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Chang S. Chan, PhD

Publications since 2011

Levine, A. J. Chan, C. S. Dudgeon, C. Puzio-Kuter, A. Hainaut, P. The Evolution of Tumors in Mice and Humans with Germline p53 Mutations. Cold Spring Harb Symp Quant Biol, In process, . (PMID: 26642854)

Joshi, S. Tolkunov, D. Aviv, H. Hakimi, A. A. Yao, M. Hsieh, J. J. Ganesan, S. Chan, C. S. White, E. The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. Cell Rep, 13:1895-1908, . (PMID: 26655904)

White, E. Mehnert, J. M. Chan, C. S. Autophagy, Metabolism, and Cancer. Clin Cancer Res, 21:5037-5046, . (PMID: 26567363, PMCID: PMC4646728)

Puzio-Kuter, A. M. Laddha, S. V. Castillo-Martin, M. Sun, Y. Cordon-Cardo, C. Chan, C. S. Levine, A. J. Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma. Cell Death Differ, In process, . (PMID: 25822339)

Dudgeon, C. Chan, C. Kang, W. Sun, Y. Emerson, R. Robins, H. Levine, A. J. The evolution of thymic lymphomas in p53 knockout mice. Genes Dev, 28:2613-2620, . (PMID: 25452272, PMCID: PMC4248292)

Ariffin, H. Hainaut, P. Puzio-Kuter, A. Choong, S. S. Chan, A. S. Tolkunov, D. Rajagopal, G. Kang, W. Lim, L. L. Krishnan, S. Chen, K. S. Achatz, M. I. Karsa, M. Shamsani, J. Levine, A. J. Chan, C. S. Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li-Fraumeni cancer predisposition syndrome. Proc Natl Acad Sci U S A, 111:15497-15501, . (PMID: 25313051, PMCID: PMC4217424)

Zhang, C. Liu, J. Wang, X. Wu, R. Lin, M. Laddha, S. V. Yang, Q. Chan, C. S. Feng, Z. MicroRNA-339-5p inhibits colorectal tumorigenesis through regulation of the MDM2/p53 signaling. Oncotarget, 5:9106-9117, . (PMID: 25193859)

Karsli-Uzunbas, G. Guo, J. Y. Price, S. M. Teng, X. Laddha, S. V. Khor, S. Kalaany, N. Y. Jacks, T. Chan, C. S. Rabinowitz, J. D. White, E. Autophagy is Required for Glucose Homeostasis and Lung Tumor Maintenance. Cancer Discov, 4:914-927, . (PMID: 24875857, PMCID: PMC4125614)

Zhang, C. Liu, J. Wu, R. Liang, Y. Lin, M. Liu, J. Chan, C. S. Hu, W. Feng, Z. Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD. Oncotarget, 5:5535-5546, . (PMID: 25114038, PMCID: PMC4170611)

Laddha, S. V. Ganesan, S. Chan, C. S. White, E. Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers. Mol Cancer Res, 12:485-490, . (PMID: 24478461, PMCID: PMC3989371)

Sagne, C. Marcel, V. Bota, M. Martel-Planche, G. Nobrega, A. Palmero, E. I. Perriaud, L. Boniol, M. Vagner, S. Cox, D. G. Chan, C. S. Mergny, J. L. Olivier, M. Ashton-Prolla, P. Hall, J. Hainaut, P. Achatz, M. I. Age at cancer onset in germline TP53 mutation carriers: association with polymorphisms in predicted G-quadruplex structures. Carcinogenesis, 35:807-815, . (PMID: 24336192, PMCID: PMC3977145)

Wong, C. Laddha, S. V. Tang, L. Vosburgh, E. Levine, A. J. Normant, E. Sandy, P. Harris, C. R. Chan, C. S. Xu, E. Y. The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors. Cell Death Dis, 5:e1450, . (PMID: 25299775, PMCID: PMC4237236)