Medical Education Building
1 Robert Wood Johnson Place, Room 478B
New Brunswick, NJ 08903
Inflammatory Bowel Disease (IBD)
Barrett's Epithelium/Esophageal Adenocarcinoma
Novel Biomarker(s) Development for Early Detection of GI Cancers
A Novel In-Vitro Model of Benign Barrett's Cell Transformation to Adenocarcinoma
Molecular Mechanism of Carcinogenesis
Chemo/Prevention Studies Using an In-Vitro Model of Transformation
Animal Models of IBD
Das KM, Dubin R, Nagai T. Isolation and characterization of colonic tissue bound antibodies from patients with idiopathic ulcerative colitis. Proc Natl Acad Sci 75:4528-4532, 1978.
Takahashi F, Das KM. Isolation and characterization of a colonic autoantigen specificity recognized by colon tissue-bound IgG from idiopathic ulcerative colitis. J Clin Invest 76:311-318, 1985.
Das KM, Vecchi M, Sakamaki S, Diamond B. The production and characterization of monoclonal antibodies to a human colonic antigen associated with ulcerative colitis: Cellular localization of the antigen using the monoclonal antibody. J Immunol 139:77-84, 1987.
Das KM, Prasad I, Garla S, Amenta P. Specialized Barrett’s epithelium shares a colon epithelial epitope as detected by a novel monoclonal antibody. Ann Int Med, 120753-756, 1994.
Glickman JN, Wang H, Das KM, Goyal RK, Spechler SJ, Antonioli D, Odze RD. Phenotype of Barrett’s esophagus and intestinal metaplasia of the distal esophagus and gastroesophageal junction. Am J Surg Pathol 25:87-94, 2001.
Lin JL-C, Geng X, Das-Bhattacharya S, Yu J-R, Reiter RS, Sastri B, Glazier KD, Mirza ZK, Wang KK, Amenta PS, Das KM, Lin JJ-C. Isolation and sequencing of a novel tropomyosin isoform preferentially associated with colon cancer. Gastroenterology 123:152-162, 2002.
Mirza ZK, Das KK, Slate J, Mapitigama RN, Amenta PS, Griffel LH, Ramsundar L, Watari J, Yokota K, Tanabe H, Sato T, Kohgo Y, Das KM. Gastric intestinal metaplasia as detected by a monoclonal antibody is highly associated with gastric adenocarcinoma. Gut, 52:807-812, 2003.
Watari J, Das KK, Amenta PS, Tanabe H, Tanaka A, Geng X, Lin J, Kohgo Y, Das KM. Effect of eradication of Helicobacter pylori on the histology and cellular phenotype of gastric intestinal metaplasia. Clin Gastro Hepatol, 6:409-417, 2008.
Bajpai M, Liu J, Geng X, Souza RF, Amenta PS, Das KM. Repeated exposure to acid and bile selectively induces colonic phenotype expression in a heterogeneous Barrett’s epithelial cell line. Lab Investig 88:643-651, 2008.
Yantiss RK, Das KM, Farraye FA, Odze RD. Alterations in the immunohistochemical expression of Das-1 and CG-3 in colonic mucosal biopsy specimens help distinguish ulcerative colitis from Crohn’s disease and from other forms of colitis. Am J Surg Pathol 32:844-850, 2008.
Watari J, Moriichi K, Tanabe H, Sato R, Fujiya M, Das KM, Kohgo Y. Differences in geneteic instability and cellular phenotype among Barrett’s, cardiac, and gastric intestinal metaplasia in a Japanese population with H. Pylori.Histopathology, 55:261-269, 2009.
Ebert EC, Geng X, Bajpai M, Pan Z, Tatar E, Das KM. Antibody to tropomyosin isoform 5 and complement induce the lysis of colonocytes in ulcerative colitis. Am J Gastroenterol 104:2996-3003, 2009.
Moriichi K, Watari J, Das KM, Tanabe H, Fujiya M, Ashida T, Kohgo Y. Effects of Helicobacter pylori infection on genetic instability, the aberrant CpG island methylation status and the cellular; phenotype in Barrett’s esophagus in a Japanese population. Int J Cancer, 124:1263-1269, 2009.
Das KM, Kong Y, Bajpai M, Kulkarni D, Geng X, Mishra L, Banerjee D, Hirshfield K. Transformation of benign Barrett’s epithelium by repeated acid and bile exposure over 65 weeks: A novel in-vitro model. Intl J Cancer, 128:274-282, 2011.
Watari J, Moriichi K, Tanabe H, Kashima S, Nomura Y, Fujiya M, Tomita T, Oshima
T, Fukui H, Miwa H, Das KM, Kohgo Y. Biomarkers predicting development of metachronous gastric cancer after endoscopic resection: an analysis of molecular pathology of Helicobacter pylori eradication. Int. J. Cancer 130:2349-2358 2012.