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Patrick J. Sinko, PhD, RPh

Publications since 2011

Gao, Y. Gu, S. Zhang, Y. Xie, X. Yu, T. Lu, Y. Zhu, Y. Chen, W. Zhang, H. Dong, H. Sinko, P. J. Jia, L. The Architecture and Function of Monoclonal Antibody-Functionalized Mesoporous Silica Nanoparticles Loaded with Mifepristone: Repurposing Abortifacient for Cancer Metastatic Chemoprevention. Small, In process, . (PMID: 27027489)

Dong, H. Ma, J. Wang, J. Wu, Z. S. Sinko, P. J. Jia, L. A Biofunctional Molecular Beacon for Detecting Single Base Mutations in Cancer Cells. Mol Ther Nucleic Acids, 5:e302, . (PMID: 27045206)

Samizadeh, M. Zhang, X. Gunaseelan, S. Nelson, A. G. Palombo, M. S. Myers, D. R. Singh, Y. Ganapathi, U. Szekely, Z. Sinko, P. J. Colorectal delivery and retention of PEG-Amprenavir-Bac7 nanoconjugates-proof of concept for HIV mucosal pre-exposure prophylaxis. Drug Deliv Transl Res, In process, . (PMID: 26712122)

Gao, Y. Jin, B. Shen, W. Sinko, P. Xie, X. Zhang, H. Jia, L. China and the United States- global partners, competitors and collaborators in nanotechnology development. Nanomedicine, In process, . (PMID: 26427355)

Lu, Y. Liang, H. Yu, T. Xie, J. Chen, S. Dong, H. Sinko, P. J. Lian, S. Xu, J. Wang, J. Yu, S. Shao, J. Yuan, B. Wang, L. Jia, L. Isolation and characterization of living circulating tumor cells in patients by immunomagnetic negative enrichment coupled with flow cytometry. Cancer, 121:3036-3045, . (PMID: 25945459)

Nelson, A. G. Zhang, X. Ganapathi, U. Szekely, Z. Flexner, C. W. Owen, A. Sinko, P. J. Drug delivery strategies and systems for HIV/AIDS pre-exposure prophylaxis and treatment. J Control Release, In process, . (PMID: 26315816)

Pinkerton, N. M. Gindy, M. E. Calero-DdelC, V. L. Wolfson, T. Pagels, R. F. Adler, D. Gao, D. Li, S. Wang, R. Zevon, M. Yao, N. Pacheco, C. Therien, M. J. Rinaldi, C. Sinko, P. J. Prud'homme, R. K. Single-Step Assembly of Multimodal Imaging Nanocarriers: MRI and Long-Wavelength Fluorescence Imaging. Adv Healthc Mater, 4:1376-1385, . (PMID: 25925128, PMCID: PMC4617688)

Tang, C. Xiao, E. Sinko, P. J. Szekely, Z. Prud'homme, R. K. Responsive foams for nanoparticle delivery. Colloids Surf B Biointerfaces, In process, . (PMID: 26091943)

D'Addio, S. M. Reddy, V. M. Liu, Y. Sinko, P. J. Einck, L. Prud'homme, R. K. Antitubercular Nanocarrier Combination Therapy: Formulation Strategies and in Vitro Efficacy for Rifampicin and SQ641. Mol Pharm, 12:1554-1563, . (PMID: 25811733, PMCID: PMC4423248)

Xie, J. Gao, Y. Zhao, R. Sinko, P. J. Gu, S. Wang, J. Li, Y. Lu, Y. Yu, S. Wang, L. Chen, S. Shao, J. Jia, L. Ex vivo and in vivo capture and deactivation of circulating tumor cells by dual-antibody-coated nanomaterials. J Control Release, In process, . (PMID: 25933713)

Yu, S. Yang, X. Zhu, Y. Xie, F. Lu, Y. Yu, T. Yan, C. Shao, J. Gao, Y. Mo, F. Cai, G. Sinko, P. J. Jia, L. Systems pharmacology of mifepristone (RU486) reveals its 47 hub targets and network: Comprehensive analysis and pharmacological focus on FAK-Src-Paxillin complex. Sci Rep, 5:7830, . (PMID: 25597938)

Xie, J. Wang, J. Chen, H. Shen, W. Sinko, P. J. Dong, H. Zhao, R. Lu, Y. Zhu, Y. Jia, L. Multivalent conjugation of antibody to dendrimers for the enhanced capture and regulation on colon cancer cells. Sci Rep, 5:9445, . (PMID: 25819426)

Xie, J. Dong, H. Chen, H. Zhao, R. Sinko, P. J. Shen, W. Wang, J. Lu, Y. Yang, X. Xie, F. Jia, L. Exploring cancer metastasis prevention strategy: interrupting adhesion of cancer cells to vascular endothelia of potential metastatic tissues by antibody-coated nanomaterial. J Nanobiotechnology, 13:9, . (PMID: 25643843, PMCID: PMC4320453)

Quintana, V. M. Torres, N. I. Wachsman, M. B. Sinko, P. J. Castilla, V. Chikindas, M. Anti - herpes simplex virus type 2 activity of the antimicrobial peptide subtilosin. J Appl Microbiol, 117:1253-1259, . (PMID: 25087911, PMCID: PMC4198449)

Rajan, S. S. Turovskiy, Y. Singh, Y. Chikindas, M. L. Sinko, P. J. Poly(ethylene glycol) (PEG)-lactic acid nanocarrier-based degradable hydrogels for restoring the vaginal microenvironment. J Control Release, In process, . (PMID: 25223229)

Chen, P. Zhang, X. Jia, L. Prud'homme, R. K. Szekely, Z. Sinko, P. J. Optimal structural design of mannosylated nanocarriers for macrophage targeting. J Control Release, In process, . (PMID: 25220160)

Sundara Rajan, S. Cavera, V. L. Zhang, X. Singh, Y. Chikindas, M. L. Sinko, P. J. Poly(ethylene glycol) (PEG)-based hydrogels for the controlled release of the antimicrobial subtilosin, for prophylaxis of bacterial vaginosis. Antimicrob Agents Chemother, 58:2747-2753, . (PMID: 24566190, PMCID: PMC3993243)

Pinkerton, N. M. Zhang, S. W. Youngblood, R. L. Gao, D. Li, S. Benson, B. R. Anthony, J. Stone, H. A. Sinko, P. J. Prud'homme, R. K. Gelation chemistries for the encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery. Biomacromolecules, 15:252-261, . (PMID: 24410445, PMCID: PMC3981107)

Ibrahim, S. Gao, D. Sinko, P. J. Selective Cytotoxicity and Combined Effects of Camptothecin or Paclitaxel with Sodium-R-Alpha Lipoate on A549 Human Non-Small Cell Lung Cancer Cells. Nutr Cancer, 66:492-499, . (PMID: 24063429, PMCID: PMC3964140)

Liu, D. Zhang, X. Gao, J. Palombo, M. Gao, D. Chen, P. Sinko, P. J. Core Functional Sequence of C-terminal GAG-binding Domain Directs Cellular Uptake of IGFBP-3-derived Peptides. Protein Pept Lett, 21:124-131, . (PMID: 24059751, PMCID: PMC3941648)

Palombo, M. Deshmukh, M. Myers, D. Gao, J. Szekely, Z. Sinko, P. J. Pharmaceutical and toxicological properties of engineered nanomaterials for drug delivery. Annu Rev Pharmacol Toxicol, 54:581-598, . (PMID: 24160695)

Xie, J. Zhao, R. Gu, S. Dong, H. Wang, J. Lu, Y. Sinko, P. J. Yu, T. Xie, F. Wang, L. Shao, J. Jia, L. The Architecture and Biological Function of Dual Antibody-Coated Dendrimers: Enhanced Control of Circulating Tumor cells and Their Hetero-Adhesion to Endothelial Cells for Metastasis Prevention. Theranostics, 4:1250-1263, . (PMID: 25285173, PMCID: PMC4184002)

Zheng, R. Po, I. Mishin, V. Black, A. T. Heck, D. E. Laskin, D. L. Sinko, P. J. Gerecke, D. R. Gordon, M. K. Laskin, J. D. The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard. Toxicol Appl Pharmacol, 272:345-355, . (PMID: 23845594)

Gao, J. Chen, P. Singh, Y. Zhang, X. Szekely, Z. Stein, S. Sinko, P. J. Novel Monodisperse PEGtide Dendrons: Design, Fabrication, and Evaluation of Mannose Receptor-Mediated Macrophage Targeting. Bioconjug Chem, In process, . (PMID: 23808323)

D'Addio, S. M. Baldassano, S. Shi, L. Cheung, L. Adamson, D. H. Bruzek, M. Anthony, J. E. Laskin, D. L. Sinko, P. J. Prud'homme, R. K. Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric nanocarriers. J Control Release, 168:41-49, . (PMID: 23419950, PMCID: PMC3662248)

Torres, N. I. Noll, K. S. Xu, S. Li, J. Huang, Q. Sinko, P. J. Wachsman, M. B. Chikindas, M. L. Safety, formulation, and in vitro antiviral activity of the antimicrobial peptide subtilosin against herpes simplex virus type 1. Probiotics Antimicrob Proteins, 5:26-35, . (PMID: 23637711, PMCID: PMC3637976)

Kutscher, H. L. Gao, D. Li, S. Massa, C. B. Cervelli, J. Deshmukh, M. Joseph, L. B. Laskin, D. L. Sinko, P. J. Toxicodynamics of rigid polystyrene microparticles on pulmonary gas exchange in mice: Implications for microemboli-based drug delivery systems. Toxicol Appl Pharmacol, 266:214-223, . (PMID: 23142466, PMCID: PMC3586786)

Malaviya, R. Venosa, A. Hall, L. Gow, A. J. Sinko, P. J. Laskin, J. D. Laskin, D. L. Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor. Toxicol Appl Pharmacol, 265:279-291, . (PMID: 22981630, PMCID: PMC3516137)

Deshmukh, M. Kutscher, H. L. Gao, D. Sunil, V. R. Malaviya, R. Vayas, K. Stein, S. Laskin, J. D. Laskin, D. L. Sinko, P. J. Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates. J Control Release, 164:65-73, . (PMID: 23041417)

Wan, J. Shi, L. Benson, B. Bruzek, M. J. Anthony, J. E. Sinko, P. J. Prudhomme, R. K. Stone, H. A. Microfluidic generation of droplets with a high loading of nanoparticles. Langmuir, 28:13143-13148, . (PMID: 22934976)

Singh, Y. Gao, D. Gu, Z. Li, S. Rivera, K. A. Stein, S. Love, S. Sinko, P. J. Influence of molecular size on the retention of polymeric nanocarrier diagnostic agents in breast ducts. Pharm Res, 29:2377-2388, . (PMID: 22569800, PMCID: PMC3442773)

Noll, K. S. Prichard, M. N. Khaykin, A. Sinko, P. J. Chikindas, M. L. The natural antimicrobial peptide subtilosin acts synergistically with glycerol monolaurate, lauric arginate, and epsilon-poly-L-lysine against bacterial vaginosis-associated pathogens but not human lactobacilli. Antimicrob Agents Chemother, 56:1756-1761, . (PMID: 22252803, PMCID: PMC3318360)

Singh, Y. Gao, D. Gu, Z. Li, S. Stein, S. Sinko, P. J. Noninvasive detection of passively targeted poly(ethylene glycol) nanocarriers in tumors. Mol Pharm, 9:144-155, . (PMID: 22077582, PMCID: PMC3257802)

Turovskiy, Y. Cheryian, T. Algburi, A. Wirawan, R. E. Takhistov, P. Sinko, P. J. Chikindas, M. L. Susceptibility of Gardnerella vaginalis Biofilms to Natural Antimicrobials Subtilosin, epsilon-Poly-L-Lysine, and Lauramide Arginine Ethyl Ester. Infect Dis Obstet Gynecol, 2012:284762, . (PMID: 23024575, PMCID: PMC3457663)

Cai, C. Y. Zhang, X. Sinko, P. J. Burakoff, S. J. Jin, Y. J. Two Sorting Motifs, a Ubiquitination Motif and a Tyrosine Motif, Are Involved in HIV-1 and Simian Immunodeficiency Virus Nef-Mediated Receptor Endocytosis. J Immunol, 186:5807-5814, . (PMID: 21482738)

Noll, K. S. Sinko, P. J. Chikindas, M. L. Elucidation of the Molecular Mechanisms of Action of the Natural Antimicrobial Peptide Subtilosin Against the Bacterial Vaginosis-associated Pathogen Gardnerella vaginalis. Probiotics Antimicrob Proteins, 3:41-47, . (PMID: 21949544, PMCID: PMC3176456)