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Thomas Shenk, PhD

Publications since 2011

O'Connor, C. DiMaggio, P. A. Jr Shenk, T. Garcia, B. A. Quantitative Proteomic Discovery of Dynamic Epigenome Changes that Control Human Cytomegalovirus Infection. Mol Cell Proteomics, 13:2399-2410, . (PMID: 24987098, PMCID: PMC4159657)

Casadevall, A. Dermody, T. S. Imperiale, M. J. Sandri-Goldin, R. M. Shenk, T. On the Need for a National Board To Assess Dual Use Research of Concern. J Virol, 88:6535-6537, . (PMID: 24696484, PMCID: PMC4054389)

Dermody, T. S. Sandri-Goldin, R. M. Shenk, T. Sequence Changes Associated with Respiratory Transmission of H7N1 Influenza Virus in Mammals. J Virol, 88:6533-6534, . (PMID: 24696481, PMCID: PMC4054340)

Sharon-Friling, R. Shenk, T. Human cytomegalovirus pUL37x1-induced calcium flux activates PKCalpha, inducing altered cell shape and accumulation of cytoplasmic vesicles. Proc Natl Acad Sci U S A, 111:E1140-E1148, . (PMID: 24616524, PMCID: PMC3970541)

Dermody, T. S. Casadevall, A. Imperiale, M. J. Sandri-Goldin, R. M. Shenk, T. The Decision to Publish an Avian H7N1 Influenza Virus Gain-of-Function Experiment. MBio, 5:e01985-e01914, . (PMID: 25316699, PMCID: PMC4205794)

Grady, S. L. Purdy, J. G. Rabinowitz, J. D. Shenk, T. Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection. Proc Natl Acad Sci U S A, 110:E5006-E5015, . (PMID: 24297925, PMCID: PMC3870743)

Koyuncu, E. Purdy, J. G. Rabinowitz, J. D. Shenk, T. Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny. PLoS Pathog, 9:e1003333, . (PMID: 23696731, PMCID: PMC3656100)

Dermody, T. S. Sandri-Goldin, R. M. Shenk, T. A new determinant of H5N1 influenza virus pathogenesis in mammals. J Virol, 87:4795-4796, . (PMID: 23449798, PMCID: PMC3624319)

Teng, M. W. Bolovan-Fritts, C. Dar, R. D. Womack, A. Simpson, M. L. Shenk, T. Weinberger, L. S. An endogenous accelerator for viral gene expression confers a fitness advantage. Cell, 151:1569-1580, . (PMID: 23260143, PMCID: PMC3552493)

O'Connor, C. M. Shenk, T. Human Cytomegalovirus pUL78 G Protein-Coupled Receptor Homologue Is Required for Timely Cell Entry in Epithelial Cells but Not Fibroblasts. J Virol, 86:11425-11433, . (PMID: 22915800, PMCID: PMC3486319)

Grady, S. L. Hwang, J. Vastag, L. Rabinowitz, J. D. Shenk, T. Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase. J Virol, 86:8259-8268, . (PMID: 22623791, PMCID: PMC3421676)

Gudleski-O'Regan, N. Greco, T. M. Cristea, I. M. Shenk, T. Increased Expression of LDL Receptor-Related Protein 1 during Human Cytomegalovirus Infection Reduces Virion Cholesterol and Infectivity. Cell Host Microbe, 12:86-96, . (PMID: 22817990, PMCID: PMC3405916)

Lee, S. H. Kalejta, R. F. Kerry, J. Semmes, O. J. O'Connor, C. M. Khan, Z. Garcia, B. A. Shenk, T. Murphy, E. BclAF1 restriction factor is neutralized by proteasomal degradation and microRNA repression during human cytomegalovirus infection. Proc Natl Acad Sci U S A, 109:9575-9580, . (PMID: 22645331, PMCID: PMC3386064)

Terry, L. J. Vastag, L. Rabinowitz, J. D. Shenk, T. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Proc Natl Acad Sci U S A, 109:3071-3076, . (PMID: 22315427, PMCID: PMC3286917)

Casadevall, A. Shenk, T. Mammalian-transmissible H5N1 virus: containment level and case fatality ratio. MBio, 3:e00054-e00012, . (PMID: 22396484, PMCID: PMC3302574)

Casadevall, A. Shenk, T. The H5N1 manuscript redaction controversy. MBio, 3:, . (PMID: 22294678, PMCID: PMC3268664)

Casadevall, A. Shenk, T. The H5N1 Moratorium Controversy and Debate. MBio, 3:, . (PMID: 23047753, PMCID: PMC3484392)

Liu, S. T. Sharon-Friling, R. Ivanova, P. Milne, S. B. Myers, D. S. Rabinowitz, J. D. Brown, H. A. Shenk, T. Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress. Proc Natl Acad Sci U S A, 108:12869-12874, . (PMID: 21768361, PMCID: PMC3150939)

Vastag, L. Koyuncu, E. Grady, S. L. Shenk, T. E. Rabinowitz, J. D. Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. PLoS Pathog, 7:e1002124, . (PMID: 21779165, PMCID: PMC3136460)

O'Connor, C. M. Shenk, T. Human cytomegalovirus pUS27 G protein-coupled receptor homologue is required for efficient spread by the extracellular route but not for direct cell-to-cell spread. J Virol, 85:3700-3707, . (PMID: 21307184, PMCID: PMC3126124)

Rabinowitz, J. D. Purdy, J. G. Vastag, L. Shenk, T. Koyuncu, E. Metabolomics in drug target discovery. Cold Spring Harb Symp Quant Biol, 76:235-246, . (PMID: 22114327)