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Grace L. Guo, MBBS, PhD

Publications since 2011

Kong, B. Zhu, Y. Li, G. Williams, J. A. Buckley, K. Tawfik, O. Luyendyk, J. P. Guo, G. L. Mice with Hepatocyte-Specific FXR Deficiency are Resistant to Spontaneous but Susceptible to Cholic Acid Induced Hepatocarcinogenesis. Am J Physiol Gastrointest Liver Physiol, In process, . (PMID: 26744468)

Zhan, L. Yang, I. Kong, B. Shen, J. Gorczyca, L. Memon, N. Buckley, B. T. Guo, G. L. Dysregulation of bile acid homeostasis in parenteral nutrition mouse model. Am J Physiol Gastrointest Liver Physiol, In process, . (PMID: 26564717)

Justin, S. Guo, G. Mechanistic Review of Drug-Induced Steatohepatitis. Toxicol Appl Pharmacol, In process, . (PMID: 26344000)

Baker, A. A. Guo, G. L. Aleksunes, L. M. Richardson, J. R. Isoform-Specific Regulation of Mouse Carboxylesterase Expression and Activity by Prototypical Transcriptional Activators. J Biochem Mol Toxicol, In process, . (PMID: 26179144)

Green, A. L. Hossain, M. M. Tee, S. C. Zarbl, H. Guo, G. L. Richardson, J. R. Epigenetic Regulation of Dopamine Transporter mRNA Expression in Human Neuroblastoma Cells. Neurochem Res, In process, . (PMID: 25963949)

Cheng, Q. Inaba, Y. Lu, P. Xu, M. He, J. Zhao, Y. Guo, G. L. Kuruba, R. de la Vega, R. Evans, R. W. Li, S. Xie, W. Chronic activation of FXR in transgenic mice caused perinatal toxicity and sensitized mice to cholesterol toxicity. Mol Endocrinol, 29:571-582, . (PMID: 25719402, PMCID: PMC4399273)

Tsuchiya, H. Costa, K. A. Lee, S. Renga, B. Jaeschke, H. Yang, Z. Orena, S. J. Goedken, M. J. Zhang, Y. Bo, K. Lebofsky, M. Rudraiah, S. Smalling, R. Guo, G. Fiorucci, S. Zeisel, S. H. Wang, L. Interactions Between Nuclear receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice. Gastroenterology, In process, . (PMID: 25701738)

Oshida, K. Vasani, N. Thomas, R. S. Applegate, D. Rosen, M. Abbott, B. Lau, C. Guo, G. Aleksunes, L. M. Klaassen, C. Corton, J. C. Identification of Modulators of the Nuclear Receptor Peroxisome Proliferator-Activated Receptor alpha (PPARalpha) in a Mouse Liver Gene Expression Compendium. PLoS One, 10:e0112655, . (PMID: 25689681, PMCID: PMC4331523)

Zhang, Y. Xu, N. Xu, J. Kong, B. Copple, B. Guo, G. L. Wang, L. E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr-1/SHP/EID1 network. Hepatology, 60:919-930, . (PMID: 24619556, PMCID: PMC4146672)

Manley, S. Ni, H. M. Williams, J. A. Kong, B. DiTacchio, L. Guo, G. Ding, W. X. Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity. Redox Biol, In process, . (PMID: 25460735, PMCID: PMC4215528)

Shang, Q. Guo, G. L. Honda, A. Shi, D. Saumoy, M. Salen, G. Xu, G. Bile acid flux through portal but not peripheral veins inhibits CYP7A1 expression without involvement of ileal FGF19 in rabbits. Am J Physiol Gastrointest Liver Physiol, 307:G479-G486, . (PMID: 24994853)

Kong, B. Huang, J. Zhu, Y. Li, G. Williams, J. A. Shen, S. Aleksunes, L. M. Richardson, J. R. Apte, U. Rudnick, D. A. Guo, G. L. Fibroblast Growth Factor 15 Deficiency Impairs Liver Regeneration in Mice. Am J Physiol Gastrointest Liver Physiol, 306:G893-G902, . (PMID: 24699334, PMCID: PMC4024724)

Schmitt, J. Kong, B. Stieger, B. Tschopp, O. Schultze, S. M. Rau, M. Weber, A. Mullhaupt, B. Guo, G. L. Geier, A. Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal. Liver Int, In process, . (PMID: 25156247, PMCID: PMC4146754)

Manley, S. Ni, H. M. Kong, B. Apte, U. Guo, G. Ding, W. X. Suppression of autophagic flux by bile acids in hepatocytes. Toxicol Sci, 137:478-490, . (PMID: 24189133, PMCID: PMC3908720)

Bailey, A. M. Zhan, L. Maru, D. Shureiqi, I. Pickering, C. R. Izzo, J. He, N. Wei, C. Baladandayuthapani, V. Liang, H. Kopetz, S. Powis, G. Guo, G. L. FXR Silencing in Human Colon Cancer by DNA methylation and KRAS Signaling. Am J Physiol Gastrointest Liver Physiol, 306:G48-G58, . (PMID: 24177031, PMCID: PMC3920083)

Kong, B. Guo, G. L. Soluble Expression of Disulfide Bond Containing Proteins FGF15 and FGF19 in the Cytoplasm of Escherichia coli. PLoS One, 9:e85890, . (PMID: 24465767, PMCID: PMC3896424)

Zhan, L. Liu, H. X. Fang, Y. Kong, B. He, Y. Zhong, X. B. Fang, J. Wan, Y. J. Guo, G. L. Genome-wide binding and transcriptome analysis of human farnesoid x receptor in primary human hepatocytes. PLoS One, 9:e105930, . (PMID: 25198545, PMCID: PMC4157742)

Li, G. Zhu, Y. Tawfik, O. Kong, B. Williams, J. A. Zhan, L. Kassel, K. M. Luyendyk, J. P. Wang, L. Guo, G. L. Mechanisms of STAT3 activation in the liver of FXR knockout mice. Am J Physiol Gastrointest Liver Physiol, 305:G829-G837, . (PMID: 24091600, PMCID: PMC3882431)

Li, G. Kong, B. Zhu, Y. Zhan, L. Williams, J. A. Tawfik, O. Kassel, K. M. Luyendyk, J. P. Wang, L. Guo, G. L. Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice. Toxicol Appl Pharmacol, 272:299-305, . (PMID: 23811326)

Shang, Q. Guo, G. L. Honda, A. Saumoy, M. Salen, G. Xu, G. FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels. J Lipid Res, 54:2606-2614, . (PMID: 23852734, PMCID: PMC3770074)

Thomas, A. M. Hart, S. N. Li, G. Lu, H. Fang, Y. Fang, J. Zhong, X. B. Guo, G. L. Hepatocyte nuclear factor 4 alpha and farnesoid X receptor co-regulates gene transcription in mouse livers on a genome-wide scale. Pharm Res, 30:2188-2198, . (PMID: 23462932, PMCID: PMC3711942)

Jiang, Y. Jin, J. Iakova, P. Hernandez, J. C. Jawanmardi, N. Sullivan, E. Guo, G. L. Timchenko, N. A. Darlington, G. J. Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice. Mech Ageing Dev, 134:407-415, . (PMID: 24007921)

Zhu, Y. Li, G. Dong, Y. Zhou, H. H. Kong, B. Aleksunes, L. M. Richardson, J. R. Li, F. Guo, G. L. Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver. Toxicol Appl Pharmacol, 266:260-266, . (PMID: 23178280, PMCID: PMC3774161)

Fang, Y. Liu, H. X. Zhang, N. Guo, G. L. Wan, Y. J. Fang, J. NURBS: a database of experimental and predicted nuclear receptor binding sites of mouse. Bioinformatics, 29:295-297, . (PMID: 23196988, PMCID: PMC3546791)

He, Y. Gong, L. Fang, Y. Zhan, Q. Liu, H. X. Lu, Y. Guo, G. L. Lehman-McKeeman, L. Fang, J. Wan, Y. J. The role of retinoic acid in hepatic lipid homeostasis defined by genomic binding and transcriptome profiling. BMC Genomics, 14:575, . (PMID: 23981290, PMCID: PMC3846674)

Borude, P. Edwards, G. Walesky, C. Li, F. Ma, X. Kong, B. Guo, G. L. Apte, U. Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice. Hepatology, 56:2344-2352, . (PMID: 22730081, PMCID: PMC3469721)

Kong, B. Wang, L. Chiang, J. Y. Zhang, Y. Klaassen, C. D. Guo, G. L. Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology, 56:1034-1043, . (PMID: 22467244, PMCID: PMC3390456)

Kong, B. Csanaky, I. L. Aleksunes, L. M. Patni, M. Chen, Q. Ma, X. Jaeschke, H. Weir, S. Broward, M. Klaassen, C. D. Guo, G. L. Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity. Toxicol Appl Pharmacol, 261:189-195, . (PMID: 22521610, PMCID: PMC3371772)

Cui, J. Y. Aleksunes, L. M. Tanaka, Y. Fu, Z. D. Guo, Y. Guo, G. L. Lu, H. Zhong, X. B. Klaassen, C. D. Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice. Am J Physiol Gastrointest Liver Physiol, 302:G979-G996, . (PMID: 22268101, PMCID: PMC3362079)

Li, G. Lin, W. Araya, J. J. Chen, T. Timmermann, B. N. Guo, G. L. A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor. Toxicol Appl Pharmacol, 258:268-274, . (PMID: 22178739, PMCID: PMC3259191)

Li, G. Thomas, A. M. Williams, J. A. Kong, B. Liu, J. Inaba, Y. Xie, W. Guo, G. L. Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. PLoS One, 7:e35895, . (PMID: 22540009, PMCID: PMC3335076)

Williams, J. A. Thomas, A. M. Li, G. Kong, B. Zhan, L. Inaba, Y. Xie, W. Ding, W. X. Guo, G. L. Tissue specific induction of p62/Sqstm1 by farnesoid X receptor. PLoS One, 7:e43961, . (PMID: 22952826, PMCID: PMC3428273)

Pacyniak, E. Hagenbuch, B. Klaassen, C. D. Lehman-McKeeman, L. Guo, G. L. Organic anion transporting polypeptides in the hepatic uptake of PBDE congeners in mice. Toxicol Appl Pharmacol, 257:23-31, . (PMID: 21884716, PMCID: PMC3220748)

Kassel, K. M. Owens, A. P. 3rd Rockwell, C. E. Sullivan, B. P. Wang, R. Tawfik, O. Li, G. Guo, G. L. Mackman, N. Luyendyk, J. P. Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet. Am J Pathol, 179:2278-2289, . (PMID: 21907177, PMCID: PMC3204032)

Luyendyk, J. P. Guo, G. L. Steatosis DeLIVERs high-sensitivity C-reactive protein. Arterioscler Thromb Vasc Biol, 31:1714-1715, . (PMID: 21775769, PMCID: PMC3198789)

Wolfe, A. Thomas, A. Edwards, G. Jaseja, R. Guo, G. L. Apte, U. Increased activation of the Wnt/beta-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid X receptor knockout mice. J Pharmacol Exp Ther, 338:12-21, . (PMID: 21430080, PMCID: PMC3126651)

Li, G. Guo, G. L. Role of Class II nuclear receptors in liver carcinogenesis. Anticancer Agents Med Chem, 11:529-542, . (PMID: 21554208)

Zhu, Y. Li, F. Guo, G. L. Tissue-specific function of farnesoid X receptor in liver and intestine. Pharmacol Res, 63:259-265, . (PMID: 21211565, PMCID: PMC3063452)

Li, T. Matozel, M. Boehme, S. Kong, B. Nilsson, L. M. Guo, G. Ellis, E. Chiang, J. Y. Overexpression of cholesterol 7alpha-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis. Hepatology, 53:996-1006, . (PMID: 21319191, PMCID: PMC3079544)

Luyendyk, J. P. Kassel, K. M. Allen, K. Guo, G. L. Li, G. Cantor, G. H. Copple, B. L. Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a model of chronic xenobiotic-induced cholestasis. Am J Pathol, 178:1117-1125, . (PMID: 21356363, PMCID: PMC3070556)

Zhang, Y. K. Guo, G. L. Klaassen, C. D. Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters. PLoS One, 6:e16683, . (PMID: 21346810, PMCID: PMC3035620)

Kong, B. Guo, G. L. Enhanced in vitro refolding of fibroblast growth factor 15 with the assistance of SUMO fusion partner. PLoS One, 6:e20307, . (PMID: 21655243, PMCID: PMC3105028)