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Eileen White, PhD

Publications since 2011

White, E. Mehnert, J. M. Chan, C. S. Autophagy, Metabolism, and Cancer. Clin Cancer Res, 21:5037-5046, . (PMID: 26567363, PMCID: PMC4646728)

Santaguida, S. Vasile, E. White, E. Amon, A. Aneuploidy-induced cellular stresses limit autophagic degradation. Genes Dev, In process, . (PMID: 26404941)

Strohecker, A. M. Joshi, S. Possemato, R. Abraham, R. T. Sabatini, D. M. White, E. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening. Oncogene, In process, . (PMID: 25772235)

Mehnert, J. M. Xie, X. Koh, J. Y. Price, S. White, E. Atg7 overcomes senescence and promotes growth of BRAFV600E-driven melanoma. Cancer Discov, In process, . (PMID: 25673642)

White, E. The role for autophagy in cancer. J Clin Invest, 125:42-46, . (PMID: 25654549, PMCID: PMC4382247)

Galluzzi, L. Bravo-San Pedro, J. M. Vitale, I. Aaronson, S. A. Abrams, J. M. Adam, D. Alnemri, E. S. Altucci, L. Andrews, D. Annicchiarico-Petruzzelli, M. Baehrecke, E. H. Bazan, N. G. Bertrand, M. J. Bianchi, K. Blagosklonny, M. V. Blomgren, K. Borner, C. Bredesen, D. E. Brenner, C. Campanella, M. Candi, E. Cecconi, F. Chan, F. K. Chandel, N. S. Cheng, E. H. Chipuk, J. E. Cidlowski, J. A. Ciechanover, A. Dawson, T. M. Dawson, V. L. De Laurenzi, V. De Maria, R. Debatin, K. M. Di Daniele, N. Dixit, V. M. Dynlacht, B. D. El-Deiry, W. S. Fimia, G. M. Flavell, R. A. Fulda, S. Garrido, C. Gougeon, M. L. Green, D. R. Gronemeyer, H. Hajnoczky, G. Hardwick, J. M. Hengartner, M. O. Ichijo, H. Joseph, B. Jost, P. J. Kaufmann, T. Kepp, O. Klionsky, D. J. Knight, R. A. Kumar, S. Lemasters, J. J. Levine, B. Linkermann, A. Lipton, S. A. Lockshin, R. A. Lopez-Otin, C. Lugli, E. Madeo, F. Malorni, W. Marine, J. C. Martin, S. J. Martinou, J. C. Medema, J. P. Meier, P. Melino, S. Mizushima, N. Moll, U. Munoz-Pinedo, C. Nunez, G. Oberst, A. Panaretakis, T. Penninger, J. M. Peter, M. E. Piacentini, M. Pinton, P. Prehn, J. H. Puthalakath, H. Rabinovich, G. A. Ravichandran, K. S. Rizzuto, R. Rodrigues, C. M. Rubinsztein, D. C. Rudel, T. Shi, Y. Simon, H. U. Stockwell, B. R. Szabadkai, G. Tait, S. W. Tang, H. L. Tavernarakis, N. Tsujimoto, Y. Vanden Berghe, T. Vandenabeele, P. Villunger, A. Wagner, E. F. Walczak, H. White, E. Wood, W. G. Yuan, J. Zakeri, Z. Zhivotovsky, B. Melino, G. Kroemer, G. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ, In process, . (PMID: 25236395)

Mathew, R. Khor, S. Hackett, S. R. Rabinowitz, J. D. Perlman, D. H. White, E. Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity. Mol Cell, 55:916-930, . (PMID: 25175026, PMCID: PMC4169768)

Karsli-Uzunbas, G. Guo, J. Y. Price, S. M. Teng, X. Laddha, S. V. Khor, S. Kalaany, N. Y. Jacks, T. Chan, C. S. Rabinowitz, J. D. White, E. Autophagy is Required for Glucose Homeostasis and Lung Tumor Maintenance. Cancer Discov, 4:914-927, . (PMID: 24875857, PMCID: PMC4125614)

Liu, Z. Chen, P. Gao, H. Gu, Y. Yang, J. Peng, H. Xu, X. Wang, H. Yang, M. Liu, X. Fan, L. Chen, S. Zhou, J. Sun, Y. Ruan, K. Cheng, S. Komatsu, M. White, E. Li, L. Ji, H. Finley, D. Hu, R. Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression. Cancer Cell, 26:106-120, . (PMID: 25026213, PMCID: PMC4166492)

Strohecker, A. M. White, E. Targeting Mitochondrial Metabolism by Inhibiting Autophagy in BRAF-Driven Cancers. Cancer Discov, 4:766-772, . (PMID: 24860158, PMCID: PMC4090279)

Laddha, S. V. Ganesan, S. Chan, C. S. White, E. Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers. Mol Cancer Res, 12:485-490, . (PMID: 24478461, PMCID: PMC3989371)

Strohecker, A. M. White, E. Autophagy promotes -driven lung tumorigenesis by preserving mitochondrial metabolism. Autophagy, 10:384-385, . (PMID: 24362353)

Andrianasolo, E. H. Haramaty, L. White, E. Lutz, R. Falkowski, P. Mode of Action of Diterpene and Characterization of Related Metabolites from the Soft Coral, Xenia elongata. Mar Drugs, 12:1102-1115, . (PMID: 24562393, PMCID: PMC3944532)

White, E. Q&A: targeting autophagy in cancer-a new therapeutic? Cancer Metab, 2:14, . (PMID: 25215185, PMCID: PMC4160717)

Michaud, M. Xie, X. Bravo-San Pedro, J. M. Zitvogel, L. White, E. Kroemer, G. An autophagy-dependent anticancer immune response determines the efficacy of melanoma chemotherapy. Oncoimmunology, 3:e944047, . (PMID: 25610726, PMCID: PMC4292732)

Guo, J. Y. Xia, B. White, E. Autophagy-mediated tumor promotion. Cell, 155:1216-1219, . (PMID: 24315093, PMCID: PMC3987898)

Strohecker, A. M. Guo, J. Y. Karsli-Uzunbas, G. Price, S. M. Chen, G. J. Mathew, R. McMahon, M. White, E. Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BRAFV600E-Driven Lung Tumors. Cancer Discov, 3:1272-1285, . (PMID: 23965987, PMCID: PMC3823822)

Guo, J. Y. White, E. Autophagy is required for mitochondrial function, lipid metabolism, growth and fate of KRAS (G12D) -driven lung tumors. Autophagy, 9:1636-1638, . (PMID: 23959381)

White, E. Exploiting the bad eating habits of Ras-driven cancers. Genes Dev, 27:2065-2071, . (PMID: 24115766, PMCID: PMC3850091)

Martino, J. J. Wall, B. A. Mastrantoni, E. Wilimczyk, B. J. La Cava, S. N. Degenhardt, K. White, E. Chen, S. Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. Oncogene, 32:4366-4376, . (PMID: 23085756)

Huo, Y. Cai, H. Teplova, I. Bowman-Colin, C. Chen, G. Price, S. Barnard, N. Ganesan, S. Karantza, V. White, E. Xia, B. Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2-Associated Hereditary Breast Cancer. Cancer Discov, 3:894-907, . (PMID: 23650262, PMCID: PMC3740014)

Guo, J. Y. Karsli-Uzunbas, G. Mathew, R. Aisner, S. C. Kamphorst, J. J. Strohecker, A. M. Chen, G. Price, S. Lu, W. Teng, X. Snyder, E. Santanam, U. Dipaola, R. S. Jacks, T. Rabinowitz, J. D. White, E. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev, 27:1447-1461, . (PMID: 23824538, PMCID: PMC3713426)

Lau, A. Zheng, Y. Tao, S. Wang, H. Whitman, S. A. White, E. Zhang, D. D. Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner. Mol Cell Biol, 33:2436-2446, . (PMID: 23589329, PMCID: PMC3700105)

Kamphorst, J. J. Cross, J. R. Fan, J. de Stanchina, E. Mathew, R. White, E. P. Thompson, C. B. Rabinowitz, J. D. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A, 110:8882-8887, . (PMID: 23671091, PMCID: PMC3670379)

Xie, X. White, E. P. Mehnert, J. M. Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma. PLoS One, 8:e55096, . (PMID: 23383069, PMCID: PMC3559441)

Fan, J. Kamphorst, J. J. Mathew, R. Chung, M. K. White, E. Shlomi, T. Rabinowitz, J. D. Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol, 9:712, . (PMID: 24301801, PMCID: PMC3882799)

Andrianasolo, E. H. Haramaty, L. Rosario-Passapera, R. Vetriani, C. Falkowski, P. White, E. Lutz, R. Ammonificins C and D, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans. Mar Drugs, 10:2300-2311, . (PMID: 23170085, PMCID: PMC3497024)

Saleem, A. Dvorzhinski, D. Santanam, U. Mathew, R. Bray, K. Stein, M. White, E. Dipaola, R. S. Effect of dual inhibition of apoptosis and autophagy in prostate cancer. Prostate, 72:1374-1381, . (PMID: 22241682)

White, E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer, 12:401-410, . (PMID: 22534666)

Bray, K. Mathew, R. Lau, A. Kamphorst, J. J. Fan, J. Chen, J. Chen, H. Y. Ghavami, A. Stein, M. Dipaola, R. S. Zhang, D. Rabinowitz, J. D. White, E. Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition. PLoS One, 7:e41831, . (PMID: 22848625, PMCID: PMC3406086)

Galluzzi, L. Vitale, I. Abrams, J. M. Alnemri, E. S. Baehrecke, E. H. Blagosklonny, M. V. Dawson, T. M. Dawson, V. L. El-Deiry, W. S. Fulda, S. Gottlieb, E. Green, D. R. Hengartner, M. O. Kepp, O. Knight, R. A. Kumar, S. Lipton, S. A. Lu, X. Madeo, F. Malorni, W. Mehlen, P. Nunez, G. Peter, M. E. Piacentini, M. Rubinsztein, D. C. Shi, Y. Simon, H. U. Vandenabeele, P. White, E. Yuan, J. Zhivotovsky, B. Melino, G. Kroemer, G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ, 19:107-120, . (PMID: 21760595, PMCID: PMC3252826)

Kamphorst, J. J. Fan, J. Lu, W. White, E. Rabinowitz, J. D. Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism. Anal Chem, 83:9114-9122, . (PMID: 22004349, PMCID: PMC3230881)

Lu, H. Huang, Y. Y. Mehrotra, S. Droz-Rosario, R. Liu, J. Bhaumik, M. White, E. Shen, Z. Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes. PLoS Genet, 7:e1002291, . (PMID: 21966279, PMCID: PMC3178617)

Mehnert, J. M. Tan, A. R. Moss, R. Poplin, E. Stein, M. N. Sovak, M. Levinson, K. Lin, H. Kane, M. Gounder, M. Lin, Y. Shih, W. J. White, E. Rubin, E. H. Karantza, V. Rationally designed treatment for solid tumors with MAPK pathway activation: a phase I study of paclitaxel and bortezomib using an adaptive dose-finding approach. Mol Cancer Ther, 10:1509-1519, . (PMID: 21680752, PMCID: PMC3155243)

Chen, H. Y. White, E. Role of autophagy in cancer prevention. Cancer Prev Res (Phila), 4:973-983, . (PMID: 21733821, PMCID: PMC3136921)

Andrianasolo, E. H. Haramaty, L. McPhail, K. L. White, E. Vetriani, C. Falkowski, P. Lutz, R. Bathymodiolamides A and B, Ceramide Derivatives from a Deep-Sea Hydrothermal Vent Invertebrate Mussel, Bathymodiolus thermophilus. J Nat Prod, 74:842-846, . (PMID: 21222464, PMCID: PMC3081957)

Guo, J. Y. Chen, H. Y. Mathew, R. Fan, J. Strohecker, A. M. Karsli-Uzunbas, G. Kamphorst, J. J. Chen, G. Lemons, J. M. Karantza, V. Coller, H. A. Dipaola, R. S. Gelinas, C. Rabinowitz, J. D. White, E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev, 25:460-470, . (PMID: 21317241, PMCID: PMC3049287)

Amaravadi, R. K. Lippincott-Schwartz, J. Yin, X. M. Weiss, W. A. Takebe, N. Timmer, W. DiPaola, R. S. Lotze, M. T. White, E. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res, 17:654-666, . (PMID: 21325294, PMCID: PMC3075808)

Mathew, R. White, E. Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night. Curr Opin Genet Dev, 21:113-119, . (PMID: 21255998, PMCID: PMC3039840)

Mathew, R. White, E. Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger. Cold Spring Harb Symp Quant Biol, 76:389-396, . (PMID: 22442109)