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Changshun Shao, PhD

Publications since 2011

Zhao, X. Jiang, B. Hu, H. Mao, F. Mi, J. Li, Z. Liu, Q. Shao, C. Gong, Y. Zebrafish cul4a, but not cul4b, modulates cardiac and forelimb development by upregulating tbx5a expression. Hum Mol Genet, 24:853-864, . (PMID: 25274780)

Li, J. Zhao, X. Xin, Q. Shan, S. Jiang, B. Jin, Y. Yuan, H. Dai, P. Xiao, R. Zhang, Q. Xiao, J. Shao, C. Gong, Y. Liu, Q. Whole-Exome Sequencing Identifies a Variant in TMEM132E Causing Autosomal-Recessive Nonsyndromic Hearing Loss DFNB99. Hum Mutat, 36:98-105, . (PMID: 25331638)

Liu, Q. Xu, X. Zhao, M. Wei, Z. Li, X. Zhang, X. Liu, Z. Gong, Y. Shao, C. Berberine induces senescence of human glioblastoma cells by downregulating EGFR-MEK-ERK signaling pathway. Mol Cancer Ther, In process, . (PMID: 25504754)

Xu, B. Wang, W. Guo, H. Sun, Z. Wei, Z. Zhang, X. Liu, Z. Tischfield, J. A. Gong, Y. Shao, C. Oxidative stress preferentially induces a subtype of micronuclei and mediates the genomic instability caused by p53 dysfunction. Mutat Res Fundam Mol Mech Mutagen, 770:1-8, . (PMID: 25302047, PMCID: PMC4186711)

Yuan, J. Han, B. Hu, H. Qian, Y. Liu, Z. Wei, Z. Liang, X. Jiang, B. Shao, C. Gong, Y. CUL4B activates Wnt/beta-catenin signaling in hepatocellular carcinoma by repressing Wnt antagonists. J Pathol, In process, . (PMID: 25430888)

Wei, Z. Guo, H. Liu, Z. Zhang, X. Liu, Q. Qian, Y. Gong, Y. Shao, C. CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop. Free Radic Biol Med, In process, . (PMID: 25464270)

Mao, F. Li, Z. Zhao, B. Lin, P. Liu, P. Zhai, M. Liu, Q. Shao, C. Sun, W. Gong, Y. Identification and Functional Analysis of a SLC33A1: c.339T>G (p.Ser113Arg) Variant in the Original SPG42 Family. Hum Mutat, In process, . (PMID: 25402622)

Dong, R. Liu, X. Zhang, Q. Jiang, Z. Li, Y. Wei, Y. Li, Y. Yang, Q. Liu, J. Wei, J. J. Shao, C. Liu, Z. Kong, B. miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma. Oncotarget, 5:10816-10829, . (PMID: 25333261, PMCID: PMC4279412)

Ji, Q. Hu, H. Yang, F. Yuan, J. Yang, Y. Jiang, L. Qian, Y. Jiang, B. Zou, Y. Wang, Y. Shao, C. Gong, Y. CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression. J Cell Sci, 127:4679-4691, . (PMID: 25189618)

Guo, H. Zhang, X. Dong, R. Liu, X. Li, Y. Lu, S. Xu, L. Wang, Y. Wang, X. Hou, D. Wei, J. J. Shao, C. Liu, Z. Integrated analysis of long noncoding RNAs and mRNAs reveals their potential roles in the pathogenesis of uterine leiomyomas. Oncotarget, 5:8625-8636, . (PMID: 25268745, PMCID: PMC4226709)

Wang, X. Xin, Q. Li, L. Li, J. Zhang, C. Qiu, R. Qian, C. Zhao, H. Liu, Y. Shan, S. Dang, J. Bian, X. Shao, C. Gong, Y. Liu, Q. Exome sequencing reveals a heterozygous DLX5 mutation in a Chinese family with autosomal-dominant split-hand/foot malformation. Eur J Hum Genet, 22:1105-1110, . (PMID: 24496061, PMCID: PMC4135423)

Ren, G. Liu, Y. Zhao, X. Zhang, J. Zheng, B. Yuan, Z. R. Zhang, L. Qu, X. Tischfield, J. A. Shao, C. Shi, Y. Tumor resident mesenchymal stromal cells endow naive stromal cells with tumor-promoting properties. Oncogene, 33:4016-4020, . (PMID: 24077286)

Chen, Q. Shou, P. Zhang, L. Xu, C. Zheng, C. Han, Y. Li, W. Huang, Y. Zhang, X. Shao, C. Roberts, A. I. Rabson, A. B. Ren, G. Zhang, Y. Wang, Y. Denhardt, D. T. Shi, Y. An Osteopontin-Integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Stem Cells, 32:327-337, . (PMID: 24123709, PMCID: PMC3961005)

Guo, H. Liu, Z. Xu, B. Hu, H. Wei, Z. Liu, Q. Zhang, X. Ding, X. Wang, Y. Zhao, M. Gong, Y. Shao, C. Chemokine receptor CXCR2 is transactivated by p53 and induces p38-mediated cellular senescence in response to DNA damage. Aging Cell, 12:1110-1121, . (PMID: 23869868)

Liu, Z. Gersbach, E. Zhang, X. Xu, X. Dong, R. Lee, P. Liu, J. Kong, B. Shao, C. Wei, J. J. miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma. Mol Cancer Res, 11:1314-1325, . (PMID: 24045973, PMCID: PMC3911890)

Li, H. Li, T. Wang, S. Wei, J. Fan, J. Li, J. Han, Q. Liao, L. Shao, C. Zhao, R. C. miR-17-5p and miR-106a are involved in the balance between osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells. Stem Cell Res, 10:313-324, . (PMID: 23399447)

He, F. Lu, D. Jiang, B. Wang, Y. Liu, Q. Liu, Q. Shao, C. Li, X. Gong, Y. X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling. Biochim Biophys Acta, 1832:595-605, . (PMID: 23357576)

Zou, Y. Mi, J. Wang, W. Lu, J. Zhao, W. Liu, Z. Hu, H. Yang, Y. Gao, X. Jiang, B. Shao, C. Gong, Y. CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. J Cell Biol, 200:743-756, . (PMID: 23479742, PMCID: PMC3601365)

Song, Y. Wang, M. Mao, F. Shao, M. Zhao, B. Song, Z. Shao, C. Gong, Y. Knockdown of Pnpla6 protein results in motor neuron defects in zebrafish. Dis Model Mech, 6:404-413, . (PMID: 22996643, PMCID: PMC3597022)

Hu, H. Yang, Y. Ji, Q. Zhao, W. Jiang, B. Liu, R. Yuan, J. Liu, Q. Li, X. Zou, Y. Shao, C. Shang, Y. Wang, Y. Gong, Y. CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis. Cancer Cell, 22:781-795, . (PMID: 23238014)

Ren, G. Zhao, X. Wang, Y. Zhang, X. Chen, X. Xu, C. Yuan, Z. R. Roberts, A. I. Zhang, L. Zheng, B. Wen, T. Han, Y. Rabson, A. B. Tischfield, J. A. Shao, C. Shi, Y. CCR2-Dependent Recruitment of Macrophages by Tumor-Educated Mesenchymal Stromal Cells Promotes Tumor Development and Is Mimicked by TNFalpha Cell Stem Cell, 11:812-824, . (PMID: 23168163, PMCID: PMC3518598)

Li, X. Xu, B. Moran, M. S. Zhao, Y. Su, P. Haffty, B. G. Shao, C. Yang, Q. 53BP1 functions as a tumor suppressor in breast cancer via the inhibition of NF-kappaB through miR-146a. Carcinogenesis, 33:2593-2600, . (PMID: 23027628)

Liu, Z. Liu, J. Segura, M. F. Shao, C. Lee, P. Gong, Y. Hernando, E. Wei, J. J. MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma. J Pathol, 228:204-215, . (PMID: 22322863)

Liu, X. Qu, X. Chen, Y. Liao, L. Cheng, K. Shao, C. Zenke, M. Keating, A. Zhao, R. C. Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation. J Immunol, 189:1182-1192, . (PMID: 22753940)

Rani, V. Neumann, C. A. Shao, C. Tischfield, J. A. Prdx1 deficiency in mice promotes tissue specific loss of heterozygosity mediated by deficiency in DNA repair and increased oxidative stress. Mutat Res, 735:39-45, . (PMID: 22583657, PMCID: PMC3389210)

Wang, X. Chen, T. Leng, L. Fan, J. Cao, K. Duan, Z. Zhang, X. Shao, C. Wu, M. Tadmori, I. Li, T. Liang, L. Sun, D. Zheng, S. Meinhardt, A. Young, W. Bucala, R. Ren, Y. MIF produced by bone marrow-derived macrophages contributes to teratoma progression after embryonic stem cell transplantation. Cancer Res, 72:2867-2878, . (PMID: 22461508)

Wang, Y. Liu, Q. Liu, Z. Li, B. Sun, Z. Zhou, H. Zhang, X. Gong, Y. Shao, C. Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells. Mutat Res, 734:20-29, . (PMID: 22561209)

Moore, C. R. Liu, Y. Shao, C. Covey, L. R. Morse, H. C. 3rd Xie, P. Specific deletion of TRAF3 in B lymphocytes leads to B-lymphoma development in mice. Leukemia, 26:1122-1127, . (PMID: 22033491, PMCID: PMC3433763)

Liu, Y. Deng, L. Nguyen, S. C. Au, C. L. Shao, C. Tischfield, J. A. Liang, L. A human cell-based reporter detects microhomology-mediated end joining. Mutat Res, 731:140-144, . (PMID: 22197482, PMCID: PMC3268871)

Zhang, X. Liu, Z. Xu, B. Sun, Z. Gong, Y. Shao, C. Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. Eur J Pharmacol, 677:47-54, . (PMID: 22227330)

Jiang, B. Zhao, W. Yuan, J. Qian, Y. Sun, W. Zou, Y. Guo, C. Chen, B. Shao, C. Gong, Y. Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. PLoS One, 7:e37070, . (PMID: 22606329, PMCID: PMC3351389)

Denissova, N. G. Tereshchenko, I. V. Cui, E. Stambrook, P. J. Shao, C. Tischfield, J. A. Ionizing radiation is a potent inducer of mitotic recombination in mouse embryonic stem cells. Mutat Res, 715:1-6, . (PMID: 21802432, PMCID: PMC3172342)

Li, X. Lu, D. He, F. Zhou, H. Liu, Q. Wang, Y. Shao, C. Gong, Y. Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradation. J Biol Chem, 286:32344-32354, . (PMID: 21795677, PMCID: PMC3173229)

Sun, Z. Han, Q. Zhu, Y. Li, Z. Chen, B. Liao, L. Bian, C. Li, J. Shao, C. Zhao, R. C. NANOG has a role in mesenchymal stem cells' immunomodulatory effect. Stem Cells Dev, 20:1521-1528, . (PMID: 21235326)

Li, X. Kong, X. Huo, Q. Guo, H. Yan, S. Yuan, C. Moran, M. S. Shao, C. Yang, Q. Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition. Cancer Sci, 102:1151-1157, . (PMID: 21371176)

Wu, J. Liu, Z. Shao, C. Gong, Y. Hernando, E. Lee, P. Narita, M. Muller, W. Liu, J. Wei, J. J. HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes. Cancer Res, 71:349-359, . (PMID: 21224353)

Xu, B. Sun, Z. Liu, Z. Guo, H. Liu, Q. Jiang, H. Zou, Y. Gong, Y. Tischfield, J. A. Shao, C. Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks. PLoS One, 6:e18618, . (PMID: 21525980, PMCID: PMC3078113)

Liu, Q. Jiang, H. Liu, Z. Wang, Y. Zhao, M. Hao, C. Feng, S. Guo, H. Xu, B. Yang, Q. Gong, Y. Shao, C. Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51. PLoS One, 6:e23427, . (PMID: 21858113, PMCID: PMC3152570)