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Karl Herrup, PhD

Publications since 2011

Vail, G. Cheng, A. Han, Y. R. Zhao, T. Du, S. Loy, M. M. Herrup, K. Plummer, M. R. ATM protein is located on presynaptic vesicles and its deficit leads to failures in synaptic plasticity. J Neurophysiol, In process, . (PMID: 27075534)

Chow, H. M. Herrup, K. Genomic integrity and the ageing brain. Nat Rev Neurosci, 16:672-684, . (PMID: 26462757)

Jiang, D. Zhang, Y. Hart, R. P. Chen, J. Herrup, K. Li, J. Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency. Brain, In process, . (PMID: 26510954)

Herrup, K. The case for rejecting the amyloid cascade hypothesis. Nat Neurosci, 18:794-799, . (PMID: 26007212)

Zhou, J. Li, H. Li, X. Zhang, G. Niu, Y. Yuan, Z. Herrup, K. Zhang, Y. W. Bu, G. Xu, H. Zhang, J. The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death. J Neurosci, 35:2624-2635, . (PMID: 25673854)

Chow, H. M. Guo, D. Zhou, J. C. Zhang, G. Y. Li, H. F. Herrup, K. Zhang, J. CDK5 activator protein p25 preferentially binds and activates GSK3beta Proc Natl Acad Sci U S A, 111:E4887-E4895, . (PMID: 25331900, PMCID: PMC4234543)

Bhaskar, K. Maphis, N. Xu, G. Varvel, N. H. Kokiko-Cochran, O. N. Weick, J. P. Staugaitis, S. M. Cardona, A. Ransohoff, R. M. Herrup, K. Lamb, B. T. Microglial derived tumor necrosis factor-alpha drives Alzheimer's disease-related neuronal cell cycle events. Neurobiol Dis, 62:273-285, . (PMID: 24141019, PMCID: PMC3877710)

Yang, Y. Hui, C. W. Li, J. Herrup, K. The interaction of the atm genotype with inflammation and oxidative stress. PLoS One, 9:e85863, . (PMID: 24465754, PMCID: PMC3896418)

Goto, S. Kamal, N. Puzio, H. Kobylarz, F. Herrup, K. Differential Responses of Individuals with Late-Stage Dementia to Two Novel Environments: A Multimedia Room and an Interior Garden. J Alzheimers Dis, 42:985-998, . (PMID: 25024307)

Herrup, K. Post-mitotic role of the cell cycle machinery. Curr Opin Cell Biol, 25:711-716, . (PMID: 24055434, PMCID: PMC3899578)

Li, J. Hart, R. P. Mallimo, E. M. Swerdel, M. R. Kusnecov, A. W. Herrup, K. EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia. Nat Neurosci, 16:1745-1753, . (PMID: 24162653, PMCID: PMC3965909)

Herrup, K. Li, J. Chen, J. The role of ATM and DNA damage in neurons: upstream and downstream connections. DNA Repair (Amst), 12:600-604, . (PMID: 23680599, PMCID: PMC3720697)

Herrup, K. Carrillo, M. C. Schenk, D. Cacace, A. Desanti, S. Fremeau, R. Bhat, R. Glicksman, M. May, P. Swerdlow, R. Van Eldik, L. J. Bain, L. J. Budd, S. Beyond amyloid: getting real about nonamyloid targets in Alzheimer's disease. Alzheimers Dement, 9:452-458.e1, . (PMID: 23809366)

Yang, Y. Wang, H. Zhang, J. Luo, F. Herrup, K. Bibb, J. A. Lu, R. Miller, R. H. Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation. Dev Biol, 378:94-106, . (PMID: 23583582, PMCID: PMC3686511)

Herrup, K. ATM and the epigenetics of the neuronal genome. Mech Ageing Dev, In process, . (PMID: 23707635)

Herrup, K. Chen, J. Li, J. Breaking news: thinking may be bad for DNA. Nat Neurosci, 16:518-519, . (PMID: 23619752)

Zhang, J. Li, H. Zhou, T. Zhou, J. Herrup, K. Cdk5 Levels Oscillate during the Neuronal Cell Cycle: Cdh1 UBIQUITINATION TRIGGERS PROTEOSOME-DEPENDENT DEGRADATION DURING S-PHASE. J Biol Chem, 287:25985-25994, . (PMID: 22654103, PMCID: PMC3406682)

Li, J. Chen, J. Ricupero, C. L. Hart, R. P. Schwartz, M. S. Kusnecov, A. Herrup, K. Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. Nat Med, 18:783-790, . (PMID: 22466704, PMCID: PMC3378917)

Chen, J. Herrup, K. Glutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress. PLoS One, 7:e33177, . (PMID: 22413000, PMCID: PMC3297635)

Herrup, K. The contributions of unscheduled neuronal cell cycle events to the death of neurons in Alzheimer's disease. Front Biosci (Elite Ed), 4:2101-2109, . (PMID: 22202022)

Wilkinson, B. L. Cramer, P. E. Varvel, N. H. Reed-Geaghan, E. Jiang, Q. Szabo, A. Herrup, K. Lamb, B. T. Landreth, G. E. Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease. Neurobiol Aging, 33:197.e21-197.e32, . (PMID: 20696495, PMCID: PMC2980562)

Li, J. Chen, J. Vinters, H. V. Gatti, R. A. Herrup, K. Stable brain ATM message and residual kinase-active ATM protein in ataxia-telangiectasia. J Neurosci, 31:7568-7577, . (PMID: 21593342, PMCID: PMC3109425)

Herrup, K. Commentary on "Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease." Addressing the challenge of Alzheimer's disease in the 21st century. Alzheimers Dement, 7:335-337, . (PMID: 21575876)

Zhang, J. Herrup, K. Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons. Cell Cycle, 10:1208-1214, . (PMID: 21415596)

Li, L. Cheung, T. Chen, J. Herrup, K. A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death. Int J Alzheimers Dis, 2011:171464, . (PMID: 21912750, PMCID: PMC3170790)