A. Animal models for hepatitis C. Curr Top Microbiol Immunol, 369:49-86, . (PMID: 23463197)

Klein, F. Halper-Stromberg, A. Horwitz, J. A. Gruell, H. Scheid, J. F. Bournazos, S. Mouquet, H. Spatz, L. A. Diskin, R. Abadir, A. Zang, T. Dorner, M. Billerbeck, E. Labitt, R. N. Gaebler, C. Marcovecchio, P. M. Incesu, R. B. Eisenreich, T. R. Bieniasz, P. D. Seaman, M. S. Bjorkman, P. J. Ravetch, J. V. Ploss, A. Nussenzweig, M. C. HIV therapy by a combination of broadly neutralizing antibodies in humanized mice. Nature, 492:118-122, . (PMID: 23103874, PMCID: PMC3809838)

Vaughan, A. M. Mikolajczak, S. A. Wilson, E. M. Grompe, M. Kaushansky, A. Camargo, N. Bial, J. Ploss, A. Kappe, S. H. Complete Plasmodium falciparum liver-stage development in liver-chimeric mice. J Clin Invest, 122:3618-3628, . (PMID: 22996664, PMCID: PMC3461911)

Pietzsch, J. Gruell, H. Bournazos, S. Donovan, B. M. Klein, F. Diskin, R. Seaman, M. S. Bjorkman, P. J. Ravetch, J. V. Ploss, A. Nussenzweig, M. C. A mouse model for HIV-1 entry. Proc Natl Acad Sci U S A, 109:15859-15864, . (PMID: 23019371, PMCID: PMC3465400)

Schoggins, J. W. Dorner, M. Feulner, M. Imanaka, N. Murphy, M. Y. Ploss, A. Rice, C. M. Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro. Proc Natl Acad Sci U S A, 109:14610-14615, . (PMID: 22908290, PMCID: PMC3437900)

Vaughan, A. M. Kappe, S. H. Ploss, A. Mikolajczak, S. A. Development of humanized mouse models to study human malaria parasite infection. Future Microbiol, 7:657-665, . (PMID: 22568719, PMCID: PMC3848604)

Ploss, A. Dubuisson, J. New advances in the molecular biology of hepatitis C virus infection: towards the identification of new treatment targets. Gut, 61 Suppl 1:i25-i35, . (PMID: 22504917)

Giang, E. Dorner, M. Prentoe, J. C. Dreux, M. Evans, M. J. Bukh, J. Rice, C. M. Ploss, A. Burton, D. R. Law, M. Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus. Proc Natl Acad Sci U S A, 109:6205-6210, . (PMID: 22492964, PMCID: PMC3341081)

Meng, X. Schoggins, J. Rose, L. Cao, J. Ploss, A. Rice, C. M. Xiang, Y. C7L family of poxvirus host range genes inhibits antiviral activities induced by type I interferons and interferon regulatory factor 1. J Virol, 86:4538-4547, . (PMID: 22345458, PMCID: PMC3318637)

Schwartz, R. E. Trehan, K. Andrus, L. Sheahan, T. P. Ploss, A. Duncan, S. A. Rice, C. M. Bhatia, S. N. Modeling hepatitis C virus infection using human induced pluripotent stem cells. Proc Natl Acad Sci U S A, 109:2544-2548, . (PMID: 22308485, PMCID: PMC3289320)

Ploss, A. Evans, M. J. Hepatitis C virus host cell entry. Curr Opin Virol, 2:14-19, . (PMID: 22440961, PMCID: PMC3311996)

Scull, M. A. Ploss, A. Exiting from uncharted territory: hepatitis C virus assembles in mouse cell lines. Hepatology, 55:645-648, . (PMID: 22287293, PMCID: PMC3270883)

Dorner, M. Ploss, A. Deconstructing hepatitis C virus infection in humanized mice. Ann N Y Acad Sci, 1245:59-62, . (PMID: 22211981)

Andrus, L. Marukian, S. Jones, C. T. Catanese, M. T. Sheahan, T. P. Schoggins, J. W. Barry, W. T. Dustin, L. B. Trehan, K. Ploss, A. Bhatia, S. N. Rice, C. M. Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells. Hepatology, 54:1901-1912, . (PMID: 22144107, PMCID: PMC3233237)

Marukian, S. Andrus, L. Sheahan, T. P. Jones, C. T. Charles, E. D. Ploss, A. Rice, C. M. Dustin, L. B. Hepatitis C virus induces interferon-lambda and interferon-stimulated genes in primary liver cultures. Hepatology, 54:1913-1923, . (PMID: 21800339, PMCID: PMC3219820)

Dorner, M. Horwitz, J. A. Robbins, J. B. Barry, W. T. Feng, Q. Mu, K. Jones, C. T. Schoggins, J. W. Catanese, M. T. Burton, D. R. Law, M. Rice, C. M. Ploss, A. A genetically humanized mouse model for hepatitis C virus infection. Nature, 474:208-211, . (PMID: 21654804, PMCID: PMC3159410)

de Jong, Y. P. Rice, C. M. Ploss, A. Evaluation of combination therapy against hepatitis C virus infection in human liver chimeric mice. J Hepatol, 54:848-850, . (PMID: 21145816)

Washburn, M. L. Bility, M. T. Zhang, L. Kovalev, G. I. Buntzman, A. Frelinger, J. A. Barry, W. Ploss, A. Rice, C. M. Su, L. A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease. Gastroenterology, 140:1334-1344, . (PMID: 21237170, PMCID: PMC3066273)

Billerbeck, E. Barry, W. T. Mu, K. Dorner, M. Rice, C. M. Ploss, A. Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2Rgamma(null) humanized mice. Blood, 117:3076-3086, . (PMID: 21252091, PMCID: PMC3062310)