Researcher Publications

Andrew Zloza, MD, PhD

Selected Publications

  1. Zloza A, Sullivan YB, Connick E, Landay AL, Al-Harthi L: CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV. Blood. 2003 Sep 15;102(6):pages 2156-64.
  2. Managlia EZ, Carroll D, Zloza A, Al-Harthi L: Immune modulation of HIV replication: relevance to HIV immuno- and neuro-pathogenesis. Curr HIV Res. 2004 Oct;2(4): pages 395-401.
  3. Zloza A, Al-Harthi L: Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration. J Leukoc Biol. 2006 Jan;79(1): pages 4-6.
  4. Kumar A, Zloza A, Moon RT, Watts J, Tenorio AR, Al-Harthi L: Active beta-catenin signaling is an inhibitory pathway for human immunodeficiency virus replication in peripheral blood mononuclear cells. J Virol. 2008 Mar;82(6):pages 2813-20.
  5. Zloza A, Schenkel JM, Tenorio AR, Martinson JA, Jeziorczak PM, Al-Harthi L: Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface. Blood. 2009 Oct 29;114(18): pages 3841-53.
  6. Schenkel JM, Zloza A, Li W, Narasipura SD, Al-Harthi L. Beta-Catenin Signaling Mediates CD4 Expression on Mature CD8+ T Cells. J Immunol. 2010 Aug 15;185(4):2013-9.
  7. Zloza A, Jagoda MC, Graves M, Kohlhapp FJ, O’Sullivan JA, Lyons GE, Lacek AT, Nishimura MI, Guevara-Patino JA. CD8-Lck Signaling Promotes T Cell Susceptibility to Transforming Growth Factor β (TGF-β)-mediated Suppression. Cancer Immunol Immunother. 2011 Feb;60(2):291-7.
  8. Bellavance EC*, Kohlhapp FJ*, Zloza A, O’Sullivan JA, McCracken J, Jagoda MC, Lacek AT, Posner MC, Guevara-Patino JA. Development of Tumor-infiltrating CD8+ T cell Memory Precursor Effector Cells (MPECs) and Anti-melanoma Memory Responses are the Result of Vaccination and TGF-β Blockade During the Perioperative Period of Tumor Resection. J Immunol. 2011 Mar 15;186(6):3309-16. *equal contribution
  9. O’Sullivan JA, Zloza A, Kohlhapp FJ, Moore TV, Lacek AT, Dulin NO, Guevara-Patiño JA. Priming with Very Low Affinity Peptide Ligands Gives Rise to CD8+ T Cell Effectors with Enhanced Function but with Greater Susceptibility to Transforming Growth Factor (TGF)β-mediated Suppression. Cancer Immunol Immunother. 2011 Nov;60(11):1543-51.
  10. Zloza A, Lyons GE, Moore TV, Chlewicki LK, Kohlhapp FJ, O’Sullivan JA, Lacek AT, Jagoda MC, TV Moore, Kumar V, Guevara-Patino JA. Engagement of NK receptor NKG2D, but not 2B4, results in self-reactive CD8+ T cells and autoimmune vitiligo. Autoimmunity. 2011 Dec;44(8):599-606.
  11. Mosenson JA, Zloza A, Klarquist J, Barfuss AJ, Guevara-Patino JA, Le Poole IC. HSP70i is a Critical Component of the Immune Response Leading to Vitiligo. Pigment Cell Melanoma Res. 2012 Jan;25(1):88-98.
  12. Zloza A*, Kohlhapp FJ*, Lyons GE*, Schenkel JM, Moore TV, Lacek AT, O'Sullivan JA, Varanasi V, Williams JW, Jagoda MC, Bellavance EC, Marzo AL, Thomas PG, Zafirova B, Polić B, Al-Harthi L, Sperling AI, Guevara-Patiño JA. NKG2D signaling on CD8(+) T cells represses T-bet and rescues CD4-unhelped CD8(+) T cell memory recall but not effector responses. Nat Med. 2012 Feb 26;18(3):422-8. *equal contribution
  13. Kohlhapp FJ, Zloza A, O'Sullivan JA, Moore TV, Lacek AT, Jagoda MC, McCracken J, Cole DJ, Guevara-Patiño JA. CD8+ T Cells Sabotage Their Own Memory Potential through IFN-γ-Dependent Modification of the IL-12/IL-15 Receptor α Axis on Dendritic Cells. J Immunol. 2012 Apr 15;188(8):3639-47
  14. Mosenson JA*, Zloza A*, Nieland JD, Garrett-Mayer E, Eby JM, Huelsmann EJ, Kumar P, Denman C, Lacek AT, Kohlhapp FJ, Alamiri A, Hughes T, Bines SD, Kaufman HL, Overbeck A., Mehrotra S, Hernandez C, Nishimura MI, Guevara-Patino JA, Le Poole IC. Mutant HSP70 reverses autoimmune depigmentation in vitiligo. Sci Transl Med. 2013 Feb 27;5(174):174ra28. *equal contribution
  15. Chesson CB, Huelsmann EJ, Lacek AT, Kohlhapp FJ, Webb MF, Nabatiyan A, Zloza A, Rudra JS. Antigenic peptide nanofibers elicit adjuvant-free CD8+ T cell responses. Vaccine. 2013 Dec 2. pii: S0264-410X(13)01581-8. doi: 10.1016/j.vaccine.2013.11.047. *shared co-last/co-corresponding authorship
  16. Rubinstein PG, Aboulafiac DM, Zloza A. Malignancies in HIV/AIDS: from epidemiology to therapeutic challenges. AIDS. 2014 Feb 20;28(4):453-65.
  17. Kaufman HL, Kim DW, Kim-Schulze S, Deraffele G, Jagoda MC, Broucek JR, Zloza A. Results of a Randomized Phase I Gene Therapy Clinical Trial of Nononcolytic Fowlpox Viruses Encoding T Cell Costimulatory Molecules. Hum Gene Ther. 2014 Mar 26.
  18. Lu R, Wu S, Zhang Y, Xia Y, Huelsmann EJ, Lacek AT, Nabatiyan A, Richards MH, Narasipura SD, Lutgen V, Chen H, Kaufman HL, Chen D, Al-Harthi L, Zloza A, Sun J. HIV Infection Accelerates Gastrointestinal Tumor Outgrowth in NSG-HuPBL Mice. AIDS Res Hum Retroviruses. 2014 Apr 3.
  19. Wood S, Jayaraman V, Huelsmann EJ, Bonish B, Burgad D, Sivaramakrishnan G, Qin S, Dipietro LA, Zloza A, Zhang C, Shafikhani SH. Pro-inflammatory chemokine CCL2 (MCP-1) promotes healing in diabetic wounds by restoring the macrophage response. PLoS One. 2014 Mar 11;9(3):e91574
  20. Zloza A, Kim DW, Kim-Schulze S, Jagoda MC, Monsurro V, Marincola FM, Kaufman HL. Immunoglobulin-like transcript 2 (ILT2) is a biomarker of therapeutic response to oncolytic immunotherapy with vaccinia viruses. J Immunother Cancer. 2014 Jan 27;2:1.
  21. Kim DW, Zloza A, Broucek J, Schenkel JM, Ruby C, Samaha G, Kaufman HL. Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells. J Transl Med. 2014 May 6;12(1):113.
  22. Zloza A, Kim DW, Broucek J, Schenkel JM, Kaufman HL. High-dose IL-2 induces rapid albumin uptake by endothelial cells through Src-dependent caveolae-mediated endocytosis. J Interferon Cytokine Res. 2014 Jun 25.
  23. Zhang YG, Wu S, Lu R, Richards MH, Huelsmann EJ, Lacek AT, Nabatiyan A, Chen D, Al-Harthi L, Zloza A, Sun J. HIV Infection Leads to Redistribution of Leaky Claudin-2 in the Intestine of Humanized SCID IL-2R-/- Hu-PBMC Mice. AIDS Res Hum Retroviruses. 2015 Apr 8.
  24. Kohlhapp FJ, Broucek J, Hughes T, Hueslmann EJ, Lusciks J, Zayas J, Dolubizno H, Fleetwood V, Grin A, Hill G, Poshepny J, Nabatiyan A, Ruby C, Snook J, Rudra, J, Schenkel J, Masopust D, Zloza A, Kaufman, H. NK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade. J Immunother Cancer. In press (JITC-D-15-00015R1; accepted April 17, 2015).

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