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Wenwei Hu, PhD

Publications since 2011

Zhang, C. Liu, J. Tan, C. Yue, X. Zhao, Y. Peng, J. Wang, X. Laddha, S. V. Chan, C. S. Zheng, S. Hu, W. Feng, Z. microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis. Oncotarget, In process, . (PMID: 26840028)

Zhang, C. Liu, J. Zhao, Y. Yue, X. Zhu, Y. Wang, X. Wu, H. Blanco, F. Li, S. Bhanot, G. Haffty, B. G. Hu, W. Feng, Z. Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis. Elife, In process, . (PMID: 26751560)

Yue, X. Zhao, Y. Zhang, C. Li, J. Liu, Z. Liu, J. Hu, W. Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction. Oncotarget, In process, . (PMID: 26716902)

Yue, X. Zhao, Y. Liu, J. Zhang, C. Yu, H. Wang, J. Zheng, T. Liu, L. Li, J. Feng, Z. Hu, W. BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function. Elife, In process, . (PMID: 26271008)

Zhao, Y. Zhang, C. Yue, X. Li, X. Liu, J. Yu, H. Belyi, V. A. Yang, Q. Feng, Z. Hu, W. Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53. Cell Death Differ, In process, . (PMID: 25857266)

Liu, J. Zhang, C. Hu, W. Feng, Z. Tumor suppressor p53 and its mutants in cancer metabolism. Cancer Lett, 356:197-203, . (PMID: 24374014, PMCID: PMC4069248)

Wu, L. Yu, H. Zhao, Y. Zhang, C. Wang, J. Yue, X. Yang, Q. Hu, W. HIF-2alpha mediates hypoxia-induced LIF expression in human colorectal cancer cells. Oncotarget, In process, . (PMID: 25726527)

Liu, J. Yu, H. Hu, W. LIF is a new p53 negative regulator. J Nat Sci, 1:e131, . (PMID: 26161442, PMCID: PMC4493903)

Yue, X. Wu, L. Hu, W. The regulation of leukemia inhibitory factor. Cancer Cell Microenviron, 2:, . (PMID: 26807429, PMCID: PMC4722946)

Liu, J. Zhang, C. Wang, X. L. Ly, P. Belyi, V. Xu-Monette, Z. Y. Young, K. H. Hu, W. Feng, Z. E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. Cell Death Differ, 21:1792-1804, . (PMID: 25146927, PMCID: PMC4211364)

Zhang, C. Liu, J. Wu, R. Liang, Y. Lin, M. Liu, J. Chan, C. S. Hu, W. Feng, Z. Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD. Oncotarget, 5:5535-5546, . (PMID: 25114038, PMCID: PMC4170611)

Liu, J. Zhang, C. Lin, M. Zhu, W. Liang, Y. Hong, X. Zhao, Y. Young, K. H. Hu, W. Feng, Z. Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma. Oncotarget, 5:2635-2647, . (PMID: 24797434, PMCID: PMC4058033)

Zhao, Y. Yu, H. Hu, W. The regulation of MDM2 oncogene and its impact on human cancers. Acta Biochim Biophys Sin (Shanghai), 46:180-189, . (PMID: 24389645, PMCID: PMC3932834)

Li, X. Yang, Q. Yu, H. Wu, L. Zhao, Y. Zhang, C. Yue, X. Liu, Z. Wu, H. Haffty, B. G. Feng, Z. Hu, W. LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway. Oncotarget, 5:788-801, . (PMID: 24553191, PMCID: PMC3996668)

Zhang, N. Huo, Q. Wang, X. Chen, X. Long, L. Guan, X. Jiang, L. Ma, T. Hu, W. Yang, Q. A genetic variant in p63 (rs17506395) is associated with breast cancer susceptibility and prognosis. Gene, 535:170-176, . (PMID: 24316488)

Yu, H. Yue, X. Zhao, Y. Li, X. Wu, L. Zhang, C. Liu, Z. Lin, K. Xu-Monette, Z. Y. Young, K. H. Liu, J. Shen, Z. Feng, Z. Hu, W. LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. Nat Commun, 5:5218, . (PMID: 25323535, PMCID: PMC4203416)

Xu-Monette, Z. Y. Moller, M. B. Tzankov, A. Montes-Moreno, S. Hu, W. Manyam, G. C. Kristensen, L. Fan, L. Visco, C. Dybkaer, K. Chiu, A. Tam, W. Zu, Y. Bhagat, G. Richards, K. L. Hsi, E. D. Choi, W. W. van Krieken, J. H. Huang, Q. Huh, J. Ai, W. Ponzoni, M. Ferreri, A. J. Wu, L. Zhao, X. Bueso-Ramos, C. E. Wang, S. A. Go, R. S. Li, Y. Winter, J. N. Piris, M. A. Medeiros, L. J. Young, K. H. MDM2 phenotypic and genotypic profiling, respective to TP53 genetic status, in diffuse large B-cell lymphoma patients treated with rituximab-CHOP immunochemotherapy: a report from the International DLBCL Rituximab-CHOP Consortium Program. Blood, 122:2630-2640, . (PMID: 23982177)

Zheng, T. Wang, J. Zhao, Y. Zhang, C. Lin, M. Wang, X. Yu, H. Liu, L. Feng, Z. Hu, W. Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. Nat Commun, 4:2996, . (PMID: 24356649, PMCID: PMC3960723)

Zhang, C. Liu, J. Liang, Y. Wu, R. Zhao, Y. Hong, X. Lin, M. Yu, H. Liu, L. Levine, A. J. Hu, W. Feng, Z. Tumour-associated mutant p53 drives the Warburg effect. Nat Commun, 4:2935, . (PMID: 24343302, PMCID: PMC3969270)

Yi, L. Lu, C. Hu, W. Sun, Y. Levine, A. J. Multiple Roles of p53-Related Pathways in Somatic Cell Reprogramming and Stem Cell Differentiation. Cancer Res, 72:5635-5645, . (PMID: 22964580)

Feng, Z. Liu, L. Zhang, C. Zheng, T. Wang, J. Lin, M. Zhao, Y. Wang, X. Levine, A. J. Hu, W. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci U S A, 109:7013-7018, . (PMID: 22509031, PMCID: PMC3345015)

Hu, W. Feng, Z. Levine, A. J. The Regulation of Multiple p53 Stress Responses is Mediated through MDM2. Genes Cancer, 3:199-208, . (PMID: 23150753, PMCID: PMC3494373)

Liu, J. Lin, M. Zhang, C. Wang, D. Feng, Z. Hu, W. TAp63gamma enhances nucleotide excision repair through transcriptional regulation of DNA repair genes. DNA Repair (Amst), 11:167-176, . (PMID: 22056305, PMCID: PMC3348579)

Zhang, C. Lin, M. Wu, R. Wang, X. Yang, B. Levine, A. J. Hu, W. Feng, Z. Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc Natl Acad Sci U S A, 108:16259-16264, . (PMID: 21930938, PMCID: PMC3182683)

Tang, M. S. Wang, H. T. Hu, Y. Chen, W. S. Akao, M. Feng, Z. Hu, W. Acrolein induced DNA damage, mutagenicity and effect on DNA repair. Mol Nutr Food Res, 55:1291-1300, . (PMID: 21714128)

Feng, Z. Zhang, C. Kang, H. J. Sun, Y. Wang, H. Naqvi, A. Frank, A. K. Rosenwaks, Z. Murphy, M. E. Levine, A. J. Hu, W. Regulation of female reproduction by p53 and its family members. FASEB J, 25:2245-2255, . (PMID: 21402718, PMCID: PMC3114525)

Hu, W. Zheng, T. Wang, J. Regulation of Fertility by the p53 Family Members. Genes Cancer, 2:420-430, . (PMID: 21779510, PMCID: PMC3135638)

Feng, Z. Zhang, C. Wu, R. Hu, W. Tumor suppressor p53 meets microRNAs. J Mol Cell Biol, 3:44-50, . (PMID: 21278451, PMCID: PMC3030969)

Zhao, Y. Kong, X. Li, X. Yan, S. Yuan, C. Hu, W. Yang, Q. Metadherin mediates lipopolysaccharide-induced migration and invasion of breast cancer cells. PLoS One, 6:e29363, . (PMID: 22195048, PMCID: PMC3241708)