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A.-N. Tony Kong, PhD

Publications since 2011

Khor, T. O. Fuentes, F. Shu, L. Paredes-Gonzalez, X. Yang, A. Y. Liu, Y. Smiraglia, D. J. Yegnasubramanian, S. Nelson, W. G. Kong, A. N. Epigenetic DNA Methylation of Anti-oxidative Stress Regulator Nrf2 in Human Prostate Cancer. Cancer Prev Res (Phila), In process, . (PMID: 25266896)

Wu, C. Jain, M. R. Li, Q. Oka, S. I. Li, W. Kong, A. N. Nagarajan, N. Sadoshima, J. Simmons, W. J. Li, H. Identification of Novel Nuclear Targets of Human Thioredoxin 1. Mol Cell Proteomics, In process, . (PMID: 25231459)

Yang, A. Y. Lee, J. H. Shu, L. Zhang, C. Su, Z. Y. Lu, Y. Huang, M. T. Ramirez, C. Pung, D. Huang, Y. Verzi, M. Hart, R. P. Kong, A. N. Genome-wide analysis of DNA methylation in UVB- and DMBA/TPA-induced mouse skin cancer models. Life Sci, In process, . (PMID: 25093921)

Paredes-Gonzalez, X. Fuentes, F. Su, Z. Y. Kong, A. N. Apigenin Reactivates Nrf2 Anti-oxidative Stress Signaling in Mouse Skin Epidermal JB6 P + Cells Through Epigenetics Modifications. AAPS J, 16:727-735, . (PMID: 24830944, PMCID: PMC4070251)

Zheng, R. Heck, D. E. Mishin, V. Black, A. T. Shakarjian, M. P. Kong, A. N. Laskin, D. L. Laskin, J. D. Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product. Toxicol Appl Pharmacol, 275:113-121, . (PMID: 24423726)

Su, Z. Y. Zhang, C. Lee, J. H. Shu, L. Wu, T. Y. Khor, T. O. Conney, A. H. Kong, A. N. Lu, Y. P. Requirement and Epigenetics Re-programming of Nrf2 in Suppression of Tumor Promoter TPA-induced Mouse Skin Cell Transformation by Sulforaphane. Cancer Prev Res (Phila), 7:319-329, . (PMID: 24441674)

Chen, L. Magesh, S. Wang, H. Yang, C. S. Kong, A. N. Hu, L. Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers. Bioorg Med Chem Lett, 24:940-943, . (PMID: 24398297, PMCID: PMC3936471)

Lee, J. H. Lee, K. R. Su, Z. Y. Boyanapalli, S. S. Barman, D. N. Huang, M. T. Chen, L. Magesh, S. Hu, L. Kong, A. N. In Vitro and in Vivo Anti-inflammatory Effects of a Novel 4,6-Bis ((E)-4-hydroxy-3-methoxystyryl)-1-phenethylpyrimidine-2(1H)-thione. Chem Res Toxicol, 27:34-41, . (PMID: 24304388)

Saw, C. L. Yang, A. Y. Huang, M. T. Liu, Y. Lee, J. H. Khor, T. O. Su, Z. Y. Shu, L. Lu, Y. Conney, A. H. Kong, A. N. Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages. Cell Biosci, 4:39, . (PMID: 25228981, PMCID: PMC4164960)

Saw, C. L. Yang, A. Y. Guo, Y. Kong, A. N. Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2-ARE pathway. Food Chem Toxicol, 62:869-875, . (PMID: 24157545)

Saw, C. L. Wu, Q. Su, Z. Y. Wang, H. Yang, Y. Xu, X. Huang, Y. Khor, T. O. Kong, A. N. Effects of Natural Phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated Gene Expression of Phase II Drug Metabolizing Enzymes and Anti-inflammation. Biopharm Drug Dispos, 34:303-311, . (PMID: 23640758)

Cheung, K. L. Lee, J. H. Shu, L. Kim, J. H. Sacks, D. B. Kong, A. N. The Ras GTPase-activating-like Protein IQGAP1 Mediates Nrf2 Protein Activation via the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Kinase (MEK)-ERK Pathway. J Biol Chem, 288:22378-22386, . (PMID: 23788642)

Wu, T. Y. Khor, T. O. Lee, J. H. Cheung, K. L. Shu, L. Chen, C. Kong, A. N. Pharmacogenetics, pharmacogenomics and epigenetics of Nrf2-regulated xenobiotic-metabolizing enzymes and transporters by dietary phytochemical and cancer chemoprevention. Curr Drug Metab, 14:688-694, . (PMID: 23869812)

Kong, A. N. Zhang, C. Su, Z. Y. Targeting epigenetics for cancer prevention by dietary cancer preventive compounds--the case of miRNA. Cancer Prev Res (Phila), 6:622-624, . (PMID: 23773911)

Wu, T. Y. Khor, T. O. Su, Z. Y. Saw, C. L. Shu, L. Cheung, K. L. Huang, Y. Yu, S. Kong, A. N. Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors. AAPS J, 15:864-874, . (PMID: 23658110, PMCID: PMC3691436)

Hu, L. Magesh, S. Chen, L. Wang, L. Lewis, T. A. Chen, Y. Khodier, C. Inoyama, D. Beamer, L. J. Emge, T. J. Shen, J. Kerrigan, J. E. Kong, A. N. Dandapani, S. Palmer, M. Schreiber, S. L. Munoz, B. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem Lett, 23:3039-3043, . (PMID: 23562243, PMCID: PMC3648997)

Zhang, C. Su, Z. Y. Khor, T. O. Shu, L. Kong, A. N. Sulforaphane Enhances Nrf2 Expression in Prostate Cancer TRAMP C1 Cells through Epigenetic Regulation. Biochem Pharmacol, 85:1398-1404, . (PMID: 23416117)

Jung, C. L. Kim, H. J. Park, J. H. Kong, A. N. Lee, C. H. Kim, J. S. Synergistic Activation of the Nrf2-Signaling Pathway by Glyceollins under Oxidative Stress Induced by Glutathione Depletion. J Agric Food Chem, In process, . (PMID: 23573869)

Su, Z. Y. Khor, T. O. Shu, L. Lee, J. H. Saw, C. L. Wu, T. Y. Huang, Y. Suh, N. Yang, C. S. Conney, A. H. Wu, Q. Kong, A. N. Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation. Chem Res Toxicol, 26:477-485, . (PMID: 23441843)

Lee, J. H. Khor, T. O. Shu, L. Su, Z. Y. Fuentes, F. Kong, A. N. Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression. Pharmacol Ther, 137:153-171, . (PMID: 23041058, PMCID: PMC3694988)

Kim, J. H. Yu, S. Chen, J. D. Kong, A. N. The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains. Oncogene, 32:514-527, . (PMID: 22370642, PMCID: PMC3538952)

Stamatelos, S. K. Androulakis, I. P. Tony Kong, A. N. Georgopoulos, P. G. A semi-mechanistic integrated toxicokinetic-toxicodynamic (TK/TD) model for arsenic(III) in hepatocytes. J Theor Biol, 317:244-256, . (PMID: 23069314)

Su, Z. Y. Shu, L. Khor, T. O. Lee, J. H. Fuentes, F. Kong, A. N. A Perspective on Dietary Phytochemicals and Cancer Chemoprevention: Oxidative Stress, Nrf2, and Epigenomics. Top Curr Chem, 329:133-162, . (PMID: 22836898)

Wang, H. Khor, T. O. Shu, L. Su, Z. Fuentes, F. Lee, J. H. Kong, A. N. Plants against Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Drug ability. Anticancer Agents Med Chem, 12:1281-1305, . (PMID: 22583408)

Smolarek, A. K. So, J. Y. Burgess, B. Kong, A. N. Reuhl, K. Lin, Y. Shih, W. J. Li, G. Lee, M. J. Chen, Y. K. Yang, C. S. Suh, N. Dietary Administration of delta- and gamma-Tocopherol Inhibits Tumorigenesis in the Animal Model of Estrogen Receptor-Positive, but not HER-2 Breast Cancer. Cancer Prev Res (Phila), 5:1310-1320, . (PMID: 22964476, PMCID: PMC3491089)

Wu, T. Y. Saw, C. L. Khor, T. O. Pung, D. Boyanapalli, S. S. Kong, A. N. In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: Involvement of Nrf2 and cell cycle/apoptosis signaling pathways. Mol Carcinog, 51:761-770, . (PMID: 21837756)

Wang, H. Khor, T. O. Yang, Q. Huang, Y. Wu, T. Y. Saw, C. L. Lin, W. Androulakis, I. P. Kong, A. N. Pharmacokinetics and Pharmacodynamics of Phase II Drug Metabolizing/Antioxidant Enzymes Gene Response by Anticancer Agent Sulforaphane in Rat Lymphocytes. Mol Pharm, 9:2819-2827, . (PMID: 22931102)

Kim, J. H. Xu, E. Y. Sacks, D. B. Lee, J. Shu, L. Xia, B. Kong, A. N. Identification and Functional Studies of a New Nrf2 partner IQGAP1: A critical role in the stability and transactivation of Nrf2. Antioxid Redox Signal, In process, . (PMID: 22793650)

Cheung, K. L. Lee, J. H. Khor, T. O. Wu, T. Y. Li, G. X. Chan, J. Yang, C. S. Kong, A. N. Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation. Mol Carcinog, In process, . (PMID: 22911891)

Saw, C. L. Yang, A. Y. Cheng, D. C. Boyanapalli, S. S. Su, Z. Y. Khor, T. O. Gao, S. Wang, J. Jiang, Z. H. Kong, A. N. Pharmacodynamics of Ginsenosides: Antioxidant Activities, Activation of Nrf2, and Potential Synergistic Effects of Combinations. Chem Res Toxicol, 25:1574-1580, . (PMID: 22780686)

Lin, H. Gounder, M. K. Bertino, J. R. Kong, A. N. DiPaola, R. S. Stein, M. N. A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies. J Pharm Biomed Anal, 66:371-375, . (PMID: 22483642, PMCID: PMC3358459)

Gifkins, D. Olson, S. H. Demissie, K. Lu, S. E. Kong, A. N. Bandera, E. V. Total and individual antioxidant intake and endometrial cancer risk: results from a population-based case-control study in New Jersey. Cancer Causes Control, 23:887-895, . (PMID: 22527166)

Shay, K. P. Michels, A. J. Li, W. Kong, A. N. Hagen, T. M. Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response. Biochim Biophys Acta, 1823:1102-1109, . (PMID: 22521877)

Yang, C. S. Suh, N. Kong, A. N. Does vitamin E prevent or promote cancer? Cancer Prev Res (Phila), 5:701-705, . (PMID: 22490437)

Huang, Y. Khor, T. O. Shu, L. Saw, C. L. Wu, T. Y. Suh, N. Yang, C. S. Kong, A. N. A gamma-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation. J Nutr, 142:818-823, . (PMID: 22457388, PMCID: PMC3327740)

Gounder, M. K. Lin, H. Stein, M. Goodin, S. Bertino, J. R. Kong, A. N. DiPaola, R. S. A validated bioanalytical HPLC method for pharmacokinetic evaluation of 2-deoxyglucose in human plasma. Biomed Chromatogr, 26:650-654, . (PMID: 21932382)

Ma, J. Cai, H. Wu, T. Sobhian, B. Huo, Y. Alcivar, A. Mehta, M. Cheung, K. L. Ganesan, S. Kong, A. N. Zhang, D. D. Xia, B. PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. Mol Cell Biol, 32:1506-1517, . (PMID: 22331464, PMCID: PMC3318596)

Inoyama, D. Chen, Y. Huang, X. Beamer, L. J. Kong, A. N. Hu, L. Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction. J Biomol Screen, 17:435-447, . (PMID: 22156223, PMCID: PMC3309107)

Smolarek, A. K. So, J. Y. Thomas, P. E. Lee, H. J. Paul, S. Dombrowski, A. Wang, C. X. Saw, C. L. Khor, T. O. Kong, A. N. Reuhl, K. Lee, M. J. Yang, C. S. Suh, N. Dietary tocopherols inhibit cell proliferation, regulate expression of ERalpha, PPARgamma, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia. Mol Carcinog, In process, . (PMID: 22389237, PMCID: PMC3374909)

Gifkins, D. Olson, S. H. Paddock, L. King, M. Demissie, K. Lu, S. E. Kong, A. N. Rodriguez-Rodriguez, L. Bandera, E. V. Total and individual antioxidant intake and risk of epithelial ovarian cancer. BMC Cancer, 12:211, . (PMID: 22656322, PMCID: PMC3406971)

Huang, Y. Li, W. Kong, A. N. Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal. Cell Biosci, 2:40, . (PMID: 23190551, PMCID: PMC3519783)

Wang, H. Lin, W. Shen, G. Khor, T. O. Nomeir, A. A. Kong, A. N. Development and validation of an LC-MS-MS method for the simultaneous determination of sulforaphane and its metabolites in rat plasma and its application in pharmacokinetic studies. J Chromatogr Sci, 49:801-806, . (PMID: 22080809)

Shu, L. Khor, T. O. Lee, J. H. Boyanapalli, S. S. Huang, Y. Wu, T. Y. Saw, C. L. Cheung, K. L. Kong, A. N. Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells. AAPS J, 13:606-614, . (PMID: 21938566, PMCID: PMC3231852)

Chen, Y. Inoyama, D. Kong, A. N. Beamer, L. J. Hu, L. Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance. Chem Biol Drug Des, 78:1014-1021, . (PMID: 21920027, PMCID: PMC3218206)

Khor, T. O. Huang, Y. Wu, T. Y. Shu, L. Lee, J. Kong, A. N. Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation. Biochem Pharmacol, 82:1073-1078, . (PMID: 21787756)

Finley, J. W. Kong, A. N. Hintze, K. J. Jeffery, E. H. Ji, L. L. Lei, X. G. Antioxidants in foods: state of the science important to the food industry. J Agric Food Chem, 59:6837-6846, . (PMID: 21627162)

Saw, C. L. Cintron, M. Wu, T. Y. Guo, Y. Huang, Y. Jeong, W. S. Kong, A. N. Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates. Biopharm Drug Dispos, 32:289-300, . (PMID: 21656528, PMCID: PMC3465716)

Saw, C. L. Huang, M. T. Liu, Y. Khor, T. O. Conney, A. H. Kong, A. N. Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane. Mol Carcinog, 50:479-486, . (PMID: 21557329)

Cheung, K. L. Yu, S. Pan, Z. Ma, J. Wu, T. Y. Kong, A. N. tBHQ-Induced HO-1 Expression Is Mediated by Calcium through Regulation of Nrf2 Binding to Enhancer and Polymerase II to Promoter Region of HO-1. Chem Res Toxicol, 24:670-676, . (PMID: 21443188)

Kim, H. J. di Luccio, E. Kong, A. N. Kim, J. S. Nrf2-mediated induction of phase 2 detoxifying enzymes by glyceollins derived from soybean exposed to Aspergillus sojae. Biotechnol J, 6:525-536, . (PMID: 21538894)

Lin, W. Hong, J. L. Shen, G. Wu, R. T. Wang, Y. Huang, M. T. Newmark, H. L. Huang, Q. Khor, T. O. Heimbach, T. Kong, A. N. Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition. Biopharm Drug Dispos, 32:65-75, . (PMID: 21341276)

Saw, C. L. Kong, A. N. Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer. Expert Opin Ther Targets, 15:281-295, . (PMID: 21261563, PMCID: PMC3465718)

Wu, T. Y. Khor, T. O. Saw, C. L. Loh, S. C. Chen, A. I. Lim, S. S. Park, J. H. Cai, L. Kong, A. N. Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis. AAPS J, 13:1-13, . (PMID: 20967519, PMCID: PMC3032091)

Saw, C. L. Wu, T. Y. Paredes-Gonzalez, X. Khor, T. O. Pung, D. Kong, A. N. Pharmacodynamics of fish oil: protective effects against prostate cancer in TRAMP mice fed with a high fat western diet. Asian Pac J Cancer Prev, 12:3331-3334, . (PMID: 22471475)