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ProtocolTrial Name and Objective

Psychological Interventions for Gynecologic Cancer

Very little is known in the psycho-oncology literature about why psychological interventions are effective or for how long these interventions exert an impact. Given many cancer patients experience recurrence and/or progression, it is important to know whether our relatively brief interventions facilitate how patients cope with this most-feared medical event. From a theoretical perspective, the study will advance our understanding of the mechanisms for change for two common treatment approaches, supportive and cognitive behavioral therapies.
Primary Objective: To evaluate the efficacy of CCI, SC, and Usual Care (UC) on patients' long-term general and cancer-specific psychological adaptation, concerns about recurrence/progression, and quality of life, and to determine whether intervention effects are moderated by disease recurrence.
Secondary Objective: To evaluate the cognitive, social, emotional, and behavioral processes which mediate CCI and SC's effects on patients' long-term general and cancer-specific psychological adaptation, concerns about recurrence/progression, and quality of life.


Revisiting the Methods to Calculate Carboplatin Dose in Women with Gynecologic Cancers A Retrospective Chart Review

The purpose of this study is to evaluate the precision and accuracy of creatinine clearance estimation by the Cockcroft-Gault, Jelliffe, and Wright formula and determine which formula is the best substitute for the gold standard of GFR estimation for the purpose of carboplatin dosing in a gynecologic oncology population.


Dietary Inflammatory Index and Ovarian Cancer Risk

Our study aims to evaluate the role of a new dietary inflammatory index in predicting ovarian cancer risk. We will also compare results with those obtained with the Healthy Eating Index.


A Phase III Trial of Adjuvant Chemotherapy as Primary Treatment for Locally Advanced Cervical Cancer Compared to Chemoradiation Alone: THE OUTBACK TRIAL (ANZGOG 0902/GOG-0274/RTOG 1174)

The aim of this study is to test the potential benefit of the addition of adjuvant chemotherapy following completion of primary chemoradiation for patients with locally advanced cervical cancer.
The primary objective will be to determine if the addition of adjuvant chemotherapy to standard cisplatin-based chemoradiation improves overall survival.
Secondary objectives will be to determine:
 Progression-free survival rates
 Acute and long-term toxicities
 Patterns of disease recurrence
 The association between radiation protocol compliance and outcomes
 Patient quality of life, including psycho-sexual health
Tertiary objectives will be to determine:
 The association between the results of a follow-up PET scan performed 4 - 6 months post completion of chemo-radiation and outcomes for all patients in the trial
 Biological predictors of patients outcomes based on translational laboratory studies of blood and tissue specimens


Phase IB Study of MK-3475 in Subjects with Select Advanced Solid Tumors

To evaluate preliminary signals of potential anti-tumor activity of MK-3475
in subjects with a given a histopathologic type of PD-L1 positive advanced solid tumor based on RECIST 1.1 as determined by the investigator in specific tumor indications