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Wenwei Hu, PhD

Publications since 2011

Liu, J. Zhang, C. Wang, X. L. Ly, P. Belyi, V. Xu-Monette, Z. Y. Young, K. H. Hu, W. Feng, Z. E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. Cell Death Differ, In process, . (PMID: 25146927)

Zhang, C. Liu, J. Wu, R. Liang, Y. Lin, M. Liu, J. Chan, C. S. Hu, W. Feng, Z. Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD. Oncotarget, 5:5535-5546, . (PMID: 25114038)

Liu, J. Zhang, C. Lin, M. Zhu, W. Liang, Y. Hong, X. Zhao, Y. Young, K. H. Hu, W. Feng, Z. Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma. Oncotarget, 5:2635-2647, . (PMID: 24797434, PMCID: PMC4058033)

Zhao, Y. Yu, H. Hu, W. The regulation of MDM2 oncogene and its impact on human cancers. Acta Biochim Biophys Sin (Shanghai), 46:180-189, . (PMID: 24389645, PMCID: PMC3932834)

Li, X. Yang, Q. Yu, H. Wu, L. Zhao, Y. Zhang, C. Yue, X. Liu, Z. Wu, H. Haffty, B. G. Feng, Z. Hu, W. LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway. Oncotarget, 5:788-801, . (PMID: 24553191, PMCID: PMC3996668)

Zhang, N. Huo, Q. Wang, X. Chen, X. Long, L. Guan, X. Jiang, L. Ma, T. Hu, W. Yang, Q. A genetic variant in p63 (rs17506395) is associated with breast cancer susceptibility and prognosis. Gene, 535:170-176, . (PMID: 24316488)

Yu, H. Yue, X. Zhao, Y. Li, X. Wu, L. Zhang, C. Liu, Z. Lin, K. Xu-Monette, Z. Y. Young, K. H. Liu, J. Shen, Z. Feng, Z. Hu, W. LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. Nat Commun, 5:5218, . (PMID: 25323535)

Liu, J. Zhang, C. Hu, W. Feng, Z. Tumor suppressor p53 and its mutants in cancer metabolism. Cancer Lett, In process, . (PMID: 24374014, PMCID: PMC4069248)

Xu-Monette, Z. Y. Moller, M. B. Tzankov, A. Montes-Moreno, S. Hu, W. Manyam, G. C. Kristensen, L. Fan, L. Visco, C. Dybkaer, K. Chiu, A. Tam, W. Zu, Y. Bhagat, G. Richards, K. L. Hsi, E. D. Choi, W. W. van Krieken, J. H. Huang, Q. Huh, J. Ai, W. Ponzoni, M. Ferreri, A. J. Wu, L. Zhao, X. Bueso-Ramos, C. E. Wang, S. A. Go, R. S. Li, Y. Winter, J. N. Piris, M. A. Medeiros, L. J. Young, K. H. MDM2 phenotypic and genotypic profiling, respective to TP53 genetic status, in diffuse large B-cell lymphoma patients treated with rituximab-CHOP immunochemotherapy: a report from the International DLBCL Rituximab-CHOP Consortium Program. Blood, 122:2630-2640, . (PMID: 23982177)

Zheng, T. Wang, J. Zhao, Y. Zhang, C. Lin, M. Wang, X. Yu, H. Liu, L. Feng, Z. Hu, W. Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. Nat Commun, 4:2996, . (PMID: 24356649, PMCID: PMC3960723)

Zhang, C. Liu, J. Liang, Y. Wu, R. Zhao, Y. Hong, X. Lin, M. Yu, H. Liu, L. Levine, A. J. Hu, W. Feng, Z. Tumour-associated mutant p53 drives the Warburg effect. Nat Commun, 4:2935, . (PMID: 24343302, PMCID: PMC3969270)

Yi, L. Lu, C. Hu, W. Sun, Y. Levine, A. J. Multiple Roles of p53-Related Pathways in Somatic Cell Reprogramming and Stem Cell Differentiation. Cancer Res, 72:5635-5645, . (PMID: 22964580)

Feng, Z. Liu, L. Zhang, C. Zheng, T. Wang, J. Lin, M. Zhao, Y. Wang, X. Levine, A. J. Hu, W. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci U S A, 109:7013-7018, . (PMID: 22509031, PMCID: PMC3345015)

Hu, W. Feng, Z. Levine, A. J. The Regulation of Multiple p53 Stress Responses is Mediated through MDM2. Genes Cancer, 3:199-208, . (PMID: 23150753, PMCID: PMC3494373)

Liu, J. Lin, M. Zhang, C. Wang, D. Feng, Z. Hu, W. TAp63gamma enhances nucleotide excision repair through transcriptional regulation of DNA repair genes. DNA Repair (Amst), 11:167-176, . (PMID: 22056305, PMCID: PMC3348579)

Zhang, C. Lin, M. Wu, R. Wang, X. Yang, B. Levine, A. J. Hu, W. Feng, Z. Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc Natl Acad Sci U S A, 108:16259-16264, . (PMID: 21930938, PMCID: PMC3182683)

Tang, M. S. Wang, H. T. Hu, Y. Chen, W. S. Akao, M. Feng, Z. Hu, W. Acrolein induced DNA damage, mutagenicity and effect on DNA repair. Mol Nutr Food Res, 55:1291-1300, . (PMID: 21714128)

Feng, Z. Zhang, C. Kang, H. J. Sun, Y. Wang, H. Naqvi, A. Frank, A. K. Rosenwaks, Z. Murphy, M. E. Levine, A. J. Hu, W. Regulation of female reproduction by p53 and its family members. FASEB J, 25:2245-2255, . (PMID: 21402718, PMCID: PMC3114525)

Hu, W. Zheng, T. Wang, J. Regulation of Fertility by the p53 Family Members. Genes Cancer, 2:420-430, . (PMID: 21779510, PMCID: PMC3135638)

Feng, Z. Zhang, C. Wu, R. Hu, W. Tumor suppressor p53 meets microRNAs. J Mol Cell Biol, 3:44-50, . (PMID: 21278451, PMCID: PMC3030969)

Zhao, Y. Kong, X. Li, X. Yan, S. Yuan, C. Hu, W. Yang, Q. Metadherin mediates lipopolysaccharide-induced migration and invasion of breast cancer cells. PLoS One, 6:e29363, . (PMID: 22195048, PMCID: PMC3241708)