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Gatza Laboratory - Select Publications

  1. Khella CA, Mehta GA, Mehta RN, and Gatza ML. (2021). Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer. Journal of Personalized Medicine 11 (2): 149
  2. Mehta GA, Angus SP, Khella CA, Tong K, Khanna P, Dixon SAH, Verzi MP, Johnson GL, and Gatza ML (2021). SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2. NPJ Breast Cancer 7 (1): 40
  3. Angus SP, et al. (2021). FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036. NPJ Breast Cancer 7 (1): 51
  4. Omene C, Ma L, Moore J, Ouyang H, Illa-Bochaca I, Chou W, Patal M, Sebastiano C, Demaria S, Mao JH, Karagoz K, Gatza ML, Barcellos-Hoff MH. (2020) Aggressive mammary cancers lacking lymphocytic infiltration arise in irradiated mice and can be prevented by dietary intervention. Cancer Immunology Research. Online 21Dec2019. PMCID: Pending
  5. Mehta GA, Khanna P, and Gatza ML. (2019). Emerging role of Sox proteins in breast cancer development and maintenance. Journal of Mammary Gland Biology and Neoplasia. 24:213-230 PMCID: PMC6790170.
  6. Karagoz K, Mehta GA, Khella CA, Khanna P, and Gatza ML (2019). Integrative proteogenomic analyses of human tumours identifies ADNP as a novel oncogenic mediator of cell cycle progression in high-grade serous ovarian cancer with poor prognosis. EBioMedicine. 50:191-202. PMCID: PMC6921307
  7. Wrobel JA, Xie L, Wang L, Liu C, Gallagher KK,Rashid N, Xiong Y, Konze KD, Jin J, Gatza ML, and Chen X (2019). Multi-omic dissection of oncogenically active epiproteomes identifies drivers of proliferative or invasive breast tumors. iScience 17:359-378. PMCID: PMC6660457
  8. Kanlikilicer P, Bayraktar R, Denizli M, Rashed M, Ivan C, Aslan B, Mitra R, Karagoz K, Bayraktar E, Zhang X, Rodriguez-Aguayo C, Kahraman N, Baydogan S, Ozkayar O, Gatza ML, Ozpolat B, Calin G, Sood AK, and Lopez-Berestein G (2018). Exosomal miRNA confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in Ovarian Cancer. EBioMedicine. Online 25-Nov-2018.   PDF
  9. Ren J, Karagoz K, Gatza ML, Sadimir E, Singer E, Foran D, Xin Q (2018). Recurrence analysis on prostate cancer patients with Gleason Score 7 using integrated histopathology whole-slide images and genomic data through deep neural networks. Journal of Medical Imaging. PDF
  10. Thomas A, Routh ED, Pullikuth A, Jin G, Su J, Chou JW, Hoadley KA, Print C, Knowlton N, Black MA, Demaria S, Wang E, Bedognetti D, Jones WD, Mehta GA, Gatza ML, Perou CM, Page DB, Triozzi P and Miller LB. (2018). Tumor mutational burden is a determinant of immune-mediated survival in breast cancer. OncoImmunology. 7(10) e140854. PMCID: Pending PDF
  11. Perekatt, AO Pooja Shah P, Cheung S, Wu A, Gandi H, Kuma N, Fang Q, Jariwala N, Patel N, Cehn L, Joshi S, Ahou A, Taketo MM, Xing J, Gatza ML, White EP, Verzi MP. (2018). SMAD4 suppresses WNT-driven de-differentiation and oncogenesis in the differentiated gut epithelium. Cancer Research 78 (17), 4878-4890. PMCID: PMC6125228. PDF
  12. Serrao A, Jenkins LM, Chumanevich A, Horst B, Liang J, Gatza ML, Lee NY, Roninson I, Broude E, and Mythreye K (2018). Mediator kinase CDK8/CDK19 drives YAP1 dependent BMP4 induced EMT in cancer. Oncogene. 37(35):4792-4808. PMCID: Pending PDF
  13. Liu J, Zhang C,  Zhao Y, Yue X, Huang S, Chen J, Wu H, Tomsky K, Teutle M, Khella CA, Gatza ML, Xia D, Gao J; Haffty BG, Hu W, Feng Z. (2017). Parkin targets HIF-1α for ubiquitination and degradation to inhibit tumor progression. Nature Communications. Online 28 Nov 2017  PDF
  14. Brighton HE, Angus SP, Bo T, Roques J, Tagliatela AC, Darr DB, Karagoz K, Sciaky N, Gatza ML, Sharpless NE, Johnson GL, and Bear JE (2017). Intravital imaging of melanoma in combination with molecular analysis reveals key changes in stromal ECM and tumor reprogramming in response to MEKi. Cancer Research. Online 27 Nov 2017 PDF
  15. Lu K, Alcivar AL, Ma J, Foo TK, Zywea S, Huo Y, Kensler TW, Gatza ML and Xia B (2017). NRF2 induction supporting breast cancer cell survival is enabled by oxidative stress-induced DPP3-KEAP1 interaction. Cancer Research. Online April 17, 2017. PDF  
  16. Mehta GA, Parker JS, Silva GO, Hoadley KA, Perou CM, Gatza ML. (2017). Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer. Breast Cancer Research and Treatment. 162(3):439-450. PDF  
  17. Mertins P, Mani DR, Ruggles KV, Gillette MA, Clauser KR, Wang P, Wang X, Qiao JW, Cao S, Petralia F, Kawaler E, Mundt F, Krug K, Tu Z, Lei JT, Gatza ML, Wilkerson M, Perou CM, Yellapantula V, Huang KL, Lin C, McLellan MD, Yan P, Davies SR, Townsend RR, Skates SJ, Wang J, Zhang B, Kinsinger CR, Mesri M, Rodriguez H, Ding L, Paulovich AG, Fenyö D, Ellis MJ, Carr SA; NCI CPTAC. (2016). Proteogenomics connects somatic mutations to signaling in breast cancer. Nature. 534(7605):55-62. PDF  
  18. Gatza ML and Carey LA (2016). Another breast cancer entity confirmed: Genomics of invasive lobular breast cancer. Journal of Clinical Oncology. 34(16):1838-9. PDF  
  19. Ciriello G*, Gatza ML*, et al. (2015). Comprehensive molecular characterization of invasive lobular breast tumors. Cell. 163(2):506-19. *Authors contributed equally PDF  
  20. Silva GO, He X, Parker JS, Gatza ML, et al.  (2015). Across Species DNA Copy Number Analyses Identifies Subtype-Specific Drivers of Breast Cancer Development. Breast Cancer Research and Treatment. 152(2):347-356. PDF  
  21. Young CD, Zimmerman LJ, Hoshino D, Formisano L, Hanker AB, Gatza ML, et al.  (2015). Activating PIK3CA mutations induce an EGFR/ERK paracrine signaling axis in basal-like breast cancer. Molecular and Cellular Proteomics. 14(7):1959-76. PDF  
  22. Tian H, Liu J, Chen J, Gatza ML, Blobe GC (2015). Fibulin-3 is a Novel TGF-β pathway Inhibitor in the Breast Cancer Microenvironment. Oncogene. Online March 2015. PDF  
  23. Gatza ML, et al. (2014). An integrated genomics approach identifies drivers of proliferation in luminal subtype human breast cancer. Nature Genetics. 46(10): 1051-1059. PDF  
  24. Shats I, Gatza ML, et al. (2013). Cooperation between E2F1 and FOXO transcription factors provides a mechanism for control of E2F1-mediated transcription by survival signaling. Cancer Research.  73(19):6056-67. PDF  
  25. Liu B, Shats I, Angus S, Gatza ML, Nevins JR (2013). Interaction of E2F7 with E2F1 and C-terminal binding protein (CtBP) provides a mechanism for E2F7-dependent transcription repression. Journal of Biological Chemistry. 288(34):245281-24589. PDF  
  26. Mythreye K, Knelson EH, Gatza CE, Gatza ML, Blobe GC. (2013). TβRIII/β-arrestin2 suppresses epithelial derived cancer progression by regulating integrin α5β1 trafficking, function, and localization. Oncogene. 32 (11): 1416–1427. PDF  
  27. Gatza ML, et al. (2011). Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes. Breast Cancer Research13(3):R62. (Highly Accessed) PDF>  
  28. Chang JT, Gatza ML, et al. (2011). SIGNATURE: A workbench for gene expression signature analysis. BMC Bioinformatics. 12(1):443. (Highly Accessed). PDF  
  29. Gatza CE, Holtzhausen A, Kirkbride KC, Morton A, Gatza ML, et al. (2011). The Type III TGF-β Receptor enhances colon cancer cell migration and anchorage independent growth. Neoplasia. 13(8): 758-770. PDF
  30. Shats I, Gatza ML, et al. (2011). Using a stem cell-based signature to guide therapeutic selection in cancer. Cancer Research. 71(5): 1772-1780. PDF
  31. Gatza ML, et al. (2010).  A pathway based classification of human breast cancer. Proc. Nat’l. Acad. Sci. 107(15):6994-6999. PDF
  32. Andrechek ER, Cardiff RD, Chang JT, Gatza ML, et al. (2009). Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potential. Proc. Nat’l Acad. Sci. 106 (38):16387-16392. PDF
  33. Mori S, Chang JT, Andrecheck ER, Matsumura N, Baba T, Yao G, Kim JW, Gatza M, et al. (2009).  Anchorage-independent cell growth signature identified tumors with metastatic potential. Oncogene. 28 (31): 2796-2805.  PDF
  34. Chang JT, Carvalho C, Mori S, Bild AH, Gatza ML, et al (2009).  A Genomic strategy to elucidate modules of oncogenic pathway signaling networks. Molecular Cell. 34(1): 104-114. PDF
  35. Gatza ML, et al. (2007). Ubiquitination of HTLV-I Tax mediates TSS complex disruption and Tax nuclear export in response to DNA damage. Retrovirology. 4: 95. PDF
  36. Gatza ML and Marriott SJ. (2006).Genotoxic stress and cellular stress alter the subcellular distribution of human T cell leukemia virus type 1 Tax through a CRM1 dependent mechanism.  Journal of Virology.  80 (13): 6657- 6668. PDF
  37. Gatza ML, et al. (2005). Impact of transforming viruses on cellular mutagenesis, genome stability, and cellular transformation. Environmental and Molecular Mutagenesis. 45 (2-3): 304-325. PDF
  38. Gatza ML, et al. (2003) Cellular Transformation by the HTLV-Tax protein, a jack-of-all-trades. Oncogene. 22 (33):5141-5149. PDF