Researcher Publications

Zhiyuan Shen, MD, PhD

Selected Publications

  1. Roberto Droz-Rosario, Huimei Lu, Jingmei Liu, NingAng Liu, Shridar Ganesan, Bing Xia, Bruce G. Haffty, and Zhiyuan Shen. Roles of BCCIP deficiency in mammary tumorigenesis. Breast Cancer Research 2017, 19:115.
  2. Huhn SC, Liu J, Ye C, Lu H, Jiang X, Feng X, Ganesan S, White E, Shen Z. Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene 2017;36:4750-66
  3. Ba Q, Li X, Huang C, Li J, Fu Y, Chen P, Duan J, Hao M, Zhang Y, Li J, Sun C, Ying H, Song H, Zhang R, Shen Z, Wang H. BCCIPbeta modulates the ribosomal and extraribosomal function of S7 through a direct interaction. Journal of molecular cell biology 2017;9:209-19
  4. Anantha RW, Simhadri S, Foo TK, Miao S, Liu J, Shen Z, Ganesan S, Xia B. Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance. Elife 2017;6
  5. Zhang C, Liu J, Huang G, Zhao Y, Yue X, Wu H, Li J, Zhu J, Shen Z, Haffty BG, Hu W, Feng Z. Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes & development 2016;30:1956-70
  6. Hong X, Liu W, Song R, Shah JJ, Feng X, Tsang CK, Morgan KM, Bunting SF, Inuzuka H, Zheng XF, Shen Z, Sabaawy HE, Liu L, Pine SR. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic acids research 2016;44:8855-69
  7. Wei L, Nakajima S, Bohm S, Bernstein KA, Shen Z, Tsang M, Levine AS, Lan L. DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination. Proceedings of the National Academy of Sciences of the United States of America 2015;112:E3495-504
  8. Yu H, Yue X, Zhao Y, Li X, Wu L, Zhang C, Liu Z, Lin K, Xu-Monette ZY, Young KH, Liu J, Shen Z, Feng Z, Hu W. LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. Nature communications 2014;5:5218
  9. Yue J, Lu H, Lan S, Liu J, Stein MN, Haffty BG, Shen Z. Identification of the DNA repair defects in a case of dubowitz syndrome. PLoS One 2013;8:e54389
  10. Jiang X, Yue J, Lu H, Campbell N, Yang Q, Lan S, Haffty BG, Yuan C, Shen Z. Inhibition of filamin-a reduces cancer metastatic potential. Int J Biol Sci 2013;9:67-77
  11. Yue J, Huhn S, Shen Z. Complex roles of filamin-A mediated cytoskeleton network in cancer progression. Cell Biosci 2013;3:7
  12. Huang YY, Dai L, Gaines D, Droz-Rosario R, Lu H, Liu J, Shen Z. BCCIP Suppresses Tumor Initiation but Is Required for Tumor Progression. Cancer Res 2013;73:7122-33
  13. Yue J, Lu H, Liu J, Berwick M, Shen Z. Filamin-A as a marker and target for DNA damage based cancer therapy. DNA Repair (Amst) 2012;11:192-200
  14. Yue J, Lan S, Yuan C, Shen Z. Prognostic values of filamin-A status for topoisomerase II poison chemotherapy. Int J Biol Sci 2012;8:442-50
  15. Huang YY, Lu H, Liu S, Droz-Rosario R, Shen Z. Requirement of mouse BCCIP for neural development and progenitor proliferation. PLoS One 2012;7:e30638
  16. Shen Z. Genomic instability and cancer: an introduction. Journal of molecular cell biology 2011;3:1-3
  17. Lu H, Huang YY, Mehrotra S, Droz-Rosario R, Liu J, Bhaumik M, White E, Shen Z. Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes. PLoS Genet 2011;7:e1002291
  18. Yue J, Wang Q, Lu H, Brenneman M, Fan F, Shen Z. The cytoskeleton protein filamin-A is required for an efficient recombinational DNA double strand break repair. Cancer Res 2009;69:7978-85
  19. Liu J, Lu H, Ohgaki H, Merlo A, Shen Z. Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas. BMC Cancer 2009;9:268
  20. Fan J, Wray J, Meng X, Shen Z. BCCIP is required for the nuclear localization of the p21 protein. Cell Cycle 2009;8:3019-24
  21. Wray J, Liu J, Nickoloff JA, Shen Z. Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress. Cancer Res 2008;68:2699-707
  22. Meng X, Yue J, Liu Z, Shen Z. Abrogation of the transactivation activity of p53 by BCCIP down-regulation. J Biol Chem 2007;282:1570-6
  23. Meng X, Fan J, Shen Z. Roles of BCCIP in chromosome stability and cytokinesis. Oncogene 2007;26:6253-60
  24. Lu H, Yue J, Meng X, Nickoloff JA, Shen Z. BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage. Nucleic acids research 2007;35:7160-70
  25. Lu H, Guo X, Meng X, Liu J, Allen C, Wray J, Nickoloff JA, Shen Z. The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. Mol Cell Biol 2005;25:1949-57

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