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Karl Herrup, PhD

Publications since 2011

Chow, H. M. Herrup, K. Genomic integrity and the ageing brain. Nat Rev Neurosci, 16:672-684, . (PMID: 26462757)

Jiang, D. Zhang, Y. Hart, R. P. Chen, J. Herrup, K. Li, J. Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency. Brain, In process, . (PMID: 26510954)

Herrup, K. The case for rejecting the amyloid cascade hypothesis. Nat Neurosci, 18:794-799, . (PMID: 26007212)

Zhou, J. Li, H. Li, X. Zhang, G. Niu, Y. Yuan, Z. Herrup, K. Zhang, Y. W. Bu, G. Xu, H. Zhang, J. The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death. J Neurosci, 35:2624-2635, . (PMID: 25673854)

Chow, H. M. Guo, D. Zhou, J. C. Zhang, G. Y. Li, H. F. Herrup, K. Zhang, J. CDK5 activator protein p25 preferentially binds and activates GSK3beta Proc Natl Acad Sci U S A, 111:E4887-E4895, . (PMID: 25331900, PMCID: PMC4234543)

Bhaskar, K. Maphis, N. Xu, G. Varvel, N. H. Kokiko-Cochran, O. N. Weick, J. P. Staugaitis, S. M. Cardona, A. Ransohoff, R. M. Herrup, K. Lamb, B. T. Microglial derived tumor necrosis factor-alpha drives Alzheimer's disease-related neuronal cell cycle events. Neurobiol Dis, 62:273-285, . (PMID: 24141019, PMCID: PMC3877710)

Yang, Y. Hui, C. W. Li, J. Herrup, K. The interaction of the atm genotype with inflammation and oxidative stress. PLoS One, 9:e85863, . (PMID: 24465754, PMCID: PMC3896418)

Goto, S. Kamal, N. Puzio, H. Kobylarz, F. Herrup, K. Differential Responses of Individuals with Late-Stage Dementia to Two Novel Environments: A Multimedia Room and an Interior Garden. J Alzheimers Dis, 42:985-998, . (PMID: 25024307)

Herrup, K. Post-mitotic role of the cell cycle machinery. Curr Opin Cell Biol, 25:711-716, . (PMID: 24055434, PMCID: PMC3899578)

Li, J. Hart, R. P. Mallimo, E. M. Swerdel, M. R. Kusnecov, A. W. Herrup, K. EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia. Nat Neurosci, 16:1745-1753, . (PMID: 24162653, PMCID: PMC3965909)

Herrup, K. Li, J. Chen, J. The role of ATM and DNA damage in neurons: upstream and downstream connections. DNA Repair (Amst), 12:600-604, . (PMID: 23680599, PMCID: PMC3720697)

Herrup, K. Carrillo, M. C. Schenk, D. Cacace, A. Desanti, S. Fremeau, R. Bhat, R. Glicksman, M. May, P. Swerdlow, R. Van Eldik, L. J. Bain, L. J. Budd, S. Beyond amyloid: getting real about nonamyloid targets in Alzheimer's disease. Alzheimers Dement, 9:452-458.e1, . (PMID: 23809366)

Yang, Y. Wang, H. Zhang, J. Luo, F. Herrup, K. Bibb, J. A. Lu, R. Miller, R. H. Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation. Dev Biol, 378:94-106, . (PMID: 23583582, PMCID: PMC3686511)

Herrup, K. ATM and the epigenetics of the neuronal genome. Mech Ageing Dev, In process, . (PMID: 23707635)

Herrup, K. Chen, J. Li, J. Breaking news: thinking may be bad for DNA. Nat Neurosci, 16:518-519, . (PMID: 23619752)

Zhang, J. Li, H. Zhou, T. Zhou, J. Herrup, K. Cdk5 Levels Oscillate during the Neuronal Cell Cycle: Cdh1 UBIQUITINATION TRIGGERS PROTEOSOME-DEPENDENT DEGRADATION DURING S-PHASE. J Biol Chem, 287:25985-25994, . (PMID: 22654103, PMCID: PMC3406682)

Li, J. Chen, J. Ricupero, C. L. Hart, R. P. Schwartz, M. S. Kusnecov, A. Herrup, K. Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. Nat Med, 18:783-790, . (PMID: 22466704, PMCID: PMC3378917)

Chen, J. Herrup, K. Glutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress. PLoS One, 7:e33177, . (PMID: 22413000, PMCID: PMC3297635)

Herrup, K. The contributions of unscheduled neuronal cell cycle events to the death of neurons in Alzheimer's disease. Front Biosci (Elite Ed), 4:2101-2109, . (PMID: 22202022)

Wilkinson, B. L. Cramer, P. E. Varvel, N. H. Reed-Geaghan, E. Jiang, Q. Szabo, A. Herrup, K. Lamb, B. T. Landreth, G. E. Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease. Neurobiol Aging, 33:197.e21-197.e32, . (PMID: 20696495, PMCID: PMC2980562)

Li, J. Chen, J. Vinters, H. V. Gatti, R. A. Herrup, K. Stable brain ATM message and residual kinase-active ATM protein in ataxia-telangiectasia. J Neurosci, 31:7568-7577, . (PMID: 21593342, PMCID: PMC3109425)

Herrup, K. Commentary on "Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease." Addressing the challenge of Alzheimer's disease in the 21st century. Alzheimers Dement, 7:335-337, . (PMID: 21575876)

Zhang, J. Herrup, K. Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons. Cell Cycle, 10:1208-1214, . (PMID: 21415596)

Li, L. Cheung, T. Chen, J. Herrup, K. A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death. Int J Alzheimers Dis, 2011:171464, . (PMID: 21912750, PMCID: PMC3170790)