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Celine Gelinas, PhD

Selected Publications

Rayet, B., Fan, Y. and Gélinas, C. (2003) Mutations in the v-Rel transactivation domain indicate altered phosphorylation and identify a subset of NF-kB-regulated cell death inhibitors important for v-Rel transforming activity. Mol. Cell. Biol. 23: 1520-1533.

Edelstein, L.C., Lagos, L., Simmons, M., Tirumalai, H. and Gélinas, C. (2003) NF-kB-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1. Mol. Cell. Biol. 23: 2749-2761.

Fan, Y., Rayet, B. and Gélinas, C. (2004) Divergent C-terminal transactivation domains of Rel/NF-kB proteins are critical determinants of their oncogenic potential. Oncogene 23: 1030-1042.

Kucharczak, J.F., Simmons, M.J., Duckett, C.S. and Gélinas, C. (2005) Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a pro-death factor. Cell Death & Differ. 12: 1225-1239.

Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson A, Chen G, Mukherjee C, Shi Y, Gélinas C, Fan Y, Nelson D, Jin S and White E. (2006) Autophagy promotes tumor cell survival and restricts necrosis, inflammation and tumorigenesis. Cancer Cell 10: 51-64.

Pegman, P.M., Smith, S.M., D'Souza, B.N., Loughran, S.T., Maier, S, Kempkes, B., Cahill, P.A., Simmons, M.J., Gélinas, C. and Walls, D.. (2006) The Epstein-Barr virus nuclear antigen 2 trans-activates the cellular anti-apoptotic bfl-1 gene by a CBF-1/RBPJ dependent pathway. J. Virol. 80: 8133-8144.

Fan Y, Gélinas C (2007) An optimal range of transcription potency is necessary for efficient cell transformation by c-Rel to ensure optimal nuclear localization and gene-specific activation Oncogene 26: 4038-4043.

Gupta N, Delrow J, Drawid, A, Sengupta AM, Fan G and Gélinas C. (2008) Repression of BLNK and BCAP is important for lymphocyte transformation by Rel proteins. Cancer Research 68: 808-814.

Simmons, M.J, Fan G, Zong, W.X., Degenhardt K, White E and Gélinas C. (2008) Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist. Oncogene 27: 1421-1428.

Dutta J, Fan G and Gélinas C. (2008) CAPERa is a novel Rel-TAD-interacting factor that inhibits lymphocyte transformation by the potent Rel/NF-kB oncoprotein v-Rel. J. Virol. 82: 10792-10802.

Mathew R, Karp C, Beaudoin B, Vuong N, Chen G, Chen H-Y, Bray K, Reddy A, Bhanot G, Gelinas C, DiPaola RS, Karantza-Wadsworth V, White E. (2009) Autophagy suppresses tumorigenesis through elimination of p62. Cell 137: 1062-1075.

Fan G, Fan Y, Gupta N, Matsuura I, Liu F, Zhen Zhou X, Lu KP and Gélinas C. (2009) Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the Rel proteins in the NF-kB family.Cancer Research 69: 4589-4597.

Drawid A, Gupta N, Nagaraj VH, Gélinas C and Sengupta A. (2009) A Hidden Markov Model with position-dependent transition probabilities accurately predicts the occupancy of a transcription factor on self-overlapping binding motifs. BMC Bioinformatics 10: 208-234.

Fan G, Simmons MJ, Ge S, Dutta-Simmons J, Kucharczak J, Ron Y, Weissmann D, Chen CC, Mukherjee C, White E and Gélinas C. (2010) Defective ubiquitin-mediated degradation of anti-apoptotic Bfl-1 predisposes to lymphoma. Blood 115: 3559-3569.

Guo JY, Chen H-Y, Mathew R, Fan J, Strohecker AM, Kamphorst JJ, Chen G, Lemmons JMS, Karantza V, Coller HA, DiPaola RS, Gélinas C, Rabinowitz JD and White E. (2011) Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes & Dev. 25: 460-470.

Medina DJ, Goodell L, Glod J, Gélinas C, Rabson AB and Strair RK. (2012) Mesenchymal stromal cells protect mantle cell lymphoma cells from spontaneous and drug-induced apoptosis through secretion of B-cell activating factor and activation of the canonical and non-canonical nuclear factor B pathways. Hematologica 97:1255-63.