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Thomas Shenk, PhD

Publications since 2011

Purdy, J. G. Shenk, T. Rabinowitz, J. D. Fatty Acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. Cell Rep, 10:1375-1385, . (PMID: 25732827)

Mathias, R. A. Greco, T. M. Oberstein, A. Budayeva, H. G. Chakrabarti, R. Rowland, E. A. Kang, Y. Shenk, T. Cristea, I. M. Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Cell, 159:1615-1625, . (PMID: 25525879)

Hwang, J. Purdy, J. G. Wu, K. Rabinowitz, J. D. Shenk, T. Estrogen-related receptor alpha is required for efficient human cytomegalovirus replication. Proc Natl Acad Sci U S A, In process, . (PMID: 25512541)

O'Connor, C. DiMaggio, P. A. Jr Shenk, T. Garcia, B. A. Quantitative Proteomic Discovery of Dynamic Epigenome Changes that Control Human Cytomegalovirus Infection. Mol Cell Proteomics, 13:2399-2410, . (PMID: 24987098, PMCID: PMC4159657)

Casadevall, A. Dermody, T. S. Imperiale, M. J. Sandri-Goldin, R. M. Shenk, T. On the Need for a National Board To Assess Dual Use Research of Concern. J Virol, 88:6535-6537, . (PMID: 24696484, PMCID: PMC4054389)

Dermody, T. S. Sandri-Goldin, R. M. Shenk, T. Sequence Changes Associated with Respiratory Transmission of H7N1 Influenza Virus in Mammals. J Virol, 88:6533-6534, . (PMID: 24696481, PMCID: PMC4054340)

Sharon-Friling, R. Shenk, T. Human cytomegalovirus pUL37x1-induced calcium flux activates PKCalpha, inducing altered cell shape and accumulation of cytoplasmic vesicles. Proc Natl Acad Sci U S A, 111:E1140-E1148, . (PMID: 24616524, PMCID: PMC3970541)

Dermody, T. S. Casadevall, A. Imperiale, M. J. Sandri-Goldin, R. M. Shenk, T. The Decision to Publish an Avian H7N1 Influenza Virus Gain-of-Function Experiment. MBio, 5:e01985-e01914, . (PMID: 25316699, PMCID: PMC4205794)

Koyuncu, E. Budayeva, H. G. Miteva, Y. V. Ricci, D. P. Silhavy, T. J. Shenk, T. Cristea, I. M. Sirtuins Are Evolutionarily Conserved Viral Restriction Factors. MBio, 5:, . (PMID: 25516616)

Casadevall, A. Shenk, T. mBio Addresses the Pause in Gain-of-Function (GOF) Experiments Involving Pathogens with Pandemic Potential (PPP). MBio, 5:, . (PMID: 25505126)

Grady, S. L. Purdy, J. G. Rabinowitz, J. D. Shenk, T. Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection. Proc Natl Acad Sci U S A, 110:E5006-E5015, . (PMID: 24297925, PMCID: PMC3870743)

Koyuncu, E. Purdy, J. G. Rabinowitz, J. D. Shenk, T. Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny. PLoS Pathog, 9:e1003333, . (PMID: 23696731, PMCID: PMC3656100)

Dermody, T. S. Sandri-Goldin, R. M. Shenk, T. A new determinant of H5N1 influenza virus pathogenesis in mammals. J Virol, 87:4795-4796, . (PMID: 23449798, PMCID: PMC3624319)

Teng, M. W. Bolovan-Fritts, C. Dar, R. D. Womack, A. Simpson, M. L. Shenk, T. Weinberger, L. S. An endogenous accelerator for viral gene expression confers a fitness advantage. Cell, 151:1569-1580, . (PMID: 23260143, PMCID: PMC3552493)

O'Connor, C. M. Shenk, T. Human Cytomegalovirus pUL78 G Protein-Coupled Receptor Homologue Is Required for Timely Cell Entry in Epithelial Cells but Not Fibroblasts. J Virol, 86:11425-11433, . (PMID: 22915800, PMCID: PMC3486319)

Grady, S. L. Hwang, J. Vastag, L. Rabinowitz, J. D. Shenk, T. Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase. J Virol, 86:8259-8268, . (PMID: 22623791, PMCID: PMC3421676)

Gudleski-O'Regan, N. Greco, T. M. Cristea, I. M. Shenk, T. Increased Expression of LDL Receptor-Related Protein 1 during Human Cytomegalovirus Infection Reduces Virion Cholesterol and Infectivity. Cell Host Microbe, 12:86-96, . (PMID: 22817990, PMCID: PMC3405916)

Lee, S. H. Kalejta, R. F. Kerry, J. Semmes, O. J. O'Connor, C. M. Khan, Z. Garcia, B. A. Shenk, T. Murphy, E. BclAF1 restriction factor is neutralized by proteasomal degradation and microRNA repression during human cytomegalovirus infection. Proc Natl Acad Sci U S A, 109:9575-9580, . (PMID: 22645331, PMCID: PMC3386064)

Terry, L. J. Vastag, L. Rabinowitz, J. D. Shenk, T. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Proc Natl Acad Sci U S A, 109:3071-3076, . (PMID: 22315427, PMCID: PMC3286917)

Casadevall, A. Shenk, T. Mammalian-transmissible H5N1 virus: containment level and case fatality ratio. MBio, 3:e00054-e00012, . (PMID: 22396484, PMCID: PMC3302574)

Casadevall, A. Shenk, T. The H5N1 manuscript redaction controversy. MBio, 3:, . (PMID: 22294678, PMCID: PMC3268664)

Casadevall, A. Shenk, T. The H5N1 Moratorium Controversy and Debate. MBio, 3:, . (PMID: 23047753, PMCID: PMC3484392)

Liu, S. T. Sharon-Friling, R. Ivanova, P. Milne, S. B. Myers, D. S. Rabinowitz, J. D. Brown, H. A. Shenk, T. Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress. Proc Natl Acad Sci U S A, 108:12869-12874, . (PMID: 21768361, PMCID: PMC3150939)

Vastag, L. Koyuncu, E. Grady, S. L. Shenk, T. E. Rabinowitz, J. D. Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. PLoS Pathog, 7:e1002124, . (PMID: 21779165, PMCID: PMC3136460)

O'Connor, C. M. Shenk, T. Human cytomegalovirus pUS27 G protein-coupled receptor homologue is required for efficient spread by the extracellular route but not for direct cell-to-cell spread. J Virol, 85:3700-3707, . (PMID: 21307184, PMCID: PMC3126124)

Rabinowitz, J. D. Purdy, J. G. Vastag, L. Shenk, T. Koyuncu, E. Metabolomics in drug target discovery. Cold Spring Harb Symp Quant Biol, 76:235-246, . (PMID: 22114327)