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Suzie Chen, PhD

Publications since 2011

Boregowda, R. K. Medina, D. J. Markert, E. Bryan, M. A. Chen, W. Chen, S. Rabkin, A. Vido, M. J. Gunderson, S. I. Chekmareva, M. Foran, D. J. Lasfar, A. Goydos, J. S. Cohen-Solal, K. A. The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma. Oncotarget, In process, . (PMID: 27102439)

Yu, L. J. Wall, B. A. Wangari-Talbot, J. Chen, S. Metabotropic glutamate receptors in cancer. Neuropharmacology, In process, . (PMID: 26896755)

Isola, A. L. Chen, S. Exosomes: The Link between GPCR Activation and Metastatic Potential? Front Genet, 7:56, . (PMID: 27092178, PMCID: PMC4824768)

Botelho, D. J. Leo, B. F. Massa, C. B. Sarkar, S. Tetley, T. D. Chung, K. F. Chen, S. Ryan, M. P. Porter, A. E. Zhang, J. Schwander, S. K. Gow, A. J. Low-dose AgNPs reduce lung mechanical function and innate immune defense in the absence of cellular toxicity. Nanotoxicology, In process, . (PMID: 26152688)

Mairhofer, D. G. Ortner, D. Tripp, C. H. Schaffenrath, S. Fleming, V. Heger, L. Komenda, K. Reider, D. Dudziak, D. Chen, S. Becker, J. C. Flacher, V. Stoitzner, P. Impaired gp100-Specific CD8 T Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma Model. J Invest Dermatol, In process, . (PMID: 26121214)

Yu, L. J. Wall, B. A. Chen, S. The current management of brain metastasis in melanoma: a focus on riluzole. Expert Rev Neurother, In process, . (PMID: 26092602)

Teh, J. L. Shah, R. La Cava, S. Dolfi, S. C. Mehta, M. S. Kongara, S. Price, S. Ganesan, S. Reuhl, K. R. Hirshfield, K. M. Karantza, V. Chen, S. Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells. Breast Cancer Res Treat, In process, . (PMID: 25859923)

Rosenberg, S. A. Niglio, S. A. Salehomoum, N. Chan, J. L. Jeong, B. S. Wen, Y. Li, J. Fukui, J. Chen, S. Shin, S. S. Goydos, J. S. Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression. Transl Oncol, 8:1-9, . (PMID: 25749171, PMCID: PMC4350641)

Huang, H. Chen, S. Van Doren, J. Li, D. Farichon, C. He, Y. Zhang, Q. Zhang, K. Conney, A. H. Goodin, S. Du, Z. Zheng, X. alpha-tomatine inhibits growth and induces apoptosis in HL-60 human myeloid leukemia cells. Mol Med Rep, In process, . (PMID: 25625536)

Savla, R. Garbuzenko, O. B. Chen, S. Rodriguez-Rodriguez, L. Minko, T. Tumor-Targeted Responsive Nanoparticle-Based Systems for Magnetic Resonance Imaging and Therapy. Pharm Res, 31:3487-3502, . (PMID: 24919932, PMCID: PMC4224753)

Wall, B. A. Yu, L. J. Khan, A. Haffty, B. Goydos, J. S. Chen, S. Riluzole is a Radio-Sensitizing Agent in an in vivo Model of Brain Metastasis Derived from GRM1 Expressing Human Melanoma Cells. Pigment Cell Melanoma Res, In process, . (PMID: 25363352)

Teh, J. L. Shah, R. Shin, S. S. Wen, Y. Mehnert, J. M. Goydos, J. Chen, S. Metabotropic glutamate receptor 1 (mGluR1) mediates melanocyte transformation via transactivation of IGF-1 Receptor. Pigment Cell Melanoma Res, 27:621-629, . (PMID: 24628914, PMCID: PMC4061214)

Baljinnyam, E. Umemura, M. Chuang, C. De Lorenzo, M. S. Iwatsubo, M. Chen, S. Goydos, J. S. Ishikawa, Y. Whitelock, J. M. Iwatsubo, K. Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling. Pigment Cell Melanoma Res, 27:611-620, . (PMID: 24725364)

Wen, Y. Y. Li, J. Koo, J. Shin, S. S. Lin, Y. Jeong, B. S. Mehnert, J. M. Chen, S. Cohen-Solal, K. Goydos, J. S. Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression. Cancer Res, 74:2499-2509, . (PMID: 24491800, PMCID: PMC4008638)

Voisin, B. Mairhofer, D. G. Chen, S. Stoitzner, P. Mueller, C. G. Flacher, V. Anatomical distribution analysis reveals lack of Langerin+ dermal dendritic cells in footpads and tail of C57BL/6 mice. Exp Dermatol, 23:354-356, . (PMID: 24629018)

Wall, B. A. Wangari-Talbot, J. Shin, S. S. Schiff, D. Sierra, J. Yu, L. J. Khan, A. Haffty, B. Goydos, J. S. Chen, S. Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells. Pigment Cell Melanoma Res, 27:263-274, . (PMID: 24330389, PMCID: PMC3947419)

Umemura, M. Baljinnyam, E. Feske, S. De Lorenzo, M. S. Xie, L. H. Feng, X. Oda, K. Makino, A. Fujita, T. Yokoyama, U. Iwatsubo, M. Chen, S. Goydos, J. S. Ishikawa, Y. Iwatsubo, K. Store-Operated Ca(2) (+) Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration. PLoS One, 9:e89292, . (PMID: 24586666, PMCID: PMC3931742)

Martino, J. J. Wall, B. A. Mastrantoni, E. Wilimczyk, B. J. La Cava, S. N. Degenhardt, K. White, E. Chen, S. Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. Oncogene, 32:4366-4376, . (PMID: 23085756)

Cui, M. Naczynski, D. J. Zevon, M. Griffith, C. K. Sheihet, L. Poventud-Fuentes, I. Chen, S. Roth, C. M. Moghe, P. V. Multifunctional Albumin Nanoparticles As Combination Drug Carriers for Intra-Tumoral Chemotherapy. Adv Healthc Mater, 2:1236-1245, . (PMID: 23495216)

Goraczniak, R. Wall, B. A. Behlke, M. A. Lennox, K. A. Ho, E. S. Zaphiros, N. H. Jakubowski, C. Patel, N. R. Zhao, S. Magaway, C. Subbie, S. A. Jenny Yu, L. Lacava, S. Reuhl, K. R. Chen, S. Gunderson, S. I. U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo. Mol Ther Nucleic Acids, 2:e92, . (PMID: 23673539)

Mehta, M. S. Dolfi, S. C. Bronfenbrener, R. Bilal, E. Chen, C. Moore, D. Lin, Y. Rahim, H. Aisner, S. Kersellius, R. D. Teh, J. Chen, S. Toppmeyer, D. L. Medina, D. J. Ganesan, S. Vazquez, A. Hirshfield, K. M. Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes. PLoS One, 8:e69851, . (PMID: 23922822, PMCID: PMC3724883)

Naczynski, D. J. Tan, M. C. Zevon, M. Wall, B. Kohl, J. Kulesa, A. Chen, S. Roth, C. M. Riman, R. E. Moghe, P. V. Rare-earth-doped biological composites as in vivo shortwave infrared reporters. Nat Commun, 4:2199, . (PMID: 23873342, PMCID: PMC3736359)

Diab, A. Jenq, R. R. Rizzuto, G. A. Cohen, A. D. Huggins, D. W. Merghoub, T. Engelhorn, M. E. Guevara-Patino, J. A. Suh, D. Hubbard-Lucey, V. M. Kochman, A. A. Chen, S. Zhong, H. Wolchok, J. D. van den Brink, M. R. Houghton, A. N. Perales, M. A. Enhanced responses to tumor immunization following total body irradiation are time-dependent. PLoS One, 8:e82496, . (PMID: 24349298, PMCID: PMC3861406)

Alb, M. Sie, C. Adam, C. Chen, S. Becker, J. C. Schrama, D. Cellular and cytokine-dependent immunosuppressive mechanisms of grm1-transgenic murine melanoma. Cancer Immunol Immunother, 61:2239-2249, . (PMID: 22674057)

Wangari-Talbot, J. Wall, B. A. Goydos, J. S. Chen, S. Functional Effects of GRM1 Suppression in Human Melanoma Cells. Mol Cancer Res, 10:1440-1450, . (PMID: 22798429, PMCID: PMC3501593)

Schiffner, S. Chen, S. Becker, J. C. Bosserhoff, A. K. Highly pigmented Tg(Grm1) mouse melanoma develops non-pigmented melanoma cells in distant metastases. Exp Dermatol, 21:786-788, . (PMID: 22882420)

McDonnell, M. E. Vera, M. D. Blass, B. E. Pelletier, J. C. King, R. C. Fernandez-Metzler, C. Smith, G. R. Wrobel, J. Chen, S. Wall, B. A. Reitz, A. B. Riluzole prodrugs for melanoma and ALS: design, synthesis, and in vitro metabolic profiling. Bioorg Med Chem, 20:5642-5648, . (PMID: 22892214, PMCID: PMC3495316)

Lee, H. J. Wall, B. A. Wangari-Talbot, J. Chen, S. Regulation of mGluR1 expression in human melanocytes and melanoma cells. Biochim Biophys Acta, In process, . (PMID: 22771868, PMCID: PMC3495084)

Teh, J. L. Chen, S. Glutamatergic signaling in cellular transformation. Pigment Cell Melanoma Res, 25:331-342, . (PMID: 22273393)

Teh, J. Chen, S. mGlu Receptors and Cancerous Growth. Wiley Interdiscip Rev Membr Transp Signal, 1:211-220, . (PMID: 22662310, PMCID: PMC3364532)

Wangari-Talbot, J. Chen, S. Genetics of melanoma. Front Genet, 3:330, . (PMID: 23372575, PMCID: PMC3555440)

Wangari-Talbot, J. Chen, S. Glutamate receptors: emerging players in melanomagenesis. Pigment Cell Melanoma Res, 24:1082-1083, . (PMID: 22216442)

Lee, H. J. Wall, B. A. Wangari-Talbot, J. Shin, S. S. Rosenberg, S. Chan, J. L. Namkoong, J. Goydos, J. S. Chen, S. Glutamatergic pathway targeting in melanoma: single-agent and combinatorial therapies. Clin Cancer Res, 17:7080-7092, . (PMID: 21844014, PMCID: PMC3218300)

Baljinnyam, E. Umemura, M. De Lorenzo, M. S. Iwatsubo, M. Chen, S. Goydos, J. S. Iwatsubo, K. Epac1 Promotes Melanoma Metastasis via Modification of Heparan Sulfate. Pigment Cell Melanoma Res, 24:680-687, . (PMID: 21539721)

Khan, A. J. Wall, B. Ahlawat, S. Green, C. Schiff, D. Mehnert, J. M. Goydos, J. S. Chen, S. Haffty, B. G. Riluzole Enhances Ionizing Radiation-Induced Cytotoxicity in Human Melanoma Cells that Ectopically Express Metabotropic Glutamate Receptor 1 In Vitro and In Vivo. Clin Cancer Res, 17:1807-1814, . (PMID: 21325066, PMCID: PMC3070864)

Baljinnyam, E. Umemura, M. De Lorenzo, M. S. Xie, L. H. Nowycky, M. Iwatsubo, M. Chen, S. Goydos, J. S. Iwatsubo, K. Gbetagamma subunits inhibit Epac-induced melanoma cell migration. BMC Cancer, 11:256, . (PMID: 21679469, PMCID: PMC3141774)