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Suzie Chen, PhD

Publications since 2011

Teh, J. L. Shah, R. Shin, S. S. Wen, Y. Mehnert, J. M. Goydos, J. Chen, S. Metabotropic glutamate receptor 1 (mGluR1) mediates melanocyte transformation via transactivation of IGF-1 Receptor. Pigment Cell Melanoma Res, 27:621-629, . (PMID: 24628914, PMCID: PMC4061214)

Baljinnyam, E. Umemura, M. Chuang, C. De Lorenzo, M. S. Iwatsubo, M. Chen, S. Goydos, J. S. Ishikawa, Y. Whitelock, J. M. Iwatsubo, K. Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling. Pigment Cell Melanoma Res, 27:611-620, . (PMID: 24725364)

Savla, R. Garbuzenko, O. B. Chen, S. Rodriguez-Rodriguez, L. Minko, T. Tumor-Targeted Responsive Nanoparticle-Based Systems for Magnetic Resonance Imaging and Therapy. Pharm Res, In process, . (PMID: 24919932)

Wen, Y. Y. Li, J. Koo, J. Shin, S. S. Lin, Y. Jeong, B. S. Mehnert, J. M. Chen, S. Cohen-Solal, K. Goydos, J. S. Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression. Cancer Res, 74:2499-2509, . (PMID: 24491800, PMCID: PMC4008638)

Wall, B. A. Wangari-Talbot, J. Shin, S. S. Schiff, D. Sierra, J. Yu, L. J. Khan, A. Haffty, B. Goydos, J. S. Chen, S. Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells. Pigment Cell Melanoma Res, 27:263-274, . (PMID: 24330389, PMCID: PMC3947419)

Umemura, M. Baljinnyam, E. Feske, S. De Lorenzo, M. S. Xie, L. H. Feng, X. Oda, K. Makino, A. Fujita, T. Yokoyama, U. Iwatsubo, M. Chen, S. Goydos, J. S. Ishikawa, Y. Iwatsubo, K. Store-Operated Ca(2) (+) Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration. PLoS One, 9:e89292, . (PMID: 24586666, PMCID: PMC3931742)

Martino, J. J. Wall, B. A. Mastrantoni, E. Wilimczyk, B. J. La Cava, S. N. Degenhardt, K. White, E. Chen, S. Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. Oncogene, 32:4366-4376, . (PMID: 23085756)

Cui, M. Naczynski, D. J. Zevon, M. Griffith, C. K. Sheihet, L. Poventud-Fuentes, I. Chen, S. Roth, C. M. Moghe, P. V. Multifunctional Albumin Nanoparticles As Combination Drug Carriers for Intra-Tumoral Chemotherapy. Adv Healthc Mater, 2:1236-1245, . (PMID: 23495216)

Goraczniak, R. Wall, B. A. Behlke, M. A. Lennox, K. A. Ho, E. S. Zaphiros, N. H. Jakubowski, C. Patel, N. R. Zhao, S. Magaway, C. Subbie, S. A. Jenny Yu, L. Lacava, S. Reuhl, K. R. Chen, S. Gunderson, S. I. U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo. Mol Ther Nucleic Acids, 2:e92, . (PMID: 23673539)

Mehta, M. S. Dolfi, S. C. Bronfenbrener, R. Bilal, E. Chen, C. Moore, D. Lin, Y. Rahim, H. Aisner, S. Kersellius, R. D. Teh, J. Chen, S. Toppmeyer, D. L. Medina, D. J. Ganesan, S. Vazquez, A. Hirshfield, K. M. Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes. PLoS One, 8:e69851, . (PMID: 23922822, PMCID: PMC3724883)

Diab, A. Jenq, R. R. Rizzuto, G. A. Cohen, A. D. Huggins, D. W. Merghoub, T. Engelhorn, M. E. Guevara-Patino, J. A. Suh, D. Hubbard-Lucey, V. M. Kochman, A. A. Chen, S. Zhong, H. Wolchok, J. D. van den Brink, M. R. Houghton, A. N. Perales, M. A. Enhanced responses to tumor immunization following total body irradiation are time-dependent. PLoS One, 8:e82496, . (PMID: 24349298, PMCID: PMC3861406)

Alb, M. Sie, C. Adam, C. Chen, S. Becker, J. C. Schrama, D. Cellular and cytokine-dependent immunosuppressive mechanisms of grm1-transgenic murine melanoma. Cancer Immunol Immunother, 61:2239-2249, . (PMID: 22674057)

Wangari-Talbot, J. Wall, B. A. Goydos, J. S. Chen, S. Functional Effects of GRM1 Suppression in Human Melanoma Cells. Mol Cancer Res, 10:1440-1450, . (PMID: 22798429, PMCID: PMC3501593)

Schiffner, S. Chen, S. Becker, J. C. Bosserhoff, A. K. Highly pigmented Tg(Grm1) mouse melanoma develops non-pigmented melanoma cells in distant metastases. Exp Dermatol, 21:786-788, . (PMID: 22882420)

McDonnell, M. E. Vera, M. D. Blass, B. E. Pelletier, J. C. King, R. C. Fernandez-Metzler, C. Smith, G. R. Wrobel, J. Chen, S. Wall, B. A. Reitz, A. B. Riluzole prodrugs for melanoma and ALS: design, synthesis, and in vitro metabolic profiling. Bioorg Med Chem, 20:5642-5648, . (PMID: 22892214, PMCID: PMC3495316)

Lee, H. J. Wall, B. A. Wangari-Talbot, J. Chen, S. Regulation of mGluR1 expression in human melanocytes and melanoma cells. Biochim Biophys Acta, In process, . (PMID: 22771868, PMCID: PMC3495084)

Teh, J. L. Chen, S. Glutamatergic signaling in cellular transformation. Pigment Cell Melanoma Res, 25:331-342, . (PMID: 22273393)

Teh, J. Chen, S. mGlu Receptors and Cancerous Growth. Wiley Interdiscip Rev Membr Transp Signal, 1:211-220, . (PMID: 22662310, PMCID: PMC3364532)

Wangari-Talbot, J. Chen, S. Genetics of melanoma. Front Genet, 3:330, . (PMID: 23372575, PMCID: PMC3555440)

Lee, H. J. Wall, B. A. Wangari-Talbot, J. Shin, S. S. Rosenberg, S. Chan, J. L. Namkoong, J. Goydos, J. S. Chen, S. Glutamatergic pathway targeting in melanoma: single-agent and combinatorial therapies. Clin Cancer Res, 17:7080-7092, . (PMID: 21844014, PMCID: PMC3218300)

Baljinnyam, E. Umemura, M. De Lorenzo, M. S. Iwatsubo, M. Chen, S. Goydos, J. S. Iwatsubo, K. Epac1 Promotes Melanoma Metastasis via Modification of Heparan Sulfate. Pigment Cell Melanoma Res, 24:680-687, . (PMID: 21539721)

Khan, A. J. Wall, B. Ahlawat, S. Green, C. Schiff, D. Mehnert, J. M. Goydos, J. S. Chen, S. Haffty, B. G. Riluzole Enhances Ionizing Radiation-Induced Cytotoxicity in Human Melanoma Cells that Ectopically Express Metabotropic Glutamate Receptor 1 In Vitro and In Vivo. Clin Cancer Res, 17:1807-1814, . (PMID: 21325066, PMCID: PMC3070864)

Baljinnyam, E. Umemura, M. De Lorenzo, M. S. Xie, L. H. Nowycky, M. Iwatsubo, M. Chen, S. Goydos, J. S. Iwatsubo, K. Gbetagamma subunits inhibit Epac-induced melanoma cell migration. BMC Cancer, 11:256, . (PMID: 21679469, PMCID: PMC3141774)