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Gary A. Brewer, PhD

Selected Publications

Sirenko, O., Lofquist, A., DeMaria, C.T., Morris, J., Brewer, G., and Haskill, J.S. Regulation of an AU-rich element binding activity associated with AUF1. 1997. Mol Cell Biol., 17:3898-3906.

Laroia, G., Cuesta, R., Brewer, G., and Schneider, R.J. 1999.  Control of cytokine mRNA decay by the heat shock-ubiquitin-proteasome pathway.  Science 284:499-502.

Lasa, M., Mahtani, K.R., Finch, A., Brewer, G., Saklatvala, J., and Clark, A.R. 2000. Regulation of cyclooxygenase-2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade.  Mol Cell Biol.  20:4265-4274.

Wilson, G.M., Lu, J., Sutphen, K., Sun, Y., Huynh, Y., and Brewer, G. Regulation of ARE-directed mRNA turnover involving reversible phosphorylation of AUF1.  2003. J Biol Chem. 278: 33029-33038.

Wilson, G.M., Lu, J., Sutphen, K., Suarez, Y., Sinha, S., Brewer, B., Villanueva-Feliciano, E., Ysla, R.M., Charles, S., and Brewer, G. Phosphorylation of p40AUF1 regulates binding to AU-rich mRNA-destabilizing elements and protein-induced changes in ribonucleoprotein structure. 2003.  J Biol Chem. 278:33039-33048.

Sinsimer, K.S., Gratacos, F.M., Knapinska, A.M., Lu, J., Krause, C.D., Wierzbowski. A.V., Maher, L.R., Scrudato, S., Rivera, Y.M., Gupta, S., Turrin, D.K., De La Cruz, M.P., Pestka, S., and Brewer, G.  2008. Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay.  Mol. Cell Biol. 28: 5223-5237.

Sarkar, S., Sinsimer, K.S., Foster, R.L., Brewer, G., and Pestka, S. 2008. AUF1 isoform-specific regulation of anti-inflammatory IL10 expression in monocytes. J Interferon Cytokine Res. 28: 679-692.

Sarkar, S., Han, J., Sinsimer, K.S., Liao, B., Foster, R.L., Brewer, G., and Pestka, S. 2011. RNA-binding protein AUF1 regulates LPS-induced IL10 expression by activating IκB kinase complex in monocytes.  Mol. Cell. Biol. 31: 602-615. 

Knapinska, A.M., Gratacós, F.M., Krause, C.D., Hernandez, K., Jensen, A.G., Bradley, J., Pestka, S. and Brewer, G. 2011.  Chaperone Hsp27 modulates AUF1 proteolysis and AU-rich element-mediated mRNA degradation.  Mol. Cell. Biol. 31: 1419-1431.

Qi, M-Y., Wang, Z-Z., Zhang, Z., Shao, Q., Zeng, A., Li, X-Q., Li, W-Q., Wang, C., Tian, F-J., Li, Q., Zou, J., Qin, Y-W., Brewer, G., Huang, S. and Jing, Q. 2012.  AU-rich element-dependent translation repression requires the cooperation of Tristetraprolin and RCK/p54.  Mol. Cell. Biol. 32: 913-928.

Wu, X. and Brewer, G. 2012. Regulation of mRNA degradation in mammalian cells: 2.0. Gene, 500: 10-21.

Zhang, Z., Qin, Y-W., Brewer, G. and Jing, Q. 2012. MicroRNA degradation and turnover: Regulating the regulators.  Wiley Interdiscip. Rev. RNA 3: 593-600.