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Chang S. Chan, PhD

Publications since 2011

Contractor, T. Kobayashi, S. da Silva, E. Clausen, R. Chan, C. Vosburgh, E. Tang, L. H. Levine, A. J. Harris, C. R. Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5. Oncotarget, In process, . (PMID: 27105526)

Zhang, C. Liu, J. Tan, C. Yue, X. Zhao, Y. Peng, J. Wang, X. Laddha, S. V. Chan, C. S. Zheng, S. Hu, W. Feng, Z. microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis. Oncotarget, In process, . (PMID: 26840028)

Levine, A. J. Chan, C. S. Dudgeon, C. Puzio-Kuter, A. Hainaut, P. The Evolution of Tumors in Mice and Humans with Germline p53 Mutations. Cold Spring Harb Symp Quant Biol, In process, . (PMID: 26642854)

Joshi, S. Tolkunov, D. Aviv, H. Hakimi, A. A. Yao, M. Hsieh, J. J. Ganesan, S. Chan, C. S. White, E. The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. Cell Rep, 13:1895-1908, . (PMID: 26655904)

White, E. Mehnert, J. M. Chan, C. S. Autophagy, Metabolism, and Cancer. Clin Cancer Res, 21:5037-5046, . (PMID: 26567363, PMCID: PMC4646728)

Puzio-Kuter, A. M. Laddha, S. V. Castillo-Martin, M. Sun, Y. Cordon-Cardo, C. Chan, C. S. Levine, A. J. Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma. Cell Death Differ, In process, . (PMID: 25822339)

Dudgeon, C. Chan, C. Kang, W. Sun, Y. Emerson, R. Robins, H. Levine, A. J. The evolution of thymic lymphomas in p53 knockout mice. Genes Dev, 28:2613-2620, . (PMID: 25452272, PMCID: PMC4248292)

Ariffin, H. Hainaut, P. Puzio-Kuter, A. Choong, S. S. Chan, A. S. Tolkunov, D. Rajagopal, G. Kang, W. Lim, L. L. Krishnan, S. Chen, K. S. Achatz, M. I. Karsa, M. Shamsani, J. Levine, A. J. Chan, C. S. Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li-Fraumeni cancer predisposition syndrome. Proc Natl Acad Sci U S A, 111:15497-15501, . (PMID: 25313051, PMCID: PMC4217424)

Zhang, C. Liu, J. Wang, X. Wu, R. Lin, M. Laddha, S. V. Yang, Q. Chan, C. S. Feng, Z. MicroRNA-339-5p inhibits colorectal tumorigenesis through regulation of the MDM2/p53 signaling. Oncotarget, 5:9106-9117, . (PMID: 25193859)

Karsli-Uzunbas, G. Guo, J. Y. Price, S. M. Teng, X. Laddha, S. V. Khor, S. Kalaany, N. Y. Jacks, T. Chan, C. S. Rabinowitz, J. D. White, E. Autophagy is Required for Glucose Homeostasis and Lung Tumor Maintenance. Cancer Discov, 4:914-927, . (PMID: 24875857, PMCID: PMC4125614)

Zhang, C. Liu, J. Wu, R. Liang, Y. Lin, M. Liu, J. Chan, C. S. Hu, W. Feng, Z. Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD. Oncotarget, 5:5535-5546, . (PMID: 25114038, PMCID: PMC4170611)

Laddha, S. V. Ganesan, S. Chan, C. S. White, E. Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers. Mol Cancer Res, 12:485-490, . (PMID: 24478461, PMCID: PMC3989371)

Sagne, C. Marcel, V. Bota, M. Martel-Planche, G. Nobrega, A. Palmero, E. I. Perriaud, L. Boniol, M. Vagner, S. Cox, D. G. Chan, C. S. Mergny, J. L. Olivier, M. Ashton-Prolla, P. Hall, J. Hainaut, P. Achatz, M. I. Age at cancer onset in germline TP53 mutation carriers: association with polymorphisms in predicted G-quadruplex structures. Carcinogenesis, 35:807-815, . (PMID: 24336192, PMCID: PMC3977145)

Wong, C. Laddha, S. V. Tang, L. Vosburgh, E. Levine, A. J. Normant, E. Sandy, P. Harris, C. R. Chan, C. S. Xu, E. Y. The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors. Cell Death Dis, 5:e1450, . (PMID: 25299775, PMCID: PMC4237236)