Researcher Publications

X. F. Steven Zheng, PhD

Selected Publications

  • Zhang, YJ, Huang, B., Wang, HY., Chang, A. and X.F. Zheng. Emerging Role of MicroRNAs in mTOR Signaling. Cell. Mol. Life Sci. 2017, Jul;74(14):2613-2625. Epub 2017 Feb 25. doi:10.1007/s00018-017-2485-1.
  • Li, Y., Kwan Tsang, C., Wang, S., Li, X., Yang, Y., Fu, L., Huang, W., Li, M., Wang, H.-Y. and Zheng, X.F. MAF1 Suppresses AKT-mTOR Signaling and Liver Cancer through Activation of PTEN Transcription. Hepatology, (2016). 63:1928-42. doi: 10.1002/hep.28507.
  • Yang, X.Z., Li, X.X., Zhang, Y.J., Rodriguez-Rodriguez, L., Xiang, M.Q., Wang, H.Y. and Zheng, X.F.* Rab1 in Cell Signaling, Cancer and Other Diseases. Oncogene, 2016, 35(44):5699-5704. doi: 10.1038/onc.2016.81
  • Wu, TJ, Wang, XW, Zhang, YJ, Meng, L.H., Kerrigan, J, Burley, SK and Zheng, X.F. Identification of a non-gatekeeper hotspot for drug-resistant mutations in mTOR kinase using a novel S. cerevisiae system, Cell Reports (2015). 11:446-459.
  • Thomas JD*, Zhang, YJ*, Wei, YH, Cho JH, Wang HY and Zheng, X.F. Rab1 is an mTORC1 activator and a colorectal oncogene, Cancer Cell (2014). 26, 754-769 (*co-first authors) (Featured in Preview by Cancer Cell 26, 601-602; Research Watch by Cancer Discovery November 10, 2014)
  • Tsang, CK, Liu, Y, Thomas, JD, Zhang, YJ and Zheng, X.F. Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance, Nature Communications (2014). 5:3446 doi:10.1038/ncomms4446
  • Wei, Y.H., Tsang, C.K., and Zheng, X.F. Regulatory Mechanisms of Pol III-dependent Transcription by TORC1, The EMBO Journal (2009). 28: 2220-2230
  • Tsang, C.K., Li, H. and Zheng, X.F. Nutrient Starvation Promotes Condensin Loading to Maintain rDNA Stability, The EMBO Journal. (2007). 26: 448-458. (This paper was featured in: EMBO Journal Online, 2007)
  • Tsang, C.K. Qi, H.Y. Liu, L.F. Zheng, X.F.* Targeting mammalian target of rapamycin (mTOR) for health and diseases, Drug Discovery Today 2007; 12: 112-124
  • Li, H., Tsang, C.K., Watkins, M., Bertram, P.G. and Zheng, X.F. Nutrient Regulates Tor1 Nuclear Localization and Association with rDNA Promoter, Nature (2006). 442, 1058-1061 (featured by Science’s STKE Vol. 2006, Issue 351, pp. tw302, 5 September 2006; Cell Metabolism 2006, 4:259-260)
  • Tsang, C.K., Bertram, P.G., Ai, W.D., Drenan, R. and Zheng, X.F. Chromatin-mediated Regulation of Nucleolar Structure and RNA Polymerase I Localization by TOR, The EMBO Journal (2003). 22: 6045-6056
  • Choi, J.H., Bertram, P.G., Drenan, R., Carvalho, J., Zhou, H. and Zheng, X.F. FKBP12-Rapamycin-Associated Protein (FRAP) Is A CLIP-170 Kinase, The EMBO Reports (2002). 3: 988-994
  • Ai, W.D., Bertram, P.B., Tsang, C.K, Chan, T.F. and Zheng, X.F. Regulation of Subtelomeric Silencing during Stress Response, Molecular Cell (2002). 10: 1295-1305
  • Choi, J., Adames, N.R., Chan, T.F., Zeng, C.B., Cooper, J.A. and Zheng, X.F. TOR Signaling Regulates Microtubule Stability and Functions. Current Biology (2000). 10: 861-864
  • Chan, T.F., Carvalho, J., Riles, L. and Zheng, X.F. A Chemical Genomics Approach towards Understanding the Global Functions of TOR. Proc Natl Acad Sci USA (2000). 97: 13227-13232.

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