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Longqin Hu, PhD

Publications since 2011

Chen, L. Magesh, S. Wang, H. Yang, C. S. Kong, A. N. Hu, L. Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers. Bioorg Med Chem Lett, 24:940-943, . (PMID: 24398297, PMCID: PMC3936471)

Lee, J. H. Lee, K. R. Su, Z. Y. Boyanapalli, S. S. Barman, D. N. Huang, M. T. Chen, L. Magesh, S. Hu, L. Kong, A. N. In Vitro and in Vivo Anti-inflammatory Effects of a Novel 4,6-Bis ((E)-4-hydroxy-3-methoxystyryl)-1-phenethylpyrimidine-2(1H)-thione. Chem Res Toxicol, 27:34-41, . (PMID: 24304388)

Jiang, Y. Hu, L. Peptide conjugates of 4-aminocyclophosphamide as prodrugs of phosphoramide mustard for selective activation by prostate-specific antigen (PSA). Bioorg Med Chem, 21:7507-7514, . (PMID: 24139844)

Voak, A. A. Gobalakrishnapillai, V. Seifert, K. Balczo, E. Hu, L. Hall, B. S. Wilkinson, S. R. An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs. J Biol Chem, 288:28466-28476, . (PMID: 23946481, PMCID: PMC3789948)

Hu, L. Magesh, S. Chen, L. Wang, L. Lewis, T. A. Chen, Y. Khodier, C. Inoyama, D. Beamer, L. J. Emge, T. J. Shen, J. Kerrigan, J. E. Kong, A. N. Dandapani, S. Palmer, M. Schreiber, S. L. Munoz, B. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem Lett, 23:3039-3043, . (PMID: 23562243, PMCID: PMC3648997)

Duan, P. Li, S. Ai, N. Hu, L. Welsh, W. J. You, G. Potent inhibitors of human organic anion transporters 1 and 3 from clinical drug libraries: discovery and molecular characterization. Mol Pharm, 9:3340-3346, . (PMID: 22973893, PMCID: PMC3490050)

Yang, Y. Voak, A. Wilkinson, S. R. Hu, L. Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation. Bioorg Med Chem Lett, 22:6583-6586, . (PMID: 23031595)

Magesh, S. Chen, Y. Hu, L. Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents. Med Res Rev, 32:687-726, . (PMID: 22549716, PMCID: PMC3393814)

Inoyama, D. Chen, Y. Huang, X. Beamer, L. J. Kong, A. N. Hu, L. Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction. J Biomol Screen, 17:435-447, . (PMID: 22156223, PMCID: PMC3309107)

Chen, Y. Inoyama, D. Kong, A. N. Beamer, L. J. Hu, L. Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance. Chem Biol Drug Des, 78:1014-1021, . (PMID: 21920027, PMCID: PMC3218206)

Hu, L. Wu, X. Han, J. Chen, L. Vass, S. O. Browne, P. Hall, B. S. Bot, C. Gobalakrishnapillai, V. Searle, P. F. Knox, R. J. Wilkinson, S. R. Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs. Bioorg Med Chem Lett, 21:3986-3991, . (PMID: 21620697)

Wu, X. Chen, Y. Aloysius, H. Hu, L. A novel high-yield synthesis of aminoacyl p-nitroanilines and aminoacyl 7-amino-4-methylcoumarins: Important synthons for the synthesis of chromogenic/fluorogenic protease substrates. Beilstein J Org Chem, 7:1030-1035, . (PMID: 21915204, PMCID: PMC3167743)