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Patrick J. Sinko, PhD, RPh

Publications since 2011

Rajan, S. S. Turovskiy, Y. Singh, Y. Chikindas, M. L. Sinko, P. J. Poly(ethylene glycol) (PEG)-lactic acid nanocarrier-based degradable hydrogels for restoring the vaginal microenvironment. J Control Release, In process, . (PMID: 25223229)

Chen, P. Zhang, X. Jia, L. Prud'homme, R. K. Szekely, Z. Sinko, P. J. Optimal structural design of mannosylated nanocarriers for macrophage targeting. J Control Release, In process, . (PMID: 25220160)

Chang, Y. C. Wang, J. D. Hahn, R. A. Gordon, M. K. Joseph, L. B. Heck, D. E. Heindel, N. D. Young, S. C. Sinko, P. J. Casillas, R. P. Laskin, J. D. Laskin, D. L. Gerecke, D. R. Therapeutic Potential of a Non-Steroidal Bifunctional Anti-Inflammatory and Anti-Cholinergic Agent against Skin Injury Induced by Sulfur Mustard. Toxicol Appl Pharmacol, In process, . (PMID: 25127551)

Sundara Rajan, S. Cavera, V. L. Zhang, X. Singh, Y. Chikindas, M. L. Sinko, P. J. Poly(ethylene glycol) (PEG)-based hydrogels for the controlled release of the antimicrobial subtilosin, for prophylaxis of bacterial vaginosis. Antimicrob Agents Chemother, 58:2747-2753, . (PMID: 24566190, PMCID: PMC3993243)

Pinkerton, N. M. Zhang, S. W. Youngblood, R. L. Gao, D. Li, S. Benson, B. R. Anthony, J. Stone, H. A. Sinko, P. J. Prud'homme, R. K. Gelation chemistries for the encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery. Biomacromolecules, 15:252-261, . (PMID: 24410445, PMCID: PMC3981107)

Ibrahim, S. Gao, D. Sinko, P. J. Selective Cytotoxicity and Combined Effects of Camptothecin or Paclitaxel with Sodium-R-Alpha Lipoate on A549 Human Non-Small Cell Lung Cancer Cells. Nutr Cancer, 66:492-499, . (PMID: 24063429, PMCID: PMC3964140)

Liu, D. Zhang, X. Gao, J. Palombo, M. Gao, D. Chen, P. Sinko, P. J. Core Functional Sequence of C-terminal GAG-binding Domain Directs Cellular Uptake of IGFBP-3-derived Peptides. Protein Pept Lett, 21:124-131, . (PMID: 24059751, PMCID: PMC3941648)

Palombo, M. Deshmukh, M. Myers, D. Gao, J. Szekely, Z. Sinko, P. J. Pharmaceutical and toxicological properties of engineered nanomaterials for drug delivery. Annu Rev Pharmacol Toxicol, 54:581-598, . (PMID: 24160695)

Xie, J. Zhao, R. Gu, S. Dong, H. Wang, J. Lu, Y. Sinko, P. J. Yu, T. Xie, F. Wang, L. Shao, J. Jia, L. The Architecture and Biological Function of Dual Antibody-Coated Dendrimers: Enhanced Control of Circulating Tumor cells and Their Hetero-Adhesion to Endothelial Cells for Metastasis Prevention. Theranostics, 4:1250-1263, . (PMID: 25285173, PMCID: PMC4184002)

Zheng, R. Po, I. Mishin, V. Black, A. T. Heck, D. E. Laskin, D. L. Sinko, P. J. Gerecke, D. R. Gordon, M. K. Laskin, J. D. The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard. Toxicol Appl Pharmacol, 272:345-355, . (PMID: 23845594)

Gao, J. Chen, P. Singh, Y. Zhang, X. Szekely, Z. Stein, S. Sinko, P. J. Novel Monodisperse PEGtide Dendrons: Design, Fabrication, and Evaluation of Mannose Receptor-Mediated Macrophage Targeting. Bioconjug Chem, In process, . (PMID: 23808323)

D'Addio, S. M. Baldassano, S. Shi, L. Cheung, L. Adamson, D. H. Bruzek, M. Anthony, J. E. Laskin, D. L. Sinko, P. J. Prud'homme, R. K. Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric nanocarriers. J Control Release, 168:41-49, . (PMID: 23419950, PMCID: PMC3662248)

Torres, N. I. Noll, K. S. Xu, S. Li, J. Huang, Q. Sinko, P. J. Wachsman, M. B. Chikindas, M. L. Safety, formulation, and in vitro antiviral activity of the antimicrobial peptide subtilosin against herpes simplex virus type 1. Probiotics Antimicrob Proteins, 5:26-35, . (PMID: 23637711, PMCID: PMC3637976)

Kutscher, H. L. Gao, D. Li, S. Massa, C. B. Cervelli, J. Deshmukh, M. Joseph, L. B. Laskin, D. L. Sinko, P. J. Toxicodynamics of rigid polystyrene microparticles on pulmonary gas exchange in mice: Implications for microemboli-based drug delivery systems. Toxicol Appl Pharmacol, 266:214-223, . (PMID: 23142466, PMCID: PMC3586786)

Malaviya, R. Venosa, A. Hall, L. Gow, A. J. Sinko, P. J. Laskin, J. D. Laskin, D. L. Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor. Toxicol Appl Pharmacol, 265:279-291, . (PMID: 22981630, PMCID: PMC3516137)

Deshmukh, M. Kutscher, H. L. Gao, D. Sunil, V. R. Malaviya, R. Vayas, K. Stein, S. Laskin, J. D. Laskin, D. L. Sinko, P. J. Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates. J Control Release, 164:65-73, . (PMID: 23041417)

Wan, J. Shi, L. Benson, B. Bruzek, M. J. Anthony, J. E. Sinko, P. J. Prudhomme, R. K. Stone, H. A. Microfluidic generation of droplets with a high loading of nanoparticles. Langmuir, 28:13143-13148, . (PMID: 22934976)

Singh, Y. Gao, D. Gu, Z. Li, S. Rivera, K. A. Stein, S. Love, S. Sinko, P. J. Influence of molecular size on the retention of polymeric nanocarrier diagnostic agents in breast ducts. Pharm Res, 29:2377-2388, . (PMID: 22569800, PMCID: PMC3442773)

Noll, K. S. Prichard, M. N. Khaykin, A. Sinko, P. J. Chikindas, M. L. The natural antimicrobial peptide subtilosin acts synergistically with glycerol monolaurate, lauric arginate, and epsilon-poly-L-lysine against bacterial vaginosis-associated pathogens but not human lactobacilli. Antimicrob Agents Chemother, 56:1756-1761, . (PMID: 22252803, PMCID: PMC3318360)

Singh, Y. Gao, D. Gu, Z. Li, S. Stein, S. Sinko, P. J. Noninvasive detection of passively targeted poly(ethylene glycol) nanocarriers in tumors. Mol Pharm, 9:144-155, . (PMID: 22077582, PMCID: PMC3257802)

Turovskiy, Y. Cheryian, T. Algburi, A. Wirawan, R. E. Takhistov, P. Sinko, P. J. Chikindas, M. L. Susceptibility of Gardnerella vaginalis Biofilms to Natural Antimicrobials Subtilosin, epsilon-Poly-L-Lysine, and Lauramide Arginine Ethyl Ester. Infect Dis Obstet Gynecol, 2012:284762, . (PMID: 23024575, PMCID: PMC3457663)

Cai, C. Y. Zhang, X. Sinko, P. J. Burakoff, S. J. Jin, Y. J. Two Sorting Motifs, a Ubiquitination Motif and a Tyrosine Motif, Are Involved in HIV-1 and Simian Immunodeficiency Virus Nef-Mediated Receptor Endocytosis. J Immunol, 186:5807-5814, . (PMID: 21482738)

Noll, K. S. Sinko, P. J. Chikindas, M. L. Elucidation of the Molecular Mechanisms of Action of the Natural Antimicrobial Peptide Subtilosin Against the Bacterial Vaginosis-associated Pathogen Gardnerella vaginalis. Probiotics Antimicrob Proteins, 3:41-47, . (PMID: 21949544, PMCID: PMC3176456)