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Kenneth D. Irvine, PhD

Publications since 2011

Park, G. S. Oh, H. Kim, M. Kim, T. Johnson, R. L. Irvine, K. D. Lim, D. S. An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2. Oncotarget, In process, . (PMID: 27006470)

Mao, Y. Kuta, A. Crespo-Enriquez, I. Whiting, D. Martin, T. Mulvaney, J. Irvine, K. D. Francis-West, P. Dchs1-Fat4 regulation of polarized cell behaviours during skeletal morphogenesis. Nat Commun, 7:11469, . (PMID: 27145737)

Ambegaonkar, A. A. Irvine, K. D. Coordination of planar cell polarity pathways through Spiny legs. Elife, In process, . (PMID: 26505959)

Durst, R. Sauls, K. Peal, D. S. deVlaming, A. Toomer, K. Leyne, M. Salani, M. Talkowski, M. E. Brand, H. Perrocheau, M. Simpson, C. Jett, C. Stone, M. R. Charles, F. Chiang, C. Lynch, S. N. Bouatia-Naji, N. Delling, F. N. Freed, L. A. Tribouilloy, C. Le Tourneau, T. LeMarec, H. Fernandez-Friera, L. Solis, J. Trujillano, D. Ossowski, S. Estivill, X. Dina, C. Bruneval, P. Chester, A. Schott, J. J. Irvine, K. D. Mao, Y. Wessels, A. Motiwala, T. Puceat, M. Tsukasaki, Y. Menick, D. R. Kasiganesan, H. Nie, X. Broome, A. M. Williams, K. Johnson, A. Markwald, R. R. Jeunemaitre, X. Hagege, A. Levine, R. A. Milan, D. J. Norris, R. A. Slaugenhaupt, S. A. Mutations in DCHS1 cause mitral valve prolapse. Nature, In process, . (PMID: 26258302)

Mao, Y. Francis-West, P. Irvine, K. D. A Fat4-Dchs1 signal between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching. Development, In process, . (PMID: 26116666)

Irvine, K. D. Harvey, K. F. Control of Organ Growth by Patterning and Hippo Signaling in Drosophila. Cold Spring Harb Perspect Biol, 7:, . (PMID: 26032720)

Sun, S. Reddy, B. V. Irvine, K. D. Localization of Hippo signalling complexes and Warts activation in vivo. Nat Commun, 6:8402, . (PMID: 26420589)

Codelia, V. A. Sun, G. Irvine, K. D. Regulation of YAP by Mechanical Strain through Jnk and Hippo Signaling. Curr Biol, 24:2012-2017, . (PMID: 25127217, PMCID: PMC4160395)

Oh, H. Slattery, M. Ma, L. White, K. P. Mann, R. S. Irvine, K. D. Yorkie Promotes Transcription by Recruiting a Histone Methyltransferase Complex. Cell Rep, 8:449-459, . (PMID: 25017066, PMCID: PMC4152371)

Zakaria, S. Mao, Y. Kuta, A. Ferreira de Sousa, C. Gaufo, G. O. McNeill, H. Hindges, R. Guthrie, S. Irvine, K. D. Francis-West, P. H. Regulation of Neuronal Migration by Dchs1-Fat4 Planar Cell Polarity. Curr Biol, 24:1620-1627, . (PMID: 24998526, PMCID: PMC4193925)

Rauskolb, C. Sun, S. Sun, G. Pan, Y. Irvine, K. D. Cytoskeletal Tension Inhibits Hippo Signaling through an Ajuba-Warts Complex. Cell, 158:143-156, . (PMID: 24995985, PMCID: PMC4082802)

Sun, G. Irvine, K. D. Control of growth during regeneration. Curr Top Dev Biol, 108:95-120, . (PMID: 24512707)

Xu, A. Irvine, K. D. Notch-ligand binding assays in Drosophila cells. Methods Mol Biol, 1187:277-284, . (PMID: 25053497)

Mani, M. Goyal, S. Irvine, K. D. Shraiman, B. I. Collective polarization model for gradient sensing via Dachsous-Fat intercellular signaling. Proc Natl Acad Sci U S A, 110:20420-20425, . (PMID: 24282293, PMCID: PMC3870718)

Sun, G. Irvine, K. D. Ajuba Family Proteins Link JNK to Hippo Signaling. Sci Signal, 6:ra81, . (PMID: 24023255, PMCID: PMC3830546)

Reddy, B. V. Irvine, K. D. Regulation of Hippo Signaling by EGFR-MAPK Signaling through Ajuba Family Proteins. Dev Cell, 24:459-471, . (PMID: 23484853, PMCID: PMC3624988)

Oh, H. Slattery, M. Ma, L. Crofts, A. White, K. P. Mann, R. S. Irvine, K. D. Genome-wide association of Yorkie with chromatin and chromatin-remodeling complexes. Cell Rep, 3:309-318, . (PMID: 23395637, PMCID: PMC3633442)

Pan, G. Feng, Y. Ambegaonkar, A. A. Sun, G. Huff, M. Rauskolb, C. Irvine, K. D. Signal transduction by the Fat cytoplasmic domain. Development, 140:831-842, . (PMID: 23318637, PMCID: PMC3557778)

Irvine, K. D. Integration of intercellular signaling through the Hippo pathway. Semin Cell Dev Biol, 23:812-817, . (PMID: 22554983, PMCID: PMC3413921)

Codelia, V. A. Irvine, K. D. Hippo signaling goes long range. Cell, 150:669-670, . (PMID: 22901800)

Ambegaonkar, A. A. Pan, G. Mani, M. Feng, Y. Irvine, K. D. Propagation of dachsous-fat planar cell polarity. Curr Biol, 22:1302-1308, . (PMID: 22727698, PMCID: PMC3418676)

Ishikawa, H. O. Xu, A. Ogura, E. Manning, G. Irvine, K. D. The Raine Syndrome Protein FAM20C Is a Golgi Kinase That Phosphorylates Bio-Mineralization Proteins. PLoS One, 7:e42988, . (PMID: 22900076, PMCID: PMC3416761)

Staley, B. K. Irvine, K. D. Hippo signaling in Drosophila: recent advances and insights. Dev Dyn, 241:3-15, . (PMID: 22174083, PMCID: PMC3426292)

Singh, A. Irvine, K. D. Drosophila as a model for understanding development and disease. Dev Dyn, 241:1-2, . (PMID: 22174082)

Reddy, B. V. Irvine, K. D. Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling. Development, 138:5201-5212, . (PMID: 22069188, PMCID: PMC3210499)

Rauskolb, C. Pan, G. Reddy, B. V. Oh, H. Irvine, K. D. Zyxin links fat signaling to the hippo pathway. PLoS Biol, 9:e1000624, . (PMID: 21666802, PMCID: PMC3110180)

Mao, Y. Mulvaney, J. Zakaria, S. Yu, T. Morgan, K. M. Allen, S. Basson, M. A. Francis-West, P. Irvine, K. D. Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development, 138:947-957, . (PMID: 21303848, PMCID: PMC3035097)

Sun, G. Irvine, K. D. Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors. Dev Biol, 350:139-151, . (PMID: 21145886, PMCID: PMC3038240)

Oh, H. Irvine, K. D. Cooperative regulation of growth by Yorkie and Mad through bantam. Dev Cell, 20:109-122, . (PMID: 21238929, PMCID: PMC3033745)