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Bing Xia, PhD

Selected Publications

  1. Cicchini M, Karantza V# and Xia B# (2014) Molecular Pathways: Autophagy in Cancer- A matter of Timing and Context.  Clin Cancer Res (in press)
  2. Simhadri S, Peterson S, Patel D, Huo Y, Cai H, Miller S, Ludwig T, Ganesan S, Bhaumik M, Bunting S, Jasin M and Xia B. (2014) Male fertility defect associated with a disruption of BRCA1-PALB2 interaction in mice. J Biol Chem pii: jbc.M114.566141. [Epub ahead of print]
  3. Nikkilä J*, Parplys AC*, Pylkäs K*, Bose M, Huo Y, Borgmann K, Rapakko K, Nieminen P, Xia B, Pospiech H# and Winqvist R#. (2013) Heterozygous mutations in PALB2 cause major DNA replication and damage response defects. Nat Commun 4:2578.
  4. Guo JY, Xia B and White E. (2013) Autophagy-mediated tumor promotion. Cell 155:1216-9.
  5. Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C# and Livingston DM# Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. (2013) Proc Natl Acad Sci USA 110:8632-7.
  6. Huo Y, Cai H, Teplova I, Bowman-Colin C, Chen G, Price S, Barnard N, Ganesan S, Karantza V, White E and Xia B. (2013) Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer. Cancer Discov 3:894-907.
  7. Anantha RW, Alcivar AL, Ma J, Cai H, Simhadri S, Ule J, König J and Xia B (2013) Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.  PloS ONE e61368
  8. Ma J, Cai H, Wu T, Sobhian B, Huo Y, Mehta M, Cheung KL, Ganesan S, Kong T, Zhang DD and Xia B. (2012) PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. Mol Cell Biol 32:1506-17.
  9. Siaud N, Barbera MA, Egashira A, Lam I, Christ N, Schlacher K, Xia B and Jasin M. (2011) Plasticity of BRCA2 function in homologous recombination: Genetic interactions of the PALB2 and DNA binding domains. PloS Genet: e1002409.
  10. Tischkowitz M# and Xia B#. (2010) PALB2/FANCN-recombining cancer and Fanconi anemia. Cancer Res 70:7353-9.
  11. Buisson R, Dion-Côté AM, Launay H Coulombe Y, Cai H, Stasiak AZ, Stasiak A, Xia B and Masson JY. (2010) Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. Nat Struct Mol Biol 17:1247-54.
  12. Zhang F, Ma J, Wu J, Ye L, Cai H., Xia B# and Yu X#. (2009)  PALB2 links BRCA1 and BRCA2 in the DNA damage response. Curr Biol 19:524-529.
  13. Erkko H*, Xia B*, Nikkilä J, Schleutker J, Syrjäkoski K, Mannermaa A, Kallioniemi A, Pylkäs K, Karppinen S, Rapakko K, Miron A, Sheng Q, Li G, Mattila H, Bell DW, Haber DA, Grip M, Jukkola-Vuorinen A, Mustonen A, Kere J, Altonen LA, Kosma V, Kataja V, Soini Y, Drapkin RI, Livingston DM # and Winqvist R # (2007) A recurrent mutation in PALB2 in Finnish cancer families. Nature 446:316-319.
  14. Xia B*, Dorsman JC*, Ameziane N, de Vries Y, Rooimans MA, Sheng Q, Pals G, Errami A, Gluckman E, Llera J, Wang W, Livingston DM #, Joenje H and de Winter, JP # (2007) Fanconi anemia is associated with a defect in the BRCA2 partner PALB2. Nature Genetics 39:165-167.
  15. Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, Liu X, Jasin M, Couch FJ, and Livingston DM. (2006) Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell 22:719-729.

* Co-first authors.

# Co-corresponding authors.