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Longqin Hu, PhD

Publications since 2011

Wen, X. Thorne, G. Hu, L. Joy, M. S. Aleksunes, L. M. Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor. J Biochem Mol Toxicol, In process, . (PMID: 25683455)

Aloysius, H. Hu, L. Targeted Prodrug Approaches for Hormone Refractory Prostate Cancer. Med Res Rev, In process, . (PMID: 25529338)

Chen, L. Magesh, S. Wang, H. Yang, C. S. Kong, A. N. Hu, L. Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers. Bioorg Med Chem Lett, 24:940-943, . (PMID: 24398297, PMCID: PMC3936471)

Lee, J. H. Lee, K. R. Su, Z. Y. Boyanapalli, S. S. Barman, D. N. Huang, M. T. Chen, L. Magesh, S. Hu, L. Kong, A. N. In Vitro and in Vivo Anti-inflammatory Effects of a Novel 4,6-Bis ((E)-4-hydroxy-3-methoxystyryl)-1-phenethylpyrimidine-2(1H)-thione. Chem Res Toxicol, 27:34-41, . (PMID: 24304388)

Jiang, Y. Hu, L. Peptide conjugates of 4-aminocyclophosphamide as prodrugs of phosphoramide mustard for selective activation by prostate-specific antigen (PSA). Bioorg Med Chem, 21:7507-7514, . (PMID: 24139844)

Voak, A. A. Gobalakrishnapillai, V. Seifert, K. Balczo, E. Hu, L. Hall, B. S. Wilkinson, S. R. An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs. J Biol Chem, 288:28466-28476, . (PMID: 23946481, PMCID: PMC3789948)

Hu, L. Magesh, S. Chen, L. Wang, L. Lewis, T. A. Chen, Y. Khodier, C. Inoyama, D. Beamer, L. J. Emge, T. J. Shen, J. Kerrigan, J. E. Kong, A. N. Dandapani, S. Palmer, M. Schreiber, S. L. Munoz, B. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem Lett, 23:3039-3043, . (PMID: 23562243, PMCID: PMC3648997)

Duan, P. Li, S. Ai, N. Hu, L. Welsh, W. J. You, G. Potent inhibitors of human organic anion transporters 1 and 3 from clinical drug libraries: discovery and molecular characterization. Mol Pharm, 9:3340-3346, . (PMID: 22973893, PMCID: PMC3490050)

Yang, Y. Voak, A. Wilkinson, S. R. Hu, L. Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation. Bioorg Med Chem Lett, 22:6583-6586, . (PMID: 23031595)

Magesh, S. Chen, Y. Hu, L. Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents. Med Res Rev, 32:687-726, . (PMID: 22549716, PMCID: PMC3393814)

Inoyama, D. Chen, Y. Huang, X. Beamer, L. J. Kong, A. N. Hu, L. Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction. J Biomol Screen, 17:435-447, . (PMID: 22156223, PMCID: PMC3309107)

Chen, Y. Inoyama, D. Kong, A. N. Beamer, L. J. Hu, L. Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance. Chem Biol Drug Des, 78:1014-1021, . (PMID: 21920027, PMCID: PMC3218206)

Hu, L. Wu, X. Han, J. Chen, L. Vass, S. O. Browne, P. Hall, B. S. Bot, C. Gobalakrishnapillai, V. Searle, P. F. Knox, R. J. Wilkinson, S. R. Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs. Bioorg Med Chem Lett, 21:3986-3991, . (PMID: 21620697)

Wu, X. Chen, Y. Aloysius, H. Hu, L. A novel high-yield synthesis of aminoacyl p-nitroanilines and aminoacyl 7-amino-4-methylcoumarins: Important synthons for the synthesis of chromogenic/fluorogenic protease substrates. Beilstein J Org Chem, 7:1030-1035, . (PMID: 21915204, PMCID: PMC3167743)