Researcher Publications

Justin M. Drake, PhD

Selected Publications

  1. Drake JM, Gabriel CL, Henry MD (2005) Assessing Tumor Growth and Distribution in a Model of Prostate Cancer Metastasis using Bioluminescence Imaging.  Clin. Exp. Metastasis. 22(8):674-684
  2. Drake JM, Strohbehn G, Moreland JG, Henry MD (2009) ZEB1 Enhances Transendothelial Migration and Represses the Epithelial Phenotype of Prostate Cancer Cells. Mol. Biol. Cell. 20(8):2207-2217. PMCID: PMC2669028.
  3. Drake JM, Danke JR, Henry MD (2010) Bone-Specific Growth Inhibition of Prostate Cancer Metastasis by Atrasentan. Cancer Biol. Ther. 9(8):605-612. Open Access.
    -Featured in a preview by Roh and Abdulkadir in Cancer Biol. Ther.
  4. Drake JM*, Barnes JM*, Madsen JM, Domann FE, Stipp CS, Henry MD (2010) ZEB1 Coordinately Regulates Laminin-332 and β4 Integrin Expression Altering the Invasive Phenotype of Prostate Cancer Cells. J. Biol. Chem. 285(44):33940-33948. PMCID: PMC2962494. *Authors contributed equally to this work
    -Rated ‘good’ by Faculty of 1000
  5. Goldstein AS*, Drake JM*, Burnes DL, Finley DS, Zhang H, Reiter RE, Huang J, Witte ON (2011) Purification and Direct Transformation of Epithelial Progenitor Cells from Primary Human Prostate. Nat. Protoc. 6(5):656-667. PMCID: PMC3092477. *Authors contributed equally to this work
  6. Drake JM, Graham NA, Stoyanova T, Sedghi A, Goldstein AS, Cai H, Smith DA, Zhang H, Komisopoulou E, Huang J, Graeber TG, Witte ON (2012) Oncogene-Specific Activation of Tyrosine Kinase Networks during Prostate Cancer Progression. PNAS. 109(5):1643-1648. PMCID: PMC3277127.
  7. Stoyanova T, Goldstein AS, Cai H, Drake JM, Huang J, Witte ON (2012) Regulated Proteolysis of Trop2 Drives Epithelial Hyperplasia and Stem Cell Self-Renewal via β-catenin Signaling. Genes Dev. 26(20):2271-2285. PMCID: PMC3475800.
  8. Drake JM, Graham NA, Lee JK, Stoyanova T, Faltermeier CF, Sudha S, Titz B, Huang J, Pienta KJ, Graeber TG, Witte ON (2013) Metastatic Castration Resistant Prostate Cancer Reveals Intrapatient Similarity and Interpatient Heterogeneity of Therapeutic Kinase Targets. PNAS. 110(49):E4762-E4769. PMCID: PMC3856845.
    -Rated ‘very good’ by Faculty of 1000
    -Genomeweb interview for a news article
  9. Stoyanova T, Cooper AR, Drake JM, Liu X, Armstrong AJ, Pienta KJ, Zhang H, Kohn DB, Huang J, Witte ON, Goldstein AS (2013) Prostate Cancer Originating in Basal Cells Progresses to Adenocarcinoma Maintained by Luminal-like Tumor-propagating Cells. PNAS. 110(50):20111-20116. PMCID: PMC3864278.
  10. Drake JM, Lee JK, Witte ON (2014) Clinical Targeting of Mutated and Wild-type Protein Tyrosine Kinases in Cancer. Mol Cell Bio. 34(10):1722-1732. PMCID: PMC4019040.
  11. Drake JM# and Huang J (2014) PIP5K1α Inhibition as a Therapeutic Strategy for Prostate Cancer. PNAS. 111(35):12578-12579. PMCID: PMC4156720. #Co-corresponding author with Jiaoti Huang
  12. Goodwin JF, Kothari V, Drake JM, Zhao S, Dylgjeri E, Dean JL, Schiewer MJ, McNair C, Jones JK, Aytes A, Magee MS, Snook AE, Zhu Z, Den RB, Birbe RC, Gomella LG, Graham NA, Vashisht AA, Wohlschlegel JA, Graeber TG, Karnes JR, Takhar M, Davicioni E, Tomlins SA, Abate-Shen C, Sharifi N, Witte ON, Feng FY, Knudsen KE (2015) DNA-PK Mediated Transcriptional Regulation Drives Tumor Progression and Metastasis. Cancer Cell. 28(1):97-113. PMCID: PMC4531387.
  13. Faltermeier CM, Drake JM, Clark PM, Smith BA, Zong Y, Volpe C, Mathis C, Morrissey C, Castor B, Huang J, Witte ON (2016) Functional Screen Identifies Kinases Driving Prostate Cancer Visceral and Bone Metastasis. PNAS. 113(2):E172-E181. PMCID: PMC4720329. -Featured in a commentary by Feng and Kothari in PNAS
  14. Drake JM*,#, Paull EO*, Graham NA, Lee JK, Smith BA, Titz, B, Stoyanova TS, Faltermeier CM, Carlin DE, Flemming DT, Wong CK, Newton Y, Sudha S, Vashisht AA, Huang J, Wohlschlegel JA, Graeber TG, Witte ON#, Stuart JM# (2016) Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer. Cell. 166(4):1041-1054. PMCID: PMC4985183. *Authors contributed equally to this work. #Co-corresponding author.
    -Editor’s choice commentary in Science Translational Medicine
    -News and Views commentary in Nature Reviews Urology
  15. Stoyanova T, Riedinger M, Lin S, Faltermeier CM, Smith BA, Zhang KX, Going C, Goldstein AS, Lee JK, Drake JM, Rice M, Hsu E, Nowroozizadeh B, Castor B, Orellana SY, Blum SM, Cheng D, Pienta KJ, Reiter R, Pitteri S, Huang J, Witte ON (2016) Activation of Notch1 Synergizes with Multiple Pathways in Promoting Castration Resistant Prostate Cancer. PNAS. 113(42):E6457-E6466. PMCID: PMC5081658.
  16. Tan VM, Cheng LC, Drake JM (2016) Complementing Genomics and Transcriptomics: Phosphoproteomics Illuminating Systems Biology in Prostate Cancer. Mol. Cell. Oncol., 3(6):e1246075. PMCID: PMC5160408.
  17. Cheng LC, Tan VM, Ganesan S, Drake JM (2017) Integrating Phosphoproteomics into the Clinical Management of Cancer. Clin. Transl. Med., 6(1):9. PMCID: PMC5309189.

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