Researcher Publications

Shridar Ganesan, MD, PhD

Selected Publications

1.Thatcher T, Ganesan S, Askar A, Rabitz H. A hybrid approach to modeling thedynamics of macromolecules. J Chem Phys 1986; 85:3655-3673.

2.Zawalich W, Zawalich K, Ganesan S, Calle R, Rasmussen H. Effects of thePhorbol elster 12-O-tetracecanoylphorbol-13-acetate on islet cell responsiveness. Biochem J 1990; 278:49-56.

3.Ganesan S, Calle R, Zawalich K, Smallwood J, Zawalich W, Rasmussen H. Glucose-induced translocation of protein kinase C in rat pancreatic islets. Proc Natl Acad Sci USA 1990; 87: 807-813.

4.Zawalich W, Zawalich K, Ganesan S, Calle R, Rasmussen H. Influence Of staurosporine on glucose-mediated and glucose-conditioned insulin secretion. Biochem J 1991; 279:807-813.

5.Ganesan S, Calle R, Zawalich K, Zawalcih W, Rasmussen H. Immunocytochemical localization of alpha-protein kinase C during glucose-induced insulin secretion in rat beta-cells. J Cell Biol 1992; 119:313-323.

6.Calle R, Ganesan S, Smallwood J, Zawalich W, Rasmussen H. MARCKS phosphorylation during glucose-induced insulin secretion from isolated pancreatic islets. J Biol Chem 1992; 267:18723-18727.

7.Scully R, Ganesan S, Brown M, De Caprio JA, Cannistra SA, Feunteun J, Schnitt S, Livingston DM. Location of BRCA1 in human breast and ovarian cancer cells. Science 1996; 272:123-125.

8.Scully R, Ganesan S, Vlasakova K, Chen J, Socolovsky M, Livingston DM. Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell 1999; 4:1093-1099.

9.Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA. Telomere Dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nature Genet. 2000 26:85-88.

10.Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, Grompe M, D'Andrea AD. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell 2001 7:249-262.

11.Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, Wahrer DC, Sgroi DC, Lane WS, Haber DA, Livingston DM. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell. 2001 105:149-160.

12.Ludwig T, Fisher P, Ganesan S, Efstratiadis A. Tumorigenesis in mice carrying a truncating Brca1 mutation. Genes Dev 2001; 15: 1188-1193.

13.Ganesan S, Silver DP, Greenberg RA, Avni D, Drapkin R, Miron A, Mok SC, Randrianarison V, Brodie S, Salstrom J, Rasmussen TP, Klimke A, Marrese C, Marahrens Y, Deng C-X, Feunteun J, Livingston DM. BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome. Cell 2002; 111: 393-405.

14.Avni, D., Yang, H., Martelli, F., Hofmann, F., ElShamy W., Ganesan S and Livingston, D. Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage. Mol. Cell 2003 Vol 12: 735-746.

15.Kanellopoulou C, Muljo SA, Kung AL, Ganesan S, Drapkin R, Jenuwein T, Livingston DM, and Rajewsky K. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev. 2005; 19: 489-501.

16.Richardson AL, Wang ZC, DeNicolo A, Brown M, Miron A, Liao X, Iglehart JD, Livingston DM, Ganesan S.  X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell, 2006; 9(2):121-132.

17.G. Alexe, G. S. Dalgin, D. Scanfeld, P. Tamayo, J. Mesirov, C. Delisi, L. Harris, N. Bernard, M. Martel, A. Levine, S. Ganesan**, G. Bhanot**, ‘High Expression of Lymphocyte Associated Genes in node-negative HER2+ breast cancer correlates with lower recurrence rates’, Cancer Research, 2007; 67(22): 10669-76.

18.Hall BH, Ianosi-Irimie M, Javidian P, Chen W, Ganesan S, Foran DJ. Computer-assisted assessmentof the human epidermal growth factor receptor 2 immunohistochemical assay in imaged histologic sections using a membrane isolation algorithm and quantitative analysis of positive controls. BMC Med Imaging. 2008 Jun 5;8:11. doi: 10.1186/1471-2342-8-11.

19.Bouwman P, Amal A, Escandell P, Pieterse M, Bartkova J, van der Gulden H, Hiddingh S, Thanasoula M, Kulkarni A, Yang Q, Haffty BG, Tommiska J, Blomqvist C,  Drapkin R, Adams DJ, Nevanlinna H, Bartek J, Tarsounas M, Ganesan S, and Jonkers J, 53BP1 loss abrogates DNA damage responses in Brca1 null cells and is associated with triple-negative and BRCA-mutated breast cancers. Nature Struc Molec Bio 2010. 17(6):688-95. PMID: 20453858, PMCID:  PMC2912507.

20.Ginjala, V, Nacerddine, K, Kulkarni, A, Oza, J, Hill, S.J, Yao, M, Citterio, E, van Lohuizen, M, and Ganesan, S. BMI1 is recruited to DNA breaks and contributes to DNA damage induced H2A ubiquitination and repair. Mol Cell Biol. 2011 31(10) 1972-82. PMID:21383063.  PMCID:  PMC3133356.

21.Bilal E, Vassallo K, Toppmeyer D, Barnard N, Rye IH, Almendro V, Russnes H, Børresen-Dale AL, Levine AJ, Bhanot G, Ganesan S. Amplified Loci on Chromosomes 8 and 17 Predict Early Relapse in ER-Positive Breast Cancers. PLoS One. 2012;7(6):e38575. PMID:   22719901, PMCID:  PMC3374812.

22.Neboori HJ, Haffty BG, Wu H, Yang Q, Aly A, Goyal S, Schiff D, Moran MS, Golhar R, Chen C, Moore D, Ganesan S. Low p53 Binding Protein 1 (53BP1) Expression Is Associated With Increased Local Recurrence in Breast Cancer Patients Treated With Breast-Conserving Surgery and Radiotherapy. Int J Radiat Oncol Biol Phys. 2012 Apr 18. [Epub ahead of print] PMID: 22520477.

23.Nacerddine K, Beaudry JB, Ginjala V, Westerman B, Mattiroli F, Song JY, van der Poel H, Ponz OB, Pritchard C, Cornelissen-Steijger P, Zevenhoven J, Tanger E, Sixma TK, Ganesan S, van Lohuizen M. Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase ligase activity, and DNA damage repair activity in mouse prostate cancer. J. Clin Invest. 2012 May 1;122(5):1920-32. PMID: 22505453, PMCID:  PMC3336972.

24.Basavanhally A, Feldman M, Shih N, Mies C, Tomaszewski J, Ganesan S, Madabhushi A. Multi-field-of-view strategy for image-based outcome prediction of multi-parametric estrogen receptor-positive breast cancer histopathology: Comparison to Oncotype DX. J. Path. Inform., 2:1, 2012.

25.Jaspers JE, Kersbergen A, Boon U, Sol W, van Deemter L, Zander SA, Drost R, Wientjens E, Ji J, Aly A, Doroshow JH, Cranston A, Martin NM, Lau A, O'Connor MJ, Ganesan S, Borst P, Jonkers J, Rottenberg S. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov. 2013 Jan;3(1):68-81. PMID: 23103855.

26.Kulkarni A, Oza J, Yao M, Sohail H, Ginjala V, Tomas-Loba A, Horejsi Z, Tan AR, Boulton SJ, Ganesan S. Tripartite motif-containing 33 (TRIM33) functions in the Poly(ADP-ribose)polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer-1 (ALC1). J Biol Chem. 2013 288(45): 32357-69. PMID: 23926104, PMCID: PMC3820871.

27.Xu J, Xiang L, Wang G, Ganesan S, Feldman M, Shih NN, Gilmore H, Madabhushi A. Sparse Non-negative Matrix Factorization (SNMF) based color unmixing for breast histopathological image analysis. Comput Med Imaging Graph. pii: S0895-6111(15)00077-4. PMID: 25958195. 2015.

28.Stein MN, Hirshfield KM, Zhong H, Singer EA, Ali SM, Ganesan S. Response to Crizotinib in a Patient with MET-mutant Papillary Renal Cell Cancer After Progression on Tivantinib. Eur Urol. 2015; 67(2): 353-4.  PMID: 25457019.

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