Yibin Kang, PhD Director of Transgenic/Knock-out Mouse Shared Resource Warner-Lambert/Parke-Davis Professor of Molecular Biology Princeton University 255 Lewis Thomas Laboratory Washington Road Princeton, NJ 08544 Phone: (609) 258-8834 Email: ykang@princeton.edu Assistant: Amanda Denzer-King (609) 258-6224 Email: adenzer@princeton.edu

Research Program Alignment

• Genomic Instability and Tumor Progression Program

Membership Type: Full

Selected Publications

Kang Y, Chen C, and Massagué J. (2003) A self-enabling TGFb response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol. Cell, 11:915-26. PMID:12718878

Kang Y, Siegel PM, Shu WP, Drobnjak M, Kakonen SM, Cordón-Cardo C, Guise TA, and Massagué J. (2003) A multigenic program mediating breast cancer metastasis to bone. Cancer Cell, 3:537-49. (Cover Article) PMID: 12842083

Kang Y and Massagué J. (2004) Epithelial-mesenchymal transition: twist in development and metastasis. Cell, 118:277-9. PMID: 15294153

Kang Y, He W, Tulley S, Gupta GP, Serganova I, Chen C, Manova-Todorava K, Blasberg R, Gerald WL, and Massagué J. (2005) Breast cancer bone metastasis mediated by Smad tumor suppressor pathway. Proc. Natl. Acad. Sci., 102: 13909-14. PMID: 16172383

Korpal M, Lee ES, Hu G, and Kang Y. (2008) The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J. Biol. Chem., 283:14910-4. PMID: 18411277

Hu G, Chong RA, Yang Q, Wei Y, Blanco MA, Li F, Reiss M, Au JL-S, Haffty B, and Kang Y. (2009) MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell, 15(1):9-20. (Cover Article) PMID: 19111877

Lu X and Kang Y. (2009) Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants. Proc. Natl. Acad. Sci., 106(23):9385-90. PMID:19458257

Korpal M, Yan J, Lu X, Xu S, Lerit D, and Kang Y. (2009) Imaging TGF-b signaling dynamics and therapeutic response in breast cancer bone metastasis. Nature Medicine, 15(8):960-6. PMID:19597504

Lu X, Wang Q, Hu G, Van Poznak C, Fleischer M, Reiss M, Massagué J, and Kang Y. (2009) ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes & Dev., 23:1882-1894. (Cover Highlight) PMID: 19608765

Lu X, Yan C, Yuan M, Wei Y, Hu G, and Kang Y. (2010) In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer. Cancer Res., 70:3905-14. (Cover Highlight) PMID: 20442288

Sethi N, Dai X, Winter CG, and Kang Y. (2011) Tumor-derived Jagged1 promotes osteolytic bone metastasis of breast cancer by activating stromal Notch signaling. Cancer Cell, 19:192-205. (Cover Article) PMID: 21295524

Korpal M, Ell BJ, Buffa FM, Ibrahim T, Terrasa AC, Mercatali L, Khan Z, Blanco MA, Goodarzi H, Hua Y, Wei Y, Hu G, Garcia B, Ragoussis J, Amadori D, Harris AL, and Kang Y. (2011) Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nature Medicine, 17:1101–1108. (Cover Article) PMID: 21822286

Blanco MA, Alečković M, Hua Y, Li T, Wei Y, Xu Z, Cristea I, and Kang Y. (2011) Identification of Staphylococcal nuclease domain containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions. J. Biol. Chem., 286:19982-92. PMID: 21478147.

Sethi N and Kang Y. (2011) Unraveling the complexity and dynamics of metastasis: from molecular understanding to targeted therapeutics. Nature Reviews Cancer, 11(10):735-748. PMID: 21941285

Lu X, Mu E, Wei Y, Riethdorf S, Yang Q, Yuan M, Yan J, Hua Y, Tiede BJ, Lu X, Reiss M, Haffty BG, Pantel K, Massagué J, and Kang Y. (2011) VCAM1 promotes osteolytic expansion of indolent bone micrometastases of breast cancer by engaging a4b1-positive osteoclast progenitors. Cancer Cell 20:701-14. (Featured Article) PMID: 22137794