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Lizhao Wu, PhD

Selected Publications

  1. Ghazaryan, S., C. Sy, T. Hu, X. An, N. Mohandas, H. Fu, M. Aladjem, V. Chang, R. Opavsky, and L. Wu.  Loss of Rb and E2f8 synergizes to trigger stressed DNA replication during erythroid terminal differentiation.  Molecular and Cellular Biology 34(15): 2833-2847 (2014). (Corresponding author). http://www.ncbi.nlm.nih.gov/pubmed/24865965
  2. Tome-Garcia, J., S. Ghazaryan, D. Li, and L. Wu.  ERBB2 increases metastatic potentials specifically in androgen-insensitive prostate cancer cells.  PLoS ONE 9(6): e99525. doi:10.1371/journal.pone.0099525 (2014). (Corresponding author). http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099525
  3. Wu, L.*, A. de Bruin*, H. Wang, T. Simmons, W. Cleghorn, L. E. Goldenberg, E. Sites, A. Sandy, A. Trimboli, S. A. Fernandez, C. Eng, C. Shapiro, and G. Leone.  Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis.  Oncogene (In press) (*Equal contributions). Advance online publication 25 November 2013; doi: 10.1038/onc.2013.511. (Corresponding author). http://www.ncbi.nlm.nih.gov/pubmed/24276244
  4. Peters, S., R. A. Hlady, J. Opavska, D. Klinkebiel, S. J. Pirruccello, G. A. Talmon, J. G. Sharp, L. Wu, R. Jaenisch, M. A. Simpson, A. R. Karpf, and R. Opavsky. Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis. Leukemia 28: 1138-1142 (2014). http://www.ncbi.nlm.nih.gov/pubmed/24292811
  5. Peters, S., R. A. Hlady, J. Opavska, D. Klinkebiel, S. Novakova, L. M. Smith, R. E. Lewis, A. R. Karpf, M. A. Simpson, L. Wu, and R. Opavsky. An essential role for Dnmt1 in prevention and maintenance of MYC-induced T-cell lymphomas.  Molecular and Cellular Biology 33: 4321-4333 (2013). http://www.ncbi.nlm.nih.gov/pubmed/24001767
  6. Hu, T., S. Ghazaryan, C. Sy, C. Wiedmeyer, V. Chang, and L. Wu. Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.  Blood 119: 4532-4542 (2012) (highlighted as a University News Release by the University of Medicine and Dentistry of New Jersey News Service on July 13, 2012). (Corresponding author). http://www.ncbi.nlm.nih.gov/pubmed/22422820
  7. Chong, J., S. Tsai, N. Sharma, R. Opavsky, R. Price, L. Wu, S. A. Fernandez, and G. Leone. E2f3a and E2f3b contribute to the control of cellular proliferation and mouse development.  Molecular and Cellular Biology 29: 414-424 (2009). http://www.ncbi.nlm.nih.gov/pubmed/19015245 
  8. Tsai, S., R. Opavsky, N. Sharma, L. Wu, S. Naidu, E. Nolan, E. Feria-Arias, C. Timmers, J. Opavska, A. de Bruin, J. Chong, P. Trikha, P. Stromberg, and G. Leone.  Mouse development with a single E2F Activator.  Nature 454: 1137-1141 (2008). http://www.ncbi.nlm.nih.gov/pubmed/18594513
  9. Wenzel, P.*, L. Wu*, E. Sites, A. de Bruin, J. Chong, W. Chen, G. Dureska, E. Sites, T. Pan, A. Sharma, K. Huang, R. Ridgway, K. Mosaliganti, R. Sharp, R. Machiraju, J. Saltz, H. Yamamoto, J. C. Cross, M. L. Robinson, and G. Leone.  Rb is critical in a mammalian tissue stem cell population.  Genes & Development 21: 85-97 (2007) (*Equal contributions). http://www.ncbi.nlm.nih.gov/pubmed/17210791
  10. Timmers, C., N. Sharma, R. Opavsky, B. Maiti, L. Wu, J. Wu, D. Orringer, P. Trikha, H. I. Saavadra, and G. Leone.  E2f1, E2f2, & E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop.  Molecular and Cellular Biology 27: 65-78 (2007). http://www.ncbi.nlm.nih.gov/pubmed/17167174
  11. Dorrance, A. M.,  S. Liu, W. Yuan, B. Becknell, K. J. Arnoczky, M. Guimond, M. P. Strout, L. Feng, T. Nakamura, L. Yu, L. J. Rush, M. Weinstein, G. Leone, L. Wu, A. Ferketich, S. P. Whitman, G. Marcucci, and M. A. Caligiuri. Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations.  Journal of Clinical Investigation 116: 2707-2716 (2006). http://www.ncbi.nlm.nih.gov/pubmed/16981007
  12. Zhang, J., J. Gray, L. Wu, G. Leone, S. Rowan, C. L. Cepko, X. Zhu, C. M. Craft, and M. A. Dyer. Rb regulates proliferation and rod photoreceptor development in the mouse retina.  Nature Genetics 36: 351-360 (2004). http://www.ncbi.nlm.nih.gov/pubmed/14991054
  13. Wu, L., A. de Bruin, H. I. Saavedra, M. Starovic, Y. Yang, A. Trimboli, J. Opavska, P. Wilson, M. C. Ostrowski, J. C. Cross, M. Weinstein, T. J. Rosol, M. L. Robinson, and G. Leone.  Extra-embryonic function of Rb is essential for embryonic development and viability.  Nature 421: 942-947 (2003) (Cover highlight/News & Views 421: 903-904). http://www.ncbi.nlm.nih.gov/pubmed/12607001
  14. de Bruin, A., L. Wu, H. I. Saavedra, P. Wilson, Y. Yang, T. J. Rosol, M. Weinstein, M. L. Robinson, and G. Leone.  Rb function in extraembryonic lineages suppresses apoptosis in the central nervous system of Rb-deficient mice.  Proceedings of National Academy of Sciences (USA) 100: 6546-6551 (2003). http://www.ncbi.nlm.nih.gov/pubmed/12732721
  15. Saavedra, H. I., L. Wu, A. de Bruin, C. Timmers, T. J. Rosol, M. Weinstein, M. L. Robinson, and G. Leone.  Specificity of E2F1, E2F2 and E2F3 in mediating phenotypes induced by loss of Rb.  Cell Growth and Differentiation 13: 215-225 (2002). http://www.ncbi.nlm.nih.gov/pubmed/12065245
  16. Wu, L., C. Timmers, B. Maiti, H. I. Saavedra, L. Sang, G. T. Chong, F. Nuckolls, P. Giangrande, F. A. Wright, M. E. Greenberg, S. Orkin, J. R. Nevins, M. L. Robinson, and G. Leone.  The E2F1, E2F2, and E2F3 transcription factors are essential for cellular proliferation.  Nature 379: 457-462 (2001). http://www.ncbi.nlm.nih.gov/pubmed/11719808
  17. Leone, G., S. Sears, E. Huang, R. Rempel, F. Nuckolls, C.-H. Park, P. Giangrande, L. Wu, H. I. Saavedra, S. J. Field, M. A. Thompson, H. Yang, Y. Fujiwara, M. E. Greenberg, S. Orkin, C. Smith, and J. R. Nevins.  Myc requires distinct E2F activities to induce S phase and apoptosis.   Molecular Cell 8: 105-113 (2001). http://www.ncbi.nlm.nih.gov/pubmed/11511364
  18. Wu, L., L. Kaufman, and P. A. Fuerst.  Isolation of microsatellite markers in Astatoreochromis alluaudi and their cross species amplification in other African cichlids.  Molecular Ecology 8: 895-897 (1999). http://www.ncbi.nlm.nih.gov/pubmed/10368970