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Yi Lisa Lyu, PhD

Selected Publications

  1. Wang Y, Lyu YL, Wang JC. Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus. Proceedings of the National Academy of Sciences of the United States of America. 2002;99(19):12114-9. doi: 10.1073/pnas.192449499. PubMed PMID: 12209014; PubMed Central PMCID: PMC129407.
  2. Lyu YL, Wang JC. Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta. Proceedings of the National Academy of Sciences of the United States of America. 2003;100(12):7123-8. doi: 10.1073/pnas.1232376100. PubMed PMID: 12773624; PubMed Central PMCID: PMC165840.
  3. Hars ES, Lyu YL, Lin CP, Liu LF. Role of apoptotic nuclease caspase-activated DNase in etoposide-induced treatment-related acute myelogenous leukemia. Cancer research. 2006;66(18):8975-9. doi: 10.1158/0008-5472.CAN-06-1724. PubMed PMID: 16982737.
  4. Lyu YL*, Lin CP, Azarova AM, Cai L, Wang JC, Liu LF*. Role of topoisomerase IIbeta in the expression of developmentally regulated genes. Molecular and cellular biology. 2006;26(21):7929- 41. doi: 10.1128/MCB.00617-06. PubMed PMID: 16923961; PubMed Central PMCID: PMC1636731.
  5. Azarova AM, Lyu YL, Lin CP, Tsai YC, Lau JY, Wang JC, Liu LF. Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(26):11014-9. doi: 10.1073/pnas.0704002104. PubMed PMID: 17578914; PubMed Central PMCID: PMC1904155.
  6. Lyu YL*, Kerrigan JE, Lin CP, Azarova AM, Tsai YC, Ban Y, Liu LF*. Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane. Cancer research. 2007;67(18):8839-46. doi: 10.1158/0008-5472.CAN-07-1649. PubMed PMID: 17875725.
  7. Nur EKA, Meiners S, Ahmed I, Azarova A, Lin CP, Lyu YL, Liu LF. Role of DNA topoisomerase IIbeta in neurite outgrowth. Brain research. 2007;1154:50-60. doi: 10.1016/j.brainres.2007.04.029. PubMed PMID: 17493591.
  8. Azarova AM, Lin RK, Tsai YC, Liu LF, Lin CP, Lyu YL*. Genistein induces topoisomerase IIbeta and proteasome-mediated DNA sequence rearrangements: Implications in infant leukemia. Biochemical and biophysical research communications. 2010;399(1):66-71. doi: 10.1016/j.bbrc.2010.07.043. PubMed PMID: 20638367; PubMed Central PMCID: PMC3376163.
  9. Lin RK, Zhou N, Lyu YL, Tsai YC, Lu CH, Kerrigan J, Chen YT, Guan Z, Hsieh TS, Liu LF. Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIalpha. The Journal of biological chemistry. 2011;286(38):33591-600. doi: 10.1074/jbc.M111.258137. PubMed PMID: 21828038; PubMed Central PMCID: PMC3190902.
  10. Tsai YC, Pestka S, Wang LH, Runnels LW, Wan S, Lyu YL, Liu LF. Interferon-beta signaling contributes to Ras transformation. PloS one. 2011;6(8):e24291. doi: 10.1371/journal.pone.0024291. PubMed PMID: 21897875; PubMed Central PMCID: PMC3163666.
  11. Cai L, Lyu YL. Analysis of Retinal Development and Diseases Using RNA-Seq. Cell & developmental biology. 2012;1(5). doi: 10.4172/2168-9296.1000e113. PubMed PMID: 23667856; PubMed Central PMCID: PMC3648879.
  12. Zhang S, Liu X, Bawa-Khalfe T, Lu LS, Lyu YL, Liu LF, Yeh ET. Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nature medicine. 2012;18(11):1639-42. doi: 10.1038/nm.2919. PubMed PMID: 23104132.
  13. Ban Y, Ho CW, Lin RK, Lyu YL*, Liu LF*. Activation of a novel ubiquitin-independent proteasome pathway when RNA polymerase II encounters a protein roadblock. Molecular and cellular biology. 2013;33(20):4008-16. doi: 10.1128/MCB.00403-13. PubMed PMID: 23938298; PubMed Central PMCID: PMC3811683.
  14. Lin RK, Ho CW, Liu LF, Lyu YL*. Topoisomerase IIbeta deficiency enhances camptothecin induced apoptosis. The Journal of biological chemistry. 2013;288(10):7182-92. doi: 10.1074/jbc.M112.415471. PubMed PMID: 23344961; PubMed Central PMCID: PMC3591627.
  15. Li Y, Hao H, Tzatzalos E, Lin RK, Doh S, Liu LF, Lyu YL*, Cai L*. Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells. Biology open. 2014;3(2):172-84. doi: 10.1242/bio.20146767. PubMed PMID: 24463367; PubMed Central PMCID: PMC3925320.