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Patrick J. Sinko, PhD, RPh

Publications since 2011

Chang, Y. C. Wang, J. D. Hahn, R. A. Gordon, M. K. Joseph, L. B. Heck, D. E. Heindel, N. D. Young, S. C. Sinko, P. J. Casillas, R. P. Laskin, J. D. Laskin, D. L. Gerecke, D. R. Therapeutic Potential of a Non-Steroidal Bifunctional Anti-Inflammatory and Anti-Cholinergic Agent against Skin Injury Induced by Sulfur Mustard. Toxicol Appl Pharmacol, In process, . (PMID: 25127551)

Sundara Rajan, S. Cavera, V. L. Zhang, X. Singh, Y. Chikindas, M. L. Sinko, P. J. Poly(ethylene glycol) (PEG)-based hydrogels for the controlled release of the antimicrobial subtilosin, for prophylaxis of bacterial vaginosis. Antimicrob Agents Chemother, 58:2747-2753, . (PMID: 24566190, PMCID: PMC3993243)

Pinkerton, N. M. Zhang, S. W. Youngblood, R. L. Gao, D. Li, S. Benson, B. R. Anthony, J. Stone, H. A. Sinko, P. J. Prud'homme, R. K. Gelation chemistries for the encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery. Biomacromolecules, 15:252-261, . (PMID: 24410445, PMCID: PMC3981107)

Ibrahim, S. Gao, D. Sinko, P. J. Selective Cytotoxicity and Combined Effects of Camptothecin or Paclitaxel with Sodium-R-Alpha Lipoate on A549 Human Non-Small Cell Lung Cancer Cells. Nutr Cancer, 66:492-499, . (PMID: 24063429, PMCID: PMC3964140)

Liu, D. Zhang, X. Gao, J. Palombo, M. Gao, D. Chen, P. Sinko, P. J. Core Functional Sequence of C-terminal GAG-binding Domain Directs Cellular Uptake of IGFBP-3-derived Peptides. Protein Pept Lett, 21:124-131, . (PMID: 24059751, PMCID: PMC3941648)

Palombo, M. Deshmukh, M. Myers, D. Gao, J. Szekely, Z. Sinko, P. J. Pharmaceutical and toxicological properties of engineered nanomaterials for drug delivery. Annu Rev Pharmacol Toxicol, 54:581-598, . (PMID: 24160695)

Zheng, R. Po, I. Mishin, V. Black, A. T. Heck, D. E. Laskin, D. L. Sinko, P. J. Gerecke, D. R. Gordon, M. K. Laskin, J. D. The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard. Toxicol Appl Pharmacol, 272:345-355, . (PMID: 23845594)

Gao, J. Chen, P. Singh, Y. Zhang, X. Szekely, Z. Stein, S. Sinko, P. J. Novel Monodisperse PEGtide Dendrons: Design, Fabrication, and Evaluation of Mannose Receptor-Mediated Macrophage Targeting. Bioconjug Chem, In process, . (PMID: 23808323)

D'Addio, S. M. Baldassano, S. Shi, L. Cheung, L. Adamson, D. H. Bruzek, M. Anthony, J. E. Laskin, D. L. Sinko, P. J. Prud'homme, R. K. Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric nanocarriers. J Control Release, 168:41-49, . (PMID: 23419950, PMCID: PMC3662248)

Torres, N. I. Noll, K. S. Xu, S. Li, J. Huang, Q. Sinko, P. J. Wachsman, M. B. Chikindas, M. L. Safety, formulation, and in vitro antiviral activity of the antimicrobial peptide subtilosin against herpes simplex virus type 1. Probiotics Antimicrob Proteins, 5:26-35, . (PMID: 23637711, PMCID: PMC3637976)

Kutscher, H. L. Gao, D. Li, S. Massa, C. B. Cervelli, J. Deshmukh, M. Joseph, L. B. Laskin, D. L. Sinko, P. J. Toxicodynamics of rigid polystyrene microparticles on pulmonary gas exchange in mice: Implications for microemboli-based drug delivery systems. Toxicol Appl Pharmacol, 266:214-223, . (PMID: 23142466, PMCID: PMC3586786)

Malaviya, R. Venosa, A. Hall, L. Gow, A. J. Sinko, P. J. Laskin, J. D. Laskin, D. L. Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor. Toxicol Appl Pharmacol, 265:279-291, . (PMID: 22981630, PMCID: PMC3516137)

Deshmukh, M. Kutscher, H. L. Gao, D. Sunil, V. R. Malaviya, R. Vayas, K. Stein, S. Laskin, J. D. Laskin, D. L. Sinko, P. J. Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates. J Control Release, 164:65-73, . (PMID: 23041417)

Wan, J. Shi, L. Benson, B. Bruzek, M. J. Anthony, J. E. Sinko, P. J. Prudhomme, R. K. Stone, H. A. Microfluidic generation of droplets with a high loading of nanoparticles. Langmuir, 28:13143-13148, . (PMID: 22934976)

Singh, Y. Gao, D. Gu, Z. Li, S. Rivera, K. A. Stein, S. Love, S. Sinko, P. J. Influence of molecular size on the retention of polymeric nanocarrier diagnostic agents in breast ducts. Pharm Res, 29:2377-2388, . (PMID: 22569800, PMCID: PMC3442773)

Noll, K. S. Prichard, M. N. Khaykin, A. Sinko, P. J. Chikindas, M. L. The natural antimicrobial peptide subtilosin acts synergistically with glycerol monolaurate, lauric arginate, and epsilon-poly-L-lysine against bacterial vaginosis-associated pathogens but not human lactobacilli. Antimicrob Agents Chemother, 56:1756-1761, . (PMID: 22252803, PMCID: PMC3318360)

Singh, Y. Gao, D. Gu, Z. Li, S. Stein, S. Sinko, P. J. Noninvasive detection of passively targeted poly(ethylene glycol) nanocarriers in tumors. Mol Pharm, 9:144-155, . (PMID: 22077582, PMCID: PMC3257802)

Turovskiy, Y. Cheryian, T. Algburi, A. Wirawan, R. E. Takhistov, P. Sinko, P. J. Chikindas, M. L. Susceptibility of Gardnerella vaginalis Biofilms to Natural Antimicrobials Subtilosin, epsilon-Poly-L-Lysine, and Lauramide Arginine Ethyl Ester. Infect Dis Obstet Gynecol, 2012:284762, . (PMID: 23024575, PMCID: PMC3457663)

Cai, C. Y. Zhang, X. Sinko, P. J. Burakoff, S. J. Jin, Y. J. Two Sorting Motifs, a Ubiquitination Motif and a Tyrosine Motif, Are Involved in HIV-1 and Simian Immunodeficiency Virus Nef-Mediated Receptor Endocytosis. J Immunol, 186:5807-5814, . (PMID: 21482738)

Noll, K. S. Sinko, P. J. Chikindas, M. L. Elucidation of the Molecular Mechanisms of Action of the Natural Antimicrobial Peptide Subtilosin Against the Bacterial Vaginosis-associated Pathogen Gardnerella vaginalis. Probiotics Antimicrob Proteins, 3:41-47, . (PMID: 21949544, PMCID: PMC3176456)

Anumolu, S. S. Menjoge, A. R. Deshmukh, M. Gerecke, D. Stein, S. Laskin, J. Sinko, P. J. Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries. Biomaterials, 32:1204-1217, . (PMID: 20950853, PMCID: PMC2995374)