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Arnold Levine, PhD

Publications since 2011

Levine, A. J. Ting, D. T. Greenbaum, B. D. P53 and the defenses against genome instability caused by transposons and repetitive elements. Bioessays, 38:508-513, . (PMID: 27172878)

Contractor, T. Kobayashi, S. da Silva, E. Clausen, R. Chan, C. Vosburgh, E. Tang, L. H. Levine, A. J. Harris, C. R. Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5. Oncotarget, In process, . (PMID: 27105526)

Chillemi, G. Kehrloesser, S. Bernassola, F. Desideri, A. Dotsch, V. Levine, A. J. Melino, G. Structural Evolution and Dynamics of the p53 Proteins. Cold Spring Harb Perspect Med, In process, . (PMID: 27091942)

Levine, A. J. Chan, C. S. Dudgeon, C. Puzio-Kuter, A. Hainaut, P. The Evolution of Tumors in Mice and Humans with Germline p53 Mutations. Cold Spring Harb Symp Quant Biol, In process, . (PMID: 26642854)

Tanne, A. Muniz, L. R. Puzio-Kuter, A. Leonova, K. I. Gudkov, A. V. Ting, D. T. Monasson, R. Cocco, S. Levine, A. J. Bhardwaj, N. Greenbaum, B. D. Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells. Proc Natl Acad Sci U S A, In process, . (PMID: 26575629)

D'Abramo, M. Besker, N. Desideri, A. Levine, A. J. Melino, G. Chillemi, G. The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain. Oncogene, In process, . (PMID: 26477317)

Marbach-Bar, N. Bahat, A. Ashkenazi, S. Golan-Mashiach, M. Haimov, O. Wu, S. Y. Chiang, C. M. Puzio-Kuter, A. Hirshfield, K. M. Levine, A. J. Dikstein, R. DTIE, a novel core promoter element that directs start site selection in TATA-less genes. Nucleic Acids Res, In process, . (PMID: 26464433)

Blanden, A. R. Yu, X. Loh, S. N. Levine, A. J. Carpizo, D. R. Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer. Drug Discov Today, In process, . (PMID: 26205328)

Zhang, X. Schulz, R. Edmunds, S. Kruger, E. Markert, E. Gaedcke, J. Cormet-Boyaka, E. Ghadimi, M. Beissbarth, T. Levine, A. J. Moll, U. M. Dobbelstein, M. MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP. Mol Cell, 59:243-257, . (PMID: 26145175)

Levine, A. J. Stem cells, aging and cancers. Aging (Albany NY), 7:457-458, . (PMID: 26186894, PMCID: PMC4543030)

Puzio-Kuter, A. M. Laddha, S. V. Castillo-Martin, M. Sun, Y. Cordon-Cardo, C. Chan, C. S. Levine, A. J. Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma. Cell Death Differ, In process, . (PMID: 25822339)

Amelio, I. Inoue, S. Markert, E. K. Levine, A. J. Knight, R. A. Mak, T. W. Melino, G. TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1alpha degradation. Proc Natl Acad Sci U S A, 112:226-231, . (PMID: 25535359, PMCID: PMC4291637)

Dudgeon, C. Chan, C. Kang, W. Sun, Y. Emerson, R. Robins, H. Levine, A. J. The evolution of thymic lymphomas in p53 knockout mice. Genes Dev, 28:2613-2620, . (PMID: 25452272, PMCID: PMC4248292)

Ariffin, H. Hainaut, P. Puzio-Kuter, A. Choong, S. S. Chan, A. S. Tolkunov, D. Rajagopal, G. Kang, W. Lim, L. L. Krishnan, S. Chen, K. S. Achatz, M. I. Karsa, M. Shamsani, J. Levine, A. J. Chan, C. S. Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li-Fraumeni cancer predisposition syndrome. Proc Natl Acad Sci U S A, 111:15497-15501, . (PMID: 25313051, PMCID: PMC4217424)

Yi, L. Sun, Y. Levine, A. Selected drugs that inhibit DNA methylation can preferentially kill p53 deficient cells. Oncotarget, 5:8924-8936, . (PMID: 25238040)

Hait, W. N. Levine, A. J. Genomic complexity: a call to action. Sci Transl Med, 6:255cm10, . (PMID: 25253671)

Greenbaum, B. D. Cocco, S. Levine, A. J. Monasson, R. Quantitative theory of entropic forces acting on constrained nucleotide sequences applied to viruses. Proc Natl Acad Sci U S A, 111:5054-5059, . (PMID: 24639520, PMCID: PMC3977288)

Chen, W. Wong, C. Vosburgh, E. Levine, A. J. Foran, D. J. Xu, E. Y. High-throughput Image Analysis of Tumor Spheroids: A User-friendly Software Application to Measure the Size of Spheroids Automatically and Accurately. J Vis Exp, :, . (PMID: 25046278, PMCID: PMC4212916)

Wong, C. Laddha, S. V. Tang, L. Vosburgh, E. Levine, A. J. Normant, E. Sandy, P. Harris, C. R. Chan, C. S. Xu, E. Y. The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors. Cell Death Dis, 5:e1450, . (PMID: 25299775, PMCID: PMC4237236)

Amelio, I. Markert, E. K. Rufini, A. Antonov, A. V. Sayan, B. S. Tucci, P. Agostini, M. Mineo, T. C. Levine, A. J. Melino, G. p73 regulates serine biosynthesis in cancer. Oncogene, In process, . (PMID: 24186203)

Formosa, A. Markert, E. K. Lena, A. M. Italiano, D. Finazzi-Agro', E. Levine, A. J. Bernardini, S. Garabadgiu, A. V. Melino, G. Candi, E. MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. Oncogene, In process, . (PMID: 24166498)

Giacobbe, A. Bongiorno-Borbone, L. Bernassola, F. Terrinoni, A. Markert, E. K. Levine, A. J. Feng, Z. Agostini, M. Zolla, L. Agro, A. F. Notterman, D. A. Melino, G. Peschiaroli, A. p63 regulates glutaminase 2 expression. Cell Cycle, 12:1395-1405, . (PMID: 23574722, PMCID: PMC3674067)

Huang, Q. Yu, L. Levine, A. J. Nussinov, R. Ma, B. Dipeptide analysis of p53 mutations and evolution of p53 family proteins. Biochim Biophys Acta, In process, . (PMID: 23583620)

Peschiaroli, A. Giacobbe, A. Formosa, A. Markert, E. K. Bongiorno-Borbone, L. Levine, A. J. Candi, E. D'Alessandro, A. Zolla, L. Finazzi Agro, A. Melino, G. miR-143 regulates hexokinase 2 expression in cancer cells. Oncogene, 32:797-802, . (PMID: 22469988)

Formosa, A. Lena, A. M. Markert, E. K. Cortelli, S. Miano, R. Mauriello, A. Croce, N. Vandesompele, J. Mestdagh, P. Finazzi-Agro, E. Levine, A. J. Melino, G. Bernardini, S. Candi, E. DNA methylation silences miR-132 in prostate cancer. Oncogene, 32:127-134, . (PMID: 22310291)

Zhang, C. Liu, J. Liang, Y. Wu, R. Zhao, Y. Hong, X. Lin, M. Yu, H. Liu, L. Levine, A. J. Hu, W. Feng, Z. Tumour-associated mutant p53 drives the Warburg effect. Nat Commun, 4:2935, . (PMID: 24343302, PMCID: PMC3969270)

Levine, A. J. Greenbaum, B. The maintenance of epigenetic states by p53: the guardian of the epigenome. Oncotarget, 3:1503-1504, . (PMID: 23237909, PMCID: PMC3681489)

Kobayashi, S. Yamada-Okabe, H. Suzuki, M. Natori, O. Kato, A. Matsubara, K. Jau Chen, Y. Yamazaki, M. Funahashi, S. Yoshida, K. Hashimoto, E. Watanabe, Y. Mutoh, H. Ashihara, M. Kato, C. Watanabe, T. Yoshikubo, T. Tamaoki, N. Ochiya, T. Kuroda, M. Levine, A. J. Yamazaki, T. LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution. Stem Cells, 30:2631-2644, . (PMID: 23081779)

Yi, L. Lu, C. Hu, W. Sun, Y. Levine, A. J. Multiple Roles of p53-Related Pathways in Somatic Cell Reprogramming and Stem Cell Differentiation. Cancer Res, 72:5635-5645, . (PMID: 22964580)

Levine, A. J. Harris, C. R. Puzio-Kuter, A. M. The Interfaces Between Signal Transduction Pathways: IGF-1/mTor, p53 and the Parkinson Disease Pathway. Oncotarget, 3:1301-1307, . (PMID: 23211569, PMCID: PMC3717794)

Weisbart, R. H. Gera, J. F. Chan, G. Hansen, J. E. Li, E. Cloninger, C. Levine, A. J. Nishimura, R. N. A cell-penetrating bispecific antibody for therapeutic regulation of intracellular targets. Mol Cancer Ther, 11:2169-2173, . (PMID: 22863609)

Tucci, P. Agostini, M. Grespi, F. Markert, E. K. Terrinoni, A. Vousden, K. H. Muller, P. A. Dotsch, V. Kehrloesser, S. Sayan, B. S. Giaccone, G. Lowe, S. W. Takahashi, N. Vandenabeele, P. Knight, R. A. Levine, A. J. Melino, G. Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A, 109:15312-15317, . (PMID: 22949650, PMCID: PMC3458363)

Tang, L. H. Contractor, T. Clausen, R. Klimstra, D. S. Du, Y. C. Allen, P. J. Brennan, M. F. Levine, A. J. Harris, C. R. Attenuation of the Retinoblastoma Pathway in Pancreatic Neuroendocrine Tumors Due to Increased Cdk4/Cdk6. Clin Cancer Res, In process, . (PMID: 22761470)

Yu, X. Vazquez, A. Levine, A. J. Carpizo, D. R. Allele-specific p53 mutant reactivation. Cancer Cell, 21:614-625, . (PMID: 22624712, PMCID: PMC3366694)

Feng, Z. Liu, L. Zhang, C. Zheng, T. Wang, J. Lin, M. Zhao, Y. Wang, X. Levine, A. J. Hu, W. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci U S A, 109:7013-7018, . (PMID: 22509031, PMCID: PMC3345015)

Hu, W. Feng, Z. Levine, A. J. The Regulation of Multiple p53 Stress Responses is Mediated through MDM2. Genes Cancer, 3:199-208, . (PMID: 23150753, PMCID: PMC3494373)

Greenbaum, B. D. Li, O. T. Poon, L. L. Levine, A. J. Rabadan, R. Viral reassortment as an information exchange between viral segments. Proc Natl Acad Sci U S A, 109:3341-3346, . (PMID: 22331898, PMCID: PMC3295259)

Freed-Pastor, W. A. Mizuno, H. Zhao, X. Langerod, A. Moon, S. H. Rodriguez-Barrueco, R. Barsotti, A. Chicas, A. Li, W. Polotskaia, A. Bissell, M. J. Osborne, T. F. Tian, B. Lowe, S. W. Silva, J. M. Borresen-Dale, A. L. Levine, A. J. Bargonetti, J. Prives, C. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell, 148:244-258, . (PMID: 22265415, PMCID: PMC3511889)

Levine, A. J. The evolution of the p53 family of genes. Cell Cycle, 11:214-215, . (PMID: 22214668)

Bilal, E. Vassallo, K. Toppmeyer, D. Barnard, N. Rye, I. H. Almendro, V. Russnes, H. Borresen-Dale, A. L. Levine, A. J. Bhanot, G. Ganesan, S. Amplified Loci on Chromosomes 8 and 17 Predict Early Relapse in ER-Positive Breast Cancers. PLoS One, 7:e38575, . (PMID: 22719901, PMCID: PMC3374812)

Wagh, K. Bhatia, A. Alexe, G. Reddy, A. Ravikumar, V. Seiler, M. Boemo, M. Yao, M. Cronk, L. Naqvi, A. Ganesan, S. Levine, A. J. Bhanot, G. Lactase persistence and lipid pathway selection in the maasai. PLoS One, 7:e44751, . (PMID: 23028602, PMCID: PMC3461017)

Wong, C. Vosburgh, E. Levine, A. J. Cong, L. Xu, E. Y. Human neuroendocrine tumor cell lines as a three-dimensional model for the study of human neuroendocrine tumor therapy. J Vis Exp, :e4218, . (PMID: 22929519, PMCID: PMC3486771)

Markert, E. K. Levine, A. J. Vazquez, A. Proliferation and tissue remodeling in cancer: the hallmarks revisited. Cell Death Dis, 3:e397, . (PMID: 23034332, PMCID: PMC3481128)

Markert, E. K. Mizuno, H. Vazquez, A. Levine, A. J. Molecular classification of prostate cancer using curated expression signatures. Proc Natl Acad Sci U S A, 108:21276-21281, . (PMID: 22123976, PMCID: PMC3248553)

Zhang, C. Lin, M. Wu, R. Wang, X. Yang, B. Levine, A. J. Hu, W. Feng, Z. Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc Natl Acad Sci U S A, 108:16259-16264, . (PMID: 21930938, PMCID: PMC3182683)

Feng, Z. Zhang, C. Kang, H. J. Sun, Y. Wang, H. Naqvi, A. Frank, A. K. Rosenwaks, Z. Murphy, M. E. Levine, A. J. Hu, W. Regulation of female reproduction by p53 and its family members. FASEB J, 25:2245-2255, . (PMID: 21402718, PMCID: PMC3114525)

Vazquez, A. Kulkarni, D. Grochola, L. F. Bond, G. L. Barnard, N. Toppmeyer, D. Levine, A. J. Hirshfield, K. M. A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence. Int J Cancer, 128:2335-2343, . (PMID: 20669227)

Mehta, M. S. Vazquez, A. Kulkarni, D. A. Kerrigan, J. E. Atwal, G. Metsugi, S. Toppmeyer, D. L. Levine, A. J. Hirshfield, K. M. Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes. Breast Cancer Res Treat, 125:861-868, . (PMID: 20658316)