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Eileen White, PhD

Publications since 2011

Mathew, R. Khor, S. Hackett, S. R. Rabinowitz, J. D. Perlman, D. H. White, E. Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity. Mol Cell, In process, . (PMID: 25175026)

Karsli-Uzunbas, G. Guo, J. Y. Price, S. M. Teng, X. Laddha, S. V. Khor, S. Kalaany, N. Y. Jacks, T. Chan, C. S. Rabinowitz, J. D. White, E. Autophagy is Required for Glucose Homeostasis and Lung Tumor Maintenance. Cancer Discov, 4:914-927, . (PMID: 24875857, PMCID: PMC4125614)

Liu, Z. Chen, P. Gao, H. Gu, Y. Yang, J. Peng, H. Xu, X. Wang, H. Yang, M. Liu, X. Fan, L. Chen, S. Zhou, J. Sun, Y. Ruan, K. Cheng, S. Komatsu, M. White, E. Li, L. Ji, H. Finley, D. Hu, R. Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression. Cancer Cell, 26:106-120, . (PMID: 25026213)

Strohecker, A. M. White, E. Targeting Mitochondrial Metabolism by Inhibiting Autophagy in BRAF-Driven Cancers. Cancer Discov, 4:766-772, . (PMID: 24860158, PMCID: PMC4090279)

Laddha, S. V. Ganesan, S. Chan, C. S. White, E. Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers. Mol Cancer Res, 12:485-490, . (PMID: 24478461, PMCID: PMC3989371)

Strohecker, A. M. White, E. Autophagy promotes -driven lung tumorigenesis by preserving mitochondrial metabolism. Autophagy, 10:384-385, . (PMID: 24362353)

Andrianasolo, E. H. Haramaty, L. White, E. Lutz, R. Falkowski, P. Mode of Action of Diterpene and Characterization of Related Metabolites from the Soft Coral, Xenia elongata. Mar Drugs, 12:1102-1115, . (PMID: 24562393, PMCID: PMC3944532)

White, E. Q&A: targeting autophagy in cancer-a new therapeutic? Cancer Metab, 2:14, . (PMID: 25215185)

Guo, J. Y. Xia, B. White, E. Autophagy-mediated tumor promotion. Cell, 155:1216-1219, . (PMID: 24315093, PMCID: PMC3987898)

Strohecker, A. M. Guo, J. Y. Karsli-Uzunbas, G. Price, S. M. Chen, G. J. Mathew, R. McMahon, M. White, E. Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BRAFV600E-Driven Lung Tumors. Cancer Discov, 3:1272-1285, . (PMID: 23965987, PMCID: PMC3823822)

Guo, J. Y. White, E. Autophagy is required for mitochondrial function, lipid metabolism, growth and fate of KRAS (G12D) -driven lung tumors. Autophagy, 9:1636-1638, . (PMID: 23959381)

White, E. Exploiting the bad eating habits of Ras-driven cancers. Genes Dev, 27:2065-2071, . (PMID: 24115766, PMCID: PMC3850091)

Martino, J. J. Wall, B. A. Mastrantoni, E. Wilimczyk, B. J. La Cava, S. N. Degenhardt, K. White, E. Chen, S. Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. Oncogene, 32:4366-4376, . (PMID: 23085756)

Huo, Y. Cai, H. Teplova, I. Bowman-Colin, C. Chen, G. Price, S. Barnard, N. Ganesan, S. Karantza, V. White, E. Xia, B. Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2-Associated Hereditary Breast Cancer. Cancer Discov, 3:894-907, . (PMID: 23650262, PMCID: PMC3740014)

Guo, J. Y. Karsli-Uzunbas, G. Mathew, R. Aisner, S. C. Kamphorst, J. J. Strohecker, A. M. Chen, G. Price, S. Lu, W. Teng, X. Snyder, E. Santanam, U. Dipaola, R. S. Jacks, T. Rabinowitz, J. D. White, E. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev, 27:1447-1461, . (PMID: 23824538, PMCID: PMC3713426)

Lau, A. Zheng, Y. Tao, S. Wang, H. Whitman, S. A. White, E. Zhang, D. D. Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner. Mol Cell Biol, 33:2436-2446, . (PMID: 23589329, PMCID: PMC3700105)

Kamphorst, J. J. Cross, J. R. Fan, J. de Stanchina, E. Mathew, R. White, E. P. Thompson, C. B. Rabinowitz, J. D. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A, 110:8882-8887, . (PMID: 23671091, PMCID: PMC3670379)

Xie, X. White, E. P. Mehnert, J. M. Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma. PLoS One, 8:e55096, . (PMID: 23383069, PMCID: PMC3559441)

Fan, J. Kamphorst, J. J. Mathew, R. Chung, M. K. White, E. Shlomi, T. Rabinowitz, J. D. Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol, 9:712, . (PMID: 24301801, PMCID: PMC3882799)

Andrianasolo, E. H. Haramaty, L. Rosario-Passapera, R. Vetriani, C. Falkowski, P. White, E. Lutz, R. Ammonificins C and D, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans. Mar Drugs, 10:2300-2311, . (PMID: 23170085, PMCID: PMC3497024)

Saleem, A. Dvorzhinski, D. Santanam, U. Mathew, R. Bray, K. Stein, M. White, E. Dipaola, R. S. Effect of dual inhibition of apoptosis and autophagy in prostate cancer. Prostate, 72:1374-1381, . (PMID: 22241682)

White, E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer, 12:401-410, . (PMID: 22534666)

Bray, K. Mathew, R. Lau, A. Kamphorst, J. J. Fan, J. Chen, J. Chen, H. Y. Ghavami, A. Stein, M. Dipaola, R. S. Zhang, D. Rabinowitz, J. D. White, E. Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition. PLoS One, 7:e41831, . (PMID: 22848625, PMCID: PMC3406086)

Kamphorst, J. J. Fan, J. Lu, W. White, E. Rabinowitz, J. D. Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism. Anal Chem, 83:9114-9122, . (PMID: 22004349, PMCID: PMC3230881)

Lu, H. Huang, Y. Y. Mehrotra, S. Droz-Rosario, R. Liu, J. Bhaumik, M. White, E. Shen, Z. Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes. PLoS Genet, 7:e1002291, . (PMID: 21966279, PMCID: PMC3178617)

Mehnert, J. M. Tan, A. R. Moss, R. Poplin, E. Stein, M. N. Sovak, M. Levinson, K. Lin, H. Kane, M. Gounder, M. Lin, Y. Shih, W. J. White, E. Rubin, E. H. Karantza, V. Rationally designed treatment for solid tumors with MAPK pathway activation: a phase I study of paclitaxel and bortezomib using an adaptive dose-finding approach. Mol Cancer Ther, 10:1509-1519, . (PMID: 21680752, PMCID: PMC3155243)

Chen, H. Y. White, E. Role of autophagy in cancer prevention. Cancer Prev Res (Phila), 4:973-983, . (PMID: 21733821, PMCID: PMC3136921)

Andrianasolo, E. H. Haramaty, L. McPhail, K. L. White, E. Vetriani, C. Falkowski, P. Lutz, R. Bathymodiolamides A and B, Ceramide Derivatives from a Deep-Sea Hydrothermal Vent Invertebrate Mussel, Bathymodiolus thermophilus. J Nat Prod, 74:842-846, . (PMID: 21222464, PMCID: PMC3081957)

Guo, J. Y. Chen, H. Y. Mathew, R. Fan, J. Strohecker, A. M. Karsli-Uzunbas, G. Kamphorst, J. J. Chen, G. Lemons, J. M. Karantza, V. Coller, H. A. Dipaola, R. S. Gelinas, C. Rabinowitz, J. D. White, E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev, 25:460-470, . (PMID: 21317241, PMCID: PMC3049287)

Amaravadi, R. K. Lippincott-Schwartz, J. Yin, X. M. Weiss, W. A. Takebe, N. Timmer, W. DiPaola, R. S. Lotze, M. T. White, E. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res, 17:654-666, . (PMID: 21325294, PMCID: PMC3075808)

Mathew, R. White, E. Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night. Curr Opin Genet Dev, 21:113-119, . (PMID: 21255998, PMCID: PMC3039840)

Mathew, R. White, E. Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger. Cold Spring Harb Symp Quant Biol, 76:389-396, . (PMID: 22442109)