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Grace L. Guo, MBBS, PhD

Publications since 2011

Shang, Q. Guo, G. L. Honda, A. Shi, D. Saumoy, M. Salen, G. Xu, G. Bile acid flux through portal but not peripheral veins inhibits CYP7A1 expression without involvement of ileal FGF19 in rabbits. Am J Physiol Gastrointest Liver Physiol, In process, . (PMID: 24994853)

Kong, B. Huang, J. Zhu, Y. Li, G. Williams, J. A. Shen, S. Aleksunes, L. M. Richardson, J. R. Apte, U. Rudnick, D. A. Guo, G. L. Fibroblast Growth Factor 15 Deficiency Impairs Liver Regeneration in Mice. Am J Physiol Gastrointest Liver Physiol, 306:G893-G902, . (PMID: 24699334, PMCID: PMC4024724)

Bailey, A. M. Zhan, L. Maru, D. Shureiqi, I. Pickering, C. R. Izzo, J. He, N. Wei, C. Baladandayuthapani, V. Liang, H. Kopetz, S. Powis, G. Guo, G. L. FXR Silencing in Human Colon Cancer by DNA methylation and KRAS Signaling. Am J Physiol Gastrointest Liver Physiol, 306:G48-G58, . (PMID: 24177031, PMCID: PMC3920083)

Kong, B. Guo, G. L. Soluble Expression of Disulfide Bond Containing Proteins FGF15 and FGF19 in the Cytoplasm of Escherichia coli. PLoS One, 9:e85890, . (PMID: 24465767, PMCID: PMC3896424)

Zhan, L. Liu, H. X. Fang, Y. Kong, B. He, Y. Zhong, X. B. Fang, J. Wan, Y. J. Guo, G. L. Genome-wide binding and transcriptome analysis of human farnesoid x receptor in primary human hepatocytes. PLoS One, 9:e105930, . (PMID: 25198545, PMCID: PMC4157742)

Li, G. Zhu, Y. Tawfik, O. Kong, B. Williams, J. A. Zhan, L. Kassel, K. M. Luyendyk, J. P. Wang, L. Guo, G. L. Mechanisms of STAT3 activation in the liver of FXR knockout mice. Am J Physiol Gastrointest Liver Physiol, 305:G829-G837, . (PMID: 24091600, PMCID: PMC3882431)

Li, G. Kong, B. Zhu, Y. Zhan, L. Williams, J. A. Tawfik, O. Kassel, K. M. Luyendyk, J. P. Wang, L. Guo, G. L. Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice. Toxicol Appl Pharmacol, 272:299-305, . (PMID: 23811326)

Shang, Q. Guo, G. L. Honda, A. Saumoy, M. Salen, G. Xu, G. FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels. J Lipid Res, 54:2606-2614, . (PMID: 23852734, PMCID: PMC3770074)

Thomas, A. M. Hart, S. N. Li, G. Lu, H. Fang, Y. Fang, J. Zhong, X. B. Guo, G. L. Hepatocyte nuclear factor 4 alpha and farnesoid X receptor co-regulates gene transcription in mouse livers on a genome-wide scale. Pharm Res, 30:2188-2198, . (PMID: 23462932, PMCID: PMC3711942)

Jiang, Y. Jin, J. Iakova, P. Hernandez, J. C. Jawanmardi, N. Sullivan, E. Guo, G. L. Timchenko, N. A. Darlington, G. J. Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice. Mech Ageing Dev, 134:407-415, . (PMID: 24007921)

Zhu, Y. Li, G. Dong, Y. Zhou, H. H. Kong, B. Aleksunes, L. M. Richardson, J. R. Li, F. Guo, G. L. Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver. Toxicol Appl Pharmacol, 266:260-266, . (PMID: 23178280, PMCID: PMC3774161)

Borude, P. Edwards, G. Walesky, C. Li, F. Ma, X. Kong, B. Guo, G. L. Apte, U. Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice. Hepatology, 56:2344-2352, . (PMID: 22730081, PMCID: PMC3469721)

Kong, B. Wang, L. Chiang, J. Y. Zhang, Y. Klaassen, C. D. Guo, G. L. Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology, 56:1034-1043, . (PMID: 22467244, PMCID: PMC3390456)

Kong, B. Csanaky, I. L. Aleksunes, L. M. Patni, M. Chen, Q. Ma, X. Jaeschke, H. Weir, S. Broward, M. Klaassen, C. D. Guo, G. L. Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity. Toxicol Appl Pharmacol, 261:189-195, . (PMID: 22521610, PMCID: PMC3371772)

Cui, J. Y. Aleksunes, L. M. Tanaka, Y. Fu, Z. D. Guo, Y. Guo, G. L. Lu, H. Zhong, X. B. Klaassen, C. D. Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice. Am J Physiol Gastrointest Liver Physiol, 302:G979-G996, . (PMID: 22268101, PMCID: PMC3362079)

Li, G. Lin, W. Araya, J. J. Chen, T. Timmermann, B. N. Guo, G. L. A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor. Toxicol Appl Pharmacol, 258:268-274, . (PMID: 22178739, PMCID: PMC3259191)

Li, G. Thomas, A. M. Williams, J. A. Kong, B. Liu, J. Inaba, Y. Xie, W. Guo, G. L. Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. PLoS One, 7:e35895, . (PMID: 22540009, PMCID: PMC3335076)

Williams, J. A. Thomas, A. M. Li, G. Kong, B. Zhan, L. Inaba, Y. Xie, W. Ding, W. X. Guo, G. L. Tissue specific induction of p62/Sqstm1 by farnesoid X receptor. PLoS One, 7:e43961, . (PMID: 22952826, PMCID: PMC3428273)