Researcher Profile
![]() | Bing Xia, PhDAssociate Professor of Radiation Oncology Cancer Institute of New Jersey Phone: (732) 235-7410 Assistant: Odalis Sanchez |
Research Program Alignment
Membership Type: Full
Research Interests
- Breast Cancer
- DNA Repair
- DNA Replication
- Genome Instability
- Homologous Recombination
- Cell Cycle Checkpoint
- Fanconi Anemia
Selected Publications
Huo Y, Cai H, Teplova I, Bowman-Colin C, Chen G, Price S, Barnard N, Ganesan S, Karantza V, White E and Xia B. (2013) Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer. Cancer Discovery (Epub ahead of print) PMID: 23650262
Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C# and Livingston DM# (2013) Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc Natl Acad Sci USA 110:8632-7. PMID: 23657012
Anantha RW, Alcivar AL, Ma J, Cai H, Simhadri S, Ule J, König J and Xia B. (2013) Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination. PloS One e61368. PMID: 23585894
Kim JH, Xu EY, Sacks DB, Lee J, Shu L, Xia B, Kong AN. Identification and Functional Studies of a New Nrf2 partner IQGAP1: A critical role in the stability and transactivation of Nrf2. Antioxid Redox Signal, In process, 2012.
Ma J, Cai H, Wu T, Sobhian B, Huo Y, Alcivar A, Mehta M, Cheung
KL, Ganesan S, Kong AN, Zhang DD, Xia
B. PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and
function. Mol Cell Biol, 32:1506-1517, 2012.
Buisson R, Dion-Cote
AM, Coulombe Y, Launay H, Cai H, Stasiak AZ, Stasiak A, Xia B, Masson JY. Cooperation
of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous
recombination. Nat Struct
Mol Biol, 17:1247-1254,
2010.
Tischkowitz
M, Xia B. PALB2/FANCN: recombining cancer and Fanconi
anemia. Cancer Res, 70:7353-7359, 2010.
Zhang F, Ma J,
Wu J, Ye L, Cai H, Xia B, Yu X. PALB2 links
BRCA1 and BRCA2 in the DNA-damage response. Curr
Biol, 19:524-529, 2009.
Erkko
H, Xia B, Nikkila J, Schleutker
J, Syrjakoski K, Mannermaa
A, Kallioniemi A, Pylkas K,
Karppinen SM, Rapakko K, Miron A, Sheng Q, Li G, Mattila
H, Bell DW, Haber DA, Grip M, Reiman M, Jukkola-Vuorinen A, Mustonen A, Kere J, Aaltonen LA, Kosma VM, Kataja V, Soini Y, Drapkin RI, Livingston
DM, Winqvist R. A recurrent
mutation in PALB2 in Finnish cancer families. Nature, 446:316-319,
2007.
Xia B, Dorsman JC, Ameziane N, de Vries Y, Rooimans MA, Sheng Q,
Pals G, Errami A, Gluckman
E, Llera J, Wang W, Livingston DM, Joenje H, de Winter JP. Fanconi
anemia is associated with a defect in the BRCA2 partner PALB2. Nat
Genet, 39:159-161, 2007.
Xia B, Sheng Q, Nakanishi K, Ohashi
A, Wu J, Christ N, Liu X, Jasin M, Couch FJ, and
Livingston DM. (2006) Control of BRCA2 cellular and clinical functions by a
nuclear partner, PALB2. Mol Cell
22:719-729. PMID: 16793542.






