Researcher Publications

Hatem E. Sabaawy, MD, PhD

Selected Publications

  1. Pine S, Yin C, Matloob Y, Sabaawy H, Sandoval C, Levendoglu-Tugal O, Ozkaynak M, and S. Jaybose. Quantitative real-time PCR detection of Occult CNS-Leukemia in children with acute lymphoblastic leukemia. Journal of Molecular Diagnostic 7: 127-32, 2005. PMID: 15681484. PMCID: PMC1867497.
  2. Sabaawy HE, Azuma M, Embree L, Tsai HJ, Starost MF, and DD Hickstein. TEL-AML1 transgenic zebrafish model of precursor B-cell acute lymphoblastic leukemia. Proceedings of the National Academy of Science, USA 103: 15166-15171, 2006. PMID: 17015828. PMCID: PMC1622794.
  3. Sabaawy HE, Yin C, Sandoval C, Levendoglu-Tugal O, Wormser G, Jaybose S, and S. Pine. Lymphoproliferative clonal origin of AIDS-related Non-Hodgkin's lymphoma. Leukemia and Lymphoma 48: 812-815, 2007. PMID: 17454643.
  4. El Ansary M, Mogawer S, Elhamid SA, Alwakil S, Aboelkasem F, Sabaawy HE*, Abdelhalim O. Immunotherapy by autologous dendritic cell vaccine in patients with advanced HCC. Journal of Cancer Research Clinical Oncology 139(1):39-48, 2012. doi: 10.1007/s00432-012-1298-8. Epub 2012 Aug 12. PMID: 22886490. * Corresponding author.
  5. Kokorina NA, Granier C, Zakharkin SO, Marshall S, Rabson A and Sabaawy HE. PDCD2 knockdown inhibits erythroid but not megakaryocytic lineage differentiation of human hematopoietic stem/progenitor cells. Experimental Hematology 40(12):1028-1042, 2012. doi:10.1016/j.exphem.2012.08.004. Epub 2012 Aug 22. PMID: 22922207.
  6. Davis S and Sabaawy HE. Tumor suppressor functions of the zebrafish ink4ab: a novel cyclin-dependent kinase inhibitor. Cancer Research 73(8 Supplement):1581, 2013.
  7. Elkheir WA, Gabr H, Awad R, Ghannam O, Barakat Y, Farghali H, El Maadawi Z, Ewes I, and HE Sabaawy. Autologous adherent BM-derived cell therapy combined with physical therapy induces partial recovery in chronic spinal cord injury patients. Cell Transplantation 23(6):729-45, 2014. doi: 10.3727/096368913X664540. Epub 2013 Feb 26. PMID: 23452836.
  8. Sabaawy, HE. Genetic heterogeneity and clonal evolution of tumor cells and their impact on precision cancer medicine. Journal of Leukemia 1(4):1000124, 2013. PMID: 24558642.
  9. Bansal N, Davis S, Tereshchenko I, Budak-Alpdogan T, Zhong H, Stein MN, Kim IY, DiPaola RS, Bertino JR, and Sabaawy HE. Enrichment of human prostate cancer cells with tumor initiating properties in mice and zebrafish xenografts by differential adhesion. Prostate 74(2):187-200, 2014. doi: 10.1002/pros.22740. PMID: 24154958.
  10. Mehta M, Khan A, Hafty B and Sabaawy HE. Radiosensitization of glioblastoma cells by modulating Bmi-1 and AKT signaling. Molecular Cancer Therapeutics 14(5):1171-80, 2015. doi: 10.1158/1535-7163.MCT-14-0708. Epub 2015 Feb 18. PMID: 25695954.
  11. Samir A, Elgamal BM, Gabr H, and Sabaawy HE. Nanotechology applications in hematological malignancies. Oncology Reports Sep;34(3):1097-105, 2015. doi: 10.3892/or.2015.4100. Epub 2015 Jul 2. PMID: 26134389.
  12. Hong X, Liu W, Song R, Shah J, Feng X, Tsang CK, Morgan K, Bunting S, Inuzuka H, Zheng XF, Shen Z, Sabaawy HE, Liu LX, Pine S. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic acid Research 2016 Aug 26. pii: gkw748. [Epub ahead of print].
  13. Pena O, Hockings C, Contento G, Rowell J, Sabaawy H, Enver T, Payne EM. Transgenic zebrafish expressing the human TEL-AML1 oncogene have aberrant developmental myelopoiesis. Blood 128(22):2711, 2016.
  14. Bansal N, Bartucci M, Yussuf S, Davis S, Huselid E, Cao L, Sydorenko N, Moon YC, Sindhu TS, Zhong H, Stein MN, Kim IY, Medina DJ, Davis TW, DiPaola RS, Bertino JR, and Sabaawy, HE. Development of inhibitors targeting Bmi-1 in patient derived prostate tumor-initiating cells. Clinical Cancer Research 2016, Jun 15. pii: clincanres.3107.2015. [Epub ahead of print]. PMID: 27307599.
  15. Bartucci M, Ferrari A, Kim IY, Ploss A, Yarmush M, Sabaawy HE. Personalized medicine approaches in prostate cancer employing patient derived 3D organoids and humanized mice. Frontiers Cell Developmental Biology 2016, PMID: 27446916, PMCID: PMC4917534, DOI: 10.3389/fcell.2016.00064.
  16. Bartucci M, Hussein MS, Huselid E, Flaherty K, Patrizii M, Amiri S, Kui C, Bigos RA, Gilleran GA, El Ansary MMS, Awad MAM, Kimball SD, Augeri DJ, Sabaawy HE. Synthesis and characterization of novel BMI-1 inhibitors targeting cellular self-renewal in hepatocellular carcinoma. Targeted Oncology 2017 Jun 6. doi: 10.1007/s11523-017-0501-x. [Epub ahead of print].
  17. Bartucci M, Flaherty K, Khiabanian H, Chen Y, Yusuff S, Patrizii M, Bansal N, Wang Y, Zhong H, Sadimin E, Aviv H, Kwon J, Stein MN, Bertino JR, DiPaola RS, Yarmush M, Kim IY, Ferrari A, and Sabaawy HE. Generation of patient derived organoids from early-stage prostate adenocarcinomas. (Under revision; Cancer Discovery).
  18. Patrizii M, Huselid E, Bartucci M, Pine SR, and Sabaawy HE. Utility of glioblastoma patient-derived orthotopic xenografts (PDOXs) in drug discovery and personalized cancer therapy. (In press; Frontiers in Oncology).

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