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A.-N. Tony Kong, PhD

Publications since 2011

Wang, R. Zhang, C. Y. Bai, L. P. Pan, H. D. Shu, L. M. Kong, A. N. Leung, E. L. Liu, L. Li, T. Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation. Int Immunopharmacol, In process, . (PMID: 25871879)

Guo, Y. Shu, L. Zhang, C. Su, Z. Y. Kong, A. N. Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1. Biochem Pharmacol, In process, . (PMID: 25640947)

Zhen, J. Guo, Y. Villani, T. Carr, S. Brendler, T. Mumbengegwi, D. R. Kong, A. N. Simon, J. E. Wu, Q. Phytochemical Analysis and Anti-Inflammatory Activity of the Extracts of the African Medicinal Plant Ximenia caffra. J Anal Methods Chem, 2015:948262, . (PMID: 25785232, PMCID: PMC4346700)

Wu, C. Jain, M. R. Li, Q. Oka, S. I. Li, W. Kong, A. N. Nagarajan, N. Sadoshima, J. Simmons, W. J. Li, H. Identification of Novel Nuclear Targets of Human Thioredoxin 1. Mol Cell Proteomics, 13:3507-3518, . (PMID: 25231459)

Boyanapalli, S. S. Paredes-Gonzalez, X. Fuentes, F. Zhang, C. Guo, Y. Pung, D. Saw, C. L. Kong, A. N. Nrf2 Knockout Attenuates the Anti-Inflammatory Effects of Phenethyl Isothiocyanate and Curcumin. Chem Res Toxicol, In process, . (PMID: 25387343)

Wang, L. Zhang, C. Guo, Y. Su, Z. Y. Yang, Y. Shu, L. Kong, A. N. Blocking of JB6 Cell Transformation by Tanshinone IIA: Epigenetic Reactivation of Nrf2 Antioxidative Stress Pathway. AAPS J, 16:1214-1225, . (PMID: 25274607)

Furnari, M. A. Saw, C. L. Kong, A. N. Wagner, G. C. Altered behavioral development in Nrf2 knockout mice following early postnatal exposure to valproic acid. Brain Res Bull, In process, . (PMID: 25454122)

Khor, T. O. Fuentes, F. Shu, L. Paredes-Gonzalez, X. Yang, A. Y. Liu, Y. Smiraglia, D. J. Yegnasubramanian, S. Nelson, W. G. Kong, A. N. Epigenetic DNA Methylation of Anti-oxidative Stress Regulator Nrf2 in Human Prostate Cancer. Cancer Prev Res (Phila), In process, . (PMID: 25266896)

Yang, A. Y. Lee, J. H. Shu, L. Zhang, C. Su, Z. Y. Lu, Y. Huang, M. T. Ramirez, C. Pung, D. Huang, Y. Verzi, M. Hart, R. P. Kong, A. N. Genome-wide analysis of DNA methylation in UVB- and DMBA/TPA-induced mouse skin cancer models. Life Sci, 113:45-54, . (PMID: 25093921)

Saw, C. L. Guo, Y. Yang, A. Y. Paredes-Gonzalez, X. Ramirez, C. Pung, D. Kong, A. N. The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: Involvement of the Nrf2-ARE signaling pathway. Food Chem Toxicol, In process, . (PMID: 25111660)

Paredes-Gonzalez, X. Fuentes, F. Su, Z. Y. Kong, A. N. Apigenin Reactivates Nrf2 Anti-oxidative Stress Signaling in Mouse Skin Epidermal JB6 P + Cells Through Epigenetics Modifications. AAPS J, 16:727-735, . (PMID: 24830944, PMCID: PMC4070251)

Zheng, R. Heck, D. E. Mishin, V. Black, A. T. Shakarjian, M. P. Kong, A. N. Laskin, D. L. Laskin, J. D. Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product. Toxicol Appl Pharmacol, 275:113-121, . (PMID: 24423726, PMCID: PMC4167054)

Su, Z. Y. Zhang, C. Lee, J. H. Shu, L. Wu, T. Y. Khor, T. O. Conney, A. H. Kong, A. N. Lu, Y. P. Requirement and Epigenetics Re-programming of Nrf2 in Suppression of Tumor Promoter TPA-induced Mouse Skin Cell Transformation by Sulforaphane. Cancer Prev Res (Phila), 7:319-329, . (PMID: 24441674)

Chen, L. Magesh, S. Wang, H. Yang, C. S. Kong, A. N. Hu, L. Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers. Bioorg Med Chem Lett, 24:940-943, . (PMID: 24398297, PMCID: PMC3936471)

Lee, J. H. Lee, K. R. Su, Z. Y. Boyanapalli, S. S. Barman, D. N. Huang, M. T. Chen, L. Magesh, S. Hu, L. Kong, A. N. In Vitro and in Vivo Anti-inflammatory Effects of a Novel 4,6-Bis ((E)-4-hydroxy-3-methoxystyryl)-1-phenethylpyrimidine-2(1H)-thione. Chem Res Toxicol, 27:34-41, . (PMID: 24304388)

Saw, C. L. Yang, A. Y. Huang, M. T. Liu, Y. Lee, J. H. Khor, T. O. Su, Z. Y. Shu, L. Lu, Y. Conney, A. H. Kong, A. N. Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages. Cell Biosci, 4:39, . (PMID: 25228981, PMCID: PMC4164960)

Saw, C. L. Yang, A. Y. Guo, Y. Kong, A. N. Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2-ARE pathway. Food Chem Toxicol, 62:869-875, . (PMID: 24157545)

Saw, C. L. Wu, Q. Su, Z. Y. Wang, H. Yang, Y. Xu, X. Huang, Y. Khor, T. O. Kong, A. N. Effects of Natural Phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated Gene Expression of Phase II Drug Metabolizing Enzymes and Anti-inflammation. Biopharm Drug Dispos, 34:303-311, . (PMID: 23640758)

Cheung, K. L. Lee, J. H. Shu, L. Kim, J. H. Sacks, D. B. Kong, A. N. The Ras GTPase-activating-like Protein IQGAP1 Mediates Nrf2 Protein Activation via the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Kinase (MEK)-ERK Pathway. J Biol Chem, 288:22378-22386, . (PMID: 23788642)

Wu, T. Y. Khor, T. O. Lee, J. H. Cheung, K. L. Shu, L. Chen, C. Kong, A. N. Pharmacogenetics, pharmacogenomics and epigenetics of Nrf2-regulated xenobiotic-metabolizing enzymes and transporters by dietary phytochemical and cancer chemoprevention. Curr Drug Metab, 14:688-694, . (PMID: 23869812)

Kong, A. N. Zhang, C. Su, Z. Y. Targeting epigenetics for cancer prevention by dietary cancer preventive compounds--the case of miRNA. Cancer Prev Res (Phila), 6:622-624, . (PMID: 23773911)

Wu, T. Y. Khor, T. O. Su, Z. Y. Saw, C. L. Shu, L. Cheung, K. L. Huang, Y. Yu, S. Kong, A. N. Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors. AAPS J, 15:864-874, . (PMID: 23658110, PMCID: PMC3691436)

Hu, L. Magesh, S. Chen, L. Wang, L. Lewis, T. A. Chen, Y. Khodier, C. Inoyama, D. Beamer, L. J. Emge, T. J. Shen, J. Kerrigan, J. E. Kong, A. N. Dandapani, S. Palmer, M. Schreiber, S. L. Munoz, B. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem Lett, 23:3039-3043, . (PMID: 23562243, PMCID: PMC3648997)

Zhang, C. Su, Z. Y. Khor, T. O. Shu, L. Kong, A. N. Sulforaphane Enhances Nrf2 Expression in Prostate Cancer TRAMP C1 Cells through Epigenetic Regulation. Biochem Pharmacol, 85:1398-1404, . (PMID: 23416117)

Jung, C. L. Kim, H. J. Park, J. H. Kong, A. N. Lee, C. H. Kim, J. S. Synergistic Activation of the Nrf2-Signaling Pathway by Glyceollins under Oxidative Stress Induced by Glutathione Depletion. J Agric Food Chem, In process, . (PMID: 23573869)

Su, Z. Y. Khor, T. O. Shu, L. Lee, J. H. Saw, C. L. Wu, T. Y. Huang, Y. Suh, N. Yang, C. S. Conney, A. H. Wu, Q. Kong, A. N. Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation. Chem Res Toxicol, 26:477-485, . (PMID: 23441843)

Lee, J. H. Khor, T. O. Shu, L. Su, Z. Y. Fuentes, F. Kong, A. N. Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression. Pharmacol Ther, 137:153-171, . (PMID: 23041058, PMCID: PMC3694988)

Kim, J. H. Yu, S. Chen, J. D. Kong, A. N. The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains. Oncogene, 32:514-527, . (PMID: 22370642, PMCID: PMC3538952)

Stamatelos, S. K. Androulakis, I. P. Tony Kong, A. N. Georgopoulos, P. G. A semi-mechanistic integrated toxicokinetic-toxicodynamic (TK/TD) model for arsenic(III) in hepatocytes. J Theor Biol, 317:244-256, . (PMID: 23069314)

Su, Z. Y. Shu, L. Khor, T. O. Lee, J. H. Fuentes, F. Kong, A. N. A Perspective on Dietary Phytochemicals and Cancer Chemoprevention: Oxidative Stress, Nrf2, and Epigenomics. Top Curr Chem, 329:133-162, . (PMID: 22836898)

Wang, H. Khor, T. O. Shu, L. Su, Z. Fuentes, F. Lee, J. H. Kong, A. N. Plants against Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Drug ability. Anticancer Agents Med Chem, 12:1281-1305, . (PMID: 22583408)

Smolarek, A. K. So, J. Y. Burgess, B. Kong, A. N. Reuhl, K. Lin, Y. Shih, W. J. Li, G. Lee, M. J. Chen, Y. K. Yang, C. S. Suh, N. Dietary Administration of delta- and gamma-Tocopherol Inhibits Tumorigenesis in the Animal Model of Estrogen Receptor-Positive, but not HER-2 Breast Cancer. Cancer Prev Res (Phila), 5:1310-1320, . (PMID: 22964476, PMCID: PMC3491089)

Wu, T. Y. Saw, C. L. Khor, T. O. Pung, D. Boyanapalli, S. S. Kong, A. N. In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: Involvement of Nrf2 and cell cycle/apoptosis signaling pathways. Mol Carcinog, 51:761-770, . (PMID: 21837756)

Wang, H. Khor, T. O. Yang, Q. Huang, Y. Wu, T. Y. Saw, C. L. Lin, W. Androulakis, I. P. Kong, A. N. Pharmacokinetics and Pharmacodynamics of Phase II Drug Metabolizing/Antioxidant Enzymes Gene Response by Anticancer Agent Sulforaphane in Rat Lymphocytes. Mol Pharm, 9:2819-2827, . (PMID: 22931102)

Kim, J. H. Xu, E. Y. Sacks, D. B. Lee, J. Shu, L. Xia, B. Kong, A. N. Identification and Functional Studies of a New Nrf2 partner IQGAP1: A critical role in the stability and transactivation of Nrf2. Antioxid Redox Signal, In process, . (PMID: 22793650)

Cheung, K. L. Lee, J. H. Khor, T. O. Wu, T. Y. Li, G. X. Chan, J. Yang, C. S. Kong, A. N. Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation. Mol Carcinog, In process, . (PMID: 22911891)

Saw, C. L. Yang, A. Y. Cheng, D. C. Boyanapalli, S. S. Su, Z. Y. Khor, T. O. Gao, S. Wang, J. Jiang, Z. H. Kong, A. N. Pharmacodynamics of Ginsenosides: Antioxidant Activities, Activation of Nrf2, and Potential Synergistic Effects of Combinations. Chem Res Toxicol, 25:1574-1580, . (PMID: 22780686)

Lin, H. Gounder, M. K. Bertino, J. R. Kong, A. N. DiPaola, R. S. Stein, M. N. A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies. J Pharm Biomed Anal, 66:371-375, . (PMID: 22483642, PMCID: PMC3358459)

Gifkins, D. Olson, S. H. Demissie, K. Lu, S. E. Kong, A. N. Bandera, E. V. Total and individual antioxidant intake and endometrial cancer risk: results from a population-based case-control study in New Jersey. Cancer Causes Control, 23:887-895, . (PMID: 22527166)

Shay, K. P. Michels, A. J. Li, W. Kong, A. N. Hagen, T. M. Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response. Biochim Biophys Acta, 1823:1102-1109, . (PMID: 22521877)

Yang, C. S. Suh, N. Kong, A. N. Does vitamin E prevent or promote cancer? Cancer Prev Res (Phila), 5:701-705, . (PMID: 22490437)

Huang, Y. Khor, T. O. Shu, L. Saw, C. L. Wu, T. Y. Suh, N. Yang, C. S. Kong, A. N. A gamma-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation. J Nutr, 142:818-823, . (PMID: 22457388, PMCID: PMC3327740)

Gounder, M. K. Lin, H. Stein, M. Goodin, S. Bertino, J. R. Kong, A. N. DiPaola, R. S. A validated bioanalytical HPLC method for pharmacokinetic evaluation of 2-deoxyglucose in human plasma. Biomed Chromatogr, 26:650-654, . (PMID: 21932382)

Ma, J. Cai, H. Wu, T. Sobhian, B. Huo, Y. Alcivar, A. Mehta, M. Cheung, K. L. Ganesan, S. Kong, A. N. Zhang, D. D. Xia, B. PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. Mol Cell Biol, 32:1506-1517, . (PMID: 22331464, PMCID: PMC3318596)

Inoyama, D. Chen, Y. Huang, X. Beamer, L. J. Kong, A. N. Hu, L. Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction. J Biomol Screen, 17:435-447, . (PMID: 22156223, PMCID: PMC3309107)

Smolarek, A. K. So, J. Y. Thomas, P. E. Lee, H. J. Paul, S. Dombrowski, A. Wang, C. X. Saw, C. L. Khor, T. O. Kong, A. N. Reuhl, K. Lee, M. J. Yang, C. S. Suh, N. Dietary tocopherols inhibit cell proliferation, regulate expression of ERalpha, PPARgamma, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia. Mol Carcinog, In process, . (PMID: 22389237, PMCID: PMC3374909)

Gifkins, D. Olson, S. H. Paddock, L. King, M. Demissie, K. Lu, S. E. Kong, A. N. Rodriguez-Rodriguez, L. Bandera, E. V. Total and individual antioxidant intake and risk of epithelial ovarian cancer. BMC Cancer, 12:211, . (PMID: 22656322, PMCID: PMC3406971)

Huang, Y. Li, W. Kong, A. N. Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal. Cell Biosci, 2:40, . (PMID: 23190551, PMCID: PMC3519783)

Wang, H. Lin, W. Shen, G. Khor, T. O. Nomeir, A. A. Kong, A. N. Development and validation of an LC-MS-MS method for the simultaneous determination of sulforaphane and its metabolites in rat plasma and its application in pharmacokinetic studies. J Chromatogr Sci, 49:801-806, . (PMID: 22080809)

Shu, L. Khor, T. O. Lee, J. H. Boyanapalli, S. S. Huang, Y. Wu, T. Y. Saw, C. L. Cheung, K. L. Kong, A. N. Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells. AAPS J, 13:606-614, . (PMID: 21938566, PMCID: PMC3231852)

Chen, Y. Inoyama, D. Kong, A. N. Beamer, L. J. Hu, L. Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance. Chem Biol Drug Des, 78:1014-1021, . (PMID: 21920027, PMCID: PMC3218206)

Khor, T. O. Huang, Y. Wu, T. Y. Shu, L. Lee, J. Kong, A. N. Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation. Biochem Pharmacol, 82:1073-1078, . (PMID: 21787756)

Finley, J. W. Kong, A. N. Hintze, K. J. Jeffery, E. H. Ji, L. L. Lei, X. G. Antioxidants in foods: state of the science important to the food industry. J Agric Food Chem, 59:6837-6846, . (PMID: 21627162)

Saw, C. L. Cintron, M. Wu, T. Y. Guo, Y. Huang, Y. Jeong, W. S. Kong, A. N. Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates. Biopharm Drug Dispos, 32:289-300, . (PMID: 21656528, PMCID: PMC3465716)

Saw, C. L. Huang, M. T. Liu, Y. Khor, T. O. Conney, A. H. Kong, A. N. Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane. Mol Carcinog, 50:479-486, . (PMID: 21557329)

Cheung, K. L. Yu, S. Pan, Z. Ma, J. Wu, T. Y. Kong, A. N. tBHQ-Induced HO-1 Expression Is Mediated by Calcium through Regulation of Nrf2 Binding to Enhancer and Polymerase II to Promoter Region of HO-1. Chem Res Toxicol, 24:670-676, . (PMID: 21443188)

Kim, H. J. di Luccio, E. Kong, A. N. Kim, J. S. Nrf2-mediated induction of phase 2 detoxifying enzymes by glyceollins derived from soybean exposed to Aspergillus sojae. Biotechnol J, 6:525-536, . (PMID: 21538894)

Lin, W. Hong, J. L. Shen, G. Wu, R. T. Wang, Y. Huang, M. T. Newmark, H. L. Huang, Q. Khor, T. O. Heimbach, T. Kong, A. N. Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition. Biopharm Drug Dispos, 32:65-75, . (PMID: 21341276)

Saw, C. L. Kong, A. N. Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer. Expert Opin Ther Targets, 15:281-295, . (PMID: 21261563, PMCID: PMC3465718)

Wu, T. Y. Khor, T. O. Saw, C. L. Loh, S. C. Chen, A. I. Lim, S. S. Park, J. H. Cai, L. Kong, A. N. Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis. AAPS J, 13:1-13, . (PMID: 20967519, PMCID: PMC3032091)

Saw, C. L. Wu, T. Y. Paredes-Gonzalez, X. Khor, T. O. Pung, D. Kong, A. N. Pharmacodynamics of fish oil: protective effects against prostate cancer in TRAMP mice fed with a high fat western diet. Asian Pac J Cancer Prev, 12:3331-3334, . (PMID: 22471475)

Zheng, X. Cui, X. X. Khor, T. O. Huang, Y. Dipaola, R. S. Goodin, S. Lee, M. J. Yang, C. S. Kong, A. N. Conney, A. H. Inhibitory Effect of a gamma-Tocopherol-Rich Mixture of Tocopherols on the Formation and Growth of LNCaP Prostate Tumors in Immunodeficient Mice. Cancers (Basel), 3:3762-3772, . (PMID: 24213110, PMCID: PMC3763395)